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51. 发明申请

WO2007021261A1 SYSTEM AND METHOD FOR DETECTING AND FILTERING UNSOLICITED AND UNDESIRED ELECTRONIC MESSAGES 审中-公开
标题翻译：用于检测和过滤非安全和不充分的电子信息的系统和方法
公开(公告)号：WO2007021261A1
公开(公告)日：2007-02-22
申请号：PCT/US2005/028510
申请日：2005-08-10
申请人： MESSAGE LEVEL, LLC , CUNNINGHAM, Brian
发明人： CUNNINGHAM, Brian
IPC分类号： G06F15/16
CPC分类号： H04L51/12 , H04L63/126 , H04L63/14
摘要： A sending device locates and stores identifying information for each electronic message sent by the device. A receiving device, upon receipt of an electronic message, locates identifying information for the electronic message and the purported sending device of the message. The receiving device communicates a confirmation request to the purported sending device which contains identifying information for the message. The sending device receives confirmation messages and replies to such messages confirming that the message was sent if identifying information in the confirmation request corresponds to identifying information stored by the sending device and denying that the message was sent if the identifying information in the confirmation request does not correspond to stored data.
摘要翻译：发送设备定位并存储由设备发送的每个电子消息的识别信息。接收设备在接收到电子消息时，定位该消息的电子消息和所声称的发送设备的识别信息。接收装置向包含用于该消息的标识信息的声称发送装置传送确认请求。发送设备接收确认消息并对这样的消息进行回复，确认如果确认请求中的识别信息对应于发送设备存储的识别信息，并且如果确认请求中的识别信息不被发送，则拒绝该消息被发送对应于存储的数据。

52. 发明申请

WO2007019024A3 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
公开(公告)号：WO2007019024A3
公开(公告)日：2007-02-15
申请号：PCT/US2006/028473
申请日：2006-07-20
申请人： SRU BIOSYSTEMS, INC. , SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , LAING, Lance, G. , LI, Peter, Y. , BINDER, Brant , JOGIKALMATH, Gangadhar , BORSODY, Alex
发明人： SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T. , LAING, Lance, G. , LI, Peter, Y. , BINDER, Brant , JOGIKALMATH, Gangadhar , BORSODY, Alex
IPC分类号： G01N21/55 , G01N21/64
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label -free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

53. 发明申请

WO2007001597A1 BIOSENSOR SUBSTRATE STRUCTURE FOR REDUCING THE EFFECTS OF OPTICAL INTERFERENCE 审中-公开
标题翻译：生物传感器基板结构，用于减少光学干扰的影响
公开(公告)号：WO2007001597A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/014429
申请日：2006-04-13
申请人： SRU BIOSYSTEMS, INC. , SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T.
发明人： SCHULZ, Stephen, C. , CUNNINGHAM, Brian, T.
IPC分类号： G02B6/26 , C12M1/34 , C12M3/00 , G02B5/28
CPC分类号： G01N21/7743
摘要： A biosensor substrate structure is provided that eliminates the effects of optical interference of light reflected from a substrate/air interface with light reflected by the biosensor's active surface (12) by incorporating a roughened or "non-specular" surface on the side of the substrate (16) opposite the biosensor' s illumination and detection apparatus (30, 38). One can generate a useful non-specular"anti-interference" surface in a number of ways in accordance with this disclosure, including (1) by adding a coating (40) of optically diffuse material, such as UV cured acrylate, to the sensor substrate (16), (2) etching or otherwise roughening the surface (17) of the sensor substrate (16), or (3) applying a grating structure to the surface (17).
摘要翻译：提供一种生物传感器基板结构，其通过在基板侧上并入粗糙或“非镜面”表面，消除了由基板/空气界面反射的光与由生物传感器的活性表面（12）反射的光的光学干涉的影响（16）与生物传感器的照明和检测装置（30,38）相对。根据本公开，可以以多种方式产生有用的非镜面“抗干扰”表面，包括（1）通过将光漫射材料（例如UV固化丙烯酸酯）的涂层（40）添加到传感器衬底（16），（2）蚀刻或以其它方式粗糙化传感器衬底（16）的表面（17），或（3）将光栅结构施加到表面（17）。

