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61. 发明申请

WO2012065185A3 METHOD AND SYSTEM FOR CELL FILTRATION 审中-公开
标题翻译：用于细胞过滤的方法和系统
公开(公告)号：WO2012065185A3
公开(公告)日：2012-08-23
申请号：PCT/US2011060656
申请日：2011-11-14
申请人： RARECYTE INC , SEUBERT RONALD C
发明人： SEUBERT RONALD C
IPC分类号： B01D69/00 , B01D63/00 , B01D71/52
CPC分类号： B01D65/08 , B01D63/087 , B01D69/02 , B01D71/52 , B01D2325/021 , B01D2325/04 , B01D2325/24
摘要： Methods and systems disclosed in the present application include membrane-like filters and methods and systems that employ these membrane-like filters to isolate circulating tumor cells and other abnormal cells from biological fluids, such as blood. The disclosed methods and systems use membrane-like filters that include a pattern or array of small, tapered apertures fabricated within a relatively thin but mechanically robust polymeric material that resists accumulation of biological-solution components and clogging during filtration of biological solutions.
摘要翻译：本申请中公开的方法和系统包括膜状过滤器和采用这些膜状过滤器从生物流体如血液中分离循环肿瘤细胞和其他异常细胞的方法和系统。所公开的方法和系统使用膜状过滤器，其包括在相对薄但机械坚固的聚合物材料内制造的小的锥形孔的图案或阵列，其抵抗生物溶液成分的积聚和生物溶液过滤期间的堵塞。

62. 发明申请

WO2011050366A2 METHODS FOR CHANGING DENSITIES ON NON-TARGET PARTICLES OF A SUSPENSION 审中-公开
标题翻译：改变悬浮剂非目标颗粒浓度的方法
公开(公告)号：WO2011050366A2
公开(公告)日：2011-04-28
申请号：PCT/US2010/053978
申请日：2010-10-25
申请人： RARECYTE, INC. , GOODWIN, Paul, C.
发明人： GOODWIN, Paul, C.
IPC分类号： C12Q1/24 , G01N33/48 , C12M1/24 , G01N15/05 , G01N5/00 , C12M1/42
CPC分类号： G01N1/4077 , G01N2001/4083 , Y10T436/255
摘要： This disclosure is directed to methods for isolating target materials from non-target materials of a suspension that have a similar density to that of the target material. A suspension suspected of containing a target material is added to a tube and float system. A solution containing molecules that interact specifically with the non-target materials to change the density of the non-target materials in also added. A float is also added to the tube, and the tube, float, and suspension are centrifuged together. The float has a specific gravity that positions the float at approximately the same level as a layer containing the target material when the tube, float and suspension are centrifuged. During centrifugation, the non-target material/molecules complexes are drawn either below the float or above float, leaving the target material between the outer surface of the float and the inner surface of the tube.
摘要翻译：本公开涉及从具有与靶材料密度相似的密度的悬浮液的非目标材料中分离目标材料的方法。将疑似含有目标材料的悬浮液加入到管和浮子系统中。含有与非目标材料特异性相互作用的分子的溶液，以改变非目标材料的密度。还将一个浮子加入管中，将管，浮子和悬浮液一起离心。当离心管，浮子和悬浮液时，浮子具有将浮子定位在与包含目标材料的层大致相同的水平处的比重。在离心过程中，非目标材料/分子复合物被绘制在浮子或漂浮浮选下方，留下浮体外表面和管内表面之间的目标材料。

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