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51. 发明申请

WO2012040964A1 放射治疗装置、辐射装置及准直装置审中-公开
公开(公告)号：WO2012040964A1
公开(公告)日：2012-04-05
申请号：PCT/CN2010/078984
申请日：2010-11-23
申请人：上海世鹏实验室科技发展有限公司 , 宋世鹏 , 王翔宇
发明人：王翔宇
IPC分类号： A61N5/01
CPC分类号： A61N5/1042 , A61N2005/1095
摘要：一种放射治疗装置、辐射装置及准直装置，其中准直装置包括：轴向中空的准直体，所述轴向中空准直体具有至少一组准直孔，每一组准直孔的中心线聚焦于一公共焦点，且每组准直孔的分布规律与所述放射源的分布规律相匹配；可旋转设于所述轴向中空准直体中的开关体，用于允许或阻挡所述放射线穿过所述准直孔。本发明可以提高对准直装置的控制精度，减小准直装置的轴向尺寸，从而可以减小准直装置重量，节省材料，而且加工和制造简单；通过同时旋转准直体和开关体实现开关体允许或阻挡所述放射线穿过所述准直孔，提高放射治疗装置从治疗状态转换为非治疗状态的速度。

52. 发明申请

WO2012029065A2 A SELF OPERATED ESTHETIC DEVICE WITH A SUBSTRATE 审中-公开
标题翻译：具有基板的自动操作的镶嵌装置
公开(公告)号：WO2012029065A2
公开(公告)日：2012-03-08
申请号：PCT/IL2011/000707
申请日：2011-09-05
申请人： VENUS CONCEPT LTD , RON EDOUTE, Orit , RON EDOUTE, Oded
发明人： RON EDOUTE, Orit , RON EDOUTE, Oded
IPC分类号： A61N5/01
CPC分类号： A61N5/00 , A61B2018/00648 , A61B2018/00702 , A61B2018/00714 , A61B2018/00732 , A61B2018/00779 , A61B2018/00791 , A61B2018/00845 , A61B2018/00875 , A61B2090/065 , A61N1/328 , A61N1/40 , A61N5/0625 , A61N2005/007 , A61N2005/0628 , A61N2005/0645 , A61N2007/0034
摘要： The present invention provides a self-operated device for treating a skin of a patient, comprising: a. a substrate having a first side and a second side; b. a plurality of RF electrodes arranged in said substrate, said RF electrodes are configured to emit RF radiation from said first side to the surface of said skin; c. at least one RF generator configured to generate pulses of current to said RF electrodes; and, d. a control unit connected to said at least one RF generator, said control unit is adapted to control the operation of said RF electrodes; wherein said control unit is adapted to control the operation of said RF electrodes according to a predetermined treatment protocol, such that the same activates or deactivates at least one of said RF electrodes at any predetermined time interval according to a predetermined pattern so as to achieve a particular therapeutic result.
摘要翻译：本发明提供一种用于治疗患者皮肤的自动操作装置，包括：a。具有第一面和第二面的基板; 湾布置在所述衬底中的多个RF电极，所述RF电极被配置为从所述第一侧向所述皮肤的表面发射RF辐射; C。至少一个RF发生器被配置为产生到所述RF电极的电流脉冲; 和，d。连接到所述至少一个RF发生器的控制单元，所述控制单元适于控制所述RF电极的操作; 其中所述控制单元适于根据预定的处理协议控制所述RF电极的操作，使得所述RF电极根据预定模式以任何预定时间间隔激活或去激活所述RF电极中的至少一个，从而实现特别治疗结果。

