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51. 发明申请

WO03006162A3 THERMAL CYCLING METHODS AND APPARATUS 审中-公开
标题翻译：热循环方法和装置
公开(公告)号：WO03006162A3
公开(公告)日：2003-05-22
申请号：PCT/CA0201075
申请日：2002-07-12
申请人： UNIV BRITISH COLUMBIA , MARZIALI ANDRE , CHOW SHU GEE
发明人： MARZIALI ANDRE , CHOW SHU GEE
IPC分类号： B01L3/00 , B01L7/00 , B01L3/14 , C12Q1/68
CPC分类号： B01L3/50851 , B01L7/52 , B01L7/54
摘要： A thermal cycling method maintains inner wall surfaces of a well at temperatures greater than a temperature of a liquid being subjected to thermal cycling. The method may be applied in performing the polymerase chain reaction (PCR). Apparatus for performing thermal cycling provides one or more wells having regions of reduced thermal conductivity.
摘要翻译：热循环方法保持井的内壁表面的温度高于经受热循环的液体的温度。该方法可以用于进行聚合酶链式反应（PCR）。用于执行热循环的设备提供一个或多个具有导热率降低的区域的井。

52. 发明申请

WO0246231A3 CAML-BINDING PEPTIDES 审中-公开
公开(公告)号：WO0246231A3
公开(公告)日：2003-04-24
申请号：PCT/CA0101769
申请日：2001-12-07
申请人： UNIV BRITISH COLUMBIA , MOISE ALEXANDRU R , JEFFERIES WILFRED A , VITALIS TIMOTHY Z , GRANT JASON R
发明人： MOISE ALEXANDRU R , JEFFERIES WILFRED A , VITALIS TIMOTHY Z , GRANT JASON R
IPC分类号： A61K38/00 , C07K14/075 , C12N15/11 , A61K38/04 , C07K14/065 , C07K14/47 , C07K14/705 , C12N15/62
CPC分类号： C07K14/005 , A61K38/00 , C07K2319/00 , C12N2710/10322
摘要： This invention provides peptides that bind to CAML, and nucleic acids encoding such peptides. These peptides and nucleic acids are useful for targeting CAML and for modulating of CAML activity so as to affect immune or inflammatory response or to evade apoptosis. Also provided are vectors for expressing such peptides and implantable medical devices comprising the peptides or nucleic acids.
摘要翻译：本发明提供了结合CAML的肽和编码这些肽的核酸。这些肽和核酸可用于靶向CAML和调节CAML活性，以便影响免疫或炎症反应或逃避凋亡。还提供了用于表达这些肽的载体和包含肽或核酸的可植入医疗装置。

53. 发明申请

WO0237122A3 STEROL GLUCOSIDE TOXINS 审中-公开
标题翻译：甾醇葡糖苷毒素
公开(公告)号：WO0237122A3
公开(公告)日：2002-12-27
申请号：PCT/CA0101567
申请日：2001-11-02
申请人： UNIV BRITISH COLUMBIA , SHAW CHRISTOPHER ARIEL , ANDERSEN RAYMOND J , WILLIAMS DAVID E , BAINS JASWINDER
发明人： SHAW CHRISTOPHER ARIEL , ANDERSEN RAYMOND J , WILLIAMS DAVID E , BAINS JASWINDER
IPC分类号： G01N33/92
CPC分类号： A01K67/027 , A01K2227/105 , A01K2267/0318 , G01N33/6896 , G01N33/92 , G01N2400/02 , G01N2800/28 , Y10T436/143333
摘要： The invention relates to the identification of sterol glucoside toxins, and provides methods for detecting and detoxifying the compounds, as well as therapeutic methods for treating subjects exposed to such toxins. In alternative embodiments, the toxins may for example include beta-sitostrol-beta-D-glucoside (5-cholesten-24b-ethyl-3b-ol-D-glucoside) or cholesterol glucoside (5-cholesten-3b-ol-3b-D-glucoside).
摘要翻译：本发明涉及甾醇葡糖苷毒素的鉴定，并且提供了用于检测和解毒所述化合物的方法，以及用于治疗暴露于这种毒素的受试者的治疗方法。在替代实施方案中，毒素可以例如包括β-葡萄糖胺-β-D-葡糖苷（5-胆甾烯-24-乙基-3β-醇-D-葡糖苷）或胆固醇葡糖苷（5-胆甾烯-3β-醇-3β- d-葡糖苷）。

