专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

WO2017161005A1 PRODUCTION OF PROTEINS IN LABYRINTHULOMYCETES 审中-公开
标题翻译：迷迭香属植物中蛋白质的生产
公开(公告)号：WO2017161005A1
公开(公告)日：2017-09-21
申请号：PCT/US2017/022539
申请日：2017-03-15
申请人： SYNTHETIC GENOMICS, INC.
发明人： CAIAZZA, Nicky C. , URANO, Jun , WIN, Maung N. , BOLES, Kent S.
IPC分类号： C07K14/705 , C12N15/79
摘要： The present invention provides recombinant host cells that produce proteins or therapeutic proteins, and nucleic acid constructs for producing the cells. The cells have nucleic acid constructs that encode a heterologous protein, for example an antibody. The nucleic acid constructs also can have a functional signal sequence that directs the secretion of the protein from the cell. The signal sequence can be any functional signal sequence, and various signal sequences are disclosed herein. The invention also provides methods of producing the proteins.
摘要翻译：本发明提供了产生蛋白质或治疗性蛋白质的重组宿主细胞，以及用于产生该细胞的核酸构建体。细胞具有编码异源蛋白质的核酸构建体，例如抗体。核酸构建体也可具有指导蛋白质从细胞分泌的功能性信号序列。信号序列可以是任何功能性信号序列，并且本文公开了各种信号序列。本发明还提供了生产蛋白质的方法。

52. 发明申请

WO2017070404A2 ENHANCED PRODUCTIVITY BY ATTENUATION OF CHLOROPHYLL BINDING PROTEIN GENES 审中-公开
标题翻译：通过抑制叶绿酸结合蛋白基因提高生产力
公开(公告)号：WO2017070404A2
公开(公告)日：2017-04-27
申请号：PCT/US2016/058000
申请日：2016-10-20
申请人： SYNTHETIC GENOMICS, INC.
发明人： MEUSER, Jonathan, E. , DIPETRILLO, Christen, G. , MCCARREN, Jay , BAILEY, Shaun
IPC分类号： C07K14/405 , C12N1/12
CPC分类号： C07K14/405 , C12N1/12 , C12N15/113 , C12N15/902 , C12N2800/80
摘要： Mutant photosynthetic algae having increased biomass productivity are provided. The mutants have attenuated expression of violaxanthin chlorophyll a binding proteins (VCP) or fucoxanthin chlorophyll a/c binding proteins (FCP), reduced chlorophyll, higher apparent ETR(II), little to no reduction in P max per cell, and decreased NPQ over a wide range of light intensities. Provided herein are constructs for attenuating or disrupting VCP or FCP genes. Also provided are methods of culturing VCP or FCP mutants for the production of biomass or other products.
摘要翻译：提供了具有提高的生物质生产力的突变光合藻类。突变体已经减弱了紫黄质叶绿素a结合蛋白（VCP）或岩藻黄质叶绿素a / c结合蛋白（FCP）的表达，减少了叶绿素，表观ETR（II）更高，P max降低很少或没有减少，每个细胞，并在广泛的光强度下NPQ下降。本文提供了用于减毒或破坏VCP或FCP基因的构建体。还提供了培养用于生产生物质或其他产品的VCP或FCP突变体的方法。

53. 发明申请

WO2016109840A9 COMPOSITIONS AND METHODS FOR HIGH EFFICIENCY IN VIVO GENOME EDITING 审中-公开
公开(公告)号：WO2016109840A9
公开(公告)日：2016-11-17
申请号：PCT/US2015068356
申请日：2015-12-31
申请人： SYNTHETIC GENOMICS INC
发明人： VERRUTO JOHN , MOELLERING ERIC
IPC分类号： C12N5/00 , C12N15/00 , C12N15/81 , C12N15/82
CPC分类号： C12N15/8213 , C12N9/1241 , C12N9/22 , C12N15/8209 , C12N15/8216 , C12N15/85 , C12N15/90 , C12N15/905 , C12N15/907 , C12Y207/07
摘要： The present invention provides cell lines for high efficiency genome editing using cas/CRISPR systems, methods of generating such cells lines, and methods of generating mutations in the genome of an organism using such cell lines.

