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61. 发明申请

WO02063013A3 HUMAN ACID PHOSPHATASE GENE 审中-公开
标题翻译：人类磷酸酶基因
公开(公告)号：WO02063013A3
公开(公告)日：2003-04-10
申请号：PCT/CA0200105
申请日：2002-02-01
申请人： MOUNT SINAI HOSPITAL CORP , DIAMANDIS ELEFTHERIOS P , DIAMANDIS MARIA , YOUSEF GEORGE
发明人： DIAMANDIS ELEFTHERIOS P , DIAMANDIS MARIA , YOUSEF GEORGE
IPC分类号： C12N1/21 , C12N9/16 , C12N15/55 , C12Q1/68 , G01N33/573 , G01N33/574 , A01K67/027 , A61K31/7088 , A61K38/46 , A61K39/395 , C07K16/40 , C12N5/10 , C12N15/11 , C12N15/63 , C12Q1/42 , G01N33/68
CPC分类号： C12N9/16 , A01K2217/05 , C12Q1/6886 , C12Q2600/158 , G01N33/573 , G01N33/574
摘要： The invention relates to nucleic acid molecules, proteins encoded by such nucleic acid molecules; and use of the proteins and nucleic acid molecules.
摘要翻译：本发明涉及核酸分子，由这种核酸分子编码的蛋白质; 并使用蛋白质和核酸分子。

62. 发明申请

WO2003025213A3 YEAST PROTEOME ANALYSIS 审中-公开
公开(公告)号：WO2003025213A3
公开(公告)日：2003-03-27
申请号：PCT/CA2002/001440
申请日：2002-09-23
申请人： MDS PROTEOMICS INC. , MOUNT SINAI HOSPITAL AND SAMUEL LUNENFELD RESEARCH INSTITUTE , BADER, Gary , CLIMIE, Shane , DUROCHER, Daniel , FIGEYS, Daniel , GRUHLER, Albrecht , HEILBUT, Adrian, Mark , HO, Yuen , MOORE, Lynda, A. , MORAN, Michael , MUSKAT, Brenda , TYERS, Michael , WOLTING, Cheryl, Deanna
发明人： BADER, Gary , CLIMIE, Shane , DUROCHER, Daniel , FIGEYS, Daniel , GRUHLER, Albrecht , HEILBUT, Adrian, Mark , HO, Yuen , MOORE, Lynda, A. , MORAN, Michael , MUSKAT, Brenda , TYERS, Michael , WOLTING, Cheryl, Deanna
IPC分类号： C12Q1/42
摘要： Methods and reagents for high throughput analysis of protein-protein interaction networks using mass spectrometry.

63. 发明申请

WO0200142A3 INTERVERTEBRAL DISC 审中-公开
公开(公告)号：WO0200142A3
公开(公告)日：2002-08-08
申请号：PCT/CA0100972
申请日：2001-06-29
申请人： MOUNT SINAI HOSPITAL CORP , KANDEL RITA
发明人： KANDEL RITA
IPC分类号： A01G23/08 , A61F2/28 , A61F2/30 , A61F2/44 , A61L27/36 , A61L27/38 , A61P17/00 , C12N5/06 , A61K48/00 , C12N5/08 , C12Q1/02
CPC分类号： A61L27/3856 , A61F2/28 , A61F2002/30678 , A61F2002/4435 , A61F2002/4445 , A61F2002/445 , A61F2310/00359 , A61L27/3612 , A61L27/3633 , A61L27/3817 , A61L2430/38
摘要： The present invention relates to an engineered biological material comprising or enriched for tissue of intervertebral disc; tissue derived from an engineered biological material; constructs comprising one or more tissues from an engineered biological material; methods for producing the engineered biological materials and constructs; and methods of using the engineered biological materials and constructs.
摘要翻译：本发明涉及包含或富含椎间盘组织的工程生物材料; 来自工程生物材料的组织; 包含来自工程生物材料的一种或多种组织的构建体; 生产工程生物材料和构建体的方法; 和使用工程生物材料和构建体的方法。

