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51. 发明申请

WO2011004377A2 INTERACTIVE ROUTE SEARCH 审中-公开
标题翻译：互动路线搜索
公开(公告)号：WO2011004377A2
公开(公告)日：2011-01-13
申请号：PCT/IL2010/000552
申请日：2010-07-08
申请人： TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD , SAFRA, Eliyahu , KANZA, Yaron , SAGIV, Yehoshua , LEVIN, Roy , YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
发明人： SAFRA, Eliyahu , KANZA, Yaron , SAGIV, Yehoshua , LEVIN, Roy
IPC分类号： G01C21/34
CPC分类号： G01C21/343
摘要： A system and method for calculating an interactive route search, where the user enters a query for locating several geographic entities of different types, and the result is a route that starts in a given location, ends in a specified target location, and goes via entities of different types that are relevant to the search. The input to the problem consists of several search queries described by keywords and constraints, where each query defines a type of geographical entities. When visited, the user confirms the entities that satisfied the user's requirements. In an interactive search, the route is computed in steps. In each step, only the next entity of the route is provided to the user. After successfully visiting geographic entities of the all the types provided in the query, the route is calculated to the target location.
摘要翻译：一种用于计算交互式路由搜索的系统和方法，其中用户输入用于定位不同类型的多个地理实体的查询，并且结果是在给定位置开始的路线，在指定的目标位置结束，并经由实体与搜索相关的不同类型的。对问题的输入由关键词和约束描述的几个搜索查询组成，其中每个查询定义一种地理实体的类型。访问时，用户确认满足用户要求的实体。在交互式搜索中，路径按步骤计算。在每个步骤中，只有路由的下一个实体被提供给用户。在成功访问查询中提供的所有类型的地理实体之后，将路由计算到目标位置。

52. 发明申请

WO2010134082A1 CHROMENONE DERIVATIVES FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的氯芬顿衍生物
公开(公告)号：WO2010134082A1
公开(公告)日：2010-11-25
申请号：PCT/IL2010/000408
申请日：2010-05-23
申请人： PROTEOLOGICS LTD , NAKACHE, Philippe
发明人： NAKACHE, Philippe
IPC分类号： C07D311/24 , A61K31/00 , A61K31/352
CPC分类号： C07D311/24
摘要： 4-Chromenone derivatives of the formula I herein that inhibit the ubiquitin-mediated degradation of p27, are useful for the treatment of cancer.
摘要翻译：抑制泛素介导的p27降解的本文式I的4-色酮酮衍生物可用于治疗癌症。

53. 发明申请

WO2010086860A2 NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开
标题翻译：神经保护性多功能化合物和包含它们的药物组合物
公开(公告)号：WO2010086860A2
公开(公告)日：2010-08-05
申请号：PCT/IL2010/000080
申请日：2010-01-31
申请人： Yeda Research and Development Co. Ltd. , Technion Research and Development Foundation Ltd. , YOUDIM, Moussa B.H. , FRIDKIN, Mati , ZHENG, Hailin
发明人： YOUDIM, Moussa B.H. , FRIDKIN, Mati , ZHENG, Hailin
IPC分类号： C07C211/38
CPC分类号： C07C259/10 , C07C211/38 , C07C271/40 , C07C2602/08 , C07C2603/74 , C07D215/34 , C07D401/06 , C07D401/12
摘要： Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition.
摘要翻译：提供多官能化合物，其包含两个或多个选自以下的官能部分：（i）赋予铁螯合剂功能的部分; （ii）赋予神经保护功能的部分; （iii）赋予组合的抗细胞凋亡，神经保护和/或神经恢复功能的部分; （iv）赋予脑MAO抑制的部分，优选在肝脏和小肠中几乎没有MAO抑制作用; （v）赋予胆碱酯酶抑制功能的部分; 和（vi）赋予N-甲基-D-天冬氨酸受体（NMDAR）抑制的部分及其药学上可接受的盐和旋光异构体。多官能化合物可用于治疗或预防可通过铁螯合治疗和/或神经保护和/或神经恢复，和/或凋亡抑制和/或MAO抑制和/或MAO抑制和/或治疗的/ 或胆碱酯酶抑制和/或NMADR抑制。