54. 发明申请

WO2016168756A1 ALGAL CHLOROPLASTIC SRP54 MUTANTS 审中-公开
公开(公告)号：WO2016168756A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027976
申请日：2016-04-15
申请人： SYNTHETIC GENOMICS, INC.
发明人： DIPETRILLO, Christen, G. , MCCARREN, Jay , SARIAGA, Leah
IPC分类号： A61K36/02 , A61K36/05 , C12N15/113 , C12N15/82
CPC分类号： C12N15/8269 , C07K14/405 , C12N1/12 , C12N15/8218 , C12N15/8247 , C12P7/64 , C12P7/649
摘要： Mutant photosynthetic microorganisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutant strains have mutated chloroplastic SRP54 genes and exhibit increased productivity with respect to wild type strains. Also provided are mutant algal strains having mutated cytosolic SRP54 genes. Provided herein are methods of producing biomass and other products such as lipids using strains having mutations in an SRP54 gene. Also included are constructs and methods for attenuating or disrupting SRP54 genes.
摘要翻译：提供了具有降低的叶绿素和增加的光合效率的突变的光合微生物。突变株具有突变的叶绿体SRP54基因，并且相对于野生型菌株表现出增加的生产力。还提供具有突变的胞质SRP54基因的突变型藻类菌株。本文提供使用在SRP54基因中具有突变的菌株来生产生物质和其它产物如脂质的方法。还包括用于减弱或破坏SRP54基因的构建体和方法。

55. 发明申请

WO2016134311A1 HIGH EFFICIENCY METHOD FOR ALGAL TRANSFORMATION 审中-公开
标题翻译：用于ALGAL转化的高效方法
公开(公告)号：WO2016134311A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018766
申请日：2016-02-19
申请人： SYNTHETIC GENOMICS, INC.
发明人： KARAS, Bogumil , WEYMAN, Philip, D. , DUPONT, Christopher, L. , ALLEN, Andrew, E.
IPC分类号： C12N1/13 , C12N5/02 , C12N5/04 , C12N15/82 , C12N15/63 , C12N15/70 , C12N1/21
CPC分类号： C12N15/79 , C12N1/12
摘要： The present invention relates to the seminal discovery of a highly efficient method of transforming algal cells. Specifically, the invention relates to a novel method of delivering a plasmid containing a nucleic acid molecule to algal cells by bacterial conjugation wherein the plasmid remains episomal in the algal cell through multiple generations.
摘要翻译：本发明涉及一种高效转化藻细胞的方法的开创性发现。具体地，本发明涉及通过细菌缀合将含有核酸分子的质粒递送至藻类细胞的新方法，其中所述质粒通过多次在藻类细胞中保留游离体。

56. 发明申请

WO2016100389A1 COMPOSITIONS OF AND METHODS FOR IN VITRO VIRAL GENOME ENGINEERING 审中-公开
标题翻译：体外病毒基因工程的组合物和方法
公开(公告)号：WO2016100389A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/065891
申请日：2015-12-15
申请人： SYNTHETIC GENOMICS, INC.
发明人： CADY, Kyle, C. , BARBU, E. Magda , DIPETRILLO, Christen
IPC分类号： C12N15/113 , C12N9/22 , C12N7/01
CPC分类号： C12N7/00 , C12N9/22 , C12N2710/16121 , C12N2795/10221 , C12N2795/10222 , C12N2795/10321 , C12N2795/10322 , C12N2795/14121 , C12N2795/14122 , C12P19/34 , C12Y301/00
摘要： The present disclosure relates to a method of in vitro engineering of nucleic acids. This disclosure further relates to in vitro engineering of viral genomes and to the improvement of viral properties by in vitro genomic engineering of viral genomes. Specifically, the disclosure relates to in vitro viral genomic digestion using RNA-guided Cas9, the assembly of a recombinant genome by the insertion of a DNA or RNA fragment into the digested viral genome and transformation of a host cell with the recombinant genome. This method also related to in vitro engineering for error correction of nucleic acids.
摘要翻译：本公开涉及核酸的体外工程方法。本公开还涉及病毒基因组的体外工程和通过病毒基因组的体外基因工程改进病毒性质。具体地，本公开涉及使用RNA引导的Cas9的体外病毒基因组消化，通过将DNA或RNA片段插入消化的病毒基因组并用重组基因组转化宿主细胞来重组基因组的装配。该方法也涉及核酸纠错的体外工程。