53. 发明申请

WO2012019162A1 SYSTEMS AND METHODS FOR REAL-TIME TUMOR TRACKING DURING RADIATION TREATMENT USING ULTRASOUND IMAGING 审中-公开
标题翻译：用超声波成像进行放射治疗的实时肿瘤追踪的系统和方法
公开(公告)号：WO2012019162A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/046853
申请日：2011-08-05
申请人： ACCURAY, INC. , MAURER, Calvin R. , JORDAN, Petr , WEST, Jay
发明人： MAURER, Calvin R. , JORDAN, Petr , WEST, Jay
IPC分类号： A61B6/00 , A61B8/00 , A61B8/08 , A61N5/00 , A61N5/10 , G06T7/00 , A61N5/01
CPC分类号： A61N5/1049 , A61B5/055 , A61B6/022 , A61B6/032 , A61B6/0457 , A61B6/4417 , A61B6/4458 , A61B6/5247 , A61B8/08 , A61B8/085 , A61B8/4218 , A61B8/4245 , A61B8/4263 , A61B8/4416 , A61B8/4444 , A61B8/483 , A61B8/5238 , A61B8/5261 , A61B90/39 , A61B2090/3995 , A61N5/1039 , A61N5/1045 , A61N5/1067 , A61N5/107 , A61N5/1077 , A61N5/1081 , A61N5/1083 , A61N2005/1054 , A61N2005/1055 , A61N2005/1058 , A61N2005/1061 , A61N2005/1062
摘要： Systems and methods for tracking a target volume, e.g., tumor, in real-time during radiation treatment are provided. Under one aspect, a system includes an ultrasound probe, an x-ray imager, a processor, and a computer-readable medium that stores a 3D image of the tumor in a first reference frame and instructions for causing the processor to: instruct the x-ray imager and ultrasound probe to substantially simultaneously obtain inherently registered x-ray and set-up ultrasound images of the tumor in a second reference frame; establish a transformation between the first and second reference frames by registering the 3D image and the x-ray image; instruct the ultrasound probe to obtain an intrafraction ultrasound image of the tumor; registering the intrafraction ultrasound image with the set-up ultrasound image; and track target volume motion based on the registered intrafraction ultrasound image.
摘要翻译：提供了用于在放射治疗期间实时跟踪目标体积（例如肿瘤）的系统和方法。在一个方面，一种系统包括超声波探头，X射线成像仪，处理器和将肿瘤的3D图像存储在第一参考系中的计算机可读介质，以及用于使处理器执行以下操作的指令：指示x 射线成像仪和超声探头基本上同时获得在第二参考系中肿瘤的固有的x射线和设置的超声图像; 通过注册3D图像和X射线图像来建立第一和第二参考帧之间的变换; 指示超声探头获得肿瘤的分数内超声图像; 用建立的超声图像记录影像内图像; 并且基于注册的分数内超声图像跟踪目标体积运动。

54. 发明申请

WO2011028789A2 IRRADIATION SYSTEM AND METHOD 审中-公开
标题翻译：照射系统和方法
公开(公告)号：WO2011028789A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047509
申请日：2010-09-01
申请人： STOKES, John P.
发明人： STOKES, John P.
IPC分类号： A61N5/06 , A61N5/01
CPC分类号： A61N5/1042 , A61N5/01 , A61N5/1081 , A61N5/1082
摘要： A radiotherapy technique for providing a radiation source having a radiation path that intersects a treatment area, activating the radiation source, and moving the radiation source in three dimensions about the treatment area, wherein the radiation source is continually directed substantially toward an isocentric point within the treatment area.
摘要翻译：一种用于提供辐射源的放射线治疗技术，该辐射源具有与治疗区域相交的辐射路径，激活辐射源并且围绕治疗区域在三维中移动辐射源，其中辐射源不断地基本上朝向治疗区域内的等中心点。