54. 发明申请

WO0218994A3 PLANAR PHOTONIC BANDGAP STRUCTURES FOR CONTROLLING RADIATION LOSS 审中-公开
标题翻译：用于控制辐射损失的平面光子带结构
公开(公告)号：WO0218994A3
公开(公告)日：2002-09-26
申请号：PCT/CA0101228
申请日：2001-08-30
申请人： UNIV BRITISH COLUMBIA , YOUNG JEFF F , COWAN ALLAN R , PACRADOUNI VIGHEN
发明人： YOUNG JEFF F , COWAN ALLAN R , PACRADOUNI VIGHEN
IPC分类号： G02B6/122 , G02B6/12
CPC分类号： B82Y20/00 , G02B6/1225
摘要： The present planar photonic bandgap structures achieve improved control over radiation losses by employing layered dielectric structures. These structures control radiation losses incurred in connection with planar photonic bandgap structures and waveguides, waveguide bends, waveguide crossings, filters, switches and fiber-coupling structures in which such planar photonic bandgap structures are used.
摘要翻译：本发明的平面光子带隙结构通过采用分层介电结构实现对辐射损耗的改进控制。这些结构控制与平面光子带隙结构和波导，波导弯曲，波导交叉，滤波器，开关以及其中使用这种平面光子带隙结构的光纤耦合结构有关的辐射损耗。

55. 发明申请

WO0200687A3 ANTIMICROBIAL PEPTIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗微生物肽及其使用方法
公开(公告)号：WO0200687A3
公开(公告)日：2002-09-06
申请号：PCT/CA0100918
申请日：2001-06-27
申请人： UNIV BRITISH COLUMBIA
发明人： HANCOCK ROBERT E W , ZHANG LIJUAN
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P31/04 , C07K7/08 , C12N1/20 , C12N7/06 , A61K38/10 , A61P31/00 , C12N15/12
CPC分类号： C07K7/08 , A61K38/00
摘要： A class of cationic, polyphemusin-like peptides having antimicrobial activity is provided. Examples of such peptides include FRWCFRVCYKGRCRYKCR (SEQ ID NO:3), RRWCFRVCYKGFCRYKCR (SEQ ID NO:4), and RRWCFRVCYRGRFCYRKCR (SEQ ID NO:11). Also provided are methods for inhibiting the growth of microbes such as bacteria, yeast and viruses utilizing the peptides of the invention. The peptides are particularly useful for inhibiting endotoxemia in a subject.
摘要翻译：提供了一类具有抗微生物活性的阳离子，聚异戊烯样肽。这样的肽的实例包括FRWCFRVCYKGRCRYKCR（SEQ ID NO：3），RRWCFRVCYKGFCRYKCR（SEQ ID NO：4）和RRWCFRVCYRGRFCYRKCR（SEQ ID NO：11）。还提供了利用本发明的肽抑制微生物如细菌，酵母和病毒生长的方法。所述肽特别可用于抑制受试者的内毒素血症。

