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51. 发明申请

WO2016100706A1 METHODS AND DEVICES USING PHOTOPLETHYSMOGRAPHY IN THE OPTIMIZATION OF CARDIOPULMONARY RESUSCITATION 审中-公开
标题翻译：使用光学显微镜优化心脏电图恢复的方法和设备
公开(公告)号：WO2016100706A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066449
申请日：2015-12-17
申请人： XHALE, INC.
发明人： MELKER, Richard
IPC分类号： A61B5/0295
CPC分类号： A61B5/0295 , A61B5/02416 , A61B5/0816 , A61B5/14551 , A61B5/4836 , A61B5/4848 , A61B5/486 , A61B5/6819 , A61B5/7275 , A61B5/7285 , A61B5/742 , A61B2505/01 , A61H31/005 , A61H31/006 , A61H31/007 , A61H2201/5043 , A61H2201/5092 , A61H2201/5094 , A61H2201/5097 , A61H2230/04 , A61H2230/207 , A61H2230/25 , A61H2230/40
摘要： Provided according to embodiments of the invention are methods of improving the effectiveness of chest compressions as part of cardiopulmonary resuscitation (CPR). Such methods include monitoring PPG signals from a PPG sensor secured to a nose during at least one chest compression and increasing, decreasing or maintaining a at least one of the depth, duration and frequency of at least one subsequent chest compression based on a waveform parameter of the PPG signals. Related devices and systems are also provided.
摘要翻译：根据本发明的实施例提供的是提高作为心肺复苏（CPR）的一部分的胸部按压的有效性的方法。这样的方法包括在至少一次胸部压缩期间监测来自固定到鼻部的PPG传感器的PPG信号，并且基于波形参数增加，减少或维持至少一个后续胸部按压的深度，持续时间和频率中的至少一个 PPG信号。还提供了相关的设备和系统。

52. 发明申请

WO2016007595A1 GUIDEWIRE NAVIGATION FOR SINUPLASTY 审中-公开
标题翻译：中国导游导航
公开(公告)号：WO2016007595A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/039506
申请日：2015-07-08
申请人： ACCLARENT, INC.
发明人： KESTEN, Randy J. , GIROTRA, Rohit
IPC分类号： A61B19/00 , A61M25/09 , A61B17/24 , A61B5/00 , A61B5/06 , G06T19/00
CPC分类号： A61B1/233 , A61B5/055 , A61B5/062 , A61B5/066 , A61B5/4887 , A61B5/6814 , A61B5/6819 , A61B5/6851 , A61B5/7425 , A61B5/743 , A61B5/7435 , A61B6/03 , A61B6/501 , A61B17/24 , A61B34/20 , A61B34/25 , A61B90/14 , A61B2034/107 , A61B2034/2051 , A61B2034/2072 , A61B2090/306 , A61B2090/365 , G06F19/00
摘要： A method includes receiving image data, receiving surgical procedure data, and generating an operation plan. The image data is associated with anatomical structures in a nasal cavity of a patient. The image data and the surgical procedure data are received through a computing system. The act of generating an operation plan includes identifying a path for a surgical instrument in accordance with the image data and in accordance with the surgical procedure data. The act of generating the operation plan is performed through a computing system. The act of generating an operation plan further includes generating one or more instructional images depicting the identified path for the surgical instrument in a depiction of anatomical structures in the nasal cavity of the patient.
摘要翻译：一种方法包括接收图像数据，接收外科手术数据并产生操作计划。图像数据与患者鼻腔中的解剖结构相关联。通过计算系统接收图像数据和外科手术数据。生成操作计划的动作包括根据图像数据并根据外科手术过程数据识别手术器械的路径。生成操作计划的行为通过计算系统执行。生成操作计划的动作还包括在描绘患者的鼻腔中的解剖结构的情况下，生成描绘用于外科器械的识别路径的一个或多个教学图像。