55. 发明申请

WO2011011731A2 SYSTEMS AND METHODS FOR TREATING CANCER USING BRACHYTHERAPY 审中-公开
标题翻译：用BRACHYTHERAPY治疗癌症的系统和方法
公开(公告)号：WO2011011731A2
公开(公告)日：2011-01-27
申请号：PCT/US2010/043121
申请日：2010-07-23
申请人： VOXEL RAD, LTD. , RAHIMIAN, Javad
发明人： RAHIMIAN, Javad
IPC分类号： A61N5/01 , A61B18/00 , A61M36/10 , A61M36/04 , A61M3/04 , A61B17/02
CPC分类号： A61B17/42 , A61B17/0206 , A61B17/0218 , A61B2017/00557 , A61B2090/3966 , A61N5/1007 , A61N5/1016 , A61N2005/1003
摘要： Systems and methods are provided for treating cervical and/or uterine cancers in brachytherapy with an intracavitary brachytherapy applicator. The system comprises a tandem adapted for insertion into a cervix of a patient. An ovoid assembly comprises first and second inflatable ovoids and an ovoid support mechanism. The first and second inflatable ovoids are adapted for insertion within fornices of a patient. First and second retractors are adapted to be coupled to the ovoid assembly. The first retractor is adapted to be positioned to retract the bladder of a patient during treatment. The second retractor is adapted to be positioned to retract the rectum of a patient during treatment. The tandem and the first and second inflatable ovoids are adapted to be coupled to a radioactive source to deliver an implant radiation dose suitable for cancer treatment at a cancerous cervical treatment site in a patient.
摘要翻译：系统和方法被提供用于在腔内近距离放射治疗器的近距离放射治疗中治疗宫颈癌和/或子宫癌。该系统包括适合插入患者的子宫颈中的串联。卵形组件包括第一和第二可充气卵形体和卵形支撑机构。第一和第二可膨胀卵形适于插入患者的穹窿内。第一和第二牵开器适于连接到卵形组件。第一牵开器适于定位成在治疗期间缩回患者的膀胱。第二牵开器适于定位成在治疗期间缩回患者的直肠。串联和第一和第二可充气卵形体适合于与放射源耦合，以在患者的癌症颈部治疗部位递送适合于癌症治疗的植入放射剂量。

56. 发明申请

WO2011004285A1 SKIN RADIATION APPARATUS AND METHOD 审中-公开
标题翻译：皮肤辐射装置和方法
公开(公告)号：WO2011004285A1
公开(公告)日：2011-01-13
申请号：PCT/IB2010/052851
申请日：2010-06-23
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , WAGENAAR CACCIOLA, Giovanna , RITZ, Arnd , GIELEN, Vincent, Stefan, David , ASHDOWN, Ian, Edward , LOVELAND, Damien
发明人： WAGENAAR CACCIOLA, Giovanna , RITZ, Arnd , GIELEN, Vincent, Stefan, David , ASHDOWN, Ian, Edward , LOVELAND, Damien
IPC分类号： A61N5/01 , A61N5/06
CPC分类号： A61N5/0616 , A61B18/20 , A61B2018/00904 , A61B2018/20351 , A61N5/01 , A61N2005/0637 , A61N2005/0652 , A61N2005/0661 , A61N2005/067
摘要： A skin radiation apparatus comprises: -a photon radiation unit (10) for generating a line-shaped radiation pattern (12) extending in a first direction (x), the photon radiation unit comprising a photon radiation source (14), -a movement facility (20, 22) for moving the line shaped radiation pattern in a second direction (y) transverse to the first direction (x), -a detection unit (30) for detecting a skin condition profile, -a control unit (40) for controlling an power density distribution for the line- shaped radiation pattern dependent on the skin condition profile detected by the detection unit (30).
摘要翻译：皮肤辐射装置包括： - 一个用于产生沿第一方向（x）延伸的线状辐射图案（12）的光子辐射单元（10），该光子辐射单元包括一个光子辐射源（14）用于沿与第一方向（x）横向的第二方向（y）移动线状辐射图案的设备（20,22）， - 用于检测皮肤状况分布的检测单元（30）， - 控制单元（40）用于根据由检测单元（30）检测到的皮肤状况轮廓来控制线状辐射图的功率密度分布。

