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51. 发明申请

WO2004110516A2 PERI-ARTERIAL BLOOD FLOW BOOSTER 审中-公开
公开(公告)号：WO2004110516A2
公开(公告)日：2004-12-23
申请号：PCT/IL2004000520
申请日：2004-06-16
申请人： TECHNION RES & DEV FOUNDATION , HOFFMAN AARON , WEIZMAN GABY
发明人： HOFFMAN AARON , WEIZMAN GABY
IPC分类号： A61M20060101 , A61M1/10 , A61M1/12 , A61N1/362 , A61M
CPC分类号： A61M1/1037 , A61M1/1008 , A61M1/106 , A61M1/1062 , A61M1/1067 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/127 , A61M2205/32
摘要： A peri-arterial blood flow booster apparatus for improving blood pressure and flow, to be implanted around a blood vessel of a patient. The booster comprises a pressure applying device (56) comprising at least one balloon (44), placed alongside a portion of the blood vessel and a restrainer (54) for restraining the balloon and providing counter-forces. It further comprises a control console (60) comprising: an inflating unit (66) for rapidly inflating and deflating the balloon, the inflating unit connected to the balloon; sensing means (68) for sensing electrocardiograph signals of the patient; a control unit (72) for controlling the operation of the inflating unit correlating to the electrocardiograph signals detected by the sensing means. When the balloon is inflated the restrainer forces it to compress the portion of the blood vessel preventing backflow and exerting forces on the blood vessel forcing blood within the portion of the blood vessel to flow antegradely.
摘要翻译：一种用于改善血液和流动的周围动脉血流增压装置，其被植入患者的血管周围。增压器包括压力施加装置（56），该压力施加装置（56）包括至少一个放置在血管的一部分上的球囊（44）和用于限制球囊并提供反作用力的限制器（54）。其还包括控制台（60），包括：充气单元（66），其用于使气囊快速充气和放气，所述充气单元连接到气囊; 感测装置（68），用于感测患者的心电图信号; 用于控制与由感测装置检测到的心电图仪信号相关的充气单元的操作的控制单元（72）。当气囊膨胀时，限制器迫使其压缩血管部分以防止回流并且在血管上施加力，迫使血管部分内的血液顺畅地流动。

52. 发明申请

WO2004003596A3 GEOMETRICAL PHASE OPTICAL ELEMENTS WITH SPACE-VARIANT SUBWAVELENGTH GRATINGS 审中-公开
标题翻译：具有空间变换子波长光栅的几何相位光学元件
公开(公告)号：WO2004003596A3
公开(公告)日：2004-03-18
申请号：PCT/IL0300541
申请日：2003-06-26
申请人： TECHNION RES & DEV FOUNDATION , HASMAN EREZ
发明人： HASMAN EREZ
IPC分类号： G02B5/18 , G02B5/30
CPC分类号： G02B27/28 , G02B5/1809 , G02B5/1819
摘要： A space variant polarization optical element for spatially manipulating polarization-dependent geometrical phases of an incident light beam. The element comprises a substrate with a plurality of zones of gratings with a continuously varying orientation. The orientation denoted by theta(x-y) is equal to half of a desired geometrical phase (DGP) modulus 2pi. Each grating has a local period that is smaller than the wavelength of the incident light beam. In other embodiments of the present invention the substrate comprises a plurality of zones of gratings with a continuously varying orientation.
摘要翻译：一种空间变化的偏振光学元件，用于空间地处理入射光束的偏振相关几何相位。该元件包括具有多个具有连续变化的取向的光栅区域的基板。由ta（x-y）表示的取向等于期望的几何相位（DGP）模量2pi的一半。每个光栅具有小于入射光束波长的局部周期。在本发明的其它实施例中，衬底包括具有连续变化的取向的多个光栅区域。

