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61. 发明申请

WO2020051133A1 LIGHT ACTIVATED ADHESIVE SCAFFOLD 审中-公开
公开(公告)号：WO2020051133A1
公开(公告)日：2020-03-12
申请号：PCT/US2019/049330
申请日：2019-09-03
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： SHARIFI, Roholah , ANDRADES, Miguel Gonzalez , CHODOSH, James
IPC分类号： A61F2/02
摘要： The present invention discloses compositions and methods for repair and reconstruction of defects and injuries to soft tissues. Some aspects of the disclosure provide methods for corneal reconstruction by applying an engineered bioadhesive, glycidyl methacrylate-substituted gelatin and a visible light activated photoinitiator in presence of visible light to the corneal defect.

62. 发明申请

WO2019173211A1 AMELIORATION OF AUTOIMMUNE UVEITIS THROUGH BLOCKADE OF CSF1R 审中-公开
公开(公告)号：WO2019173211A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020539
申请日：2019-03-04
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： CONNOR, Kip M. , OKUNIKI, Yoko
IPC分类号： A61K39/395 , A61P19/02 , A61P29/00
摘要： Methods and compositions for treating conditions including autoimmune uveitis using inhibitors of Colony stimulating factor 1 receptor (CSF1R).

63. 发明申请

WO2018208970A1 BIOMARKERS FOR AGE-RELATED MACULAR DEGENERATION 审中-公开
公开(公告)号：WO2018208970A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/031878
申请日：2018-05-09
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： DE CARVALHO LAINS, Ines Maria , HUSAIN, Deeba , MILLER, Joan W.
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6848 , G01N33/5038 , G01N2800/16
摘要： This disclosure relates to biomarkers for Age-Related Macular Degeneration (AMD) and methods of use thereof, e.g., methods of the use of biomarkers for determining that a subject has Age-related Macular Degeneration (AMD) or determining the stage of AMD in a subject.

64. 发明申请

WO2017189944A1 METHODS FOR CORRECTING OTOACOUSTIC EMISSION MEASUREMENTS 审中-公开
标题翻译：用于校正耳声发射测量的方法
公开(公告)号：WO2017189944A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/030020
申请日：2017-04-28
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： CHARAZIAK, Karolina , SHERA, Christopher
IPC分类号： A61B5/12 , A61B5/0484 , G01H15/00
CPC分类号： A61B5/12 , A61B5/6817 , A61B5/7203 , A61B2560/0223 , G01H15/00
摘要： The methods disclosed herein enable calculating otoacoustic emission (OAE) pressure independent of the acoustic load imposed by the ear canal and the OAE probe measurement system, e.g., for hearing tests. The OAE pressure is calculated in a form of either the first outgoing wave at the eardrum, referred as emitted pressure level ( P EPL ), or as a Thvenin-equivalent OAE source pressure level ( P TPL ) at the eardrum, as derived from a simple tube model of an ear canal. In both methods the OAE sound pressure level ( P SPL ), ear canal reflectance ( R EC ), OAE probe source reflectance ( R S ), and one-way ear canal delay (τ) are measured at the entrance of the ear canal with the OAE probe. In contrast to P SPL , both methods result in an emission pressure that is not confounded by the effects of the residual ear canal space or the impedance of the OAE measurement system.
摘要翻译：本文所公开的方法能够独立于由耳道和OAE探针测量系统施加的声学负载来计算耳声发射（OAE）压力，例如用于听力测试。 OAE压力是以耳膜上的第一次出射波（称为发射压力水平（P EPL））或作为Thvenin等效OAE源的形式计算的从耳道的简单管模型导出的耳膜处的压力水平（P _{TPL ）。在这两种方法中，OAE声压级（SPL ），耳道反射率（EC ），OAE 使用OAE探针在耳道入口处测量探头源反射率（R S）和单向耳道延迟（τ）。与P _{SPL 不同，这两种方法都导致发射压力不受残余耳道空间的影响或OAE测量系统的阻抗的影响。 / p>}}

65. 发明申请

WO2017143091A1 MOBILE DEVICE APPLICATION FOR OCULAR MISALIGNMENT MEASUREMENT 审中-公开
标题翻译：移动设备在眼球偏差测量中的应用
公开(公告)号：WO2017143091A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018213
申请日：2017-02-16
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： TOMASI, Matteo , PUNDLIK, Shrinivas , HOUSTON, Kevin Edward , LUO, Gang
IPC分类号： A61B3/00 , A61B3/08 , A61B3/10 , A61B3/14 , H04N5/225
CPC分类号： A61B3/00 , A61B3/08 , A61B3/085 , A61B3/10 , A61B3/14 , A61B3/152 , G06K9/00604 , G06K9/0061 , G06K9/00912 , G06K9/2027 , G06K9/209 , G06K9/22
摘要： Disclosed are a mobile device and method which include acquiring, by an image acquisition unit installed in a mobile device, an image of eyes of a patient while light provided by a light source reflects from an optical surface of the eyes of the patient; and obtaining, by a processor installed in the mobile device, ocular misalignment measurements, including a magnitude and a direction of ocular misalignment in the eyes of the patient, using the acquired image or set of images.
摘要翻译：公开了一种移动设备和方法，包括：由安装在移动设备中的图像获取单元获取患者眼睛的图像，同时由光源提供的光从光学表面反射病人的眼睛; 以及通过安装在移动设备中的处理器使用所获取的图像或图像集合来获得包括患者眼睛中的眼睛未对准的大小和方向的眼未对准测量结果。