54. 发明申请

WO2006041840A2 METHOD FOR THE VERIFICATION OF ELECTRONIC MESSAGE DELIVERY AND FOR THE COLLECTION OF DATA RELATED TO ELECTRONIC MESSAGES SENT WITH FALSE ORIGINATION ADDRESSES 审中-公开
标题翻译：用于验证电子消息传送的方法和用于收集与虚假地址相关的电子消息的数据的方法
公开(公告)号：WO2006041840A2
公开(公告)日：2006-04-20
申请号：PCT/US2005/035676
申请日：2005-10-04
申请人： MESSAGE LEVEL, LLC , CUNNINGHAM, Brian
发明人： CUNNINGHAM, Brian
IPC分类号： G06F15/16
CPC分类号： G06Q10/107 , H04L51/12 , H04L51/28
摘要： Upon receipt of an electronic message purported to have been sent by a sending device a receiving device transmits a confirmation request to the sending device requesting that the sending device confirm or deny that it originated the message. If the sending device replies confirming that it originated the message, the sending device prepares a data record indicating that the message was delivered. If the sending device replies denying that it originated the message, it requests data from the receiving device related to the message. Upon receipt of a reply denying that the sending device originated the message and requesting data related to the message, the receiving device transmits data related to the message to the sending device.
摘要翻译：在接收到发送装置发送的电子消息后，接收装置向发送装置发送请求发送装置确认或拒绝发送该消息的确认请求。如果发送设备回复确认其发起消息，则发送设备准备指示消息被传递的数据记录。如果发送设备回复拒绝其发起消息，则它从与该消息相关的接收设备请求数据。在接收到拒绝发送设备发起消息并请求与消息相关的数据的回复时，接收设备向发送设备发送与该消息相关的数据。

55. 发明申请

WO2005031349A3 LABEL-FREE METHODS FOR PERFORMING ASSAYS USING A COLORIMETRIC RESONANT REFLECTANCE OPTICAL BIOSENSOR 审中-公开
标题翻译：使用比色反射式光学生物传感器进行检测的无标签方法
公开(公告)号：WO2005031349A3
公开(公告)日：2005-06-02
申请号：PCT/US2004030893
申请日：2004-09-22
申请人： SRU BIOSYSTEMS INC , LIN BO , CUNNINGHAM BRIAN T , LI PETER
发明人： LIN BO , CUNNINGHAM BRIAN T , LI PETER
IPC分类号： B01L3/00 , C12Q1/68 , G01N21/25 , G01N21/47 , G01N33/543 , G02B5/18
CPC分类号： B01L3/5085 , C12Q1/6816 , C40B30/04 , C40B30/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/7743 , G01N33/54366 , G01N33/54373 , G02B5/1809 , Y10S435/808 , Y10S436/805 , Y10S436/809
摘要： The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods.
摘要翻译：本发明提供了确定细胞相互作用的组合物和方法，其比常规方法更快并且需要使用比常规方法更少的试剂。

56. 发明申请

WO2005033660A2 FLEXURAL PLATE WAVE SENSOR 审中-公开
标题翻译：柔性板波传感器
公开(公告)号：WO2005033660A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/032061
申请日：2004-09-30
申请人： THE CHARLES STARK DRAPER LABORATORY, INC. , WEINBERG, Marc, S. , CUNNINGHAM, Brian , HILDEBRANT, Eric
发明人： WEINBERG, Marc, S. , CUNNINGHAM, Brian , HILDEBRANT, Eric
IPC分类号： G01N
CPC分类号： G01N29/022 , G01L9/0025 , G01N2291/0423 , G01N2291/0427 , Y10T29/42
摘要： A flexural plate wave sensor including a flexural plate having a length and a width and a comb pattern over the flexural plate with drive teeth disposed across the entire length of the flexural plate to reduce the number of eigenmodes excited in the plate and thereby simplifying the operation and design of the flexure plate wave sensor.
摘要翻译：一种弯曲板式波片传感器，其包括弯曲板上的长度和宽度的弯曲板以及弯曲板上的梳状图案，驱动齿设置在弯曲板的整个长度上，以减少板中激发的本征模的数量，从而简化了操作和挠性板波传感器的设计。

57. 发明申请

WO2003087299A3 METHODS OF CHARACTERIZING MOLECULAR INTERACTION SITES ON PROTEINS 审中-公开
公开(公告)号：WO2003087299A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/010209
申请日：2003-04-04
申请人： SUNESIS PHARMACEUTICALS, INC. , ARKIN, Michelle , CUNNINGHAM, Brian , DeLANO, Warren , FUCINI, Raymond
发明人： ARKIN, Michelle , CUNNINGHAM, Brian , DeLANO, Warren , FUCINI, Raymond
IPC分类号： G01N33/53
摘要： The present invention is directed to methods of characterizing molecular interaction sites on a biological target molecule. The methods involve contacting a polypeptide with a library of ligand candidates each of which is capable of tethering to the polypeptide at a site of interest, and analyzing the physicochemical properties of the ligand candidates tethering to the polypeptide. The methods herein are useful for discovery of and development of small molecule drugs.

