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61. 发明申请

WO2003068983A1 USE OF THE AXL RECEPTOR FOR DIAGNOSIS AND TREATMENT OF RENAL DISEASE 审中-公开
标题翻译：使用AXL受体进行诊断和治疗肾病
公开(公告)号：WO2003068983A1
公开(公告)日：2003-08-21
申请号：PCT/US2003/004186
申请日：2003-02-12
申请人： QUARK BIOTECH, INC. , MOR, Orna
发明人： MOR, Orna
IPC分类号： C12Q1/00
CPC分类号： G01N33/6893 , C12Q1/485 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2800/042 , G01N2800/347
摘要： The invention is directed to a process of identifying a compound capable of inhibiting the activity of a human Axl receptor that comprises contacting the Axl receptor or cells expressing the Axl receptor with the compound; measuring the Axl receptor activity in the presence of the compound; and comparing the activity measured to that measured in the absence of the compound under controlled conditions, wherein a decrease identifies the compound as being capable of inhibiting the activity. Therapeutic and diagnostic applications are also described.
摘要翻译：本发明涉及鉴定能够抑制人类Axl受体活性的化合物的方法，该方法包括使Ax1受体或表达Ax1受体的细胞与该化合物接触; 在化合物存在下测量Ax1受体活性; 并将测量的活性与在控制条件下不存在化合物时测量的活性进行比较，其中减少将该化合物鉴定为能够抑制该活性。还描述了治疗和诊断应用。

62. 发明申请

WO2003058201A3 METHODS FOR IDENTIFYING MARKER GENES FOR CANCER 审中-公开
公开(公告)号：WO2003058201A3
公开(公告)日：2003-07-17
申请号：PCT/US2002/041825
申请日：2002-12-31
申请人： QUARK BIOTECH, INC. , THE CLEVELAND CLINIC FOUNDATION , FEINSTEIN, Elena , GUDKOV, Andrei, V.
发明人： FEINSTEIN, Elena , GUDKOV, Andrei, V.
IPC分类号： C12Q1/00
摘要： The invention describes a method of identifying tissue-specific tumor markers and diagnostic and therapeutic methods and compositions of using the same. More specifically, the invention presents a method for a rational search of diagnostic and prognostic cancer markers and therapeutic targets among the genes negatively regulated by tumor suppressor genes.

63. 发明申请

WO2003025203A2 PREDICTION OF CANCER BY DETECTION OF ATM MUTATIONS 审中-公开
标题翻译：通过检测ATM突变预测癌症
公开(公告)号：WO2003025203A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/030015
申请日：2002-09-20
申请人： QUARK BIOTECH, INC. , GILAD, Shlomit , YAHALOM, Joachim
发明人： GILAD, Shlomit , YAHALOM, Joachim
IPC分类号： C12Q
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2600/156
摘要： There is provided a method of testing a subject to determine if the subject has a predisposition for developing a cancer, a cancer of epithelial origin such as lung cancer, colon cancer, prostate cancer, ovarian cancer, bladder cancer, and cancer of the pancreas, and also a lymphoproliferative malignancy such as Hodgkin's disease and non-Hodgkin's lymphoma. This method includes the steps of detecting a mutation in the open reading frame of the ATM gene (SEQ.ID.NO:1) in a cDNA sample or a genomic DNA sample from the subject, which mutation is selected from the group consisting of the mutations set forth in Table 3 and Table 4; or, detecting a mutation in the mRNA corresponding to the open reading frame of the ATM gene (SEQ.ID.NO:1) in a mRNA sample from the subject, which mutation is selected from the group consisting of RNA complementary to the mutations set forth in Table 3 and Table 4, wherein the presence of such a mutation indicates that the subject has a predisposition for developing cancer. Also provided is an isolated cDNA molecule having a nucleotide sequence which differs from the sequence set forth in SEQ.ID.NO:1 by a mutation selected from the group consisting of mutations 378 T→A, 3383 A→G, 1636 C→G, 2614 C→T, 6437 G→C, 2932 T→C, 2289 T→A, 6096 A→T, 6176 C→T, 6919 C→T, 2442 C→A, 3925 G→A, 6067 G→A, 2119 T→C, 1810 C→T, and 4388 T→G. An oligonucleotide probe which is capable of detecting a mutation in the open reading frame of the ATM gene is also provided. Additionally, kits for detection and prediction of cancer are provided.
摘要翻译：提供了一种测试受试者以确定受试者是否具有发展癌症，上皮来源癌症如肺癌，结肠癌，前列腺癌，卵巢癌，膀胱癌和胰腺癌的倾向的方法，以及淋巴增生性恶性肿瘤如霍奇金病和非霍奇金淋巴瘤。该方法包括检测cDNA样品中的ATM基因（SEQ ID NO：1）的开放阅读框中的突变或来自受试者的基因组DNA样品中的突变，所述突变选自表3和表4所示的突变; 或者检测来自受试者的mRNA样品中与ATM基因（SEQ ID NO：1）的开放阅读框相对应的mRNA的突变，该突变选自与突变组互补的RNA 在表3和表4中，其中存在这样的突变表明受试者具有发生癌症的倾向。还提供了具有与SEQ.ID.NO:1所示序列不同的核苷酸序列的分离的cDNA分子，其选自突变378T} A，3383A} G，1636C} G ，2614 C} T，6437 G} C，2932 T} C，2289 T} A，6096 A} T，6176 C} T，6919 C} T，2442 C} A，3925 G} A，6067 G} A ，2119 T} C，1810 C} T和4388 T} G。还提供了能够检测ATM基因的开放阅读框中的突变的寡核苷酸探针。此外，还提供了用于癌症检测和预测的试剂盒。

