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51. 发明申请

WO2008091659A2 METHODS AND COMPOSITIONS FOR PREDICTING AND TREATING DRUG RESISTANT STRAINS OF INFLUENZA VIRUS 审中-公开
标题翻译：预防和治疗流感病毒的耐药菌株的方法和组合物
公开(公告)号：WO2008091659A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/000923
申请日：2008-01-24
申请人： NIMAN, Henry, L.
发明人： NIMAN, Henry, L.
IPC分类号： C12Q1/70 , C12N7/04 , C12N15/44 , A61K39/145 , A61P31/16
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/16122 , C12N2760/16222 , C12N2760/16322 , C12Q1/701
摘要： The instant invention provides methods for determining, predicting and characterizing the genetic variability of viruses, in particular, influenza. Accordingly, the invention provides methods for identifying virulent pathogens, genetic mutations within pathogens that are relevant to animal health, and methods and compositions for prophylactic or therapeutic intervention against such pathogens.
摘要翻译：本发明提供了用于确定，预测和表征病毒，特别是流感的遗传变异性的方法。因此，本发明提供了用于鉴定有毒病原体，与动物健康有关的病原体内的遗传突变的方法，以及用于针对这种病原体的预防或治疗干预的方法和组合物。

52. 发明申请

WO2008033517A9 CELL CULTURE IMPROVEMENTS 审中-公开
公开(公告)号：WO2008033517A9
公开(公告)日：2008-03-20
申请号：PCT/US2007/020027
申请日：2007-09-13
申请人： ABBOTT LABORATORIES , PLA, Itzcoatl, A. , MATUCK, Joseph, C. , FANN, John, C. , SCHULZ, Christof , ROY, Nicole, A. , BRUTON, David F. , MCINTIRE, James , CHANG, Yu-Hsiang, David , SEEWOESTER, Thomas
发明人： PLA, Itzcoatl, A. , MATUCK, Joseph, C. , FANN, John, C. , SCHULZ, Christof , ROY, Nicole, A. , BRUTON, David F. , MCINTIRE, James , CHANG, Yu-Hsiang, David , SEEWOESTER, Thomas
IPC分类号： C12N5/00 , C12N5/02
摘要： The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.

53. 发明申请

WO2008021263A2 METHODS OF INDENTIFYING ANTIBODIES THAT BIND OLIGOMERIC FORMS OF CHEMOKINES AND USES THEREOF 审中-公开
标题翻译：鉴定结合趋化因子寡聚体形式的抗体及其用途的方法
公开(公告)号：WO2008021263A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/017833
申请日：2007-08-10
申请人： MEDAREX, INC. , SRINIVASAN, Mohan , BELL, Alasdair, Fraser , WANG WONG, Susan, Chien-szu
发明人： SRINIVASAN, Mohan , BELL, Alasdair, Fraser , WANG WONG, Susan, Chien-szu
IPC分类号： G01N33/68 , G01N33/563 , C07K16/00 , A61K39/395
CPC分类号： C07K16/24 , C07K2317/34 , C07K2317/55 , G01N33/6854 , G01N33/6863 , G01N2500/00
摘要： The present invention is directed to methods of identifying an antibody or an antigen-binding portion thereof that specifically recognizes and binds an oligomeric form of a chemokine.
摘要翻译：本发明涉及鉴定特异性识别和结合趋化因子寡聚形式的抗体或其抗原结合部分的方法。

54. 发明申请

WO2007120720A2 USES AND COMPOSITIONS FOR TREATMENT OF CROHN'S DISEASE 审中-公开
标题翻译：用于治疗高血糖病的用途和组合物
公开(公告)号：WO2007120720A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008962
申请日：2007-04-10
申请人： ABBOTT BIOTECHNOLOGY LTD. , POLLACK, Paul, F. , HOFFMAN, Rebecca, S. , RENZ, Cheryl
发明人： POLLACK, Paul, F. , HOFFMAN, Rebecca, S. , RENZ, Cheryl
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/21
摘要： The invention provides methods, uses and compositions for the treatment of Crohn's disease. The invention describes methods and uses for treating Crohn's disease, wherein a TNFcc inhibitor, such as a human TNF oc antibody, or antigen-binding portion thereof, is used to induce and maintain remission of Crohn's disease in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment of Crohn's disease in a subject.
摘要翻译：本发明提供了用于治疗克罗恩病的方法，用途和组合物。本发明描述了用于治疗克罗恩病的方法和用途，其中TNFα抑制剂如人TNFα抗体或其抗原结合部分用于诱导和维持患者克罗恩病的缓解。还描述了确定受试者中TNFα抑制剂治疗克罗恩病的功效的方法。