53. 发明申请

WO0185011A2 WAVELET DEPULSING OF ULTRASOUND ECHO SEQUENCES 审中-公开
标题翻译：超声波ECHO序列的波段分布
公开(公告)号：WO0185011A2
公开(公告)日：2001-11-15
申请号：PCT/US0113590
申请日：2001-04-27
申请人： TECHNION RES & DEV FOUNDATION , FRIEDMAN MARK M , ADAM DAN , MICAILOVICH OLEG
发明人： ADAM DAN , MICAILOVICH OLEG
IPC分类号： A61B8/08 , G01S15/89 , G06K9/00 , A61B
CPC分类号： G01S7/52077 , A61B8/08 , A61B8/587 , G01S15/8977 , G06K9/00516 , G06T5/003 , G06T2207/10132 , G06T2207/30004
摘要： Methods and associated apparatuses for imaging a target. An echo sequence image of the target is acquired and a log spectrum of at least a portion of the echo sequence image is computed. A point spread function is estimated by one of two methods. According to the first method, a low-resolution wavelet projection of the echo sequence log spectrum is used as an estimate of the log spectrum of the point spread function. According to the second method, an outlier-resistant wavelet transform of the echo sequence log spectrum is effected, followed by soft-thresholding and an inverse wavelet transform. Under both methods, a frequency domain phase of the point spread function also is estimated. the relevant portion of the echo sequence image is deconvolved using the estimated point spread function.
摘要翻译：用于对目标进行成像的方法和相关设备。获取目标的回波序列图像，并计算回波序列图像的至少一部分的对数谱。点扩散函数由两种方法之一估计。根据第一种方法，使用回波序列对数谱的低分辨率小波投影作为点扩散函数的对数谱的估计。根据第二种方法，对回波序列对数谱的异常小波变换进行软阈值和逆小波变换。在这两种方法下，估计了点扩散函数的频域相位。使用估计的点扩散函数对回波序列图像的相关部分进行去卷积。

54. 发明申请

WO0120295A3 PLASMON RESONANCE PHASE IMAGING 审中-公开
标题翻译： PLASMON共振相位成像
公开(公告)号：WO0120295A3
公开(公告)日：2001-10-04
申请号：PCT/IL0000559
申请日：2000-09-12
申请人： TECHNION RES & DEV FOUNDATION , LIPSON STEPHEN , NOTCOVICH ARIEL
发明人： LIPSON STEPHEN , NOTCOVICH ARIEL
IPC分类号： G01N21/55 , G01B9/02
CPC分类号： G01N21/553 , G01N21/45
摘要： A device for measuring simultaneously the phase at each point of an image formed by light reflected from a sample in which the phase has been modified by plasma resonance in a thin conducting layer, the device comprising a thick transparent substrate (10) on which a thin layer of conducting material is deposited (13); a light source (1); an interferometer; an imaging means (9); and a processing means.
摘要翻译：一种用于同时测量由在薄导电层中通过等离子体共振修饰相位的样品反射的光形成的每个点处的相位的装置，该器件包括厚的透明衬底（10），薄的透明衬底沉积导电材料层（13）; 光源（1）; 干涉仪成像装置（9）; 和处理装置。

55. 发明申请

WO0018771A3 PROCESS FOR THE PREPARATION OF CORROLES AND SEVERAL SUCH NEW COMPOUNDS, INCLUDING CHIRAL DERIVATIVES, AND THE USE THEREOF 审中-公开
标题翻译：制备对角线和几种这类新化合物，包括手性衍生物的方法及其用途
公开(公告)号：WO0018771A3
公开(公告)日：2000-07-20
申请号：PCT/IL9900501
申请日：1999-09-15
申请人： TECHNION RES & DEV FOUNDATION , GROSS ZEEV , SIMKHOVICH LILIYA , NITSA GALILI NACHSHON , SALTSMAN IRINA
发明人： GROSS ZEEV , SIMKHOVICH LILIYA , NITSA GALILI NACHSHON , SALTSMAN IRINA
IPC分类号： C07C2/54 , C07C29/48 , C07D487/22
CPC分类号： C07D301/14 , C07B2200/07 , C07C29/48 , C07C2531/22 , C07D487/22 , C07C33/20 , C07C33/22
摘要： The present invention relates to a new process for the preparation of corroles. The synthetic approach relies on a solvent-free condensation of an aldehyde with a pyrrole. Further disclosed are several new corroles, salts, optically active isomers and complexes thereof.
摘要翻译：本发明涉及一种制备咔咯的新方法。合成方法依赖于醛与吡咯的无溶剂缩合。还公开了几种新的咔唑，盐，光学活性异构体及其络合物。

56. 发明申请

WO0005410A3 METHOD FOR DETECTING PROTEIN-PROTEIN INTERACTIONS AND A KIT THEREFOR 审中-公开
标题翻译：检测蛋白质 - 蛋白质相互作用的方法及其制备方法
公开(公告)号：WO0005410A3
公开(公告)日：2000-06-29
申请号：PCT/IL9900404
申请日：1999-07-22
申请人： TECHNION RES & DEV FOUNDATION , ARONHEIM AMI
发明人： ARONHEIM AMI
IPC分类号： C12Q1/68 , C12N15/10
CPC分类号： C12Q1/6897
摘要： A method for detecting an interaction between two tester proteins. In a cell incapable of activating a Ras protein, two nucleic acid sequences are expressed. One sequence encodes for a fusion protein comprising a mutant Ras protein incapable of localizing at the cell membrane and not requiring an exchange factor fused to one of the tester proteins. The other sequence encodes for the other tester protein fused to a plasma membrane localization domain. An interaction between the two fusion proteins leads to the expression of a functional Ras protein that is detected as an altered cell phenotype.
摘要翻译：一种检测两种测试蛋白之间相互作用的方法。在不能激活Ras蛋白的细胞中，表达了两个核酸序列。一个序列编码融合蛋白，其包含不能在细胞膜定位并且不需要与一种测试蛋白融合的交换因子的突变型Ras蛋白。另一个序列编码与质膜定位结构域融合的其他测试蛋白。两种融合蛋白之间的相互作用导致功能性Ras蛋白的表达，其被检测为改变的细胞表型。