64. 发明申请

WO02055728A2 COMPOSITIONS AND METHODS FOR REGULATING RECEPTOR CLUSTERING 审中-公开
标题翻译：用于调节受体聚集的组合物和方法
公开(公告)号：WO02055728A2
公开(公告)日：2002-07-18
申请号：PCT/CA0200002
申请日：2002-01-11
申请人： MOUNT SINAI HOSPITAL CORP , DENNIS JIM , DEMETRIOU MICHAEL
发明人： DENNIS JIM , DEMETRIOU MICHAEL
IPC分类号： A61P43/00 , C07K14/47 , G01N33/50 , C12Q1/00
CPC分类号： G01N33/5091 , C07K14/4726 , G01N33/5008 , G01N2333/4724 , G01N2500/00 , Y10T436/143333
摘要： The invention relates to isolated complexes comprising one or more galectin associated with a Mgat5 modified glycan or polylactosamine modified glycan, and isolated lectin-Mgt5 modified glycan lattice comprising an array of mulitvalent interactions among lectins, Mgat5 modified glycans, polylactosamine modified glycans, and/or glycoproteins. Methods for evaluating a test compound for its ability to regulate receptor clustering through glycans on cell surfaces; and methods for regulating receptor clustering on cell surfaces comprising altering glycans on the cell surface associated with receptor clustering are also disclosed.
摘要翻译：本发明涉及包含与Mgat5修饰的聚糖或多聚乳糖胺改性聚糖相关的一种或多种半乳凝素的分离复合物，以及分离的凝集素-Mt5修饰的聚糖晶格，其包含凝集素，Mgat5修饰聚糖，多聚乳糖胺修饰聚糖和/或糖蛋白。评价试验化合物通过细胞表面聚糖调节受体聚集的能力的方法; 还公开了调节受体聚集在细胞表面上的方法，包括改变与受体聚集相关的细胞表面上的聚糖。

65. 发明申请

WO0011141A3 TRNA BINDING DOMAIN 审中-公开
标题翻译： TRNA绑定域
公开(公告)号：WO0011141A3
公开(公告)日：2000-06-02
申请号：PCT/CA9900779
申请日：1999-08-24
申请人： MOUNT SINAI HOSPITAL CORP , HOGUE CHRISTOPHER
发明人： HOGUE CHRISTOPHER
IPC分类号： A61K38/00 , C07K14/32 , C12N9/00 , C12Q1/68 , G01N33/53 , A61K38/16 , A61P31/04 , A61P31/12 , A61P39/06 , C07K16/12 , C12N15/52
CPC分类号： G01N33/5308 , A61K38/00 , C07K14/32 , C12N9/93 , C12Y601/01001 , G01N2500/04
摘要： There is disclosed a substantially pure peptide comprising the following sequence: [ML] -X(3) -[LIVMC] -X(3) -[GMNEHK] -[MLFYI] -X(2) -[ST] -X(3) -[SAIG] - [RMIK] -X(2) -[MIVA] -X(2) -[GNRHK] -X-[IVLF] -X-[LIV] -[NDSRGAL] -X(3) -[LIVSQ] -X(2) -[PILVTAC] wherein X represents any amino acid. Also disclosed is a method for determining whether a nucleic acid comprises a tRNA anticodon stem-loop. Another aspect comprises a method for identifying a substance which binds to a wherein the binding is detected by assaying for conjugates, for free substance, or for non-complexed peptide. Also described is a method of determining whether a test compound is an agonist or antagonist of a tRNA synthetase-tRNA anticodon stem-loop interaction or ribosomal S4 protein-tRNA anticodon stem-loop interaction. There is also described a method for obtaining a substantially pure nucleic acid comprising a tRNA anticodon stem-loop from a mixture of different nucleic acids. Finally, there is described a pharmaceutical composition for inhibiting the interaction of a tRNA, with a tRNA synthetase or ribosomal protein along with other related aspects.
摘要翻译：公开了包含以下序列的基本上纯的肽：[ML] -X（3） - [LIVMC] -X（3） - [GMNEHK] - [MLFYI] -X（2） - [ST] -X ） - [SAIG] - [RMIK] -X（2） - [MIVA] -X（2） - [GNRHK] -X- [IVLF] -X- [LIV] - [NDSRGAL] -X（3） LIVSQ] -X（2） - [PILVTAC]其中X表示任何氨基酸。还公开了一种用于确定核酸是否包含tRNA反密码子茎环的方法。另一方面包括鉴定与其结合的物质的方法，其中通过测定缀合物，游离物质或非复合肽检测结合。还描述了确定测试化合物是否是tRNA合成酶-tRNA反密码子茎 - 环相互作用或核糖体S4蛋白-tRNA反密码子茎 - 环相互作用的激动剂或拮抗剂的方法。还描述了从不同核酸的混合物获得包含tRNA反密码子茎环的基本上纯的核酸的方法。最后，描述了用于抑制tRNA与tRNA合成酶或核糖体蛋白相互作用的药物组合物以及其它相关方面。