54. 发明申请

WO2010064240A1 UV-CURABLE INORGANIC-ORGANIC HYBRID RESIN AND METHOD FOR PREPARATION THEREOF 审中-公开
标题翻译：紫外光固化无机混合树脂及其制备方法
公开(公告)号：WO2010064240A1
公开(公告)日：2010-06-10
申请号：PCT/IL2009/001138
申请日：2009-12-03
申请人： Soreq Nuclear Research Center , GVISHI, Raz
发明人： GVISHI, Raz
IPC分类号： C08G77/58 , G02B1/00 , G03F7/075 , H01L23/29
CPC分类号： C08G77/58 , G02B1/04 , G03F7/0037 , G03F7/0043 , G03F7/0388 , G03F7/0757 , H01L23/296 , H01L2924/0002 , C08L83/04 , H01L2924/00
摘要： The present invention relates to a method for preparation of an ultraviolet (UV)-curable inorganic-organic hybrid resin containing about or less than 4% volatiles and less than 30% organic residues. The UV-curable inorganic-organic hybrid resin obtained according to this method can be UV-cured within a markedly very short time and enables, upon curing, the formation of a transparent shrink- and crack-free glass-like product having high optical quality, high thermal stability and good bonding properties. In view of these properties, this hybrid resin can be used in various applications such as electro-optic, microelectronic, stereolithography and biophotonic applications.
摘要翻译：本发明涉及含有约4％以下挥发物和少于30％有机残余物的紫外线（UV）可固化无机 - 有机杂化树脂的制备方法。根据该方法得到的紫外线固化性无机 - 有机杂化树脂可以在非常短的时间内进行紫外线固化，并且在固化时能够形成具有高光学质量的透明收缩和无裂纹的玻璃状产品，热稳定性好，粘合性好。鉴于这些性质，该混合树脂可用于各种应用中，例如电光，微电子，立体光刻和生物光子学应用。

55. 发明申请

WO2009133560A1 NON-HYDROLYZABLE AND PERMEABLE CYCLIC BIS-[NUCLEOTIDE MONOPHOSPHATE] DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：不可水解和可渗透的循环双 - [核苷酸单磷酸酯]衍生物及其用途
公开(公告)号：WO2009133560A1
公开(公告)日：2009-11-05
申请号：PCT/IL2009/000456
申请日：2009-04-30
申请人： SMART ASSAYS , MAYER, Raphael
发明人： MAYER, Raphael
IPC分类号： C07H21/02 , A61K31/7084 , A61P31/04
CPC分类号： C07H21/02
摘要： The present invention provides novel non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and pharmaceutical compositions comprising thereof. The cyclic bis-[nucleotide monophosphate] derivatives of the present invention are useful for treatment of bacterial infections, in particular, for disruption of bacterial regulation and/or signal transduction, disruption or reduction of bacterial pathogenicity, and/or disruption or reduction of a bacterial pathogenicity related activity such as biofilm formation.
摘要翻译：本发明提供新的不可水解和可渗透的环状双 - [核苷酸单磷酸酯]衍生物及其组合物。本发明的环状双 - [核苷酸单磷酸酯]衍生物可用于治疗细菌感染，特别是用于细菌调节和/或信号转导的破坏，破坏或减少细菌致病性，和/或破坏或减少细菌致病性相关活性如生物膜形成。

