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    • 55. 发明申请
    • SELECTIVE SAMPLING FOR ASSESSING STRUCTURAL SPATIAL FREQUENCIES WITH SPECIFIC CONTRAST MECHANISMS
    • 用特定对比机制评估结构性空间频率的选择性采样
    • WO2017062882A1
    • 2017-04-13
    • PCT/US2016/056147
    • 2016-10-07
    • BIOPROTONICS LLC
    • CHASE, David, R.JAMES, Timothy, W.JAMES, Kristin, E.
    • A61B5/055G01R33/48G01R33/385G01R33/54
    • A61B5/055A61B5/0033A61B5/4842G01R33/4833G01R33/561G01R33/56509
    • The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k- values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in- vivo resolution than is obtainable with current MRI techniques.
    • 所公开的实施例提供了一种用于以分辨率低至几十微米获取MR数据的方法,用于体内诊断和监测病理学,其中精细组织纹理的变化可用作疾病发作和进展的标志。 骨病,肿瘤,神经系统疾病和涉及纤维化生长和/或破坏的疾病都是目标病态。 此外,该技术可以用于需要非常高分辨率表征精细尺度形态的任何生物或物理系统中。 该方法提供在k空间中快速获取所选择的值,并且以定义的组织体积内的微秒数量级的时间尺度上采集的各个k值的多次连续采集,以及以这种方式的多个测量的后续组合 以使SNR最大化。 缩小的采集量以及沿所选方向仅在k空间中的选择值的获取使得比目前的MRI技术可获得更高的体内分辨率。
    • 58. 发明申请
    • MR IMAGING USING A STACK-OF-STARS ACQUISITION
    • 使用星空数据采集成像
    • WO2016202707A1
    • 2016-12-22
    • PCT/EP2016/063413
    • 2016-06-12
    • KONINKLIJKE PHILIPS N.V.
    • BECK, Gabriele Marianne
    • G01R33/48G01R33/561G01R33/563
    • G01R33/4826G01R33/5601G01R33/5611G01R33/56308
    • The invention relates to a method of MR imaging of at least an object (10) placed in an examination volume of a MR device (1). It is an object of the invention to enable fast MR imaging using the stack-of-stars acquisition scheme with a reduced level of streaking artifacts. The method of the invention comprises: • - subjecting the object (10) to an imaging sequence of at least one RF pulse and switched magnetic field gradients, • - acquiring MR signals according to a stack-of-stars scheme, wherein the MR signals are acquired as radial k-space profiles (S 1-S 12) from a number of parallel slices (21-27) arranged at different positions along a slice direction, wherein the radial density of the k-space profiles (SI-SI2) varies as a function of the slice position, wherein the radial density is higher at more central k- space positions and lower at more peripheral k-space positions and wherein k-space profiles are acquired at a higher temporal density from slices at more central positions than from slices at more peripheral k-space positions, and • - reconstructing a MR image from the MR signals.
    • 本发明涉及放置在MR装置(1)的检查体积中的至少一个物体(10)的MR成像方法。 本发明的一个目的是使用具有降低的条纹伪影水平的采用星群的采集方案实现快速MR成像。 本发明的方法包括: - 对物体(10)进行至少一个RF脉冲和切换的磁场梯度的成像序列, - 根据星星方案获取MR信号,其中MR信号 从沿着切片方向布置在不同位置的多个平行切片(21-27)被采集为径向k空间轮廓(S1-S12),其中k-空间轮廓(SI-SI2)的径向密度 作为切片位置的函数而变化,其中径向密度在更多中心k空间位置处较高,并且在更多外围k空间位置处较低,并且其中在更多中心位置处的切片获得更高时间密度的k空间分布 而不是在更多外围k空间位置处的切片,以及•从MR信号重建MR图像。
    • 59. 发明申请
    • MRI WITH VARIABLE DENSITY SAMPLING
    • 具有可变密度采样的MRI
    • WO2016198362A1
    • 2016-12-15
    • PCT/EP2016/062819
    • 2016-06-07
    • KONINKLIJKE PHILIPS N.V.
    • ZHAO, ChenguangHUANG, FengYANG, Ming
    • G01R33/48G01R33/561
    • G01R33/4826G01R33/4818G01R33/482G01R33/4822G01R33/4824G01R33/561
    • The invention provides a device for producing a magnetic resonance image. The device comprises a collecting unit adapted for collecting k space samples that are located on a non-Cartesian grid in a non-Cartesian coordinate space or non-uniformly located on a Cartesian grid in a Cartesian coordinate space, the non-Cartesian/Cartesian coordinate space adapted to be decomposed into a plurality of subspaces, each of which extends along one or more coordinate axes of the non-Cartesian/Cartesian coordinate space; a weight calculation unit (203) adapted for calculating a decomposed sample density weight function of the k space samples in each individual subspace and determining a density weight function in the non-Cartesian/Cartesian coordinate space via a multiplication of the decomposed sample density weight functions of the k space samples in the plurality of subspaces; a gridding unit adapted for interpolating the k space samples in the non-Cartesian/Cartesian coordinate space onto a uniform Cartesian grid in a k space based on the density weight function of the k space samples in the non-Cartesian/Cartesian coordinate space; and a reconstructing unit adapted for reconstructing the magnetic resonance image based on the interpolated k space samples. By means of the invention, fast, preferably on-demand, calculation of the sampling density weights may be achieved.
    • 本发明提供一种用于产生磁共振图像的装置。 该装置包括收集单元,其适于收集位于非笛卡尔坐标空间中的非笛卡尔网格上的非空间样本,或非均匀地位于笛卡尔坐标空间中的笛卡尔网格上的非笛卡尔/笛卡尔坐标 适于分解成多个子空间的空间,每个子空间沿着非笛卡尔/笛卡尔坐标空间的一个或多个坐标轴延伸; 权重计算单元(203),用于计算每个单独子空间中的k空间样本的分解样本密度权重函数,并且通过分解的样本密度权重函数的乘积来确定非笛卡尔/笛卡尔坐标空间中的密度权重函数 的多个子空间中的k个空间样本; 网格单元,用于基于非笛卡尔/笛卡尔坐标空间中的k空间样本的密度权重函数,将非笛卡尔/笛卡尔坐标空间中的k个空间样本内插到k空间中的均匀笛卡尔网格上; 以及重建单元,其适于基于插值的k空间样本重建所述磁共振图像。 通过本发明,可以实现快速,优选按需的采样密度权重的计算。