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51. 发明申请

WO1992013537A1 ILOPROST EFFECTIVE AGAINST CEREBRAL MALARIA 审中-公开
标题翻译：有效反对疟疾疟疾
公开(公告)号：WO1992013537A1
公开(公告)日：1992-08-20
申请号：PCT/DE1992000091
申请日：1992-02-07
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , BLITSTEIN-WILLINGER, Eveline , SLIWA, Karin
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： A61K31/557
CPC分类号： A61K31/557 , Y02A50/411
摘要： PCT No. PCT/DE92/00091 Sec. 371 Date Dec. 3, 1993 Sec. 102(e) Date Dec. 3, 1993 PCT Filed Feb. 7, 1992.This invention relates to the use of iloprost for the production of an agent for treating cerebral malaria.

52. 发明申请

WO1992009618A1 8-ENE-19, 11'beta'-BRIDGED STEROIDS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM 审中-公开
标题翻译： 8-ENE-19,11β-阻塞甾体，其制备和含有它们的药物制剂
公开(公告)号：WO1992009618A1
公开(公告)日：1992-06-11
申请号：PCT/EP1991002239
申请日：1991-11-27
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , OTTOW, Eckhardt , NEEF, Günter , ELGER, Walter , SCHNEIDER, Martin , FRITZEMEIER, Karl-Heinrich
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： C07J53/00
CPC分类号： C07J53/002 , C07J63/008
摘要： Described are 8-ene-19, 11β-bridged steroids of general formula (I) which have a new structural feature in the form of a double bond between the 8 position and the 9 position. Also described is a method of preparing them. The substituents R?1, R4-Y, R4'¿-Y', X and Z are as defined in the specification. The new compounds have, in particular, a strong anti-progestational action and are suitable for the preparation of pharmaceutical formulations.

53. 发明申请

WO1992000992A1 ANTI-ANDROGENIC [3,2-c]PYRAZOLE AND [3,2-d]TRIAZOLE STEROIDS 审中-公开
标题翻译：抗发黄[3,2-c]吡唑和[3,2-d]三唑类甾体
公开(公告)号：WO1992000992A1
公开(公告)日：1992-01-23
申请号：PCT/EP1991001253
申请日：1991-07-04
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , HOFMEISTER, Helmut , BITTLER, Dieter , MICHNA, Horst , HABENICHT, Ursula , FRITZEMEIER, Karl-Heinrich , NISHINO, Yukishige
IPC分类号： C07J71/00
CPC分类号： C07J71/0047
摘要： The invention discloses [3,2-c]pyrazole and [3,2-d]triazole steroids of general formula (I), wherein X stands for the CH group or a nitrogen atom, R1 stands for an alkylsulfonyl group R-SO¿2? and also, if X is the CH group, for an acyl group -R-CO-, R in each case denoting an alkyl group with 1 to 3 carbon atoms, and the other substituents have the meaning given in the description, and a process for producing them. The new compounds exhibit a marked anti-androgenic activity together with peripheral selectivity and can be used in the manufacture of drugs.

54. 发明申请

WO1991010663A1 2,13-DISUBSTITUTED ERGOLINS, THEIR PREPARATION AND THEIR USE IN DRUGS 审中-公开
标题翻译： 2,13-分解的白蛋白，其制备及其在药物中的用途
公开(公告)号：WO1991010663A1
公开(公告)日：1991-07-25
申请号：PCT/DE1991000039
申请日：1991-01-15
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , SAUER, Gerhard , SCHRÖTER, Bernd , BRUMBY, Thomas , WACHTEL, Helmut , LÖSCHMANN, Peter-Andreas
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： C07D457/12
CPC分类号： C07D457/12
摘要： Described are compounds of the formula (I) and their acid addition salts, in which R?2, R6, R13¿ and X have the meaning given in the application, plus a method of preparing the compounds and drugs containing them.