56. 发明申请

WO0190361A3 MODULATION OF INFLAMMATION BY PROTEASE-TREATED MCP-3 CHEMOKINE 审中-公开
标题翻译：通过蛋白酶处理的MCP-3 CHEMOKINE进行调节
公开(公告)号：WO0190361A3
公开(公告)日：2002-08-08
申请号：PCT/CA0100741
申请日：2001-05-25
申请人： UNIV BRITISH COLUMBIA , OVERALL CHRISTOPHER MARK , MCQUIBBAN G ANGUS , CLARK-LEWIS IAN
发明人： MCQUIBBAN G ANGUS , CLARK-LEWIS IAN
IPC分类号： A61K38/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K14/52 , C12N15/19 , A61K38/19
CPC分类号： C07K14/523 , A61K38/00
摘要： The invention provides methods of inhibiting the biological activity or the in vivo biological activity of CC-chemokines (including native MCP-3), such as methods of inhibiting inflammation, comprising administering to a host an effective amount of a CC-chemokine receptor antagonist of the present invention. In some embodiments, the invention may provide methods of modulating an immune response in a host, or treating inflammation or autoimmune disease in a host suffering from such diseases, comprising administering to the host an effective amount of a CC-chemokine receptor antagonist of the present invention. Another aspect of the present invention is directed to pharmaceutical compositions comprising an antagonistically effective amount of a CC-chemokine receptor antagonist of the present invention and a pharmaceutically acceptable carrier. In alternative aspects, the invention provides compounds and methods for cancer treatment that facilitate an effective immune response.
摘要翻译：本发明提供抑制CC趋化因子（包括天然MCP-3）的生物学活性或体内生物学活性的方法，例如抑制炎症的方法，包括向宿主施用有效量的CC-趋化因子受体拮抗剂本发明。在一些实施方案中，本发明可以提供调节宿主中的免疫应答或在患有这些疾病的宿主中治疗炎症或自身免疫性疾病的方法，包括向宿主施用有效量的本发明的CC-趋化因子受体拮抗剂发明。本发明的另一方面涉及包含拮抗有效量的本发明的CC-趋化因子受体拮抗剂和药学上可接受的载体的药物组合物。在替代方面，本发明提供了促进有效免疫应答的用于癌症治疗的化合物和方法。

57. 发明申请

WO0190387A3 GENE REGULATORY REGION THAT PROMOTES ROOT-SPECIFIC TRANSCRIPTION AND ITS USES 审中-公开
标题翻译：促进根特异性转录及其用途的基因监管区域
公开(公告)号：WO0190387A3
公开(公告)日：2002-06-27
申请号：PCT/IB0101137
申请日：2001-05-24
申请人： UNIV BRITISH COLUMBIA , KUNST LJERKA , SMITH MARK ANDREW , MOON HANGSIK
发明人： KUNST LJERKA , SMITH MARK ANDREW , MOON HANGSIK
IPC分类号： C12N9/10 , C12N15/82 , C12N15/67
CPC分类号： C12N9/1029 , C12N15/8227
摘要： Nucleic acid sequence which directs root-specific transcription of contiguous genes in plants is provided. This sequence may be used in transgenic plants to promote expression of endogenous and foreign genes in roots to enhance plant resistance to diseases and pests, stress (salt) tolerance, and improve nutritive value of edible root plants. In addition, this sequence may be useful for the production of recombinant proteins in roots aimed at molecular farming and phytoremediation.
摘要翻译：提供了指导植物中连续基因的根特异性转录的核酸序列。该序列可用于转基因植物，以促进内源和外源基因在根中的表达，以增强植物对疾病和害虫的抵抗力，胁迫（盐）耐受性，并提高食用根植物的营养价值。此外，该序列可用于生产用于分子养殖和植物修复的根中的重组蛋白质。

