专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

WO2004092146A3 N- (((((1,3-THIAZOL-2-YL) AMINO) CARBONYL) PHENYL) SULFONYL) PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES 审中-公开
标题翻译： N-（（（（（（1,3-THIAZOL-2-YL）氨基）羰基）苯基）磺酰基）苯乙胺衍生物及其治疗糖尿病的相关化合物
公开(公告)号：WO2004092146A3
公开(公告)日：2004-12-29
申请号：PCT/US2004011650
申请日：2004-04-14
申请人： INST FOR PHARM DISCOVERY INC , VAN ZANDT MICHAEL C , FANG HAIQUAN , HU SHAOJING , WHITEHOUSE DARREN
发明人： VAN ZANDT MICHAEL C , FANG HAIQUAN , HU SHAOJING , WHITEHOUSE DARREN
IPC分类号： A61K20060101 , A61K31/19 , A61K31/40 , A61K31/415 , A61K31/426 , A61K31/4406 , A61K31/445 , A61K31/4965 , A61P3/10 , C07C311/21 , C07D211/34 , C07D213/55 , C07D231/06 , C07D231/12 , C07D277/00 , C07D277/46
CPC分类号： C07C311/21 , C07C233/80 , C07C311/29 , C07C311/44 , C07C311/48 , C07C2603/24 , C07D213/55 , C07D231/06 , C07D231/12 , C07D277/46
摘要： The present invention relates to compounds and pharmaceutically acceptable salts of formula (I), which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.

42. 发明申请

WO2004083867A2 HUMAN G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF CELL DEATH-RELATED DISORDERS 审中-公开
标题翻译：人G蛋白相关受体及其调节因子治疗细胞死亡相关疾病
公开(公告)号：WO2004083867A2
公开(公告)日：2004-09-30
申请号：PCT/US2004008191
申请日：2004-03-15
申请人： ARENA PHARM INC , VILLEGAS SONIA , KELNER GREGORY , UNETT DAVID , GATLIN JOEL
发明人： VILLEGAS SONIA , KELNER GREGORY , UNETT DAVID , GATLIN JOEL
IPC分类号： C07C233/58 , C07C235/40 , C07C235/82 , C07C237/24 , C07C237/42 , C07C237/48 , C07C255/57 , C07C255/58 , C07C311/16 , C07C311/21 , C07C317/44 , C07C323/62 , G01N33/566 , G01N33/68 , G01N33/74
CPC分类号： G01N33/6887 , C07C233/58 , C07C235/40 , C07C235/82 , C07C237/24 , C07C255/58 , C07C311/16 , C07C311/21 , C07C317/44 , C07C323/62 , C07C2603/26 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2500/04
摘要： The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In certain embodiments, the GPCR is human. In certain embodiments, the GPCR is expressed endogenously by neuronal cells or muscle cells. In certain embodiments, the GPCR is neuroprotective or myoprotective. In certain embodiments, the GPCR is a Humanin receptor. The present invention also relates to methods of using a modulator of said GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for the prevention or treatment of neurodegenerative diseases in general, including Alzheimer's disease, Parkinson's disease, prion-associated disease, stroke and motor-neuron disease in particular, peripheral neuropathy, cerebral amyloid beta-protein angiopathy, and ischemic heart disease, including myocardial infarction and congestive heart failure.
摘要翻译：本发明涉及鉴定候选化合物是G蛋白偶联受体（GPCR）的调节剂的方法。在某些实施方案中，GPCR是人。在某些实施方案中，GPCR由神经元细胞或肌肉细胞内源性表达。在某些实施方案中，GPCR是神经保护的或保护性的。在某些实施方案中，GPCR是人受体。本发明还涉及使用所述GPCR的调节剂的方法。优选的调节剂是激动剂。本发明的激动剂可用作预防或治疗一般的神经变性疾病的治疗剂，包括阿尔茨海默氏病，帕金森病，朊病毒相关疾病，中风和运动神经元疾病，特别是周围神经病，脑淀粉样蛋白β-蛋白血管病和缺血性心脏病，包括心肌梗死和充血性心力衰竭。