55. 发明申请

WO1991008735A1 PHARMACEUTICAL PREPARATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO1991008735A1
公开(公告)日：1991-06-27
申请号：PCT/DE1990000950
申请日：1990-12-07
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , RÖSSLING, Georg , SACHSE, Andreas , ZAUMSEIL, Rolf, Peter , RIEDL, Jutta
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： A61K09/127
CPC分类号： A61Q19/08 , A61K8/14 , A61K8/362 , A61K9/127 , A61K31/19
摘要： The description relates to pharmaceutical preparations characterized by containing α,φ-n-alkane dicarboxylic acids with 7 to 13 carbon atoms, their physiologically acceptable salts or their esters which can be split by skin enzymes in liposome dispersions. These preparations are preferably used for the topical treatment of skin diseases and for treating ageing skin.

56. 发明申请

WO1991005599A1 PROCESS FOR MAKING AQUEOUS DISPERSIONS 审中-公开
标题翻译：制备水性分散体的方法
公开(公告)号：WO1991005599A1
公开(公告)日：1991-05-02
申请号：PCT/DE1990000767
申请日：1990-10-05
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , RÖSSLING, Georg , SACHSE, Andreas
IPC分类号： B01D61/36
CPC分类号： B01D61/364 , A61K9/1277 , A61K49/0466 , B01D61/362
摘要： The description relates to a process for making aqueous dispersions in which the liquids are removed from a possibly multi-phase liquid mixture by means of diaphragm distillation.
摘要翻译：描述涉及一种制备水分散体的方法，其中通过隔膜蒸馏从可能的多相液体混合物中除去液体。

57. 发明申请

WO1991005557A1 USE OF ANTIGESTAGENS IN THE MANUFACTURE OF MEDICAMENTS 审中-公开
标题翻译：抗生素在药物制造中的应用
公开(公告)号：WO1991005557A1
公开(公告)日：1991-05-02
申请号：PCT/DE1990000781
申请日：1990-10-11
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , MICHNA, Horst , SCHNEIDER, Martin , EL ETREBY, M., Fathy
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： A61K31/565
CPC分类号： A61K31/565 , A61K31/135 , A61K2300/00
摘要： Antigestagens (competitive progesterone antagonists) are suitable for the manufacture of medicaments to treat breast cancers with an increased content of tumour cells in the S phase of the cell cycle, regarded as of high risk.

58. 发明申请

WO1990004397A1 PREPARATION FOR TRANSDERMAL APPLICATION CONTAINING GESTODENE 审中-公开
标题翻译：含有GESTODENE的透皮应用的制备
公开(公告)号：WO1990004397A1
公开(公告)日：1990-05-03
申请号：PCT/EP1989001200
申请日：1989-10-11
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , GÜNTHER, Clemens , TÄUBER, Ulrich , SCHMIDT-GOLLWITZER, Karin , RIEDL, Jutta , TACK, Johannes-Wilhelm
IPC分类号： A61K31/565
CPC分类号： A61K9/7061 , A61K9/7069 , A61K9/7084 , A61K31/565 , A61K2300/00
摘要： A preparation for transdermal application contains gestodene possibly in combination with one or two oestrogens.
摘要翻译：用于经皮施用的制剂含有可能与一种或两种雌激素组合的孕烯雌酚。