57. 发明申请

WO2016011162A1 LID MECHANISM 审中-公开
标题翻译：引导机制
公开(公告)号：WO2016011162A1
公开(公告)日：2016-01-21
申请号：PCT/US2015/040584
申请日：2015-07-15
申请人： SYNTHETIC GENOMICS, INC.
发明人： WARDEN, Laurence , BEAVER, Scott, W. , BECKER, Mark, H.
IPC分类号： B65D55/00
CPC分类号： B01L3/508 , B01L3/50853 , B01L3/527 , B01L7/52 , B01L2300/041 , B01L2300/045 , B60K2015/0425 , B65D43/14 , B65D43/18 , B65D43/26 , G01N2035/00287 , G01N2035/00346
摘要： The invention provides a lid mechanism suitable for use with automated instrumentation. The lid mechanism has a compact design enabling it to function in very small spaces, and therefore on very compact instrumentation. One embodiment of the lid mechanism has a nut positioned around a jackscrew; a motor translationally attached to the nut for driving rotational motion of the nut around the jackscrew and vertical motion of the jackscrew; a main shaft positioned around the jackscrew with a bearing support positioned on the main shaft; a moving support comprising a bearing guide track and positioned on the main shaft so that the bearing support is positioned within the bearing guide track; and a lid plate positioned on the moving support so that vertical movement of the moving support causes vertical movement of the lid plate and rotational movement of the moving support causes rotational movement of the lid plate. Also provided is an automated laboratory instrument having a lid mechanism of the invention.
摘要翻译：本发明提供一种适用于自动化仪器的盖子机构。盖机构具有紧凑的设计，使其能够在非常小的空间中工作，因此在非常紧凑的仪器上。盖机构的一个实施例具有位于千斤顶附近的螺母; 平行地连接到螺母的电机，用于驱动螺母围绕起重螺丝的旋转运动和顶起螺丝的垂直运动; 主轴围绕所述起重螺丝定位，所述轴承支撑件定位在所述主轴上; 移动支撑件，其包括轴承导轨并定位在所述主轴上，使得所述轴承支撑件定位在所述轴承导轨内; 以及位于移动支撑件上的盖板，使得移动支撑件的垂直运动导致盖板的垂直运动，并且移动支撑件的旋转运动导致盖板的旋转运动。还提供了具有本发明的盖机构的自动化实验室仪器。

58. 发明申请

WO2015179844A2 LABYRINTHULOMYCETE STRAINS FOR PRODUCING DOCOSAHEXAENOIC ACID 审中-公开
标题翻译：用于生产DOCOSAHEXAENOIC酸的乳酸菌菌株
公开(公告)号：WO2015179844A2
公开(公告)日：2015-11-26
申请号：PCT/US2015/032308
申请日：2015-05-22
申请人： SYNTHETIC GENOMICS, INC.
发明人： RADAKOVITS, Randor, R. , CHAMPAGNE, Michele, L.
IPC分类号： C12P7/64 , A61K31/232
CPC分类号： C12N1/00 , A23D9/00 , A23K20/158 , C07C53/126 , C07C57/03 , C12N1/10 , C12N1/36 , C12N15/01 , C12P7/6409 , C12P7/6427 , C12P7/649 , C12R1/00 , C12R1/90 , Y02E50/13 , Y02P30/20
摘要： Improved labyrinthulomycetes strains that produce microbial oils having increased docosahexaenoic acid (DHA) content are disclosed. The strains have increased productivity with respect to a wild type strain. Also provided are microbial oil compositions having increased DHA content. Methods of improving strains for the production of lipid, such as DHA, are also included.
摘要翻译：公开了产生具有增加的二十二碳六烯酸（DHA）含量的微生物油的改进的迷路囊霉菌菌株。菌株相对于野生型菌株具有提高的生产力。还提供了具有增加的DHA含量的微生物油组合物。还包括改善用于生产脂质的菌株如DHA的方法。

