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61. 发明申请

WO2009007753A3 4- (3-AMINOPYRAZOLE) -PYRIMIDINE DERIVATIVEE AND THEIR USE AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2009007753A3
公开(公告)日：2009-01-15
申请号：PCT/GB2008/050553
申请日：2008-07-09
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , GUAN, Huiping , IOANNIDIS, Stephanos , LAMB, Michelle , PENG, Bo , SU, Mei , WANG, Tao
发明人： GUAN, Huiping , IOANNIDIS, Stephanos , LAMB, Michelle , PENG, Bo , SU, Mei , WANG, Tao
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , A61K31/506 , A61P35/00
摘要： The present invention relates to compounds of Formula (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a treatment for myeloproliferative disorders and cancer.

62. 发明申请

WO2008005344A3 SYNTHESIS OF 3-(5-NITROCYCLOHEX-1-ENYL) ACRYLIC ACID AND ESTERS THEREOF 审中-公开
标题翻译： 3-（5-硝基环己-1-烯基）丙烯酸及其酯的合成
公开(公告)号：WO2008005344A3
公开(公告)日：2008-04-03
申请号：PCT/US2007015152
申请日：2007-06-29
申请人： SCHERING CORP , THIRUVENGADAM TIRUVETTIPURAM K , WANG TAO , CHIU JOHN S , LIAO JING
发明人： THIRUVENGADAM TIRUVETTIPURAM K , WANG TAO , CHIU JOHN S , LIAO JING
IPC分类号： C07C201/06 , C07C205/55 , C07C251/44
CPC分类号： C07C251/44 , C07C201/06 , C07C249/08 , C07C2601/16 , C07C205/56 , C07C251/42
摘要： This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by a molybdenum VI/VII peroxo complex, the process comprising: (a) providing a substrate of Formula I containing an oxime functional group; Chemical formula should be inserted here as it appears on the abstract in paper form. wherein R 1 and R 2 are selected independently from linear, branched or cyclic alkyl and linear, branched or cyclic alkenyl groups, optionally substituted, with the proviso that at least one of R 1 or R 2 contains a carbon/carbon double bond; and (b) contacting said substrate of Formula I with a molybdenum oxidation complex, thereby oxidizing said oxime functional group to a nitro functional group to yield the structure of Formula III. Chemical formula should be inserted here as it appears on the abstract in paper form. Where R 1 and R 2 are as defined above.
摘要翻译：该申请公开了提供一种通过直接（一步）氧化由钼VI / VII过氧络合物介导的肟官能团将硝基官能团引入到还含有不饱和度和/或氧官能度位点的化合物中的方法该方法包括：（a）提供含有肟官能团的式I的底物; 化学式应插入此处，因为它以摘要形式出现在纸上。其中R 1和R 2独立地选自任选取代的直链，支链或环状烷基和直链，支链或环状烯基，条件是至少一个 R 1或R 2含有碳/碳双键; 和（b）使所述式I的底物与钼氧化络合物接触，由此将所述肟官能团氧化成硝基官能团以产生式III的结构。化学式应插入此处，因为它以摘要形式出现在纸上。其中R 1和R 2如上所定义。

63. 发明申请

WO2007146550A2 ALKENE PIPERIDINE DERIVATIVES AS ANTIVIRAL AGENTS 审中-公开
标题翻译： ALKENE PIPERIDINE DERIVATIVES作为抗病毒剂
公开(公告)号：WO2007146550A2
公开(公告)日：2007-12-21
申请号：PCT/US2007069330
申请日：2007-05-21
申请人： SQUIBB BRISTOL MYERS CO , WANG TAO , HAN YING , KADOW JOHN F , ZHANG ZHONGXING , MEANWELL NICHOLAS A
发明人： WANG TAO , HAN YING , KADOW JOHN F , ZHANG ZHONGXING , MEANWELL NICHOLAS A
CPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D413/06 , C07D413/14
摘要： This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.
摘要翻译：本公开提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。特别地，本公开涉及具有独特抗病毒活性的烯烃哌啶衍生物。更具体地，本公开涉及可用于治疗HIV和AIDS的化合物。

64. 发明申请

WO2006123113A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2006123113A2
公开(公告)日：2006-11-23
申请号：PCT/GB2006/001760
申请日：2006-05-12
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , WANG, Bin , WANG, Tao
发明人： WANG, Bin , WANG, Tao
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14
摘要： This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译：本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。这些新型化合物为癌症提供治疗。

65. 发明申请

WO2006087538A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2006087538A1
公开(公告)日：2006-08-24
申请号：PCT/GB2006/000522
申请日：2006-02-15
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , HAN, Yongxin , LAMB, Michelle , MOHR, Peter , YU, Dingwei , WANG, Bin , WANG, Tao
发明人： HAN, Yongxin , LAMB, Michelle , MOHR, Peter , YU, Dingwei , WANG, Bin , WANG, Tao
IPC分类号： C07D471/04 , C07D403/12 , C07D401/12 , C07D473/32 , A61K31/41 , A61K31/435 , A61K31/495 , A61P35/00
CPC分类号： C07D471/04 , C07D401/12 , C07D403/12 , C07D473/32
摘要： This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译：本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。这些新型化合物为癌症提供治疗。