57. 发明申请

WO2010047923A3 METHODS AND SYSTEMS FOR TREATING BREAST CANCER USING EXTERNAL BEAM RADIATION 审中-公开
标题翻译：使用外部束辐射治疗乳腺癌的方法和系统
公开(公告)号：WO2010047923A3
公开(公告)日：2010-07-29
申请号：PCT/US2009058662
申请日：2009-09-28
申请人： VARIAN MED SYS INC , STAR-LACK JOSH , HUMBER DAVID , KNOTT KARLA , ZANKOWSKI COREY , GREEN MICHAEL C , VIRSHUP GARY , CLAYTON JAMES , SVATOS MICHELLE MARIE
发明人： STAR-LACK JOSH , HUMBER DAVID , KNOTT KARLA , ZANKOWSKI COREY , GREEN MICHAEL C , VIRSHUP GARY , CLAYTON JAMES , SVATOS MICHELLE MARIE
IPC分类号： A61N5/10 , A61B6/00 , A61N5/01
CPC分类号： A61N5/1042 , A61B6/04 , A61B6/0435 , A61B6/4071 , A61B6/4458 , A61B6/4488 , A61B6/502 , A61B6/583
摘要： A radiation apparatus includes a radiation source movable in translational and/or rotational degrees of freedom, and a structure adapted to support a body. The structure is provided with an opening to allow a portion of the body passing through to be exposed to at least a portion of the therapeutic radiation while in use.
摘要翻译：辐射装置包括可在平移和/或旋转自由度上移动的辐射源以及适于支撑身体的结构。该结构设置有开口以允许身体的一部分穿过以在使用时暴露于至少一部分治疗辐射。

58. 发明申请

WO2010063008A2 HEAD AND NECK RADIATION LOCALIZATION USING ORAL APPLIANCE 审中-公开
标题翻译：用口头器具进行头颈部辐射定位
公开(公告)号：WO2010063008A2
公开(公告)日：2010-06-03
申请号：PCT/US2009/066017
申请日：2009-11-27
申请人： OREGON HEALTH & SCIENCE UNIVERSITY , GAGNON, Patrick, James , HOLLAND, John, M.
发明人： GAGNON, Patrick, James , HOLLAND, John, M.
IPC分类号： A61N5/01 , A61G15/02
CPC分类号： A61N5/1049 , A61B90/39 , A61G15/02 , A61N5/1042 , A61N5/107 , A61N2005/1061
摘要： In various embodiments, methods, apparatuses, and systems for accurate patient positioning and motion tracking before and/or during head and neck radiation therapy, such as intensity modulated radiation therapy, are provided. In exemplary embodiments, a computing system may be endowed with one or more components of the disclosed apparatuses and/or systems and may be employed to perform one or more methods as disclosed herein. Exemplary embodiments provide head and neck radiation localization using, in part, an oral appliance.
摘要翻译：在各种实施例中，提供了用于在头部和颈部放射疗法之前和/或期间精确患者定位和运动追踪的方法，装置和系统，诸如调强放射疗法。在示例性实施例中，计算系统可以被赋予所公开的装置和/或系统的一个或多个组件，并且可以被采用来执行如本文所公开的一个或多个方法。示例性实施例部分地使用口腔器具提供头部和颈部辐射定位。