59. 发明申请

WO2015143381A3 COMPOSITIONS AND METHODS FOR PRODUCING CHEMICALS AND DERIVATIVES THEREOF 审中-公开
标题翻译：生产化学品及其衍生物的组合物和方法
公开(公告)号：WO2015143381A3
公开(公告)日：2015-11-12
申请号：PCT/US2015021848
申请日：2015-03-20
申请人： SYNTHETIC GENOMICS INC
发明人： KAMBOURAKIS SPIROS , GRIFFIN BENJAMIN M , MARTIN KEVIN V
IPC分类号： C12P7/58 , C12N9/04 , C12P7/42 , C12P17/04
CPC分类号： C12P7/58 , C12P7/44 , C12P17/06
摘要： The present invention provides methods for producing a product of one or more enzymatic pathways. The pathways used in the methods of the invention involve one or more conversion steps such as, for example, an enzymatic conversion of guluronic acid into D-glucarate (Step 7); an enzymatic conversion of 5-ketogluconate (5-KGA) into L-Iduronic acid (Step 15); an enzymatic conversion of L-Iduronic acid into Idaric acid Step 7b); and an enzymatic conversion of 5-ketocluconate into 4,6-dihydroxy 2,5-diketo hexanoate (2,5-DDH) (Step 16). In some embodiments the methods of the invention produce 2,5-furandicarboxylic acid (FDCA) as a product. The methods include both enzymatic and chemical conversions as steps. Various pathways are also provided for converting glucose into 5-dehdyro-4-deoxy-glucarate (DDG), and for converting glucose into 2,5-furandicarboxylic acid (FDCA). The methods also involve the use of engineered enzymes that perform reactions with high specificity and efficiency. Additional products that can be produce include metabolic products such as, but not limited to, guluronic acid, L-iduronic acid, idaric acid, glucaric acid. Any of the products can be produced using glucose as a substrate or using any intermediate in any of the methods or pathways of the invention.
摘要翻译：本发明提供了用于生产一种或多种酶途径的产物的方法。用于本发明方法的途径涉及一个或多个转化步骤，例如古洛糖醛酸到D-葡萄糖酸的酶促转化（步骤7）; 5-酮葡糖酸（5-KGA）到L-艾杜糖醛酸的酶转化（步骤15）; 将L-艾杜糖醛酸转化为二酸的步骤7b）; 和5-酮基葡萄糖酸盐到4,6-二羟基2,5-二酮基己酸酯（2,5-DDH）的酶促转化（步骤16）。在一些实施方案中，本发明的方法产生2,5-呋喃二甲酸（FDCA）作为产物。该方法包括作为步骤的酶促和化学转化。还提供了各种途径将葡萄糖转化为5-脱氢-4-脱氧葡萄糖酸（DDG），并将葡萄糖转化为2,5-呋喃二甲酸（FDCA）。这些方法还涉及使用工程化酶进行具有高特异性和效率的反应。可以生产的其它产品包括代谢产物，例如但不限于古洛糖醛酸，L-艾杜糖醛酸，癸二酸，葡糖二酸。可以使用葡萄糖作为底物或使用本发明的任何方法或途径中的任何中间产物产生任何产物。

60. 发明申请

WO2015168541A1 TAMPER-RESISTANT ASSEMBLY FOR SECURING VALUABLE MATERIAL 审中-公开
标题翻译：用于保护有价值材料的防篡改组件
公开(公告)号：WO2015168541A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028778
申请日：2015-05-01
申请人： SYNTHETIC GENOMICS, INC.
发明人： WARDEN, Laurence , NEWMAN-LEHMAN, Tei , GIBSON, Daniel
IPC分类号： G08B13/00 , G08B13/02 , G08B13/14
CPC分类号： B65D61/00 , B01L3/50851 , B01L9/523 , B01L2200/026 , B01L2200/028 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/0887 , B65B5/04 , B65B7/28 , B65C1/04 , B65D25/108 , B65D25/205 , B65D43/0235 , B65D2101/0007 , B65D2101/0092 , G01N21/6428 , G01N21/6486 , G01N21/77 , G01N2021/6439
摘要： The invention provides a tamper resistant assembly that that securely contains a valuable material. The assembly has a container for holding the valuable material, an optional carrier that contains the container, one or more cover components that enclose the valuable material in the container, and one or more labels having a plurality of devices that reveal tampering by distortion of at least one of the plurality of devices. The label(s) are positioned so that dislodging a cover component causes a detectable distortion in at least one of the plurality of devices, thereby revealing tampering with the assembly. In one embodiment the label can be affixed partially to a surface of a cover component and partially to a surface of the container or the optional carrier. Also disclosed are methods of detecting tampering and method of manufacturing a temper-resistant assembly. Because the assembly allows a remote validator to validate the assembly prior to providing essential instructions or authorization for conducting procedures on valuable material contained by the assembly, the manufacturer is assured that its procedures are being provided only to authorized persons.
摘要翻译：本发明提供一种安全地包含有价值材料的防篡改组件。组件具有用于容纳有价值材料的容器，容纳容器的可选载体，将容器中的有价值材料包围的一个或多个盖部件以及一个或多个标签，其具有多个通过在多个装置中的至少一个。定位标签使得移除覆盖部件在多个装置中的至少一个装置中引起可检测的变形，从而显示对组件的篡改。在一个实施例中，标签可以部分地固定到盖部件的表面并且部分地固定到容器的表面或可选的载体上。还公开了检测篡改的方法和制造耐回火组件的方法。由于组件允许远程验证器在组装之前提供必要的指令或授权进行有价值的材料的程序验证组件，所以制造商保证其程序仅提供给授权的人员。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式