53. 发明申请

WO2015092618A1 OPPOSING ACCELEROMETERS FOR A HEART RATE MONITOR 审中-公开
标题翻译：用于心率监测器的对位加速度计
公开(公告)号：WO2015092618A1
公开(公告)日：2015-06-25
申请号：PCT/IB2014/066745
申请日：2014-12-10
申请人： KONINKLIJKE PHILIPS N.V.
发明人： RUSSELL, James, Knox , DURIC, Haris , LIU, Chenguang
IPC分类号： A61B5/00 , A61B5/024 , A61B5/11
CPC分类号： A61B5/024 , A61B5/0245 , A61B5/0402 , A61B5/11 , A61B5/6803 , A61B5/6819 , A61B5/6838 , A61B5/7214 , A61B5/742 , A61N1/3925
摘要： A heart rate monitor (40) for detecting a pulse of a person (10) employs a platform (43), a plurality of multi-axis accelerometers (41R, 41L) and a pulse detector (44). The multi-axis accelerometers (41R, 41L) are adjoined to the platform (43) to generate differential mode signals (A ZR , A ZL ) indicative of a sensing by the accelerometers (41) of physiological motion (12) of the person (10) relative to acceleration sensing axes (42R, 42L) and to generate common mode signals (A XR , A XL , A YR , A YL ) indicative of a sensing by the accelerometers (41R, 41L) of extraneous motion by the person (10) relative to the acceleration sensing axes (42R, 42L). The pulse detector (44) is operably connected to the multi-axis accelerometers (41R, 41L) to generate a pulse signal (PS)as a function of a vertical alignment of the acceleration sensing axes (42R, 42L) combining the differential mode signals (A ZR , A ZL ) and cancelling the common mode signals (A XR , A XL , A YR , A YL ).
摘要翻译：用于检测人（10）的脉搏的心率监视器（40）采用平台（43），多个多轴加速度计（41R，41L）和脉冲检测器（44）。多轴加速度计（41R，41L）与平台（43）相邻，以产生指示人（10）的生理运动（12）的加速度计（41）的感测的差模信号（AZR，AZL）相对于加速度感测轴（42R，42L）并且产生指示由加速度计（41R，41L）感测到人（10）相对于加速度的外部运动的共模信号（AXR，AXL，AYR，AYL）感测轴（42R，42L）。脉冲检测器（44）可操作地连接到多轴加速度计（41R，41L），以产生作为组合差模信号的加速度感测轴（42R，42L）的垂直对准的函数的脉冲信号（PS）（AZR，AZL）并取消共模信号（AXR，AXL，AYR，AYL）。

54. 发明申请

WO2015061313A1 DEVICES, SYSTEMS AND METHODS FOR DETECTING A BILATERAL DIFFERENTIAL IN OLFACTORY THRESHOLD FOR PURE ODORANTS 审中-公开
标题翻译：用于检测纯气味的OLFACTORY THRESHOLD中的双相差异的装置，系统和方法
公开(公告)号：WO2015061313A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/061574
申请日：2014-10-21
申请人： INSPIRED TECHNOLOGIES, INC.
发明人： MILLS, Gregory B.
IPC分类号： A61M15/08
CPC分类号： A61B5/4011 , A61B5/0875 , A61B5/4088 , A61B5/6819 , A61B5/742
摘要： The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present invention relates to devices, systems and methods for detecting an asymmetric differential in a patient's olfactory detection threshold (left vs right nostril) which, when present, may be used as a device to detect, diagnose and/or monitor olfactory deterioration resulting from certain neurodegenerative disorders such as Alzheimer's disease.
摘要翻译：本系统通过测量和确定患者对左鼻孔和右鼻孔的嗅觉检测阈值在各种实施例中针对用于检测，评估和/或监测嗅觉功能障碍的装置，系统和方法。更具体地，本发明涉及用于检测患者嗅觉检测阈值（左对右鼻孔）中的不对称差异的装置，系统和方法，其当存在时可用作检测，诊断和/或监测嗅觉的装置由某些神经退行性疾病如阿尔茨海默病引起的恶化。