55. 发明申请

WO2007084672A3 MONOCLONAL ANTIBODIES AGAINST CD30 LACKING IN FUCOSYL AND XYLOSYL RESIDUES 审中-公开
公开(公告)号：WO2007084672A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/001451
申请日：2007-01-17
申请人： MEDAREX, INC. , BLACK, Amelia, Nancy , PASSMORE, David, B. , SRINIVASAN, Mohan , DICKEY, Lynn, F. , COX, Kevin, M. , PEELE, Charles, G. , WANG, Ming-Bo
发明人： BLACK, Amelia, Nancy , PASSMORE, David, B. , SRINIVASAN, Mohan , DICKEY, Lynn, F. , COX, Kevin, M. , PEELE, Charles, G. , WANG, Ming-Bo
IPC分类号： C07K16/28 , A61P35/00 , A61P37/00
摘要： The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to Iyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the growth of CD30 + cells, such as tumor cells, are also provided.

56. 发明申请

WO2007067730A3 HUMAN MONOCLONAL ANTIBODIES TO PROTEIN TYROSINE KINASE 7 ( PTK7 ) AND THEIR USE 审中-公开
公开(公告)号：WO2007067730A3
公开(公告)日：2007-06-14
申请号：PCT/US2006/046837
申请日：2006-12-08
申请人： MEDAREX, INC. , LU, Li-sheng , TERRETT, Jonathan, Alexander , PAN, Chin
发明人： LU, Li-sheng , TERRETT, Jonathan, Alexander , PAN, Chin
IPC分类号： C07K16/30 , C07K16/40 , A61P35/00
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

57. 发明申请

WO2007053358A2 METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES 审中-公开
标题翻译：用编码的文库鉴定化合物感兴趣的方法
公开(公告)号：WO2007053358A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/041356
申请日：2006-10-23
申请人： PRAECIS PHARMACEUTICALS, INC. , MORGAN, Barry , HALE, Stephen , ARICO-MUENDEL, Christopher, C. , CLARK, Matthew , WAGNER, Richard , ISRAEL, David, I. , GEFTER, Malcolm, L. , KAVARANA, Malcolm, J. , CREASER, Steffen, Phillip , FRANKLIN, George, J. , CENTRELLA, Paulo, A. , ACHARYA, Raksha, A. , BENJAMIN, Dennis , HANSEN, Nils Jakob, Vest
发明人： MORGAN, Barry , HALE, Stephen , ARICO-MUENDEL, Christopher, C. , CLARK, Matthew , WAGNER, Richard , ISRAEL, David, I. , GEFTER, Malcolm, L. , KAVARANA, Malcolm, J. , CREASER, Steffen, Phillip , FRANKLIN, George, J. , CENTRELLA, Paulo, A. , ACHARYA, Raksha, A. , BENJAMIN, Dennis , HANSEN, Nils Jakob, Vest
CPC分类号： C12N15/1068 , C07H21/00
摘要： The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译：本发明提供了通过筛选包含编码寡核苷酸标签的分子文库来鉴定感兴趣的化合物的方法。

58. 发明申请

WO2007047829A2 NOVEL HETERODIMERIC PROTEINS AND USES THEREOF 审中-公开
标题翻译：新型杂交蛋白及其用途
公开(公告)号：WO2007047829A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/040860
申请日：2006-10-17
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , MCKENNA, Sean, D. , CAMPBELL, Robert, K. , JIANG, Xuliang , DE LUCA, Giampiero , YANG, Meijia
发明人： MCKENNA, Sean, D. , CAMPBELL, Robert, K. , JIANG, Xuliang , DE LUCA, Giampiero , YANG, Meijia
IPC分类号： C07K14/525
CPC分类号： C07K14/52 , C07K14/525 , C07K14/5412 , C07K14/56 , C07K14/59 , C07K14/61 , C07K2319/70
摘要： This disclosure relates to hybrid proteins including at least two polypeptide chains, with each polypeptide chain including an amino acid sequence of a cytokine or a fragment thereof linked to an amino acid sequence of a subunit of a heterodimeric proteinaceous hormone. Also disclosed are methods of making and using such hybrid proteins in the treatment of various diseases.
摘要翻译：本公开涉及包括至少两条多肽链的杂合蛋白，每条多肽链包括与异二聚体蛋白质激素亚基的氨基酸序列连接的细胞因子或其片段的氨基酸序列。还公开了制备和使用这些杂合蛋白质以治疗各种疾病的方法。

