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    • 62. 发明申请
    • METHOD OF TREATING CANCER USING ADENOSINE AND ITS ANALOGS
    • 使用腺嘌呤及其类似物治疗癌症的方法
    • WO2004030621A3
    • 2004-12-09
    • PCT/US0330701
    • 2003-09-30
    • UNIV BOSTONRAVID KATYALU JUN
    • RAVID KATYALU JUN
    • A61K31/7076A61K31/70
    • A61K31/137A61K31/56A61K31/7076
    • The present invention provides methods of treating individuals having malignancies associated with estrogen receptor activity comprising administering to an individual affected with said malignancy, an effective amount of adenosine analog in a pharmaceutical carrier to downregulate or diminish estrogen receptors in the cells. The invention further provides methods of identifying novel adenosine analogues capable of treating malignant cells expressing estrogen receptors. The invention also provides kits comprising adenosine analogs for downregulating estrogen receptors in cells and kits for screening for novel adenosine analogs capable of downregulating estrogen receptors. Further, the invention provides uses of adenosine analogs in downregulation of estrogen receptors, cell growth and cell cycle, as well as pharmaceutical compositions comprising adenosine analogs effective in suppressing cellular growth, cell cycle or downregulating estrogen receptors.
    • 本发明提供了治疗患有与雌激素受体活性相关的恶性肿瘤的个体的方法,其中包括对受到所述恶性肿瘤影响的个体施用有效量的药物载体中的腺苷类似物以下调或减少细胞中的雌激素受体。 本发明还提供鉴定能够治疗表达雌激素受体的恶性细胞的新型腺苷类似物的方法。 本发明还提供了包含用于下调细胞中雌激素受体的腺苷类似物的试剂盒和用于筛选能够下调雌激素受体的新型腺苷类似物的试剂盒。 此外,本发明提供了腺苷类似物在下调雌激素受体,细胞生长和细胞周期中的用途,以及包含有效抑制细胞生长,细胞周期或下调雌激素受体的腺苷类似物的药物组合物的用途。
    • 63. 发明申请
    • METHOD OF TREATING CANCER USING ADENOSINE AND ITS ANALOGS
    • 用腺苷及其类似物治疗癌症的方法
    • WO2004030621A2
    • 2004-04-15
    • PCT/US2003/030701
    • 2003-09-30
    • THE TRUSTEES OF BOSTON UNIVERSITYRAVID, KatyaLU, Jun
    • RAVID, KatyaLU, Jun
    • A61K
    • A61K31/137A61K31/56A61K31/7076
    • The present invention provides methods of treating individuals having malignancies associated with estrogen receptor activity comprising administering to an individual affected with said malignancy, an effective amount of adenosine analog in a pharmaceutical carrier to downregulate or diminish estrogen receptors in the cells. The invention further provides methods of identifying novel adenosine analogues capable of treating malignant cells expressing estrogen receptors. The invention also provides kits comprising adenosine analogs for downregulating estrogen receptors in cells and kits for screening for novel adenosine analogs capable of downregulating estrogen receptors. Further, the invention provides uses of adenosine analogs in downregulation of estrogen receptors, cell growth and cell cycle, as well as pharmaceutical compositions comprising adenosine analogs effective in suppressing cellular growth, cell cycle or downregulating estrogen receptors.
    • 本发明提供了治疗患有与雌激素受体活性相关的恶性肿瘤的个体的方法,包括向患有所述恶性肿瘤的个体施用有效量的药物载体中的腺苷类似物以下调或减少雌激素受体 细胞。 本发明还提供了鉴定能够治疗表达雌激素受体的恶性细胞的新型腺苷类似物的方法。 本发明还提供了包含用于下调细胞中雌激素受体的腺苷类似物和用于筛选能够下调雌激素受体的新型腺苷类似物的试剂盒的试剂盒。 此外,本发明提供腺苷类似物在下调雌激素受体,细胞生长和细胞周期中的用途,以及包含有效抑制细胞生长,细胞周期或下调雌激素受体的腺苷类似物的药物组合物。