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    • 63. 发明申请
    • EVALUATION OF IMMEDIATE-EFFECT SKIN MOLDING AGENTS USING DISC
    • 使用光盘评估立即效果的皮肤成型剂
    • WO2008024694A2
    • 2008-02-28
    • PCT/US2007/076268
    • 2007-08-20
    • ELC MANAGEMENT LLCAFRIAT, IsabelleRAFAILOVICH, Miriam
    • AFRIAT, IsabelleRAFAILOVICH, Miriam
    • A61K49/00
    • A61K49/0006A61K49/0008
    • The present invention pertains to methods of characterizing the effects on the skin of skin-molding agents and to methods of characterizing the physical behavior of the skin-molding agents themselves. A preferred embodiment of the present invention uses a non-invasive, in vivo form of digital image speckle correlation to track deformation of human skin caused by the application of a skin-molding agent, in particular, an immediate-effect skin molding agent. The skin-molding agent may or may not be part of a composition. The application to the skin of a skin-molding agent may or may not be part of a treatment regimen. The present invention may be applied to any surface of the human body, to non-humans and to inert matter. Unlike in vitro methods and unlike invasive, in vivo methods that tension the skin with an apparatus, the present invention relies on the applied skin-molding agent to create before and after deformation images. From those images, it is possible to develop quantitative and qualitative characterizations of skin's movement and of the skin-molding agent itself. These characterizations will aid in the development of improved and/or customized skin molding agents and improved compositions comprising skin-molding agents. Generally, the data collected by the methods described herein, may also suggest improved and/or customized treatment regimens for molding the skin.
    • 本发明涉及表征对皮肤成型剂的皮肤的作用的方法以及表征皮肤成型剂本身的物理性能的方法。 本发明的优选实施方案使用数字图像斑点相关性的非侵入式体内形式来跟踪由皮肤成型剂(特别是立即效果的皮肤模塑剂)的应用引起的人体皮肤的变形。 皮肤成型剂可以是或可以不是组合物的一部分。 对皮肤成型剂的皮肤的应用可以是或可以不是治疗方案的一部分。 本发明可以应用于人体的任何表面,非人类和惰性物质。 与体外方法不同,不同于用设备拉紧皮肤的侵入性体内方法,本发明依赖于所应用的皮肤成型剂在变形图像之前和之后产生。 从这些图像,可以开发皮肤运动和皮肤成型剂本身的定量和定性表征。 这些特征将有助于开发改进和/或定制的表皮成型剂和改进的包含表皮成型剂的组合物。 通常,通过本文所述方法收集的数据也可以建议用于模塑皮肤的改进和/或定制的治疗方案。