43. 发明申请

WO2004080951A2 SULFONIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：硫酸，其衍生物和含有它们的药物组合物
公开(公告)号：WO2004080951A2
公开(公告)日：2004-09-23
申请号：PCT/EP2004050293
申请日：2004-03-11
申请人： DOMPE SPA , ALLEGRETTI MARCELLO , ARAMINI ANDREA , CESTA MARIA CANDIDA , BERTINI RICCARDO , BIZZARRI CINZIA , COLOTTA FRANCESCO
发明人： ALLEGRETTI MARCELLO , ARAMINI ANDREA , CESTA MARIA CANDIDA , BERTINI RICCARDO , BIZZARRI CINZIA , COLOTTA FRANCESCO
IPC分类号： A61K31/10 , A61K31/18 , A61P29/00 , C07C309/24 , C07C309/29 , C07C309/65 , C07C309/73 , C07C311/08 , C07C311/13 , C07C311/16 , C07C311/21 , C07C311/27 , C07C311/35 , C07C311/51 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/32 , C07D207/333
CPC分类号： C07D207/333 , C07C309/24 , C07C309/65 , C07C309/73 , C07C311/08 , C07C311/13 , C07C311/27 , C07C311/35 , C07C311/51 , C07D207/27
摘要： Selected sulfonic acids, their derivatives and pharmaceutical compositions containing such compounds are useful in inhibiting the chernotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCRI and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, the selected sulfonic acids and their derivativas are devoid of cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
摘要翻译：选择的磺酸，其衍生物和含有这些化合物的药物组合物可用于抑制由白细胞介素-8（IL-8）与CXCR1和CXCR2膜受体相互作用诱导的嗜中性粒细胞（PMN白细胞）的切割型活化。所述化合物用于预防和治疗由所述活化引起的病理学。值得注意的是，选择的磺酸及其衍生物没有环加氧酶抑制活性，并且特别可用于治疗中性粒细胞依赖性病理如牛皮癣，溃疡性结肠炎，黑素瘤，慢性阻塞性肺病（COPD），大疱性类天疱疮，类风湿关节炎，特发性纤维化，肾小球性肾炎，以及预防和治疗由缺血和再灌注引起的损伤。