66. 发明申请

WO2017127619A1 DETECTING HIDDEN HEARING LOSS 审中-公开
标题翻译：检测隐藏的听力损失
公开(公告)号：WO2017127619A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014244
申请日：2017-01-20
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： LIBERMAN, M. Charles , MAISON, Stephane
IPC分类号： A61B1/227 , A61B5/042 , A61B5/12
CPC分类号： A61B5/125 , A61B5/126
摘要： Non-invasive methods of detecting hidden hearing loss (cochlear synaptopathy) based on detection of an abnormal ratio of Summating Potential (SP)/Action Potential (AP) (SP/AP) Ratios.
摘要翻译：基于检测Sumulative Potential（SP）/动作电位（AP）（SP / AP）比率的异常比率来检测隐藏的听力损失（耳蜗突触症）的非侵入性方法。

67. 发明申请

WO2017060832A3 OPTICAL PROXIMITY SENSING SYSTEM FOR ATRAUMATIC COCHEA IMPLANT SURGERY 审中-公开
标题翻译：光学近接植入式手术近距离传感系统
公开(公告)号：WO2017060832A3
公开(公告)日：2017-05-26
申请号：PCT/IB2016055959
申请日：2016-10-05
申请人： ECOLE POLYTECHNIQUE FED DE LAUSANNE (EPFL) , MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： PSALTIS DEMETRI , PU YE , MOSER CHRISTOPHE , STANKOVIC KONSTANTINA
IPC分类号： A61N1/36 , A61B5/00 , H04R25/00
CPC分类号： A61N1/36036 , A61B5/0059 , H04R2225/67
摘要： The design of a proximity sensor to be integrated into cochlea implants is described. The sensor allows the anticipation of contact between the cochlear implant and intracochlear structures, including the cochlear canal wall and basilar membrane, providing a feedback or an alarm to the surgeon performing the implant insertion such that trauma to the cochlea is avoided. This helps to preserve any residual hearing ability in patients who receive the surgical implant.
摘要翻译：描述了集成到耳蜗植入物中的接近传感器的设计。该传感器允许预期耳蜗植入物和耳蜗内结构（包括耳蜗管壁和基底膜）之间的接触，从而向执行植入物插入的外科医生提供反馈或警报，从而避免对耳蜗造成损伤。这有助于保留接受手术植入物的患者的任何残余听力。

68. 发明申请

WO2017066529A1 HIGH-DOSE STATINS FOR AGE-RELATED MACULAR DEGENERATION 审中-公开
标题翻译：与年龄相关的黄斑变性的高剂量患者
公开(公告)号：WO2017066529A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056987
申请日：2016-10-14
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： VAVVAS, Demetrios
IPC分类号： A61K31/40 , A61K31/395 , G01N33/00 , G01N33/50
CPC分类号： A61K31/40 , A61K31/22 , A61K31/366 , A61K31/404 , A61K31/4418 , A61K31/47 , A61K31/505 , A61K2300/00
摘要： Methods of using a high-dose statin for treatment of AMD in a patient can be used to regress drusen and/or drusenoid pigment epithelial detachments (PEDs), to prevent atrophy of the RPE and/or one or more photoreceptors, to prevent vision loss and/or improve visual acuity, and/or to prevent progression from dry AMD to wet AMD.
摘要翻译：在患者中使用高剂量他汀治疗AMD的方法可用于使玻璃疣和/或类蕊样色素上皮脱离（PED）退化，以防止RPE和/或一种或更多的光感受器，以防止视力丧失和/或改善视敏度，和/或防止干性AMD进展为湿性AMD。

69. 发明申请

WO2017019994A2 ANCESTRAL VIRUS SEQUENCES AND USES THEREOF 审中-公开
标题翻译： ANCECTRAL病毒序列及其用途
公开(公告)号：WO2017019994A2
公开(公告)日：2017-02-02
申请号：PCT/US2016/044819
申请日：2016-07-29
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY , SCHEPENS EYE RESEARCH INSTITUTE
发明人： VANDENBERGHE, Luk H. , ZINN, Eric
IPC分类号： C12Q1/68
CPC分类号： C12Q1/701 , C12N2750/14143

70. 发明申请

WO2016179496A1 METHODS OF DELIVERING AN AGENT TO THE EYE 审中-公开
标题翻译：向眼睛递送药剂的方法
公开(公告)号：WO2016179496A1
公开(公告)日：2016-11-10
申请号：PCT/US2016/031218
申请日：2016-05-06
申请人： MASSACHUSETTS EYE AND EAR INFIRMARY
发明人： COMANDER, Jason , ELIOTT, Dean , KIM, Leo , VANDENBERGHE, Luk H.
IPC分类号： A61B19/00 , A61F2/00 , A61F9/00 , A61F9/007 , A61M5/00
CPC分类号： A61F9/0008 , A61F9/00727 , A61F9/00736
摘要： Methods of delivering agents to structures within the eye are provided.
摘要翻译：提供将药物递送到眼睛内的结构的方法。

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