55. 发明申请

WO2015021300A1 HAND-HELD MICRO-RAMAN BASED DETECTION INSTRUMENT AND METHOD OF DETECTION 审中-公开
标题翻译：手持式微型拉曼探测仪及其检测方法
公开(公告)号：WO2015021300A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/050182
申请日：2014-08-07
申请人： WAYNE STATE UNIVERSITY , SERAPH BIOSCIENCES, LLC
发明人： AUNER, Gregory William , SHANLEY, Charles , BRUSATORI, Michelle , TWOMEY, Tara , SANT, David
IPC分类号： G01J3/44
CPC分类号： C12Q1/04 , A61B5/0075 , A61B5/445 , A61B5/6815 , A61B5/6819 , A61B5/682 , A61B5/6846 , C12Q1/14 , G01J3/0208 , G01J3/0264 , G01J3/0272 , G01J3/0291 , G01J3/44 , G01J3/4406 , G01J3/4412 , G01N21/65 , G01N2201/0221 , G01N2333/11 , G01N2333/31 , G01N2333/34
摘要： A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
摘要翻译：基于拉曼光谱的系统和检查和询问方法提供了用于快速和成本有效地筛选各种基于蛋白质的化合物如细菌，病毒，药物和组织异常的方法。手持式分光镜包括用于产生拉曼移位采样信号的激光和光学系列，用于信号调节和目标检测的信号处理和识别算法，其中包括超高分辨率微滤器和成像检测器阵列的组合，以提供特定分析在与目标病原体相关的离散光谱带内的目标光谱峰。

56. 发明申请

WO2014168718A1 DEVICES AND METHODS FOR MONITORING DIRECTIONAL BLOOD FLOW AND PULSE WAVE VELOCITY WITH PHOTOPLETHYSMOGRAPHY 审中-公开
标题翻译：用于监测方向血液流动和脉搏波速度的装置和方法
公开(公告)号：WO2014168718A1
公开(公告)日：2014-10-16
申请号：PCT/US2014/026359
申请日：2014-03-13
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , XHALE, INC.
发明人： MELKER, Richard, J. , COHEN, Sean
IPC分类号： A61B5/0205
CPC分类号： A61B5/0261 , A61B5/021 , A61B5/02108 , A61B5/0295 , A61B5/082 , A61B5/087 , A61B5/4064 , A61B5/6819 , A61B5/7278 , A61B2562/043 , A61B2562/046 , A61B2562/164
摘要： Provided according to embodiments of the invention are methods of monitoring the direction of blood flow that include processing with a computer photoplethysmography (PPG) signal streams from a sensor array on a body site of the individual to determine the direction and/or velocity of the blood flow at the body site of the individual. In some embodiments, direction of the blood flow at the body site is determined by the phase difference between at least three PPG signal streams from the sensor array, wherein the at least three PPG signal streams are generated from emissions of the at least three emitters.
摘要翻译：根据本发明的实施例提供的是监测血流方向的方法，其包括使用来自个体的身体部位上的传感器阵列的计算机光谱体积描记术（PPG）信号流进行处理以确定血液的方向和/或速度流动在个体的身体部位。在一些实施例中，身体部位处的血流的方向由来自传感器阵列的至少三个PPG信号流之间的相位差确定，其中至少三个PPG信号流由至少三个发射器的发射产生。

