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51. 发明申请

WO2007050583A2 AROMATIC DI-ACID-CONTAINING POLY (ESTER AMIDE) POLYMERS AND METHODS OF USE 审中-公开
标题翻译：含芳香酸二酸的聚（酯酰胺）聚合物和使用方法
公开(公告)号：WO2007050583A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041441
申请日：2006-10-25
申请人： MEDIVAS, LLC , GOMURASHVILI, Zaza, D. , KATSARAVA, Ramaz , JENKINS, Turner, Daniel , TURNELL, William
发明人： GOMURASHVILI, Zaza, D. , KATSARAVA, Ramaz , JENKINS, Turner, Daniel , TURNELL, William
IPC分类号： C08F283/04
CPC分类号： A61L31/06 , A61K47/593 , A61K47/595 , A61L27/26 , C08F283/04 , C08G69/44 , C08L51/08 , C08L53/00 , C08L77/12 , C08L2666/02
摘要： The present invention provides biodegradable, biocompatible aromatic di-acid- containing poly(ester amide) (PEA) polymers with thermo-mechanical properties that can be readily tailored by selection of various combinations and proportions of the di-acid residues in the polymers. The polymers are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The polymer compositions and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.
摘要翻译：本发明提供具有热机械性能的可生物降解的，生物相容的含芳族二酸的聚（酯酰胺）（PEA）聚合物，其可通过选择各种组合和比例的二 - 聚合物中的酸残基。这些聚合物适用于生产释放药物的生物可降解颗粒和植入式手术装置，如支架和内固定装置。聚合物组合物和手术装置通过酶促作用在体内生物降解以随时间以受控方式释放生物活性剂以及生物相容性分解产物，包括一种到多种不同的氨基酸。

52. 发明申请

WO2005112587A2 WOUND HEALING POLYMER COMPOSITIONS AND METHODS FOR USE THEREOF 审中-公开
标题翻译： WOUND HEALING POLYMER组合物及其使用方法
公开(公告)号：WO2005112587A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/016678
申请日：2005-05-12
申请人： MEDIVAS, LLC , CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, G. , GOPALAN, Sindhu, M.
发明人： CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, G. , GOPALAN, Sindhu, M.
IPC分类号： A61K35/44
CPC分类号： A61K35/44 , A61K9/0024 , A61K38/00 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L26/0019 , A61L26/0066 , A61L31/10 , A61L31/148 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/604 , A61L2300/64 , C08L77/12 , C08L79/02
摘要： The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyratevalerate copolymers, and copolymers of the cyclic diester monomer, 3(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
摘要翻译：本发明提供生物活性聚合物组合物，其可配制成通过调节组合物的各种组分以受控的速率释放伤口愈合剂。组合物可用于外部伤口敷料中，作为用于将伤口愈合剂递送至内部身体部位的聚合物植入物，或作为可植入手术装置的表面上的涂层，以递送共价连接到生物相容的可生物降解聚合物和/或嵌入在水凝胶内。还提供了使用本发明生物活性聚合物组合物促进伤口，特别是慢性伤口的自然愈合的方法。可用于形成血液相容的亲水层或涂层的可生物降解的共聚物聚酯的实例包括共聚酯酰胺，共聚酯氨基甲酸酯，乙交酯 - 丙交酯共聚物，乙交酯 - 己内酯共聚物，聚-3-羟基丁酸戊酯共聚物和环状二酯单体的共聚物， 3（S）[（烷氧基羰基）甲基] -1,4-二恶烷-2,5-二酮与L-丙交酯。乙交酯 - 丙交酯共聚物包括使用乙醇酸与L-乳酸的单体摩尔比在5:95至95:5范围内形成的聚（乙交酯-L-丙交酯）共聚物，优选乙醇酸与L-乳酸的单体摩尔比，乳酸范围为45:65至95:5。乙交酯 - 己内酯共聚物包括乙交酯和ε-己内酯嵌段共聚物，例如Monocryl或Poliglecaprone。

53. 发明申请

WO2001050946A3 FLEXIBLE STABILIZER ARM FOR FORCIBLY HOLDING AN OBJECT AGAINST A SURFACE 审中-公开
公开(公告)号：WO2001050946A3
公开(公告)日：2001-07-19
申请号：PCT/US2001/000865
申请日：2001-01-10
申请人： MEDIVAS, LLC , CARPENTER, Kenneth, W. , FOURMONT, Michelle , SASAMINE, Kazuo
发明人： CARPENTER, Kenneth, W. , FOURMONT, Michelle , SASAMINE, Kazuo
IPC分类号： A61F2/00
摘要： The present invention provides a flexible stabilizer arm assembly (2) that can be positioned in a desired three-dimensioned attitude and then fixed in place to forceably holding an object against an undulating surface. In one embodiment, the invention assembly (2) comprises a mounting base (4) for attachment of the arm (3) to a stationary fixture, a flexible arm (3) of multiple articulated elongate links (16) rotatably joined to adjacent links (16), a freely rotatable turret joint (50) at the distal end of the arm (3) that is adapted to attach an appendage in freely rotatable fashion to the distal end of the arm (3).

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