44. 发明申请

WO2004052847A3 TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS 审中-公开
标题翻译：三环类甾体激素核受体调节剂
公开(公告)号：WO2004052847A3
公开(公告)日：2004-09-10
申请号：PCT/US0316213
申请日：2003-06-13
申请人： LILLY CO ELI , COGHLAN MICHAEL JOSEPH , GREEN JONATHAN EDWARD , GRESE TIMOTHY ALAN , JADHAV PRABHAKAR KONDAJI , MATTHEWS DONALD PAUL , STEINBERG MITCHELL IRVIN , FALES KEVIN ROBERT , BELL MICHAEL GREGORY
发明人： COGHLAN MICHAEL JOSEPH , GREEN JONATHAN EDWARD , GRESE TIMOTHY ALAN , JADHAV PRABHAKAR KONDAJI , MATTHEWS DONALD PAUL , STEINBERG MITCHELL IRVIN , FALES KEVIN ROBERT , BELL MICHAEL GREGORY
IPC分类号： C07D295/08 , A61K31/015 , A61K31/03 , A61K31/04 , A61K31/045 , A61K31/055 , A61K31/09 , A61K31/10 , A61K31/335 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/435 , A61K31/4402 , A61K31/4406 , A61K31/4436 , A61K31/4453 , A61K31/4965 , A61K31/5377 , A61K31/55 , A61P1/04 , A61P1/16 , A61P3/04 , A61P3/08 , A61P3/10 , A61P3/12 , A61P3/14 , A61P5/26 , A61P5/38 , A61P5/46 , A61P7/04 , A61P7/10 , A61P9/00 , A61P9/02 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P17/10 , A61P19/02 , A61P19/10 , A61P25/02 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07C22/04 , C07C22/08 , C07C25/22 , C07C25/24 , C07C33/38 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/215 , C07C43/225 , C07C43/23 , C07C47/548 , C07C47/57 , C07C49/835 , C07C205/06 , C07C205/35 , C07C211/32 , C07C211/45 , C07C215/76 , C07C217/84 , C07C233/07 , C07C233/65 , C07C233/84 , C07C235/16 , C07C251/40 , C07C251/48 , C07C255/50 , C07C261/04 , C07C271/14 , C07C275/28 , C07C307/10 , C07C311/03 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/32 , C07C321/28 , C07C323/49 , C07D209/08 , C07D209/34 , C07D211/18 , C07D213/127 , C07D213/16 , C07D213/65 , C07D213/73 , C07D213/76 , C07D213/81 , C07D221/16 , C07D223/20 , C07D231/12 , C07D231/18 , C07D233/26 , C07D233/64 , C07D233/84 , C07D235/26 , C07D241/12 , C07D241/20 , C07D241/26 , C07D261/08 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D295/092 , C07D295/22 , C07D295/26 , C07D313/14 , C07D333/80 , C07D337/12 , C07D337/14 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D471/04 , C07D487/04 , C07D491/044 , A61K31/18 , A61K31/553 , C07D235/14 , C07D313/12
CPC分类号： C07D213/16 , C07C22/04 , C07C22/08 , C07C25/24 , C07C33/38 , C07C39/17 , C07C39/23 , C07C39/42 , C07C43/215 , C07C43/225 , C07C43/23 , C07C47/548 , C07C47/57 , C07C49/835 , C07C69/00 , C07C69/618 , C07C69/65 , C07C205/06 , C07C205/34 , C07C205/35 , C07C211/28 , C07C211/32 , C07C211/45 , C07C215/76 , C07C217/84 , C07C233/07 , C07C233/65 , C07C233/84 , C07C235/16 , C07C251/40 , C07C251/48 , C07C255/50 , C07C261/04 , C07C271/14 , C07C275/28 , C07C307/10 , C07C311/03 , C07C311/08 , C07C311/09 , C07C311/16 , C07C311/20 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/32 , C07C321/28 , C07C323/49 , C07C2601/02 , C07C2603/32 , C07C2603/40 , C07C2603/78 , C07C2603/86 , C07D209/08 , C07D209/34 , C07D211/96 , C07D213/06 , C07D213/73 , C07D213/76 , C07D213/81 , C07D221/16 , C07D223/20 , C07D231/12 , C07D231/18 , C07D233/26 , C07D233/68 , C07D233/84 , C07D235/26 , C07D241/12 , C07D241/20 , C07D261/08 , C07D261/10 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D295/088 , C07D295/26 , C07D313/12 , C07D333/78 , C07D333/80 , C07D337/12 , C07D401/06 , C07D405/06 , C07D409/04 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/044
摘要： The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula (I): or a pharmaceutically acceptable salt thereof. In addition, the present invention provides novel pharmaceutical compounds of Formula (I), including the pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions which comprise as an active ingredient a compound of Formula (I).
摘要翻译：本发明涉及治疗对类固醇激素核受体调节敏感的病理性疾病的方法，该方法包括给需要治疗的患者施用有效量的式（I）化合物或其药学上可接受的盐。此外，本发明提供了式（I）的新型药物化合物，包括其药学上可接受的盐，以及包含式（I）化合物作为活性成分的药物组合物。

