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51. 发明申请

WO0175067A8 NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
公开(公告)号：WO0175067A8
公开(公告)日：2004-10-14
申请号：PCT/US0108631
申请日：2001-03-30
申请人： HYSEQ INC , DRMANAC RODOJE T , LIU CHENGHUA , TANG Y TOM
发明人： DRMANAC RODOJE T , LIU CHENGHUA , TANG Y TOM
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C07K14/81 , C12N5/02 , C12N9/00 , C12N15/12 , C12P21/06 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/8107
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

52. 发明申请

WO0175067A2 NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
公开(公告)号：WO0175067A2
公开(公告)日：2001-10-11
申请号：PCT/US0108631
申请日：2001-03-30
申请人： HYSEQ INC , DRMANAC RODOJE T , LIU CHENGHUA , TANG Y TOM
发明人： DRMANAC RODOJE T , LIU CHENGHUA , TANG Y TOM
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C07K14/81 , C12N5/02 , C12N9/00 , C12N15/12 , C12P21/06 , C12Q1/68 , C12N
CPC分类号： C07K14/47 , A61K38/00 , C07K14/8107
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

53. 发明申请

WO0175067A9 NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
公开(公告)号：WO0175067A9
公开(公告)日：2002-10-31
申请号：PCT/US0108631
申请日：2001-03-30
申请人： HYSEQ INC , DRMANAC RODOJE T , LIU CHENGHUA , TANG Y TOM
发明人： DRMANAC RODOJE T , LIU CHENGHUA , TANG Y TOM
IPC分类号： A61K38/00 , C07H21/04 , C07K14/47 , C07K14/81 , C12N5/02 , C12N9/00 , C12N15/12 , C12P21/06 , C12Q1/68 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/8107
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

54. 发明申请

WO2004087874A3 NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：新型核酸和多糖
公开(公告)号：WO2004087874A3
公开(公告)日：2005-12-22
申请号：PCT/US2004009202
申请日：2004-03-24
申请人： NUVELO INC , TANG Y TOM , ZHOU PING , WANG JIAN-RUI , WANG ZHI WEI , HU TIANHUA , DRMANAC RADOJE T
发明人： TANG Y TOM , ZHOU PING , WANG JIAN-RUI , WANG ZHI WEI , HU TIANHUA
IPC分类号： C07K14/47 , C12N20060101 , C12N15/11
CPC分类号： C07K14/47
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences enclosed by these nucleic acids and uses thereof.
摘要翻译：本发明提供新的核酸，由这些核酸包围的新的多肽序列及其用途。

55. 发明申请

WO02100898A3 POLYPEPTIDE HAVING AN ACTIVITY TO SUPPORT PROLIFERATION OR SURVIVAL OF HEMATOPOIETIC STEM CELL AND HEMATOPOIETIC PROGENITOR CELL, AND DNA CODING FOR THE SAME 审中-公开
标题翻译：具有活性支持增殖或存活HEMATOPOIETIC STEM细胞和HEMATOPOIETIC PROGENITOR细胞的多肽以及其同源DNA编码
公开(公告)号：WO02100898A3
公开(公告)日：2003-05-30
申请号：PCT/JP0205807
申请日：2002-06-11
申请人： KIRIN BREWERY , NISHIKAWA MITSUO , DRMANAC RADOJE T , LABAT IVAN , LEE JUHI , TANG Y TOM , STACHE-CRAIN BIRGIT
发明人： NISHIKAWA MITSUO , DRMANAC RADOJE T , LABAT IVAN , LEE JUHI , TANG Y TOM , STACHE-CRAIN BIRGIT
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/06 , A61P43/00 , C07K14/47 , C07K14/475 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/0789 , C12N5/10 , C12N15/12 , C07K16/22 , C12N5/06
CPC分类号： C12N5/0647 , A61K38/00 , C07K14/475
摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.
摘要翻译：通过比较支持造血干细胞或造血祖细胞的增殖或存活的细胞之间的表达基因和不支持增殖的细胞，分离编码具有支持造血干细胞或造血祖细胞增殖或存活的活性的多肽的基因或生存。通过使用分离的基因表达的基质细胞或分离的基因的基因产物来支持造血干细胞或造血祖细胞的增殖或存活。