66. 发明申请

WO9927088A3 NOVEL GENE AND PROTEIN EXPRESSED IN NEURAL AND PANCREATIC TISSUES 审中-公开
标题翻译：新型基因和蛋白质在神经和胰腺组织中表达
公开(公告)号：WO9927088A3
公开(公告)日：1999-08-12
申请号：PCT/CA9801058
申请日：1998-11-19
申请人： MOUNT SINAI HOSPITAL CORP , DONOVIEL DORIT , BERNSTEIN ALAN
发明人： DONOVIEL DORIT , BERNSTEIN ALAN
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C12N15/12 , A01K67/027 , A61K38/17 , C12N5/10 , G01N33/566
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K16/18
摘要： A nucleic acid molecule, designated Sel-1L (Sel-1 like; also previously known as Hip-1), which is widely expressed in adult mouse and human tissues with particularly high levels in the pancreas and in the floor plate of the neural tube. Sel-1L has also been localized within intracellular vesicles. The gene maps to 14q24.3-31 in close proximity to the insulin diabetes locus (IDDML). The nucleic acid molecules encodes a protein designated "SEL-1L Protein".
摘要翻译：称为Sel-1L（Sel-1，也称为Hip-1）的核酸分子，其在胰腺和神经管的底板中具有特别高水平的成年小鼠和人组织中广泛表达。 Sel-1L也已经位于胞内囊泡内。该基因位于邻近胰岛素糖尿病基因座（IDDML）的14q24.3-31处。核酸分子编码称为“SEL-1L蛋白”的蛋白质。

67. 发明申请

WO9902724A2 METHODS FOR IDENTIFYING GENES EXPRESSED IN SELECTED LINEAGES, AND A NOVEL GENES IDENTIFIED USING THE METHODS 审中-公开
标题翻译：识别选定细胞系中表达的基因的方法和使用方法鉴定的新基因
公开(公告)号：WO9902724A2
公开(公告)日：1999-01-21
申请号：PCT/CA9800667
申请日：1998-07-10
申请人： MOUNT SINAI HOSPITAL CORP , STANFORD WILLIAM , CARUANA GEORGINA , HIDAKA MICHIHIRO , BERNSTEIN ALAN
发明人： STANFORD WILLIAM , CARUANA GEORGINA , HIDAKA MICHIHIRO , BERNSTEIN ALAN
IPC分类号： C07K14/47 , C12Q1/68 , C07K14/435 , C07K16/18
CPC分类号： C07K14/47 , C12Q1/68 , C12Q1/6897
摘要： The invention relates to vectors, compositions, and methods, for identifying genes primarily expressed in selected lineages. The invention also relates to novel genes primarily expressed in selected lineages, proteins encoded by the novel genes and truncations, analogs, homologs, and isoforms of the proteins; and, uses of the proteins and genes.
摘要翻译：本发明涉及用于鉴定主要在选择谱系中表达的基因的载体，组合物和方法。本发明还涉及主要在选择的谱系中表达的新基因，由新基因编码的蛋白质和蛋白质的截短，类似物，同系物和同种型; 以及蛋白质和基因的使用。

68. 发明申请

WO9747296A3 COMPOSITIONS COMPRISING VANADIUM COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS AND ARTHROPATHIES 审中-公开
标题翻译：包含VANADIUM化合物用于治疗增生性疾病和ARTHROPATHIES的组合物
公开(公告)号：WO9747296A3
公开(公告)日：1998-03-05
申请号：PCT/CA9700405
申请日：1997-06-12
申请人： MOUNT SINAI HOSPITAL CORP , CRUZ TONY
发明人： CRUZ TONY
IPC分类号： A61K31/07 , A61K31/195 , A61K31/28 , A61K31/35 , A61K31/355 , A61K31/375 , A61K31/415 , A61K31/555 , A61K31/565 , A61K33/04 , A61K33/24 , A61K33/30 , A61K33/32 , A61K33/34 , A61K45/06 , A61P35/00 , A61P43/00
CPC分类号： A61K33/24 , A61K31/28 , A61K31/555 , A61K45/06 , A61K31/195 , A61K2300/00
摘要： The present invention relates to the use of vanadium compounds as antiproliferative and anti-metastatic agents, to treat arthropathy and drug resistant tumors in animals; to compositions containing vanadium compounds adapted for such uses; to methods for the treatment of proliferative disorders, to methods of reducing the ability of a tumor to metastasize, to methods for treating drug resistant tumors and to methods for treating arthropathies, such as arthritis.

