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61. 发明申请

WO1994009748A1 COMMAND-CURABLE COMPOSITION 审中-公开
标题翻译：命令可固化组合物
公开(公告)号：WO1994009748A1
公开(公告)日：1994-05-11
申请号：PCT/GB1993002238
申请日：1993-11-01
申请人： BRITISH TECHNOLOGY GROUP LIMITED , ANSTICE, Helen, Mary , NICHOLSON, John, William
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： A61K06/083
CPC分类号： A61K6/0835 , C08L43/02 , C08L33/00
摘要： A light-curable dental cement composition contains (a) the reaction product of vinyl phosphonyl chloride and pentane 1,5 diol, (b) a photopolymerisation initiator, (c) ion-leachable aluminosilicate glass powder, (d) poly(vinyl phosphonic acid), (e) bisGMA as a photopolymerisable dimethacrylate resin, and water, inert filler and silanising agent. Upon mixing, glass is added last, the composition is put in place and, when ready, it is light-irradiated for 30 or 40 seconds to polymerise (e). The composition is immediately firm and the phosphonate groups adhere to tooth material while further slow curing by acid-base reaction continues.
摘要翻译：光固化牙科用水泥组合物包含（a）乙烯基膦酰氯和戊烷1,5-二醇的反应产物，（b）光聚合引发剂，（c）离子可浸出的铝硅酸盐玻璃粉末，（d）聚（乙烯基膦酸），（e）作为可光聚合二甲基丙烯酸酯树脂的双GMA，以及水，惰性填料和硅烷化剂。混合后，最后加入玻璃，将组合物放在适当的位置，准备好后照射30或40秒以聚合（e）。该组合物立即牢固，并且膦酸酯基团粘附到牙齿材料上，同时通过酸碱反应进一步缓慢固化。

62. 发明申请

WO1994006797A1 NOVEL BIOREDUCTIVE AGENTS 审中-公开
标题翻译：新生代剂
公开(公告)号：WO1994006797A1
公开(公告)日：1994-03-31
申请号：PCT/GB1993001950
申请日：1993-09-15
申请人： BRITISH TECHNOLOGY GROUP LIMITED
发明人： BRITISH TECHNOLOGY GROUP LIMITED , ADAMS, Gerald, Edward , FIELDEN, Edward, Martin , NAYLOR, Matthew, Alexander , STRATFORD, Ian, James
IPC分类号： C07D487/04
CPC分类号： C07D471/14 , C07D487/04
摘要： Quinoxaline or pyrido pyrazine derivatives of formula (I) wherein R1 is: hydrogen, alkyl, alkoxy, alkylamino, dialkylamino, aminoalkylamino, aminoalkyl(N-alkyl)amino or aminoalkoxy unsubstituted or substituted on the terminal amino group by one or two alkyl groups or a divalent group which forms a saturated heterocyclic ring together with the nitrogen atom to which it is attached, hydroxyalkylamino or haloalkylamino or an N-alkyl derivative thereof, or hydroxyalkoxy or haloalkoxy; a heterocyclic group which is a 1-pyrrolidino, 1-piperidino, 1-morpholino group, unsubstituted or substituted; or a 1-piperazino group which is unsubstituted or substituted substituents in the 2- or 3-position and in the 4-position is unsubstituted or N-substituted by haloalkyl, cycloalkyl, pyridyl or phenyl; R2 is a hydrocarbyl or heterocyclyl aromatic group unsubstituted or substituted; X is -CH= or -N=; and X1 is hydrogen or halogen; and pharmaceutically acceptable salts thereof are useful in the treatment of tumours, and in particular hypoxic tumours. Processes for producing the compounds and pharmaceutical compositions comprising them.
摘要翻译：式（I）的喹喔啉或吡啶并吡嗪衍生物，其中R 1是：氢，烷基，烷氧基，烷基氨基，二烷基氨基，氨基烷基氨基，氨基烷基（N-烷基）氨基或氨基烷氧基，其未被取代或在末端氨基上被一个或两个烷基取代或与其连接的氮原子一起形成饱和杂环的二价基团，羟烷基氨基或卤代烷基氨基或其N-烷基衍生物，或羟基烷氧基或卤代烷氧基; 作为未取代或取代的1-吡咯烷子基，1-哌啶子基，1-吗啉代基的杂环基; 或在2-或3-位和4-位是未取代或取代的取代基的1-哌嗪基是未被取代的或被卤代烷基，环烷基，吡啶基或苯基取代的N-取代基。 R2是未取代或取代的烃基或杂环基芳基; X是-CH =或-N =; 且X 1为氢或卤素; 及其药学上可接受的盐可用于治疗肿瘤，特别是低氧性肿瘤。用于生产化合物的方法和包含它们的药物组合物。

