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    • 68. 发明申请
    • PROCESS FOR THE MANUFACTURE OF AN AMINO ESTER
    • 氨基酸制备方法
    • WO2015071500A1
    • 2015-05-21
    • PCT/EP2014/074942
    • 2014-11-18
    • RHODIA OPERATIONS
    • MARION, PhilippeMORVAN, Didier
    • C07C227/04C07C253/30
    • C07C227/04C07C253/30C08G69/44C07C255/23C07C229/08
    • Process for the manufacture of an amino ester of formula (I) R 1 -O-C(O)-(CH 2 ) n -NH 2 (I) in which n is an integer from 10 to 15 from an unsaturated ester responding to formula (II) R 1 -O-C(O)-(CH 2 ) m -CH=CH-R 2 (II) in which R 1 is either H or a saturated alkyl group containing from 1 to 5 carbon atoms; R 2 is either H or an alkyl group containing from 1 to 10 carbon atoms, either saturated or containing 1 or 2 unsaturations and bearing optionally a hydroxyl, a carboxylic or an ester group, and m is equal to 7, 8, 9, 10 or 11; said process comprising: submitting the unsaturated ester of formula (II) to a catalytic cross-metathesis reaction with a pentenenitrile chosen among 2-pentenenitrile or 3-pentenenitrile in order to obtain a ester-nitrile responding to formula (III) R 1 -O-C(O)-(CH 2 ) m -CH=CH-(CH 2 ) p -CN (III) in which m is equal to 7, 8, 9, 10 or 11 and p is equal to 0 or 1, and submitting the obtained ester-nitrile of formula (III) to an hydrogenation in order to obtain the amino ester of formula (I).
    • 制备式(I)的氨基酯的方法R1-OC(O) - (CH2)n-NH2(Ⅰ),其中n为响应式(Ⅱ)的不饱和酯的10至15的整数R1 -OC(O) - (CH 2)m -CH = CH-R 2(II),其中R 1是H或含有1至5个碳原子的饱和烷基; R 2是H或含有1至10个碳原子的烷基,其为饱和的或含有1或2个不饱和基团,并且任选具有羟基,羧基或酯基,m等于7,8,9,10或 11; 所述方法包括:将式(II)的不饱和酯与选自2-戊烯腈或3-戊烯腈的戊烯腈进行催化交叉复分解反应,以获得响应式(III)的酯腈R1-OC( O) - (CH 2)m -CH = CH-(CH 2)p -CN(III),其中m等于7,8,9,10或11,p等于0或1,并将所得酯 (III)的腈与氢化反应,得到式(I)的氨基酯。