56. 发明申请

WO2006104536A8 POLYNUCLEOTIDES ENCODING STEM CELL FACTOR-LIKE PROTEINS 审中-公开
标题翻译：编码干细胞因子蛋白质的多核苷酸
公开(公告)号：WO2006104536A8
公开(公告)日：2007-05-03
申请号：PCT/US2006001992
申请日：2006-01-18
申请人： NUVELO INC , BOYLE BRYAN J , EMTAGE PETER C R , FUNK WALTER , TANG Y TOM , ZHAO JINGSONG
发明人： BOYLE BRYAN J , EMTAGE PETER C R , FUNK WALTER , TANG Y TOM , ZHAO JINGSONG
IPC分类号： C07H21/04 , C07K1/00 , C12P19/34 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to stem cell factor-like proteins SCF A2, SCF A4 or SCF A4v, and polynucleotides encoding the proteins, having gastrointestinal epithelial cell proliferative activity. The invention further relates to the use of pharmaceutical compositions comprising SCF A2, SCF A4 or SCF A4v, for the prevention or treatment of disorders associated with the degeneration of the epithelial mucosa.
摘要翻译：本发明涉及干细胞因子样蛋白SCF A2，SCF A4或SCF A4v，和编码具有胃肠上皮细胞增殖活性的蛋白质的多核苷酸。本发明进一步涉及包含SCF A2，SCF A4或SCF A4v的药物组合物用于预防或治疗与上皮粘膜退化相关的病症的用途。

57. 发明申请

WO2006104536A3 POLYNUCLEOTIDES ENCODING STEM CELL FACTOR-LIKE PROTEINS 审中-公开
标题翻译：编码干细胞因子样蛋白的多核苷酸
公开(公告)号：WO2006104536A3
公开(公告)日：2007-03-15
申请号：PCT/US2006001992
申请日：2006-01-18
申请人： NUVELO INC , BOYLE BRYAN J , EMTAGE PETER C R , FUNK WALTER , TANG Y TOM , ZHAO JINGSONG
发明人： BOYLE BRYAN J , EMTAGE PETER C R , FUNK WALTER , TANG Y TOM , ZHAO JINGSONG
IPC分类号： C07H21/04 , C07K1/00 , C12P19/34 , C12P21/06
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention relates to stem cell factor-like proteins SCF A2, SCF A4 or SCF A4v, and polynucleotides encoding the proteins, having gastrointestinal epithelial cell proliferative activity. The invention further relates to the use of pharmaceutical compositions comprising SCF A2, SCF A4 or SCF A4v, for the prevention or treatment of disorders associated with the degeneration of the epithelial mucosa.
摘要翻译：本发明涉及干细胞因子样蛋白SCF A2，SCF A4或SCF A4v，以及编码蛋白质的多核苷酸，具有胃肠上皮细胞增殖活性。本发明还涉及包含SCF A2，SCF A4或SCF A4v的药物组合物在预防或治疗与上皮粘膜变性相关的病症中的应用。