59. 发明申请

WO1990002740A1 2-OXA-BICYCLO[2.2.1]HEPTANE DERIVATIVES AND DRUGS CONTAINING SAID COMPOUNDS 审中-公开
标题翻译： 2-OXA-BICYCLO [2.2.1] HEPTANE衍生物和含有化合物的药物
公开(公告)号：WO1990002740A1
公开(公告)日：1990-03-22
申请号：PCT/DE1989000585
申请日：1989-09-07
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , KLAR, Ulrich , VORBRÜGGEN, Helmut , REHWINKEL, Hartmut , THIERAUCH, Karl-Heinz , STÜRZEBECHER, Claus-Steffen
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： C07D307/00
CPC分类号： C07D307/00 , C07D405/06 , C07D405/12 , C07F7/1804
摘要： 2-oxa-bicyclo[2.2.1]heptane derivatives according to formula (I) and their enantiomers, where for example A represents -(CH2)n-, (E)-CH=CH- or (Z)-CH=CH-, -C=C, -O- or -S-; B represents hydrogen, C1-C10 alkyl, -OR , halogen, C=N, -N3, -COOR ; R represents oxygen or a -CH2 group; R represents (a), (b), -COOR , Z represents -(CH2)p-, (E)-CH=CH-, -C=C-; W represents a direct bond, a free or functionally altered hydroxymethylene group or a free or functionally altered group (c), where the OH-group can be in the alpha or beta position; D represents a direct bond, a saturated alkylene group with 1 to 5 C atoms, a branched saturated or a linear or branched unsaturated alkylene group with 2 to 5 C atoms; E represents a direct bond, -C=C- or -CH=CR -; R represents hydrogen, C1-C10 alkyl, C3-C10-cycloalkyl, optionally substituted C6-C12-aryl or a 5 or 6 member heterocyclic residue; and if R represents hydrogen, their salts with physiologically suitable bases, as well as the alpha -, beta - or gamma -cyclodextrinclathrates, as well as compounds of formula (I) encapsulated with liposomes; process for producng them and drugs containing said compounds.
摘要翻译：（I）的2-氧杂双环[2.2.1]庚烷衍生物及其对映异构体，其中例如A表示 - （CH 2）n - ，（E）-CH = CH-或（Z）-CH = CH - ， - C = C，-O-或-S-; B表示氢，C 1 -C 10烷基，-OR 2，卤素，C = N，-N 3，-COOR 3; R 1表示氧或-CH 2基; R 4表示（a），（b），-COOR 5，Z表示 - （CH 2）p - ，（E）-CH = CH-，-C = C-; W表示直接键，游离或功能改变的羟基亚甲基或游离或功能改变的基团（c），其中OH基可以在α或β位; D表示直接键，具有1至5个C原子的饱和亚烷基，具有2至5个C原子的支链饱和或直链或支链不饱和亚烷基; E表示直接键，-C = C-或-CH = CR 7 - ; R 8表示氢，C 1 -C 10烷基，C 3 -C 10 - 环烷基，任选取代的C 6 -C 12 - 芳基或5或6元杂环残基; 并且如果R 5代表氢，它们与生理学上适合的碱的盐，以及α，β或γ-环糊精，以及用脂质体包封的式（I）化合物; 生产它们的方法和含有所述化合物的药物。

60. 发明申请

WO1988007520A1 PROCESS FOR THE MANUFACTURE OF 4-(PHENYLMETHYL) ASPARTATE 审中-公开
标题翻译：制备4-（苯基甲基）山梨糖醇的方法
公开(公告)号：WO1988007520A1
公开(公告)日：1988-10-06
申请号：PCT/DE1988000183
申请日：1988-03-17
申请人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN , WILSCHOWITZ, Ludwig
发明人： SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN
IPC分类号： C07C99/00
CPC分类号： C07C227/18 , C07C229/24
摘要： A process for the manufacture of 4-(phenylmethyl) aspartate from aspartic acid and benzyl alcohol is characterized in that a reaction mixture containing 10 to 40 mol of benzyl alcohol and 1 to 5 mol of acetyl chloride per mol of aspartic acid is used, that the reaction is carried out at a temperature between-10 DEG C and 50 DEG C, and that the product is precipitated, when reaction is complete, by neutralization with organic bases.
摘要翻译：从天冬氨酸和苄醇制备天冬氨酸4-（苯基甲基）天冬酰胺的方法的特征在于，使用每摩尔天冬氨酸含有10-40摩尔苄醇和1-5摩尔乙酰氯的反应混合物，反应在-10℃至50℃的温度下进行，当反应完成时，产物通过用有机碱中和而沉淀。

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