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51. 发明申请

WO2013168005A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESTLESS LEG SYNDROME AND FIBROMYALGIA 审中-公开
标题翻译：用于治疗轻度综合征和纤维母细胞瘤的组合物和方法
公开(公告)号：WO2013168005A2
公开(公告)日：2013-11-14
申请号：PCT/IB2013051266
申请日：2013-02-16
申请人： KANDULA MAHESH
发明人： KANDULA MAHESH
CPC分类号： A61K31/222 , A61K31/135 , A61K31/197 , A61K31/202 , A61K31/232 , A61K31/24 , A61K31/385 , A61K31/44 , A61K31/616 , A61K31/618 , A61K45/06 , C07C235/60 , C07C2601/14 , C07D339/04 , A61K2300/00
摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of fibromyalgia, restless leg syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of motor neurone disease, diabetic neuropathy, postherpetic neuralgia, acute opioid withdrawal management, obsessive-compulsive disorder, premature ejaculation, PTSD, injury, post-operative pain, osteoarthritis, rheumatoid arthritis, multiple sclerosis, spinal cord injury1, migraine, HIV related neuropathic pain, bipolar depression, depression, stress, cancer pain and lower back pain.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I）化合物和用于治疗纤维肌痛，不宁腿综合征的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。此类组合物可用于治疗运动神经元疾病，糖尿病性神经病，带状疱疹后神经痛，急性阿片类药物戒断管理，强迫症，早泄，PTSD，损伤，手术后疼痛，骨关节炎，类风湿性关节炎，多发性硬化，脊髓损伤1，偏头痛，艾滋病相关神经性疼痛，双相抑郁，抑郁，压力，癌症疼痛和腰痛。

52. 发明申请

WO2013168003A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的组合物和方法
公开(公告)号：WO2013168003A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/051093
申请日：2013-02-10
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： A61K31/7008 , C07H5/06 , C07H5/04 , A61K9/00 , A61K9/08 , A61P3/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P13/12 , A61P19/02 , A61P25/00 , A61P29/00
CPC分类号： C07H15/26 , A61K9/0019 , A61K9/0095 , A61K31/7028 , A61K47/542 , A61K47/549 , C07H13/04 , C07H13/06 , C07H15/18
摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of inflammation may he formulated for oral buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of Type II diabetes, Type I diabetes, insulin resistance, cardiovascular disease, arrhythmia, atherosclerosis, coronary artery disease, hypertriglyceridemia, dyslipidemia, retinopathy, nephropathy, neuropathy, macular adema, arthritis, osteoarthritis, rheumatoid arthritis, inflammatory bowel syndrome, neudegeneration, Alzheimer's disease, Huntington's disease. Ulcerative colitis, Crohn's disease. Multiple Sclerosis, muscular dystropthy, metabolic syndrome, fatty liver, bone diseases, inflammatory diseases.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I）化合物和用于治疗炎症的方法的药物组合物可以配制成用于口腔颊，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射剂。此类组合物可用于治疗II型糖尿病，I型糖尿病，胰岛素抵抗，心血管疾病，心律失常，动脉粥样硬化，冠状动脉疾病，高甘油三酯血症，血脂异常，视网膜病变，肾病，神经病，黄斑水肿，关节炎，骨关节炎，类风湿性关节炎，炎症性肠综合征，新生代，阿尔茨海默病，亨廷顿氏病。溃疡性结肠炎，克罗恩病。多发性硬化症，肌营养不良，代谢综合征，脂肪肝，骨病，炎症性疾病。

53. 发明申请

WO2013167995A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF HYPERGLYCEMIA 审中-公开
标题翻译：用于治疗高血压的组合物和方法
公开(公告)号：WO2013167995A2
公开(公告)日：2013-11-14
申请号：PCT/IB2013/050903
申请日：2013-02-03
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
CPC分类号： C07D211/46
摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of hyperglycemia may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications, macrovascular complications, lipid disorders, prediabetes, obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映异构体，立体异构体和水合物。包含有效量的式（I）化合物的药物组合物和治疗方法的高血糖可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。这些组合物可用于治疗胰岛素抵抗，糖尿病，尿崩症，1型糖尿病，2型糖尿病，微血管并发症，大血管并发症，脂质障碍，糖尿病前期，肥胖症，心律失常，心肌梗塞，中风，神经病，肾并发症，高甘油三酯血症，心血管并发症和餐后高血糖症。