64. 发明申请

WO0246364A9 GENES ASSOCIATED WITH MECHANICAL STRESS, EXPRESSION PRODUCTS THEREFROM, AND USES THEREOF 审中-公开
标题翻译：与机械应力相关的基因，其表达产物及其用途
公开(公告)号：WO0246364A9
公开(公告)日：2003-01-23
申请号：PCT/US0146400
申请日：2001-12-04
申请人： QUARK BIOTECH INC , EINAT PAZ , SEGEV ORIT , SKALITER RAMI , FEINSTEIN ELENA , FAERMAN ALEXANDER , SAMACH AVIVA
发明人： EINAT PAZ , SEGEV ORIT , SKALITER RAMI , FEINSTEIN ELENA , FAERMAN ALEXANDER , SAMACH AVIVA
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/02 , A61P19/08 , A61P19/10 , C07K14/47 , C07K14/51 , C07K14/705 , C07K16/18 , C12N15/12 , C12P21/02 , C12Q1/68 , C12N
CPC分类号： C07K14/47 , A61K48/00 , C07K14/51 , C12Q1/6883 , C12Q2600/158
摘要： The disclosure relates to mechanical stress induced genes, and functional equivalents, such as those from humans and from mice, probes therefor, tests to identify such genes, expression products of such genes, uses for such genes and expression products, e.g., in diagnosis (for instance risk determination), treatment, prevention, or control, of osteoporosis or factors or processes which lead to osteoporosis; and, to diagnostic, treatment, prevention, or control methods or processes, as well as compositions therefor and methods or processes for making and using such compositions, and receptors therefor and methods or processes for obtaining and using such receptors.
摘要翻译：本公开涉及机械应激诱导的基因和功能等同物，例如来自人和小鼠的那些，其探针，用于鉴定这些基因的测试，这些基因的表达产物，这些基因和表达产物的用途，例如在诊断（例如风险确定），治疗，预防或控制骨质疏松症或导致骨质疏松症的因素或过程; 以及诊断，治疗，预防或控制方法或过程，以及其组合物以及用于制备和使用这些组合物及其受体的方法或方法以及用于获得和使用这些受体的方法或方法。