63. 发明申请

WO1994004937A1 METHOD OF AND APPARATUS FOR NMR TESTING 审中-公开
标题翻译： NMR测试方法和装置
公开(公告)号：WO1994004937A1
公开(公告)日：1994-03-03
申请号：PCT/GB1993001702
申请日：1993-08-11
申请人： BRITISH TECHNOLOGY GROUP LIMITED
发明人： BRITISH TECHNOLOGY GROUP LIMITED , COUNSELL, Christopher, John, Robert
IPC分类号： G01R33/56
CPC分类号： G01R33/5615 , G01R33/56518
摘要： The invention provides a method of and apparatus for NMR testing in wich an object to be imaged is subjected to a magnetic field, the field having a gradient component for encoding spatial information about the object, applying excitation pulses at selected intervals to excite nuclear magnetic resonance, (at least two of the intervals and the encoding gradient component during those intervals being selected such that, for such intervals, the values of the integral of the gradient component with respect to the interval duration are proportioned according to consecutive powers of an integer, I, greater than two); and detecting the resonance response signals. The invention in one embodiment overcomes disadvantages suffered by the prior art in that no special equipment is required to switch rapidly oscillating field gradients.
摘要翻译：本发明提供了一种用于核磁共振测试的方法和装置，其中待成像物体经受磁场，该场具有用于编码关于物体的空间信息的梯度分量，以选定的间隔施加激发脉冲以激发核磁共振（在间隔期间的至少两个间隔和编码梯度分量被选择使得对于这样的间隔，梯度分量相对于间隔持续时间的积分的值根据整数的连续功率成比例，我，大于二）; 并检测共振响应信号。本发明在一个实施例中克服了现有技术所遭受的缺点，因为不需要专门的设备来切换快速振荡的场梯度。

64. 发明申请

WO1994004905A1 PASSIVE DUST SAMPLER 审中-公开
标题翻译：被动式吸尘器
公开(公告)号：WO1994004905A1
公开(公告)日：1994-03-03
申请号：PCT/GB1993001694
申请日：1993-08-10
申请人： BRITISH TECHNOLOGY GROUP LIMITED , BROWN, Richard, Colin
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01N01/22
CPC分类号： G01N1/2273 , B03C3/28 , G01N1/2202 , G01N1/24 , G01N2001/2223 , G01N2001/2276 , Y10S55/39
摘要： A personal dust sampler, (3 cm2), hangs from a ribbon (10) attached to the user's clothing and requires no pump or power source. Dust in the air is captured by a charged PVC sheet (2) exposed at (2a) but framed by a metal foil (25) and surmounted by a metal conductor plate (6) parallel to (2). The plate (6) is supported by conductive gridwork (3) removeably attached via a flange (30) to a metal base (21). The dust captured is determined by weighing or by measuring the charge loss of the PVC sheet (2).
摘要翻译：个人灰尘取样器（3 cm2）悬挂在连接到使用者服装上的色带（10）上，不需要泵或电源。空气中的灰尘被暴露在（2a）处的带电荷的PVC片（2）捕获，但被金属箔（25）框架并且被平行于（2）的金属导体板（6）所覆盖。板（6）由可通过凸缘（30）可移除地附接到金属基座（21）的导电格栅（3）支撑。捕获的尘埃是通过称重或通过测量PVC片材（2）的电荷损失来确定的。

65. 发明申请

WO1993011441A1 IMPROVEMENTS IN NQR TESTING 审中-公开
标题翻译： NQR测试中的改进
公开(公告)号：WO1993011441A1
公开(公告)日：1993-06-10
申请号：PCT/GB1992002254
申请日：1992-12-04
申请人： BRITISH TECHNOLOGY GROUP LIMITED , SMITH, John, Alec, Sydney , SHAW, Julian, David
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01R33/44
CPC分类号： G01R33/441
摘要： A method of Nuclear Quadrupole Resonance testing includes the steps of applying to a sample in which selected nuclei have an integral spin quantum number a series of at least three pulses of electromagnetic waves at a single radiofrequency to excite quadrupole resonance of the selected nuclei (waveform (a)), and detecting responses at a plurality of times when echo response signals are expected to occur (waveform (b)).