58. 发明申请

WO1997008313A1 VARIANTS OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR, THEIR USES, AND PROCESSES FOR THEIR PORDUCTION 审中-公开
标题翻译：血管内皮细胞生长因子的变异及其使用及其过程
公开(公告)号：WO1997008313A1
公开(公告)日：1997-03-06
申请号：PCT/US1996013621
申请日：1996-08-23
申请人： GENENTECH, INC. , KEYT, Bruce , NGUYEN, Francis, Hung , FERRARA, Napoleone , CUNNINGHAM, Brian, C. , WELLS, James, A. , LI, Bing
发明人： GENENTECH, INC.
IPC分类号： C12N15/12
CPC分类号： C07K14/515 , A61K38/00 , C07K14/52 , G01N33/74 , G01N2500/00
摘要： The present invention involves the preparation of vascular endothelial growth factor (VEGF) variants which provide materials that are selective in respect of binding characteristics to the kinase domain region and the FMS-like tyrosine-kinase region, respectively KDR and FLT-1. The respective KDR and FLT-1 receptors are bound by corresponding domains within the VEGF compound domains. The variants hereof define those two binding regions and modify them so as to introduce changes that interrupt the binding to the respective domain. In this fashion the final biological characteristics of the VEGF molecule are selectively modified.
摘要翻译：本发明涉及血管内皮生长因子（VEGF）变体的制备，其提供关于与激酶结构域和FMS样酪氨酸激酶区分别为KDR和FLT-1的结合特性有选择性的材料。相应的KDR和FLT-1受体由VEGF化合物结构域内的相应结构域结合。其变体定义了这两个绑定区域并对其进行了修改，以便引入中断与相应域的绑定的更改。以这种方式，VEGF分子的最终生物学特性被选择性地修饰。

59. 发明申请

WO1992003478A1 METAL ION MEDIATED RECEPTOR BINDING OF POLYPEPTIDE HORMONES 审中-公开
标题翻译：金属离子介导的多肽受体结合
公开(公告)号：WO1992003478A1
公开(公告)日：1992-03-05
申请号：PCT/US1991005856
申请日：1991-08-16
申请人： GENENTECH, INC. , BASS, Steven, H. , CUNNINGHAM, Brian, C. , FUH, Germaine , LOWMAN, Henry, B. , MATTHEWS, David, J. , WELLS, James, A.
发明人： GENENTECH, INC.
IPC分类号： C07K13/00
CPC分类号： C07K14/72 , A61K38/00 , C07K14/57554 , C07K14/61
摘要： Novel methods are disclosed for modulating the action of polypeptide hormones on mammalian cells, organs or whole mammals. Polypeptide hormone action is controlled by effecting the binding specificity of the polypeptide hormone for distinct receptors. The specificity for the receptor is mediated by the ability of a metal ion to complex between the polypeptide hormone and its receptor. Soluble variants of the hormone receptor may be used to modulate the action or serum half-life of the complexed polypeptide hormone. An example of such a polypeptide hormone system is human growth hormone (hGH) wherein receptor specificity is modulated by the metal cofactor zinc. Under low zinc conditions, hGH preferentially binds to human growth hormone receptor or binding protein, under high zinc conditions, hGH preferentially binds to human prolactin receptor or soluble prolactin receptor variants. This is the first indication that a metal ion can mediate a direct interaction between a polypeptide hormone and an extracellular receptor or binding protein.
摘要翻译：公开了用于调节哺乳动物细胞，器官或整个哺乳动物的多肽激素的作用的新方法。多肽激素作用通过影响多种激素对不同受体的结合特异性来控制。受体的特异性是由金属离子在多肽激素及其受体之间复合的能力所介导的。可以使用激素受体的可溶性变体来调节复合多肽激素的作用或血清半衰期。这种多肽激素系统的一个实例是人生长激素（hGH），其中受体特异性被金属辅因子锌调节。在低锌条件下，hGH优先与人生长激素受体或结合蛋白结合，在高锌条件下，hGH优先与人催乳素受体或可溶性催乳素受体变体结合。这是金属离子可以介导多肽激素和细胞外受体或结合蛋白之间的直接相互作用的第一个迹象。

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