65. 发明申请

WO0122864A9 SEQUENCES CHARACTERISTIC OF BLADDER CANCER 审中-公开
标题翻译：乳腺癌的序列特征
公开(公告)号：WO0122864A9
公开(公告)日：2002-12-12
申请号：PCT/US0041005
申请日：2000-09-27
申请人： QUARK BIOTECH INC , FEINSTEIN ELENA , MOR ORNA , KOHN KENNETH I
发明人： FEINSTEIN ELENA , MOR ORNA
IPC分类号： C12P21/08 , C12Q1/68 , A61K31/70 , A61K38/00 , A61K39/395 , C07H21/02 , C07H21/04 , C07K16/00 , C12N15/63
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： There is provided a method of diagnosing the presence of bladder cancer in a patient by analyzing a tissue sample from the patient for the presence of at least one expressed gene wherein the presence of the expressed gene is indicative of bladder cancer. Also provided by the present invention is a polynucleotide sequence whose expression is indicative of bladder cancer. A marker for bladder cancer is also provided. There are also provided methods of diagnosing bladder cancer by screening for the presence of at least one expressed gene wherein the presence of the expressed gene is indicative of bladder cancer. Methods of treating and regulating bladder cancer-associated pathologies by administering to a patient a therapeutically effective amount of a ribozyme, antisense olignucleotide, or agonist against the nucleic acids sequences of the present invention are alos provided.
摘要翻译：提供了一种通过分析来自患者的组织样品中至少一种表达基因的存在来诊断患者膀胱癌的存在的方法，其中所表达的基因的存在指示膀胱癌。本发明还提供了表达膀胱癌的多核苷酸序列。还提供了膀胱癌的标记物。还提供了通过筛选至少一种表达基因的存在来诊断膀胱癌的方法，其中表达的基因的存在指示膀胱癌。通过向患者施用治疗有效量的针对本发明的核酸序列的核酶，反义寡核苷酸或激动剂来治疗和调节膀胱癌相关病理学的方法是提供的。

66. 发明申请

WO2002086084A3 SEQUENCE CHARACTERISTICS OF BLADDER CANCER 审中-公开
公开(公告)号：WO2002086084A3
公开(公告)日：2002-10-31
申请号：PCT/US2002/012774
申请日：2002-04-04
申请人： QUARK BIOTECH, INC. , FEINSTEIN, Elena , MOR, Orna
发明人： FEINSTEIN, Elena , MOR, Orna
IPC分类号： C12Q1/68
摘要： There is provided a method of diagnosing the presence of bladder cancer in a patient by analyzing a tissue sample from the patient for the presence of a least one expressed gene wherein the presence of the expressed gene is indicative of bladder cancer. Also provided by the present invention is a polynucleotide sequence whose expression is indicative of bladder cancer. A marker for bladder cancer is also provided. There are also provided methods of diagnosing bladder cancer by screening for the presence of at least one expressed gene wherein the presence of the expressed gene is indicative of bladder cancer. Methods of treating and regulating bladder cancer-associated pathologies by administering a patient a therapeutically effective amount of chemical compound are also provided.

67. 发明申请

WO2002058623A3 INHIBITORS OF SPERMIDINE SYNTHASE FOR THE TREATMENT OF OSTEOARTHRITIS AND CARTILAGE REHABILITATION 审中-公开
公开(公告)号：WO2002058623A3
公开(公告)日：2002-08-01
申请号：PCT/US2001/048192
申请日：2001-12-12
申请人： QUARK BIOTECH, INC. , SHIONOGI & CO., LTD. , BAR, Dganit , FEINSTEIN, Elena , SEGEV, Orit
发明人： BAR, Dganit , FEINSTEIN, Elena , SEGEV, Orit
IPC分类号： A01N43/04
摘要： This invention provides a method for the treatment of a subject in need of treatment for ostheoarthritis comprising administering to said subject an amount of an inhibitor of spermidien biosynthesis sufficient to effect a substantial inhibition of spermidien biosynthesis. This invention also provides the use of an inhibitor of spermidine biosynthesis in the treatment of a subject in need of treatment of osteoarthritis in an amount sufficient to effect a substantial inhibition of spermidine biosynthesis. This invention further provides a method of preparing a therapeutic composition for the treatment of a subject in need of a treatment for osteoarthritis and the invention further provides a method of identifying an inhibitor of spermidine biosynthesis, whereby the inhibitor is a spermidine synthase inhibitor.

68. 发明申请

WO2002045472A3 SEQUENCE SPECIFIC AND SEQUENCE NON-SPECIFIC METHODS AND MATERIALS FOR cDNA NORMALIZATION AND SUBTRACTION 审中-公开
公开(公告)号：WO2002045472A3
公开(公告)日：2002-06-13
申请号：PCT/IB2001/001343
申请日：2001-07-11
申请人： QUARK BIOTECH, INC
发明人： MUGASIMANGALAM, Raja, C.
IPC分类号： C12Q1/68
摘要： This invention provides methods for constructing a normalized cDNA library, constructing a low copy gene library, preparing a probe from a biological sample and a kit for constructing a normalized cDNA library.

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