54. 发明申请

WO2013167990A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEPRESSION 审中-公开
标题翻译：用于治疗呕吐的组合物和方法
公开(公告)号：WO2013167990A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/050850
申请日：2013-02-01
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07C217/60 , A61K31/135 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/00 , A61P35/00
CPC分类号： C07D339/04 , A61K47/48038 , A61K47/48061 , A61K47/542 , A61K47/545 , C07C219/08 , C07C2601/14 , C07D209/14 , C07D213/20 , C07D213/66 , C07D495/04
摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for treating or preventing depression may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of major depressive disorder (MDD), anxiety, neurological diseases, general anxiety disorder, sodal phobia, panic disorder, vasomotor symptoms, diabetic neuropathy, epilepsy, bipolar disorder, migraine, schizophrenia, cancer, menopause, HIV and familial adenomatous polyposis.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I）化合物的药物组合物，以及用于治疗或预防抑郁症的方法可以配制成口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。这些组合物可用于治疗重度抑郁症（MDD），焦虑症，神经性疾病，一般焦虑症，心律失常症，惊恐障碍，血管舒缩症状，糖尿病性神经病，癫痫，双相情感障碍，偏头痛，精神分裂症，癌症，绝经期，HIV 和家族性腺瘤性息肉病。

55. 发明申请

WO2013167988A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF COUGH 审中-公开
标题翻译：组合物和治疗方法
公开(公告)号：WO2013167988A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/050787
申请日：2013-01-30
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07D339/04 , C07C69/608 , C07C69/612 , C07C43/235 , A61K31/09 , A61K31/215 , A61K9/08 , A61P11/06 , A61P11/14 , A61P11/00 , A61P25/04 , A61P37/08
CPC分类号： A61K47/48061 , A61K47/48038 , A61K47/542 , A61K47/545 , C07C43/23 , C07C323/59 , C07D339/04
摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for treating or preventing cough may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of acute respiratory tract infections, asthma, gout, fibromyalgia, facilitating conception, promoies secondary mucosal secretions in the respiratory system, muscle relaxant, allergy, asthma, chronic obstructive pulmonary disorders, spasms, respiratory and neurological diseases.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I）化合物的药物组合物，以及用于治疗或预防咳嗽的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。这样的组合物可用于治疗急性呼吸道感染，哮喘，痛风，纤维肌痛，促进受孕，促进呼吸系统中的继发性粘膜分泌物，肌肉松弛剂，过敏，哮喘，慢性阻塞性肺病，痉挛，呼吸和神经疾病。

56. 发明申请

WO2013024376A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ATHEROTHROMBOSIS 审中-公开
标题翻译：用于治疗恶性肿瘤的组合物和方法
公开(公告)号：WO2013024376A1
公开(公告)日：2013-02-21
申请号：PCT/IB2012/053673
申请日：2012-07-19
申请人： KANDULA, mahesh
发明人： KANDULA, mahesh
IPC分类号： C07D211/96 , A61K31/445 , A61K9/08 , A61K9/00 , A61P9/10 , A61P9/14 , A61P9/00
CPC分类号： C07D211/96 , A61K31/445 , A61K47/542 , A61K47/551
摘要： The disclosures herein provide compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, enantiomers, stereoisomers, solvates, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for peroral administration- transdermal administration, transmucosal, syrups, topical, extended release, sustained release, or injection. Such compositions may foe used to treatment of vascular disorders or conditions such as thrombotic cerebrovascular or cardiovascular disease or its associated complications.
摘要翻译：本文的公开内容提供式I化合物或其药学上可接受的盐，以及多晶型物，对映异构体，立体异构体，溶剂化物和其水合物。这些盐可以配制成药物组合物。药物组合物可以配制用于经口给药 - 透皮给药，经粘膜，糖浆，局部，延长释放，持续释放或注射。这样的组合物可能会用于治疗血管疾病或病症如血栓性脑血管或心血管疾病或其相关并发症。

57. 发明申请

WO2013024320A1 2, 6 XYLIDINE DERIVATIVES FOR THE TREATMENT OF PAIN 审中-公开
标题翻译： 2，用于治疗疼痛的XYLIDINE衍生物
公开(公告)号：WO2013024320A1
公开(公告)日：2013-02-21
申请号：PCT/IB2011/003108
申请日：2011-09-09
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07D339/04 , A61K31/385 , A61P35/00
CPC分类号： A61K31/385 , C07D339/04
摘要： The disclosure herein provides a composition compound of formula 1. The disclosure also provides a method of synthesizing the compound of formula 1. The compound of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, and hydrates thereof may be formulated as pharmaceutical composition to be used for treatment of pain. The pharmaceutical composition of compound of formula 1 or the final compound may be formulated for noninvasive peroral, topical (example transdermal), enteral, transmucosal, targeted delivery, sustained release delivery, delayed release, pulsed release and parenteral methods. Such compositions may be used to treat chronic pain manifested with chronic diseases or its associated complications. The compound of formula 1 may also be offered as a kit.
摘要翻译：本文的公开内容提供了式1的组合物化合物。本公开还提供了合成式1化合物的方法。式1化合物或其药学上可接受的盐，以及多晶型物，溶剂合物和其水合物可以配制成用于治疗疼痛的药物组合物。式1化合物或最终化合物的药物组合物可以配制用于非侵入性口服，局部（透皮），肠内，经粘膜，靶向递送，持续释放递送，延迟释放，脉冲释放和肠胃外方法。这种组合物可用于治疗慢性疾病或其相关并发症所表现的慢性疼痛。式1的化合物也可以作为试剂盒提供。