66. 发明申请

WO1993000904A1 DIHYDROPYRIMIDO-QUINOXALINES AND DIHYDROPYRIMIDO-PYRIDOPYRAZINES USEFUL FOR TREATING TUMOURS 审中-公开
标题翻译：用于治疗肿瘤的二羟基二咪喹啉和二羟基吡啶二吡咯烷酮
公开(公告)号：WO1993000904A1
公开(公告)日：1993-01-21
申请号：PCT/GB1992001204
申请日：1992-07-03
申请人： BRITISH TECHNOLOGY GROUP LIMITED , ADAMS, Gerald, Edward , FIELDEN, Edward, Martin , NAYLOR, Matthew, Alexander , STRATFORD, Ian, James
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： A61K31/505
CPC分类号： A61K31/505
摘要： Dihydropyrimido-quinoxalines and dihydropyrimido-pyridopyrazines are useful in the treatment of cancer and in particular the treatment of hypoxic tumours.

67. 发明申请

WO1992017793A1 NQR METHODS AND APPARATUS 审中-公开
标题翻译： NQR方法和装置
公开(公告)号：WO1992017793A1
公开(公告)日：1992-10-15
申请号：PCT/GB1992000577
申请日：1992-04-01
申请人： BRITISH TECHNOLOGY GROUP LIMITED , SMITH, John, Alec, Sydney , SHAW, Julian, David
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： G01R33/44
CPC分类号： G01R33/446 , G01R33/34007 , G01R33/34061 , G01R33/341 , G01R33/3415 , G01R33/441 , G01R33/4804 , G01R33/5659
摘要： A method for detecting the presence within a larger article of a specific substance containing quadrupolar atomic nuclei includes performing tests of parts of the article by placing the article adjacent to an array of coils (10), energising with an rf source (20) the coils (10) in periods within a cyclic sequence to irradiate parts of the article with rf pulses of one or more frequencies at or close to a resonant frequency of quadrupolar atomic nuclei within the substance to be detected, connecting the coils (10) in other periods within the cyclic sequence to a phase-sensitive detecting and measuring circuit (15, 24-26) to measure response signals due to nuclear quadrupole resonances, and summing the response signals detected at corresponding instants over a number of cyclic sequences. Apparatus for detecting the presence of a specific substance analogous to the above method is also disclosed.

68. 发明申请

WO1997043026A1 APPARATUS AND METHOD FOR MANIPULATING PARTICLES IN A LIQUID MEDIUM BY ULTRASONIC WAVES 审中-公开
标题翻译：通过超声波处理液体介质中的颗粒的装置和方法
公开(公告)号：WO1997043026A1
公开(公告)日：1997-11-20
申请号：PCT/GB1997001239
申请日：1997-05-08
申请人： BRITISH TECHNOLOGY GROUP LIMITED , SCHRAM, Cornelius, John
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： B01D21/00
CPC分类号： B01D21/283 , B01D43/00 , B01J19/10
摘要： The invention relates to an apparatus and a method for munipulating particles in a liquid medium by ultrasonic waves. A vessel is provided for receiving the particle-carrying liquid, as well as means, such as an ultrasonic transducer for generating an ultrasonic standing wave in the vessel such that particles are attracted to nodal fronts of the standing wave. The standing wave is intermittently suppressed, whilst the particle-carrying liquid is oscillated relative to the transducer. If the oscillation and the intermittency are carried out in synchronisation, the particles can be shepherded from one nodal front to another in a prescribed direction to concentrate them for separation from the liquid medium. The invention has application to separation or concentration of inorganic or organic particulate matter in laboratory or industrial processes.
摘要翻译：本发明涉及一种通过超声波在液体介质中调节颗粒的装置和方法。提供容器用于接收载运液体，以及诸如用于在容器中产生超声波驻波的超声波换能器的装置，使得颗粒被吸引到驻波的节点。驻波被间歇地抑制，而颗粒携带液体相对于换能器振荡。如果振荡和间歇性同步进行，则颗粒可以从规定的方向从一个节点前面传播到另一个节点，以将它们集中以与液体介质分离。本发明适用于实验室或工业过程中无机或有机颗粒物质的分离或浓缩。