56. 发明申请

WO2009095924A1 HEXAVALENT CHROMIUM DETECTOR 审中-公开
标题翻译：十六进制铬检测器
公开(公告)号：WO2009095924A1
公开(公告)日：2009-08-06
申请号：PCT/IL2009/000122
申请日：2009-02-01
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD , VAN DER BOOM, Milko E , GUPTA, Tarkeshwar , DE RUITER, Graham
发明人： VAN DER BOOM, Milko E , GUPTA, Tarkeshwar , DE RUITER, Graham
IPC分类号： C07F15/00 , C07F15/02 , G01N31/22 , G01N33/18 , H01L51/00
CPC分类号： C07F15/0026 , C07D213/72 , C07F15/0053 , C07F15/025 , G01N31/22 , G01N33/1813
摘要： The present invention relates to a molecular-based system for the optical detection, quantification and detoxification of hexavalent chromium (Cr 6+ ) by reversible metal-substrate electron transfer. More particularly, the invention provides a Cr 6+ sensor device comprising a divalent osmium (Os 2+ )-, iron (Fe 2+ )-or ruthenium (Ru 2+ )-based pyridyl complex capable of changing its oxidation state in response to a reduction of Cr 6+ at the presence of H + , thereby causing a reversible and optically readable change in optical properties of said complex. The Os 2+ -, Fe 2+ -or Ru 2+ -based pyridyl complex used according to the invention can be used for selective detection and quantification of Cr 6+ , as well as for catalytic detoxification of Cr 6+ .
摘要翻译：本发明涉及通过可逆金属 - 基质电子转移对六价铬（Cr6 +）的光学检测，定量和解毒的基于分子的系统。更具体地，本发明提供了一种Cr6 +传感器装置，其包括能够响应于Cr 6+在存在下的Cr 6+的还原而改变其氧化态的二价锇（Os2 +） - ，铁（Fe2 +）或钌（Ru2 +） - H +，从而导致所述复合物的光学性质的可逆和光可读变化。根据本发明使用的Os2 +，Fe2 +或Ru2 +的吡啶基复合物可用于Cr6 +的选择性检测和定量，以及Cr6 +的催化解毒。

57. 发明申请

WO2009093252A1 LIVE UPLINK TRANSMISSIONS AND BROADCASTING MANAGEMENT SYSTEM AND METHOD 审中-公开
标题翻译：实时上传传输和广播管理系统及方法
公开(公告)号：WO2009093252A1
公开(公告)日：2009-07-30
申请号：PCT/IL2009/000099
申请日：2009-01-25
申请人： LIVEU LTD , ALTMAN, Baruch, Yosef
发明人： ALTMAN, Baruch, Yosef
IPC分类号： H04H60/04
CPC分类号： H04H60/04 , H04H20/04 , H04H60/72 , H04H60/73 , H04N21/2187 , H04N21/2543 , H04N21/26283 , H04N21/6371 , H04N21/64322 , H04N21/8405 , H04N21/8586
摘要： A live uplink transmission and broadcasting management system and method for managing a plurality of live uplink transmissions and broadcasting events, the system comprising: (i) a publication portal for publishing transmissions of live events; (ii) a database for storing metadata, system data, broadcast data and user data; (iii) a broadcast manager adapted for receiving and processing in real-time metadata information related to a plurality of live uplink transmission events wherein each live uplink transmission event transmits in a plurality of uplink channels, wherein processed metadata information generate data elements adapted for being used in telecom and datacom real time management applications, said broadcast manager also adapted for updating the publication portal with live event information and (iv)a set of Quality of Service (QoS) management methods to coordinate the usage of Uplink transmissions based on the received metadata and their processing in the broadcast manager
摘要翻译：一种用于管理多个实时上行链路传输和广播事件的实时上行链路传输和广播管理系统和方法，所述系统包括：（i）用于发布现场活动的传输的出版门户; （ii）用于存储元数据，系统数据，广播数据和用户数据的数据库; （iii）广播管理器，适于接收和处理与多个实况上行链路传输事件相关的实时元数据信息，其中每个活动上行链路传输事件在多个上行链路信道中传输，其中处理的元数据信息生成适于被存在的数据元素用于电信和数据通信实时管理应用中，所述广播管理器还适应于通过实时事件信息来更新出版门户，以及（iv）一组服务质量（QoS）管理方法，以便根据接收到的上行链路传输的使用来协调使用元数据及其在广播管理器中的处理