58. 发明申请

WO2013008182A1 PRODRUGS OF GABA ANALOGS 审中-公开
标题翻译： GABA类似物的原理
公开(公告)号：WO2013008182A1
公开(公告)日：2013-01-17
申请号：PCT/IB2012/053529
申请日：2012-07-10
申请人： KANDULA, mahesh
发明人： KANDULA, mahesh
IPC分类号： C07C229/08 , C07D211/26 , A61K31/27 , A61K31/195 , A61K31/445 , A61P20/00
CPC分类号： C07C271/22 , A61K47/542 , C07C2601/14
摘要： The disclosures herein provide compounds of formula Ϊ, formula II, formula 111 and formula IV or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transdermal administration, transmucosal, syrups, topical, extended or sustained release, or injection. Such compositions may be used to treatment of neurological disease and conditions such as neuropathic pain, diabetic neuropathic pain, epilepsy, restless leg syndrome, and other diseases related sub-chronic and chronic pain or its associated complications.
摘要翻译：本文的公开内容提供了式I，式II，式111和式IV化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映异构体，立体异构体及其水合物。这些盐可以配制成药物组合物。药物组合物可以配制用于口服给药，透皮给药，经粘膜，糖浆，局部，延长或持续释放或注射。这样的组合物可用于治疗神经疾病和病症，例如神经性疼痛，糖尿病性神经性疼痛，癫痫，不宁腿综合征以及其它与慢性和慢性疼痛相关的疾病或其相关并发症。

59. 发明申请

WO2011107881A2 COMPOUNDS, COMPOSITIONS, FORMULATIONS AND THEIR USES THEREOF 审中-公开
标题翻译：化合物，组合物，配方及其用途
公开(公告)号：WO2011107881A2
公开(公告)日：2011-09-09
申请号：PCT/IB2011/000592
申请日：2011-02-26
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
CPC分类号： C07D339/04 , C07C323/59 , C07D417/12
摘要： A compound, composition, method of synthesizing and using the compound of formula 1 are disclosed. The compound of formula I also comprises of salts, polymorphs, solvates, and hydrates thereof. The compound may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for peroral, topical, transmucosal, inhalation, targeted delivery and sustained release formulations. Such compositions may be used to treat hepatic and genetic disorders related to copper overload. Multiple other compounds may be added with the instant claimed compounds and may be delivered as a pharmaceutical dose suitable for treating Wilson's disease.
摘要翻译：公开了合成和使用式1化合物的化合物，组合物，方法。式I化合物还包括其盐，多晶型物，溶剂合物和其水合物。该化合物可以配制成药物组合物。药物组合物可以配制用于口服，局部，经粘膜，吸入，靶向递送和持续释放制剂。这样的组合物可用于治疗与铜超负荷相关的肝脏和遗传疾病。可以与即时要求保护的化合物一起加入多种其它化合物，并且可以作为适合治疗威尔逊氏病的药物剂量递送。

60. 发明申请

WO2015028957A3 COMPOUNDS AND METHODS FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
标题翻译：用于治疗呼吸道疾病的化合物和方法
公开(公告)号：WO2015028957A3
公开(公告)日：2015-08-13
申请号：PCT/IB2014064103
申请日：2014-08-28
申请人： KANDULA MAHESH
发明人： KANDULA MAHESH
IPC分类号： A61K31/00
CPC分类号： C07D409/12 , C07D405/12
摘要： The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for the treatment of respiratory diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of asthma, bronchiectasis, chronic obstructive lung disease including COPD, bronchitis and emphysema, chronic rhinosinusitis, hypersensitivity pneumonitis, lung cancer and neoplasms of respiratory and intrathoracic organs, lung fibrosis, chronic pleural disease, pneumoconiosis, pulmonary eosinophilia, pulmonary heart disease and diseases of pulmonary circulation including pulmonary embolism, pulmonary hypertension and rhinitis, sarcoidosis, sleep apnoea syndrome.
摘要翻译：本发明涉及式I和式II的化合物或其可药用盐，以及其多晶型物，溶剂化物，对映异构体，立体异构体和水合物。可以配制包含有效量的式I或式II的化合物的药物组合物以及用于治疗呼吸疾病的方法用于口服，口腔，直肠，局部，透皮，透粘膜，静脉内，肠胃外施用，糖浆或注射。这些组合物可用于治疗哮喘，支气管扩张，慢性阻塞性肺病，包括COPD，支气管炎和肺气肿，慢性鼻窦炎，过敏性肺炎，肺癌和呼吸和胸内器官肿瘤，肺纤维化，慢性胸膜疾病，肺尘埃沉着病，肺嗜酸性粒细胞增多，肺心病和肺循环疾病，包括肺栓塞，肺高血压和鼻炎，结节病，睡眠呼吸暂停综合征。

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