45. 发明申请

WO2004056319A3 SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS 审中-公开
标题翻译：取代的N-苯基磺酰胺卡那霉素拮抗剂
公开(公告)号：WO2004056319A3
公开(公告)日：2004-09-02
申请号：PCT/US0340745
申请日：2003-12-18
申请人： ELAN PHARM INC , GRANT FRANCINE S , DAPPEN MICHAEL S , XU YING-ZI , BARTULIS SARAH , HOLCOMB RYAN C , KASAR RAMESH A , PLEISS MICHAEL A , THORSETT EUGENE D , YE MICHAEL , KONRADI ANDREI W
发明人： GRANT FRANCINE S , DAPPEN MICHAEL S , XU YING-ZI , BARTULIS SARAH , HOLCOMB RYAN C , KASAR RAMESH A , PLEISS MICHAEL A , THORSETT EUGENE D , YE MICHAEL , KONRADI ANDREI W
IPC分类号： A61K20060101 , C07C311/21 , C07D211/26 , C07D213/40 , C07D213/56 , C07D213/74 , C07D243/24 , C07D295/13 , C07D295/185 , C07D401/04 , C07D401/06 , C07D471/04
CPC分类号： C07D213/40 , C07C311/21 , C07D207/337 , C07D211/26 , C07D211/34 , C07D213/56 , C07D213/74 , C07D239/26 , C07D243/24 , C07D295/13 , C07D295/185 , C07D401/04 , C07D471/04
摘要： Disclosed are certain substituted N-phenylsulfonamide derivatives and related compounds. These compounds are useful as bradykinin antagonists to relieve adverse symptoms in mammals mediated, at least in part, by bradykinin including pain, inflammation, bronchoconstriction, cerebral edema, etc.
摘要翻译：公开了某些取代的N-苯基磺酰胺衍生物和相关化合物。这些化合物可用作缓激肽拮抗剂，以缓解哺乳动物中至少部分由缓激肽介导的不良症状，包括疼痛，炎症，支气管收缩，脑水肿等。

46. 发明申请

WO2004018414A3 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2004018414A3
公开(公告)日：2004-06-17
申请号：PCT/US0324797
申请日：2003-08-22
申请人： UPJOHN CO , THORARENSEN ATLI , RUBLE CRAIG J , ROMERO DONNA L
发明人： THORARENSEN ATLI , RUBLE CRAIG J , ROMERO DONNA L
IPC分类号： A61K31/195 , A61P31/02 , C07C235/42 , C07C235/56 , C07C235/84 , C07C239/18 , C07C239/20 , C07C255/60 , C07C311/16 , C07C311/17 , C07C311/21 , C07C311/29 , C07C311/38 , C07C313/06 , C07C313/24 , C07C317/44 , C07C323/60 , C07C323/62 , C07C323/63 , C07C331/14 , C07D205/04 , C07D207/12 , C07D207/26 , C07D207/32 , C07D207/40 , C07D207/48 , C07D209/08 , C07D209/48 , C07D211/96 , C07D213/30 , C07D213/32 , C07D213/42 , C07D213/76 , C07D213/82 , C07D215/14 , C07D215/58 , C07D217/08 , C07D231/16 , C07D231/56 , C07D235/22 , C07D249/14 , C07D249/18 , C07D263/32 , C07D263/58 , C07D265/26 , C07D277/04 , C07D277/74 , C07D279/02 , C07D295/192 , C07D295/26 , C07D307/33 , C07D307/52 , C07D307/68 , C07D307/70 , C07D309/12 , C07D317/68 , C07D319/18 , C07D333/22 , C07D333/24 , C07D333/70 , C07D335/16 , C07D403/12 , C07D405/06 , C07D409/12 , C07D413/12 , C07D471/04 , A61K31/167 , A61K31/18 , A61K31/33
CPC分类号： C07C235/42 , C07C235/56 , C07C235/84 , C07C239/18 , C07C239/20 , C07C255/60 , C07C311/16 , C07C311/17 , C07C311/21 , C07C311/29 , C07C311/38 , C07C313/06 , C07C313/24 , C07C317/44 , C07C323/60 , C07C323/62 , C07C323/63 , C07C331/14 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D207/26 , C07D207/325 , C07D207/40 , C07D207/48 , C07D209/08 , C07D209/48 , C07D211/96 , C07D213/30 , C07D213/32 , C07D213/42 , C07D213/76 , C07D213/82 , C07D215/14 , C07D215/58 , C07D217/08 , C07D231/16 , C07D231/56 , C07D235/22 , C07D249/14 , C07D249/18 , C07D263/32 , C07D263/58 , C07D265/26 , C07D277/04 , C07D277/74 , C07D279/02 , C07D295/192 , C07D295/26 , C07D307/33 , C07D307/52 , C07D307/68 , C07D307/70 , C07D309/12 , C07D317/68 , C07D319/18 , C07D333/22 , C07D333/24 , C07D333/70 , C07D335/16 , C07D403/12 , C07D405/06 , C07D409/12 , C07D413/12 , C07D471/04
摘要： The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing group; R4 is an optionally substituted aryl. The compounds of formula I are antibacterial agents that are useful for sterilization sanitation, antisepsis, and disinfection.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中X = NH Y = CO，CS，-C（= N-CN）或X和Y一起形成烯烃或C 3 -C 5环烷基; R1是-COOH; R2是吸电子基团; R4是任选取代的芳基。式I化合物是用于消毒卫生，消毒和消毒的抗菌剂。