58. 发明申请

WO2009093250A3 TARGETING OF INNATE IMMUNE RESPONSE TO TUMOR SITE 审中-公开
公开(公告)号：WO2009093250A3
公开(公告)日：2009-07-30
申请号：PCT/IL2009/000097
申请日：2009-01-25
申请人： GAVISH-GALILEE BIO APPLICATIONS LTD , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , PITCOVSKI, Jacob , SHAHAR, Ehud , GORODETSKY, Raphael
发明人： PITCOVSKI, Jacob , SHAHAR, Ehud , GORODETSKY, Raphael
IPC分类号： A61K47/48 , A61P35/00
摘要： The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies.

59. 发明申请

WO2009053972A1 MODIFIED ACTIVATED CARBON AS ADSORBENT FOR ANIONIC AND CATIONIC INORGANIC POLLUTANTS 审中-公开
标题翻译：改性活性炭作为阳离子和阳离子无机污染物的吸附剂
公开(公告)号：WO2009053972A1
公开(公告)日：2009-04-30
申请号：PCT/IL2008/001370
申请日：2008-10-22
申请人： TOXSORB LTD , RYTWO, Giora , GONEN, Yotam
发明人： RYTWO, Giora , GONEN, Yotam
IPC分类号： B01J20/20 , B01J20/32 , B01J39/24 , B01J41/18 , B01J20/34 , C02F1/28
CPC分类号： B01J20/20 , B01J20/3204 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3441 , B01J39/24 , B01J41/18 , C02F1/283 , C02F1/288 , C02F1/683 , C02F2101/103 , C02F2101/12 , C02F2101/20 , C02F2101/22 , C02F2101/305
摘要： Activated carbon modified by a cationic or anionic modifier or by a chelant is used as sorbent for removing heavy metal complexes and anionic and/or cationic inorganic contaminants and optionally organic contaminants from a fluid.
摘要翻译：用阳离子或阴离子改性剂或螯合剂改性的活性炭用作吸附剂，用于从流体中除去重金属络合物和阴离子和/或阳离子无机污染物和任选的有机污染物。

60. 发明申请

WO2009053971A1 PROCESS FOR INHIBITING NAPHTHENIC ACID CORROSION 审中-公开
标题翻译：抑制硫酸腐蚀的方法
公开(公告)号：WO2009053971A1
公开(公告)日：2009-04-30
申请号：PCT/IL2008/001369
申请日：2008-10-22
申请人： OIL REFINERIES LTD , GROYSMAN, Alec , PENNER, Joseph
发明人： GROYSMAN, Alec , PENNER, Joseph
IPC分类号： C10G7/10 , C10G75/02
CPC分类号： C10G7/10 , C10G75/02
摘要： The invention provides a process for inhibiting corrosion in refinery operations, in particular, for inhibiting naphthenic acid corrosion of the inner metallic surfaces of a refining apparatus induced during distillation of an acidic and corrosive crude oils, utilizing corrosion inhibitors selected from (i) tannic acid; (ii) certain high-density alcohols; (iii) certain heavy vacuum gas oil fractions distilled from acidic high sulfur content crude oils; or (iv) certain high molecular weight residues remaining after distillation of naphthenic acid mixtures.
摘要翻译：本发明提供了一种用于在炼油操作中抑制腐蚀的方法，特别是用于抑制在酸性和腐蚀性原油蒸馏期间诱导的精炼装置的内部金属表面的环烷酸腐蚀，利用腐蚀抑制剂，其选自（i）单宁酸 ; （ii）某些高密度醇; （iii）从酸性高硫含量原油中蒸馏的某些重质减压瓦斯油馏分; 或（iv）在蒸馏环烷酸混合物后剩余的某些高分子量残余物。

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