66. 发明申请

WO2006076452A2 AN EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS 审中-公开
标题翻译：乙酰胺类似物的选择性合成
公开(公告)号：WO2006076452A2
公开(公告)日：2006-07-20
申请号：PCT/US2006001015
申请日：2006-01-12
申请人： SCHERING CORP , SUDHAKAR ANANTHA , KWOK DAW-IONG , WU GEORGE G , GREEN MICHAEL D , THIRUVENGADAM TIRUVETTIPURAM K , LIM NGIAP KIE , WANG TAO , HUANG MINGSHENG
发明人： SUDHAKAR ANANTHA , KWOK DAW-IONG , WU GEORGE G , GREEN MICHAEL D , THIRUVENGADAM TIRUVETTIPURAM K , LIM NGIAP KIE , WANG TAO , HUANG MINGSHENG
IPC分类号： C07D307/92 , C07C235/28 , C07D295/18 , C07D317/72 , C07D405/06 , C07D493/10
CPC分类号： C07D493/10 , C07C235/28 , C07D295/185 , C07D307/92 , C07D317/72 , C07D405/06
摘要： This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence: (Formulae 8A, 7B).
摘要翻译：本申请公开了一种用于合成烟肼类似物的新方法，以及由此制备的化合物。合成通过包括环状缩酮酰胺途径，手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。由此制备的化合物可用作凝血酶受体拮抗剂。本文公开的化学合成例如以下合成顺序：（式8A，7B）。

67. 发明申请

WO2005104722A3 CRUDE EXTRACTS FROM ANDROGRAPHIS PANICULATA 审中-公开
标题翻译：从。PAN。。。。。。。
公开(公告)号：WO2005104722A3
公开(公告)日：2006-03-02
申请号：PCT/US2005014288
申请日：2005-04-26
申请人： HUTCHISON MEDIPHARMA ENTPR LTD , YAN XIAOQIANG , WANG TAO , MA ZHIMING , ZHANG WEIHAN , DUAN JIFEN , CAI YU
发明人： YAN XIAOQIANG , WANG TAO , MA ZHIMING , ZHANG WEIHAN , DUAN JIFEN , CAI YU
IPC分类号： A61K36/19 , A61K35/78
CPC分类号： A61K36/19 , A61K31/365
摘要： This invention relates to a method of inhibiting TNFa or IL-1ß expression with an extract of Andrographis paniculata. The extract contains andrographolide, 14-deoxy-andrographolide, 14-deoxy-I 1, 12-dehydrogenandrographolide, and neoandrographolide.
摘要翻译：本发明涉及用穿心莲子提取物抑制TNFα或IL-1β表达的方法。提取物含有穿心莲内酯，14-脱氧穿心莲内酯，14-脱氧-11,12-脱氢穿心莲内酯和新穿心莲内酯。

68. 发明申请

WO2005103010A2 CHEMICAL COMPOUNDS 审中-公开
标题翻译：用于治疗癌症的吡咯衍生物
公开(公告)号：WO2005103010A2
公开(公告)日：2005-11-03
申请号：PCT/GB2005/001512
申请日：2005-04-20
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , LYNE, Paul , WANG, Bin , WANG, Tao
发明人： LYNE, Paul , WANG, Bin , WANG, Tao
IPC分类号： C07D231/06
CPC分类号： C07D231/06 , C07D231/38
摘要： This invention relates to novel compounds having the formul and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
摘要翻译：本发明涉及具有方法及其药物组合物及其使用方法的新化合物。这些新型化合物为癌症提供治疗。

69. 发明申请

WO2005087223A1 ANDROGRAPHOLIDE AND ANALOGUES AS INHIBITORS OF TNFα AND IL-1βEXPRESSION 审中-公开
标题翻译：作为TNFalpha和IL-1beta表达的抑制剂的石蜡和类似物
公开(公告)号：WO2005087223A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/008317
申请日：2005-03-11
申请人： HUTCHISON MEDIPHARMA LTD. , YAN, Xiaoqiang , WANG, Tao , MA, Zhiming , PAN, Ke , ZHANG, Weihan , HONG, Jianrong , DUAN, Jeff , CAI, Yu
发明人： YAN, Xiaoqiang , WANG, Tao , MA, Zhiming , PAN, Ke , ZHANG, Weihan , HONG, Jianrong , DUAN, Jeff , CAI, Yu
IPC分类号： A61K31/341
CPC分类号： A61K31/365
摘要： This invention relates to a method of inhibiting the expression of TNTα or IL-1β with a compound of the following formula: wherein R 1 and R 2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.
摘要翻译：本发明涉及用下式化合物抑制TNTα或IL-1β的表达的方法：其中R1和R2如本文所定义。它还涉及用这种化合物治疗炎症性肠病的方法。

70. 发明申请

WO2002020797A3 GENES ENCODING POLYPEPTIDES FROM METHYLOMONAS SP. INVOLVED EXOPOLYSACCHARIDE PRODUCTION 审中-公开
公开(公告)号：WO2002020797A3
公开(公告)日：2002-03-14
申请号：PCT/US2001/026831
申请日：2001-08-28
申请人： E.I. DUPONT DE NEMOURS AND COMPANY , KOFFAS, Mattheos , ODOM, James, M. , WANG, Siqun , WANG, Tao , YE, Rick, W.
发明人： KOFFAS, Mattheos , ODOM, James, M. , WANG, Siqun , WANG, Tao , YE, Rick, W.
IPC分类号： C07K14/195
摘要： Genes have been isolated from a Methylomonas sp encoding elements of the exopolysaccharide biosynthetic pathway. The genes and gene products are the first isolated from an organisms capable of utilizing single carbon (C1) substrates as energy sources. The genes are useful for engineering other C1 utilizing microorganisms to make altered levels of exopolysaccharide which is used in a variety of commercial applications.

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