57. 发明申请

WO9637199A8 USE OF R-ENANTIOMER OF N-PROPARGYL-1-AMINOINDAN, SALTS, AND COMPOSITIONS THEREOF 审中-公开
标题翻译： N-丙基-1-氨基茚的R-增效剂，其盐及其组合物的使用
公开(公告)号：WO9637199A8
公开(公告)日：1999-08-12
申请号：PCT/US9607465
申请日：1996-05-22
申请人： TEVA PHARMA , TECHNION RES & DEV FOUNDATION , YOUDIM MOUSSA B H , FINBERG JOHN P M , LEVY RUTH , STERLING JEFFREY , LERNER DAVID , YELLIN HAIM , VEINBERG ALEX
发明人： YOUDIM MOUSSA B H , FINBERG JOHN P M , LEVY RUTH , STERLING JEFFREY , LERNER DAVID , YELLIN HAIM , VEINBERD ALEX
IPC分类号： A61P9/10 , A61K20060101 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/195 , A61K31/215 , A61K45/06 , A61P20060101 , A61P9/00 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , C07C20060101 , C07C211/30 , C07C211/38 , C07C211/42
CPC分类号： C07C211/42 , A61K31/135 , A61K31/195 , A61K31/205 , A61K31/215 , A61K45/06 , C07C211/30 , C07C2602/08 , A61K2300/00
摘要： The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, a memory disorder, dementia, depression, hyperactive syndrome, an effective illness, a neurodegenerative disease, a neurotoxic injury, stroke, brain ischemia, a head trauma injury, a spinal trauma injury, neurotrauma, schizophrenia, an attention deficit disorder, multiple sclerosis, or withdrawal symptoms, using R(+)-N-propargyl-1-aminoindan or the pharmaceutically acceptable salt of the subject invention. The subject invention further provides a method of preventing nerve damage in a subject. Finally, the subject invention provides methods of preparing R(+)-N-propargyl-1-aminoindan, a salt thereof, and racemic N-propargyl-1-aminoindan.
摘要翻译：本发明提供了R（+） - N-炔丙基-1-氨基茚满及其药学上可接受的盐，以及含有它们的药物组合物。本发明还提供了治疗患有帕金森病，记忆障碍，痴呆，抑郁症，多动症综合征，有效疾病，神经变性疾病，神经毒性损伤，中风，脑缺血，头部创伤损伤，脊髓损伤的受试者的方法使用R（+） - N-炔丙基-1-氨基茚满或本发明的药学上可接受的盐，创伤，神经损伤，精神分裂症，注意力缺陷障碍，多发性硬化或戒断症状。本发明进一步提供一种预防受试者的神经损伤的方法。最后，本发明提供了制备R（+） - N-炔丙基-1-氨基茚满其盐和外消旋的N-炔丙基-1-氨基茚满的方法。

58. 发明申请

WO2015140802A3 DELIVERY SYSTEM COMPRISING A PROTEOLYTIC ENZYME OR EFFECTOR THEREOF FOR USE IN A METHOD FOR ORAL TREATMENT AND USES THEREOF 审中-公开
标题翻译：包含蛋白酶或其效应物的递送系统用于口服治疗方法及其用途
公开(公告)号：WO2015140802A3
公开(公告)日：2015-11-12
申请号：PCT/IL2015050288
申请日：2015-03-19
申请人： TECHNION RES & DEV FOUNDATION
发明人： SCHROEDER AVRAHAM D , ZINGER ASSAF YOSEF , HERMAN AVISHAY
IPC分类号： A61K38/48
CPC分类号： A61K38/4886 , A61C7/00 , A61C19/063 , A61K9/0063 , A61K9/127 , C12Y304/24007
摘要： The present disclosure provides a delivery system comprising (i) a physiologically acceptable carrier and (ii) a proteolytic enzyme or effector thereof for use in a method for relaxing fibers within a subject's oral cavity. In some embodiments, the relaxation is for use in tooth manipulation (particularly repositioning). In some embodiments, the method involves the use of the proteolytic enzyme or effector thereof at a concentration effective to cause relaxation of fibers between the tooth's alveolar bone and gingiva while maintaining integrity of the fibers surrounding the tooth. Also disclosed herein are methods for fiber relaxation and/or repositioning of tooth making use of the proteolytic enzyme or effector thereof.
摘要翻译：本公开提供了递送系统，其包含（i）生理上可接受的载体和（ii）蛋白水解酶或其效应物，用于在受试者的口腔内使纤维松弛的方法。在一些实施例中，松弛用于牙齿操作（特别是重新定位）。在一些实施方案中，该方法包括使用有效浓度的蛋白水解酶或其效应物，以使牙齿的牙槽骨和牙龈之间的纤维松弛，同时保持牙齿周围纤维的完整性。本文还公开了用于纤维松弛和/或重新定位使用蛋白水解酶或其效应物的牙齿的方法。