69. 发明申请

WO1997010021A1 DEVICE AND METHOD FOR TRANSCUTANEOUS SURGERY 审中-公开
标题翻译：用于手术治疗的装置和方法
公开(公告)号：WO1997010021A1
公开(公告)日：1997-03-20
申请号：PCT/GB1996002263
申请日：1996-09-12
申请人： BRITISH TECHNOLOGY GROUP LIMITED , BYRNE, Phillip, Owen , ELLIOTT, Thomas, Stuart, Jackson
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： A61M25/01
CPC分类号： A61M25/0111 , A61B90/40
摘要： This invention relates to a device and method for use in transcutaneous surgical procedures, such as transcutaneous catheterisation and surgical biopsy. To provide that the operative parts of instrumentation to be introduced into the patient's body are shielded from contact with the patient's skin, and thereby to inhibit transfer of microorganisms from the skin into the body, there is provided a transcutaneous indwelling shield device for insertion into a skin aperture, comprising a transcutaneous distal portion providing an instrument access port, connecting to a proximal portion of shallow dished form of substantially greater dimension than said access port, the proximal portion tapering inwardly to said distal portion to readily guide the distal tip of the instrument to said access port. The distal portion serves as a wound retractor, and to this end at least the distal portion may be of resilient form to be resiliently deformed from a first, relatively open, configuration to a second, relatively closed, configuration. The invention has particular application in the field of central venous catheterisation.
摘要翻译：本发明涉及用于经皮手术的装置和方法，例如经皮导管插入术和外科活检。为了提供要引入患者体内的仪器的操作部分被屏蔽以免与患者的皮肤接触，从而阻止微生物从皮肤转移到体内，提供了一种用于插入到皮肤中的经皮留置屏蔽装置皮肤孔，包括提供仪器进入口的经皮远端部分，其连接到具有比所述进入口大得多的尺寸的浅盘形形状的近端部分，所述近端部分向内渐缩到所述远端部分，以容易地引导所述器械的远端到所述访问端口。远侧部分用作缠绕的牵开器，并且为此，至少远端部分可以是弹性形式，以从第一相对开放的构造弹性变形到第二相对封闭的构型。本发明在中心静脉导管插入术中具有特殊的应用。

70. 发明申请

WO1997000642A1 METHOD AND APPARATUS FOR USE IN IMAGING A BODY 审中-公开
标题翻译：用于成像身体的方法和装置
公开(公告)号：WO1997000642A1
公开(公告)日：1997-01-09
申请号：PCT/GB1996001499
申请日：1996-06-21
申请人： BRITISH TECHNOLOGY GROUP LIMITED , BOONE, Kevin, Graham , HOLDER, David, Simon
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： A61B05/05
CPC分类号： A61B5/0536 , A61B5/0042
摘要： The present invention relates to imaging, and more particularly to a method and apparatus for use in imaging a body by means of the technique of electrical impedance tomography (EIT). A plurality of electrodes (E, to E16) are provided in electrical contact with the body (10) around the periphery of the body. A first electrical input signal is applied to at least one of the electrodes over a first time period (T1), and a second electrical input signal, which is preferably in inverted form of the first, is then applied to the at least one of the electrodes over a subsequent, second time period (T2). The resulting electrical output signal is measured at one or more of the remaining electrodes over the first and second time periods and the difference between the measured signal obtained during the first time period and that obtained during the second time period is calculated to provide a difference signal. The difference signal can be stored and used for image reconstruction. The invention has particular application in imaging neurological function within the body, where the impedance changes associated with neuronal depolarisations are very small and the resulting electrical signals measured at the body periphery are even smaller. By use of this technique electrical signals corresponding to the dynamic components of impedance change can be reinforced whilst those corresponding to other unwanted components can be cancelled.
摘要翻译：本发明涉及成像，更具体地涉及一种通过电阻抗层析成像（EIT）技术用于成像身体的方法和装置。多个电极（E，至E16）设置成与身体（10）电连接在身体周围。第一电输入信号在第一时间段（T1）中被施加到至少一个电极，然后将优选地以第一时间的反向形式的第二电输入信号施加到第一时间段电极在随后的第二时间段（T2）中。所得到的电输出信号在第一和第二时间段的一个或多个剩余电极处测量，并且计算在第一时间段期间获得的测量信号与在第二时间段期间获得的测量信号之间的差，以提供差分信号。差分信号可以存储并用于图像重建。本发明在体内成像神经功能方面具有特别的应用，其中与神经元去极化相关的阻抗变化非常小，并且在体周边测量的所得电信号甚至更小。通过使用这种技术，可以加强对应于阻抗变化的动态分量的电信号，而可以取消对应于其它不需要的部件的电信号。

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