59. 发明申请

WO2007044362A2 ALLELE-SPECIFIC RNA INTERFERENCE 审中-公开
标题翻译： ALLELE特异性RNA干扰
公开(公告)号：WO2007044362A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/038704
申请日：2006-10-02
申请人： UNIVERSITY OF MASSACHUSETTS , XU, Zuoshang
发明人： XU, Zuoshang
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/333 , C12N2310/336 , C12N2310/53 , C12N2320/51 , C12Y115/01001
摘要： Human diseases caused by dominant, gain-of-function mutations develop in heterozygotes bearing one mutant and one wild-type copy of a gene. Because the wild- type gene often performs important functions, whereas the mutant gene is toxic, any therapeutic strategy must selectively inhibit the mutant while retaining wild-type gene expression. The present invention includes methods of specifically inhibiting the expression of a mutant allele, while preserving the expression of a co-expressed wild-type allele using RNAi, a therapeutic strategy for treating genetic disorders associated with dominant, gain-of-function gene mutations. The invention also includes small interfering RNAs (siRNAs) and small hairpin RNAs (shRNAs) that selectively suppress mutant, but not wild-type, expression of copper zinc superoxide dismutase (SODl), which causes inherited amyotrophic lateral sclerosis (ALS). The present invention further provides asysmmetric siRNAs and shRNAs with enhanced efficacy and specificity and mediating RNAi.
摘要翻译：由携带一个突变体和一个野生型基因拷贝的杂合子产生显性，功能获得性突变引起的人类疾病。由于野生型基因经常执行重要功能，而突变基因是有毒的，所以任何治疗策略都必须选择性抑制突变体，同时保留野生型基因表达。本发明包括特异性抑制突变等位基因表达的方法，同时使用RNAi保留共表达野生型等位基因的表达，所述治疗策略用于治疗与显性功能获得性基因突变相关的遗传疾病。本发明还包括选择性抑制引起遗传性肌萎缩性侧索硬化症（ALS）的铜锌超氧化物歧化酶（SOD1）的突变而非野生型表达的小干扰RNA（siRNA）和小发夹RNA（shRNA）。本发明进一步提供了具有增强的功效和特异性并介导RNAi的asysmmetric siRNA和shRNA。

60. 发明申请

WO2007022255A2 PHARMACEUTICAL FORMULATIONS FOR SUSTAINED RELEASE 审中-公开
标题翻译：可持续释放的药物制剂
公开(公告)号：WO2007022255A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/031968
申请日：2006-08-15
申请人： PRAECIS PHARMACEUTICALS, INC. , BARKER, Nicholas , WOLFE, Janet, L.
发明人： BARKER, Nicholas , WOLFE, Janet, L.
IPC分类号： A61K38/00 , A61K47/48
CPC分类号： A61K47/61 , A61K38/00 , A61K47/38 , A61K47/585
摘要： Sustained delivery pharmaceutical compositions comprising a solid ionic complex of a pharmaceutically active compound and an ionic macromolecule are provided by the present invention. The pharmaceutical compositions of the invention allow for loading of high concentrations of pharmaceutically active compounds and for delivery of a pharmaceutically active compound for prolonged periods of time, e.g., one month, after administration. Methods for preparing these pharmaceutical compositions, as well as methods of using them to treat a subject are also provided.
摘要翻译：本发明提供了包含药物活性化合物和离子大分子的固体离子配合物的持续递送药物组合物。本发明的药物组合物允许给药后装载高浓度的药物活性化合物和递送药物活性化合物较长时间，例如一个月。还提供了制备这些药物组合物的方法，以及使用它们治疗受试者的方法。

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