69. 发明申请

WO1997015318A1 PEPTIDE INHIBITORS OF A PHOSPHOTYROSINE-BINDING DOMAIN CONTAINING PROTEIN 审中-公开
标题翻译：含有蛋白质结合蛋白的蛋白质的肽抑制剂
公开(公告)号：WO1997015318A1
公开(公告)日：1997-05-01
申请号：PCT/US1996017080
申请日：1996-10-24
申请人： MOUNT SINAI HOSPITAL CORPORATION , ASAHI CHEMICAL INDUSTRY CO., LTD. , VAN DER GEER, Peter , WILEY, Sandra , GISH, Gerald , PAWSON, Tony , TOMA, Kazunori
发明人： MOUNT SINAI HOSPITAL CORPORATION , ASAHI CHEMICAL INDUSTRY CO., LTD.
IPC分类号： A61K38/08
CPC分类号： C07K14/715 , A61K38/00 , C07K14/71
摘要： A peptide of the formula (I): X -A -A -X -Asn-X -X -P.Tyr-X -X -X X , wherein X represents Lys, Arg, His, Ser, Thr, Tyr, Asn, Leu, Val or Glu, A represents Trp, Leu, Ala, Ser, Ile, Glu, Met, Gly, Cys, Phe, Pro or Val, and A represents Ala, Val, Leu, Ile, Ser, Met, Phe, Gly, Cys, Trp or Pro, X represents Glu, Asn, Tyr, Thr, Ser, Asp or Ile, X represents Pro, Met, Trp, Phe, Ala, Lys, Val, Leu, Ile, Gly or Cys, X represents Leu, Ala, Glu, Gln, Asp, Asn, Tyr, Thr or Ser, X represents Phe, Trp, Pro, Leu, Ala, Val, Ile, Gly, Cys, Met, Arg or Ser, X represents Ser, Thr, Tyr, Asn, Glu, Met, Ala, Leu, Val or Gly, X represents Asp, Glu, Ala, Val, Leu, Ile, Gly, Cys, Phe, Trp, Met, Pro, Ser or Asn and X which may be present or absent represents Phe, Trp, Pro, Leu, Ala, Val, Ile, Gly, Cys, Met, Asp, Ser or Arg which interferes with the interaction of a PTB domain containing protein with a PTB domain binding site, and truncations and analogues of the peptide.
摘要翻译：式（I）的肽：X 1 -A 1 -A 2 -X 2 -As n -X 3 -X 4 -P.Tyr-X 5 - X 6 -X X 7-，其中X 1表示Lys，Arg，His，Ser，Thr，Tyr，Asn，Leu，Val或Glu，A 1表示Trp，Leu， Ala，Ser，Ile，Glu，Met，Gly，Cys，Phe，Pro或Val，A 2代表Ala，Val，Leu，Ile，Ser，Met，Phe，Gly，Cys，Trp或Pro， 2表示Glu，Asn，Tyr，Thr，Ser，Asp或Ile，X 3表示Pro，Met，Trp，Phe，Ala，Lys，Val，Leu，Ile，Gly或Cys，X 4表示Leu ，Ala，Glu，Gln，Asp，Asn，Tyr，Thr或Ser，X 5表示Phe，Trp，Pro，Leu，Ala，Val，Ile，Gly，Cys，Met，Arg或Ser，X 6，表示Ser，Thr，Tyr，Asn，Glu，Met，Ala，Leu，Val或Gly，X 7表示Asp，Glu，Ala，Val，Leu，Ile，Gly，Cys，Phe，Trp，Met，Pro，可能存在或不存在的Ser或Asn和X 8表示干扰与包含的PTB结构域相互作用的Phe，Trp，Pro，Leu，Ala，Val，Ile，Gly，Cys，Met，Asp，Ser或Arg 具有PTB结构域结合位点的蛋白质，以及t的截短和类似物他的肽。

70. 发明申请

WO1995019177A1 VANADATE COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS, METASTASES AND DRUG RESISTANT TUMORS 审中-公开
标题翻译：用于治疗增生性疾病，化学药物和耐药性肿瘤的VANADATE化合物
公开(公告)号：WO1995019177A1
公开(公告)日：1995-07-20
申请号：PCT/CA1995000019
申请日：1995-01-18
申请人： MOUNT SINAI HOSPITAL CORPORATION , CRUZ, Tony
发明人： MOUNT SINAI HOSPITAL CORPORATION
IPC分类号： A61K33/24
CPC分类号： A61K45/06 , A61K31/28 , A61K31/555 , A61K33/24 , A61K31/195 , A61K2300/00
摘要： The present invention relates to the use of vanadate compounds or derivatives or analogues of vanadate compounds as antiproliferative and anti-metastatic agents, and/or to treat drug resistant tumors in animals; to compositions containing vanadate compounds adapted for such use; to methods for the treatment of proliferative disorders, to methods of reducing the ability of a tumor to metastasize, and to methods for treating drug resistant tumors. The invention also relates to methods for testing for substances which affect cell proliferation.
摘要翻译：本发明涉及钒酸盐化合物或钒酸盐化合物的衍生物或类似物在抗增殖和抗转移剂中的用途，和/或用于治疗动物中耐药性肿瘤; 包含适于这种使用的含有钒酸盐化合物的组合物; 用于治疗增殖性疾病的方法，降低肿瘤转移能力的方法以及治疗耐药性肿瘤的方法。本发明还涉及用于测试影响细胞增殖的物质的方法。

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