57. 发明申请

WO2014150528A1 METHODS, DEVICES AND SYSTEMS FOR PHOTOPLETHYSMOGRAPHY AT THE NASAL COLUMELLA 审中-公开
标题翻译：方法，在NASAL COLUMELLA上进行光学显微镜的设备和系统
公开(公告)号：WO2014150528A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/023506
申请日：2014-03-11
申请人： XHALE, INC.
发明人： RICH, David , KERSEY, Andrew
IPC分类号： A61B5/00 , A61B5/087 , A61B5/1455 , A61B5/024
CPC分类号： A61B5/02427 , A61B5/0873 , A61B5/0878 , A61B5/097 , A61B5/14552 , A61B5/6819 , A61B5/6832 , A61B5/6838 , A61B2560/0425 , A61B2562/164
摘要： Provided according to embodiments of the invention are photoplethysmography (PPG) sensors, systems and methods of using the same. In some embodiments of the invention, methods of obtaining a photoplethysmography (PPG) signals include securing a PPG sensor onto a nasal columella of an individual; and obtaining a PPG signal from the PPG sensor.
摘要翻译：根据本发明的实施例提供的是光电容积描记术（PPG）传感器，系统及其使用方法。在本发明的一些实施例中，获得光电体积描记术（PPG）信号的方法包括将PPG传感器固定在个体的鼻腔上; 并从PPG传感器获得PPG信号。

58. 发明申请

WO2013090705A1 SYSTEMS AND METHODS FOR USING PHOTOPLETHYSMOGRAPHY IN THE ADMINISTRATION OF NARCOTIC REVERSAL AGENTS 审中-公开
标题翻译：在光学反应剂管理中使用光电子能谱的系统和方法
公开(公告)号：WO2013090705A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/069724
申请日：2012-12-14
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , MELKER, Richard, J. , DENNIS, Donn, M.
发明人： MELKER, Richard, J. , DENNIS, Donn, M.
IPC分类号： A61B5/1455 , A61M5/172 , A61B5/00 , A61B5/0205 , A61B5/08 , A61B5/083
CPC分类号： A61B5/4839 , A61B5/0002 , A61B5/01 , A61B5/02007 , A61B5/0205 , A61B5/02055 , A61B5/0464 , A61B5/0476 , A61B5/0496 , A61B5/082 , A61B5/0836 , A61B5/1106 , A61B5/1135 , A61B5/14517 , A61B5/14546 , A61B5/14551 , A61B5/20 , A61B5/4806 , A61B5/4848 , A61B5/6817 , A61B5/6819 , A61B5/682 , A61B5/746 , A61M5/168 , A61M5/1723 , A61M15/0065 , A61M15/0066 , A61M16/0051 , A61M16/0057 , A61M16/026 , A61M16/0672 , A61M16/0683 , A61M16/12 , A61M16/14 , A61M19/00 , A61M31/007 , A61M39/281 , A61M2016/0027 , A61M2016/0036 , A61M2202/0208 , A61M2205/3569 , A61M2205/3592 , A61M2205/502 , A61M2230/06 , A61M2230/205 , A61M2230/42
摘要： Provided according to embodiments of the present invention are methods of monitoring and treating respiratory depression that include securing a photoplethysmography (PPG) sensor to a central source site of an individual; administering a central nervous system (CNS) depressant to the individual; processing PPG signals from the PPG sensor with a computer in communication with the PPG sensor; and administering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range. Related systems are also described.
摘要翻译：根据本发明的实施例提供的是监测和治疗呼吸抑制的方法，其包括将光体积描记术（PPG）传感器固定到个体的中心源位置; 对个体施用中枢神经系统（CNS）抑制剂; 使用与PPG传感器通信的计算机处理来自PPG传感器的PPG信号; 以及如果PPG信号或其衍生的生理参数在预设值范围之外，则向个体施用麻醉反转剂。还描述了相关系统。