58. 发明申请

WO0222780A8 METHODS AND MATERIALS RELATING TO NEUROPILIN-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开
标题翻译：与神经营养样多聚体和多核苷酸相关的方法和材料
公开(公告)号：WO0222780A8
公开(公告)日：2003-12-11
申请号：PCT/US0128590
申请日：2001-09-11
申请人： HYSEQ INC , TANG Y TOM
发明人： TANG Y TOM
IPC分类号： C07K14/71 , C07H21/04 , C12N15/11
CPC分类号： C07K14/71
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human neuropilin-like polypeptides including Neuropilin-Hyl and Neuropilin-Hy2. Polynucleotide of the invention comprises of nucleic acid sequence isolated from cDNA library prepared from human fetal liver-spleen (Columbia University) mRNA (SEQ ID NO:1) for Neuropilin-Hyl. Polynucleotide of the invention also comprises of nucleic acid sequence isolated from cDNA library prepared from human bone marrow (Clontech) mRNA (SEQ ID NO: 5) for Neuropilin-Hy2. Other aspects of the invention include vectors containing processes for producing novel human neuropilin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供了由这样的多核苷酸和突变体或其变体编码的新型多核苷酸和多肽，其对应于新型人类神经丝氨酸样多肽，包括Neuropilin-Hyl和Neuropilin-Hy2。本发明的多核苷酸包含从用于Neuropilin-Hyl的人胎肝脾（哥伦比亚大学）mRNA（SEQ ID NO：1）制备的cDNA文库中分离的核酸序列。本发明的多核苷酸还包含从用于Neuropilin-Hy2的人骨髓（Clontech）mRNA（SEQ ID NO：5）制备的cDNA文库中分离的核酸序列。本发明的其它方面包括含有生产新型人类神经丝氨酸样多肽的方法的载体和对这些多肽具有特异性的抗体。

59. 发明申请

WO0222780A3 METHODS AND MATERIALS RELATING TO NEUROPILIN-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开
标题翻译：关于神经毡样多肽和多核苷酸的方法和材料
公开(公告)号：WO0222780A3
公开(公告)日：2002-08-08
申请号：PCT/US0128590
申请日：2001-09-11
申请人： HYSEQ INC , TANG Y TOM
发明人： TANG Y TOM
IPC分类号： C07K14/71 , C07H21/04 , C12N15/11
CPC分类号： C07K14/71
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human neuropilin-like polypeptides including Neuropilin-Hyl and Neuropilin-Hy2. Polynucleotide of the invention comprises of nucleic acid sequence isolated from cDNA library prepared from human fetal liver-spleen (Columbia University) mRNA (SEQ ID NO:1) for Neuropilin-Hyl. Polynucleotide of the invention also comprises of nucleic acid sequence isolated from cDNA library prepared from human bone marrow (Clontech) mRNA (SEQ ID NO: 5) for Neuropilin-Hy2. Other aspects of the invention include vectors containing processes for producing novel human neuropilin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供了由这些多核苷酸及其突变体或变体编码的新型多核苷酸和多肽，其对应于新颖的人类神经毡蛋白样多肽，包括神经毡蛋白-Hyl和神经毡蛋白-Hy2。本发明的多核苷酸包含从人胎肝脾脏（哥伦比亚大学）mRNA（SEQ ID NO：1）制备的用于神经纤毛蛋白-Hyl的cDNA文库分离的核酸序列。本发明的多核苷酸还包含从人骨髓（Clontech）mRNA（SEQ ID NO：5）制备的用于神经毡蛋白-Hy2的cDNA文库分离的核酸序列。本发明的其他方面包括含有用于产生新型人类神经毡蛋白样多肽的方法的载体和对这些多肽具有特异性的抗体。

60. 发明申请

WO2005091777A3 METHODS AND MATERIALS RELATING TO INSULIN GROWTH FACTOR-LIKE (IGFL) POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开
标题翻译：与胰岛素生长因子（IGFL）多肽和多核苷酸相关的方法和材料
公开(公告)号：WO2005091777A3
公开(公告)日：2007-04-26
申请号：PCT/US2005003374
申请日：2005-02-02
申请人： NUVELO INC , EMTAGE PETER C R , HU TIANHUA , TANG Y TOM
发明人： EMTAGE PETER C R , HU TIANHUA , TANG Y TOM
IPC分类号： A61K8/18 , A61K38/30 , A61Q13/00 , C07H21/04 , C07K14/65 , C12N5/02 , C12N15/00 , C12N15/09 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/65 , A61K38/00 , C07H21/04
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel insulin growth factor-like (IGFL) polypeptides. Other aspects of the invention include vectors containing processes for producing novel IGFL polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新型胰岛素生长因子样（IGFL）多肽的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。本发明的其它方面包括含有生产新型IGFL多肽的方法的载体和对这些多肽具有特异性的抗体。

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