47. 发明申请

WO03029199A9 BENZENE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF 审中-公开
标题翻译：苯并噻吩衍生物，其制备方法和用途
公开(公告)号：WO03029199A9
公开(公告)日：2003-09-25
申请号：PCT/JP0209995
申请日：2002-09-27
申请人： TAKEDA CHEMICAL INDUSTRIES LTD , MATSUMOTO TAKAHIRO , YAMAMOTO MASATAKA , NAGABUKURO HIROSHI , MOCHIZUKI MANABU
发明人： MATSUMOTO TAKAHIRO , YAMAMOTO MASATAKA , NAGABUKURO HIROSHI , MOCHIZUKI MANABU
IPC分类号： A61K31/17 , A61K31/216 , A61K31/357 , A61K31/36 , A61K31/4045 , A61K31/4184 , A61K31/42 , A61K31/44 , A61K31/4409 , A61K31/445 , A61K31/4453 , A61K31/4468 , A61K31/495 , A61K31/55 , A61K31/551 , A61P1/06 , A61P1/08 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P9/00 , A61P9/02 , A61P9/10 , A61P11/02 , A61P13/02 , A61P15/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/02 , C07C275/38 , C07C275/42 , C07C309/66 , C07C311/08 , C07C311/21 , C07C311/47 , C07C317/42 , C07C323/42 , C07C323/44 , C07C323/62 , C07D207/14 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/16 , C07D211/46 , C07D211/52 , C07D211/58 , C07D211/62 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/65 , C07D213/74 , C07D213/75 , C07D215/08 , C07D215/38 , C07D217/02 , C07D223/12 , C07D233/54 , C07D235/30 , C07D261/14 , C07D277/82 , C07D295/13 , C07D295/192 , C07D295/215 , C07D307/14 , C07D307/52 , C07D317/66 , C07D321/10 , C07D333/16 , C07D295/20 , C07D317/58 , C07D319/18
CPC分类号： C07D207/27 , A61K31/17 , A61K31/216 , A61K31/357 , A61K31/36 , A61K31/4045 , A61K31/4184 , A61K31/42 , A61K31/44 , A61K31/4409 , A61K31/445 , A61K31/4453 , A61K31/4468 , A61K31/495 , A61K31/55 , A61K31/551 , C07C275/38 , C07C275/42 , C07C309/66 , C07C311/08 , C07C311/21 , C07C311/47 , C07C317/42 , C07C323/42 , C07C323/44 , C07C323/62 , C07C2601/08 , C07C2601/14 , C07D207/14 , C07D209/08 , C07D209/16 , C07D211/46 , C07D211/52 , C07D211/58 , C07D211/62 , C07D213/30 , C07D213/40 , C07D213/56 , C07D213/65 , C07D213/74 , C07D213/75 , C07D215/08 , C07D215/38 , C07D217/02 , C07D223/12 , C07D233/54 , C07D235/30 , C07D261/14 , C07D277/82 , C07D295/13 , C07D295/192 , C07D295/215 , C07D307/14 , C07D307/52 , C07D317/66 , C07D321/10 , C07D333/16
摘要： Novel benzene derivatives represented by the general formula (||), which exhibit vanilloid receptor agonism and are useful as preventive and therapeutic drugs for pollakisuria and urinary incontinence, analgesic, or the like: (||) wherein R , R and R are each independently hydrogen, halogeno, or hydrocarbyl; R is hydrocarbyl or a heterocyclic group; R is hydrocarbyl, NR R , or OR (wherein R is hydrogen or hydrocarbyl and R is a non-aromatic group, or alternatively R and R together with the nitrogen atom adjacent thereto may form a ring; and R is hydrocarbyl or a heterocyclic group); R is hydrocarbyl or a heterocyclic group (except quinolyl) and R is hydrogen or hydrocarbyl, or R and R together with the nitrogen atom adjacent thereto may form a ring; and R is hydrogen or hydrocarbyl.
摘要翻译：由通式（||）表示的新型苯衍生物，其表现出香草素受体激动作用，并且可用作预防和治疗药物用于预防和尿失禁，止痛剂等：（||）其中R 1， 4>和R 6各自独立地为氢，卤素或烃基; R 2是烃基或杂环基; R 3是烃基，NR 7 R 7或OR 8（其中R 7'是氢或烃基，R 7是非芳族基团，或者R 7 和R 7与其相邻的氮原子一起形成环; R 8是烃基或杂环基）。 R 5为烃基或杂环基（喹啉基除外），R 5为氢或烃基，或R 5和R 5与其相邻的氮原子一起形成环; 和R 5“是氢或烃基。