58. 发明申请

WO0214213A3 HYDROGEN GENERATION FROM WATER SPLIT REACTION 审中-公开
标题翻译：氢分离反应生成氢
公开(公告)号：WO0214213A3
公开(公告)日：2002-04-11
申请号：PCT/CA0101115
申请日：2001-08-01
申请人： UNIV BRITISH COLUMBIA
发明人： CHAKLADER ASOKE CHANDRA DAS
IPC分类号： C01B3/08
CPC分类号： C01B3/08 , Y02E60/36
摘要： A method of producing Hydrogen by reacting a metal selected from the group consisting of Aluminum (Al), Magnesium (Mg), Silicon (Si) and Zinc (Zn) with water in the presence of an effective amount of a catalyst at a pH of between 4 and 10 to produce Hydrogen. The catalyst or other additive is selected to prevent or slow down deposition of the reaction products on the (impair reactions with the) metal that tend to passivate the metal and thereby facilitates the production of said Hydrogen.
摘要翻译：在有效量的催化剂存在下，将选自铝（Al），镁（Mg），硅（Si）和锌（Zn）的金属与水反应的pH值为 4至10之间产生氢气。选择催化剂或其它添加剂以防止或减缓反应产物沉积（倾向于钝化金属的金属的损害反应），从而促进所述氢的生成。

59. 发明申请

WO0224947A2 CANCER ASSOCIATED PROTEIN KINASES AND THEIR USES 审中-公开
标题翻译：癌症相关蛋白激酶及其用途
公开(公告)号：WO0224947A2
公开(公告)日：2002-03-28
申请号：PCT/IB0102237
申请日：2001-09-20
申请人： KINETEK PHARMACEUTICALS INC , UNIV BRITISH COLUMBIA , YOGANATHAN THILLAINATHAN , DELANEY ALLEN D
发明人： YOGANATHAN THILLAINATHAN , DELANEY ALLEN D
IPC分类号： G01N33/50 , A61P35/00 , C12N15/09 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/574 , A61K31/70
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Detection of expression of the provided protein kinase in cancers is useful as a diagnostic, for determining the effectiveness of drugs, and determining patient prognosis. The encoded polypeptides further provides a target for screening pharmaceutical agents effective in inhibiting the growth or metastasis of tumor cells.
摘要翻译：检测所提供的蛋白激酶在癌症中的表达可用作诊断，用于确定药物的有效性以及确定患者的预后。所编码的多肽进一步提供用于筛选有效抑制肿瘤细胞生长或转移的药物的靶标。

60. 发明申请

WO0143347A3 WEIGHTED FAIR QUEUING SCHEDULER 审中-公开
标题翻译：加权公平排队赛
公开(公告)号：WO0143347A3
公开(公告)日：2002-03-07
申请号：PCT/CA0001448
申请日：2000-12-08
申请人： UNIV BRITISH COLUMBIA , TAYYAR HAITHAM F , ALNUWEIRI HUSSEIN
发明人： TAYYAR HAITHAM F , ALNUWEIRI HUSSEIN
IPC分类号： H04L12/56 , H04L29/08 , G06F9/50
CPC分类号： H04L69/329 , H04L47/2441 , H04L47/50 , H04L47/564 , H04L47/621 , H04L47/623 , H04L67/325 , H04L67/327
摘要： A scheduler which uses a GPS simulation to determine an order in which to service entities uses a novel dynamic data structure with a sophisticated, but simple, pointer update mechanism. Preferred embodiments of the scheduler perform a fixed amount of work per scheduling event. A scheduling event can be either computing a new virtual finish timestamp upon a new arrival to the scheduler, or determining which entities are to leave the GPS system because their finish timestamp has expired. The scheduler may be used in packet scheduling in a packet handling device, such as a router, scheduling access of software processes to a computer processor or the like. The scheduler may implement weighted fair queuing (WFQ) scheduling.
摘要翻译：使用GPS模拟来确定服务实体使用具有复杂但简单的指针更新机制的新型动态数据结构的顺序的调度器。调度器的优选实施例执行每个调度事件的固定量的工作。调度事件可以是在新到达调度器时计算新的虚拟完成时间戳，或者确定哪些实体要离开GPS系统，因为它们的完成时间戳已经过期。调度器可以用于诸如路由器之类的分组处理设备中的分组调度，将计算机处理程序的访问调度到计算机处理器等。调度器可以实现加权公平排队（WFQ）调度。

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