59. 发明申请

WO2011101847A3 FLOW CONTROL ON A VERTICAL AXIS WIND TURBINE (VAWT) 审中-公开
标题翻译：垂直轴风力涡轮机（VAWT）的流量控制
公开(公告)号：WO2011101847A3
公开(公告)日：2012-07-26
申请号：PCT/IL2011000165
申请日：2011-02-16
申请人： TECHNION RES & DEV FOUNDATION , GREENBLATT DAVID , SASSON BENYAMIN , SCHULMAN MAGEN
发明人： GREENBLATT DAVID , SASSON BENYAMIN , SCHULMAN MAGEN
IPC分类号： F03D7/06 , F03D3/06
CPC分类号： H04L65/105 , F03D7/06 , H04L65/1053 , Y02E10/74
摘要： A control system is presented for controlling operation of a vertical axis wind turbine (VAWT) for generating energy from an incoming fluid flow. The control system comprises at least one flow affecting arrangement associated with at least one blade of the VAWT and a control unit connected to said flow affecting arrangement, the flow affecting arrangement comprising two flow affecting units located in two opposite sides of the blade respectively at a leading edge thereof, each flow affecting unit being operable for creating a blowing jet at the respective side of the blade thereby inducing an increase in a fluid flow momentum, the control unit being configured and operable for selectively activating the flow affecting units in alternating fashion according to a predetermined time pattern to oscillate the blowing jet at the opposite sides of the blade.
摘要翻译：提出了一种用于控制用于从进入的流体流中产生能量的垂直轴风力涡轮机（VAWT）的操作的控制系统。控制系统包括与VAWT的至少一个叶片相关联的至少一个流动影响装置和连接到所述流动影响装置的控制单元，所述流动影响装置包括分别位于叶片的两个相对侧中的两个流动影响单元每个流动影响单元可操作用于在叶片的相应侧面处产生吹风喷射，从而引起流体流动动量的增加，该控制单元被构造和操作以用于以交替方式选择性地启动流动影响单元到预定的时间模式，以便在叶片的相对侧振荡喷吹。

60. 发明申请

WO2012056407A8 ANTIBODIES WHICH BIND SOLUBLE T-CELL RECEPTOR LIGANDS 审中-公开
标题翻译：抗体可溶性T细胞受体配体
公开(公告)号：WO2012056407A8
公开(公告)日：2012-07-12
申请号：PCT/IB2011054775
申请日：2011-10-26
申请人： TECHNION RES & DEV FOUNDATION , UNIV OREGON HEALTH & SCIENCE , US DEPT VETERANS AFFAIRS , REITER YORAM , DAHAN RONY , VANDENBARK ARTHUR A
发明人： REITER YORAM , DAHAN RONY , VANDENBARK ARTHUR A
IPC分类号： C07K16/28
CPC分类号： C07K16/2809 , C07K16/2833 , G01N33/564
摘要： Provided are isolated high affinity entities which comprise an antigen binding domain which specifically binds a soluble T-cell receptor ligand comprising a two- domain beta1-alpha1 of a major histocompatibility complex (MHC) class II, wherein said antigen binding domain does not bind a complex comprising a four-domain alpha1-beta1/alpha2-beta2 MHC class II. Also provided are methods and kits using same for detecting and sequestering soluble two-domain T cell receptor ligands in a sample.
摘要翻译：提供了分离的高亲和力实体，其包含特异性结合可溶性T细胞受体配体的抗原结合结构域，所述可溶性T细胞受体配体包含II类主要组织相容性复合体（MHC）的二结构域β1-α1，其中所述抗原结合结构域不结合复合物包含四结构域α1-β1/α2-β2MHC II类。还提供了使用其在样品中检测和螯合可溶性双结构域T细胞受体配体的方法和试剂盒。

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