59. 发明申请

WO2009142545A3 CHARGED PARTICLE CANCER THERAPY PATIENT POSITIONING METHOD AND APPARATUS 审中-公开
标题翻译：充电颗粒癌治疗患者定位方法和装置
公开(公告)号：WO2009142545A3
公开(公告)日：2010-04-22
申请号：PCT/RU2009000247
申请日：2009-05-21
申请人： BALAKIN VLADIMIR YEGOROVICH
发明人： BALAKIN VLADIMIR YEGOROVICH
IPC分类号： H05H13/04 , A61N5/01 , A61N5/10 , H05H7/04 , H05H7/10
CPC分类号： A61N5/10 , A61N2005/1087 , G03B42/02 , G21K1/087 , G21K1/093 , G21K1/14 , H01J3/14 , H01J3/34 , H05H7/04 , H05H7/08 , H05H7/10 , H05H13/04
摘要： The invention comprises a patient positioning and/or repositioning system, such as a laying, semi-vertical, or seated patient positioning, alignment, and/or control method and apparatus used in conjunction with multi-axis charged particle radiation therapy. Patient positioning constraints optionally include one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are preferably movable and/or under computer control for rapid positioning, repositioning, and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the charged particle beam path to accurately and precisely target the tumor, and/or in system verification and validation.
摘要翻译：本发明包括与多轴带电粒子放射治疗结合使用的患者定位和/或重新定位系统，例如铺设，半垂直或就座的患者定位，对准和/或控制方法和装置。患者定位限制可选地包括以下中的一个或多个：座椅支撑件，后支撑件，头部支撑件，臂支撑件，膝盖支撑件和脚支撑件。一个或多个定位限制优选地可移动和/或在计算机控制下进行，用于快速定位，重新定位和/或固定患者。系统可选地使用位于与粒子束癌治疗系统的质子束路径基本相同的路径中的X射线束。生成的图像可用于：相对于质子束路径精细调整身体对准，以控制带电粒子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

60. 发明申请

WO2009142544A3 CHARGED PARTICLE CANCER THERAPY BEAM PATH CONTROL METHOD AND APPARATUS 审中-公开
标题翻译：充电颗粒癌治疗光束路径控制方法和装置
公开(公告)号：WO2009142544A3
公开(公告)日：2010-04-22
申请号：PCT/RU2009000246
申请日：2009-05-21
申请人： BALAKIN VLADIMIR YEGOROVICH
发明人： BALAKIN VLADIMIR YEGOROVICH
IPC分类号： H05H13/04 , A61N5/01 , A61N5/10 , H05H7/00 , H05H7/08 , H05H7/10
CPC分类号： G21K1/087 , A61N2005/1087 , G21K1/093 , G21K1/14 , H05H7/04 , H05H7/08 , H05H7/10 , H05H13/04
摘要： The invention comprises a charged particle beam path coupling an injector, synchrotron accelerator, beam transport system, targeting system, and/or patient interface method and apparatus. Preferably, the injector comprises: a negative ion beam source, a two phase ion source vacuum system, an ion beam focusing lens, and/or a tandem accelerator. Preferably, the synchrotron comprises turning magnets, edge focusing magnets, magnetic field concentration magnets, winding and correction coils, flat magnetic field incident surfaces, and/or extraction elements. Preferably, the synchrotron, beam transport system, targeting system, and patient interface combine to allow multi-axis / multi-field irradiation, where multi-axis control comprises control of horizontal and vertical beam position, beam energy, and/or beam intensity and multi-field control comprises control of patient rotation and distribution of delivered energy in and about the tumor in a time controlled, targeted, accurate, precise, dosage controlled, and/or efficient manner.
摘要翻译：本发明包括连接注射器，同步加速器，束输送系统，靶向系统和/或患者接口方法和装置的带电粒子束路径。优选地，喷射器包括：负离子束源，两相离子源真空系统，离子束聚焦透镜和/或串联加速器。优选地，同步加速器包括转动磁体，边缘聚焦磁体，磁场集中磁体，绕组和校正线圈，平坦磁场入射表面和/或提取元件。优选地，同步加速器，光束传输系统，瞄准系统和患者接口组合以允许多轴/多场照射，其中多轴控制包括水平和垂直光束位置，光束能量和/或光束强度的控制，以及多场控制包括以时间控制的，靶向的，准确的，精确的，剂量控制的和/或有效的方式来控制患者旋转和在肿瘤中和周围分布的能量。

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