59. 发明申请

WO2012064367A3 TREATMENT OF RUMINANT EXHALATIONS 审中-公开
标题翻译：治疗人体免疫系统
公开(公告)号：WO2012064367A3
公开(公告)日：2012-08-02
申请号：PCT/US2011001884
申请日：2011-11-10
申请人： SEARETE LLC , CALDEIRA KENNETH G , HYDE RODERICK A , ISHIKAWA MURIEL Y , KARE JORDIN T , LATHAM JOHN , MYHRVOLD NATHAN P , SALTER STEPHEN H , TEGREENE CLARENCE T , TUCKERMAN DAVID B , WEAVER THOMAS ALLAN , WHITMER CHARLES , WOOD JR LOWELL L , WOOD VICTORIA Y H
发明人： CALDEIRA KENNETH G , HYDE RODERICK A , ISHIKAWA MURIEL Y , KARE JORDIN T , LATHAM JOHN , MYHRVOLD NATHAN P , SALTER STEPHEN H , TEGREENE CLARENCE T , TUCKERMAN DAVID B , WEAVER THOMAS ALLAN , WHITMER CHARLES , WOOD JR LOWELL L , WOOD VICTORIA Y H
IPC分类号： G01N33/497 , A01K29/00
CPC分类号： B01D53/72 , A61B5/0022 , A61B5/082 , A61B5/1112 , A61B5/6819 , A61B2503/40 , B01J12/007 , B01J2219/00063 , B01J2219/00186 , B01J2219/00198 , B01J2219/00202 , B01J2219/00213 , B01J2219/00231 , B01J2219/00238 , B01J2219/1943 , Y10T436/203332 , Y10T436/214
摘要： An apparatus comprising a device suitable for retention in a nasal passage of a ruminant, the device is arranged to pass a ruminant exhalation. The device includes a first structure configured to oxidize methane gas in the ruminant exhalation and to pass products of the oxidized methane gas toward a nasal passage exit.
摘要翻译：一种包括适于保留在反刍动物的鼻通道中的装置的装置，该装置被布置成通过反刍动物呼气。该装置包括构造成氧化反刍动物呼气中的甲烷气体并使氧化甲烷气体的产物朝向鼻通道出口的第一结构。

60. 发明申请

WO2012064367A2 TREATMENT OF RUMINANT EXHALATIONS 审中-公开
标题翻译：治疗暴饮暴食
公开(公告)号：WO2012064367A2
公开(公告)日：2012-05-18
申请号：PCT/US2011/001884
申请日：2011-11-10
申请人： SEARETE LLC , CALDEIRA, Kenneth G. , HYDE, Roderick A. , ISHIKAWA, Muriel Y. , KARE, Jordin T. , LATHAM, John , MYHRVOLD, Nathan P. , SALTER, Stephen H. , TEGREENE, Clarence T. , TUCKERMAN, David B. , WEAVER, Thomas Allan , WHITMER, Charles , WOOD, JR., Lowell L. , WOOD, Victoria Y.H.
发明人： CALDEIRA, Kenneth G. , HYDE, Roderick A. , ISHIKAWA, Muriel Y. , KARE, Jordin T. , LATHAM, John , MYHRVOLD, Nathan P. , SALTER, Stephen H. , TEGREENE, Clarence T. , TUCKERMAN, David B. , WEAVER, Thomas Allan , WHITMER, Charles , WOOD, JR., Lowell L. , WOOD, Victoria Y.H.
IPC分类号： G01N33/00 , G01N1/22 , B01J19/00 , C07C31/02
CPC分类号： B01D53/72 , A61B5/0022 , A61B5/082 , A61B5/1112 , A61B5/6819 , A61B2503/40 , B01J12/007 , B01J2219/00063 , B01J2219/00186 , B01J2219/00198 , B01J2219/00202 , B01J2219/00213 , B01J2219/00231 , B01J2219/00238 , B01J2219/1943 , Y10T436/203332 , Y10T436/214
摘要： Methane gas in a ruminant exhalation may be oxidized to reduce the amount of methane gas output by the ruminant.
摘要翻译：反刍动物呼气中的甲烷气体可能被氧化，以减少反刍动物输出的甲烷气体的量。

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