48. 发明申请

WO02089740A3 SULFONAMIDES 审中-公开
标题翻译：磺胺类药物
公开(公告)号：WO02089740A3
公开(公告)日：2003-02-27
申请号：PCT/US0214537
申请日：2002-05-07
申请人： SMITHKLINE BEECHAM CORP , DHANAK DASHYANT , GALLAGHER TIMOTHY F , KNIGHT STEVEN D
发明人： DHANAK DASHYANT , GALLAGHER TIMOTHY F , KNIGHT STEVEN D
IPC分类号： A61K31/18 , A61K31/381 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/10 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P31/04 , A61P43/00 , C07C311/21 , C07C311/29 , C07D333/34 , A61K31/275 , A61K31/38 , A61K31/506 , C07C255/63 , C07C311/44 , C07D409/04
CPC分类号： C07C311/21 , C07C311/29 , C07D333/34
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
摘要翻译：本发明涉及磺酰胺，含有它们的药物组合物，以及它们作为尿素调节素II拮抗剂的用途。

49. 发明申请

WO0192273A3 BENZENEDICARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：二苯甲酸衍生物
公开(公告)号：WO0192273A3
公开(公告)日：2002-07-25
申请号：PCT/US0117309
申请日：2001-05-29
申请人： GUILFORD PHARM INC
发明人： JACKSON PAUL F , TSUKAMOTO TAKASHI , SLUSHER BARBARA S , WANG ERIC
IPC分类号： A61P13/08 , A61P21/00 , A61P27/06 , C07C63/307 , C07C63/68 , C07C65/05 , C07C65/40 , C07C229/38 , C07C229/60 , C07C235/80 , C07C259/06 , C07C259/10 , C07C317/44 , C07C323/12 , C07C323/56 , C07C323/62 , C07D231/06 , C07D307/52 , C07F9/38 , A61K31/10 , A61K31/185 , A61K31/415 , C07C63/26 , C07C63/30 , C07C205/57 , C07C205/60 , C07C229/28 , C07C233/64 , C07C237/06 , C07C311/21 , C07C321/20 , C07C321/30 , C07C323/00 , C07C381/04
CPC分类号： C07D231/06 , C07C63/307 , C07C63/68 , C07C65/05 , C07C65/40 , C07C229/38 , C07C229/60 , C07C235/80 , C07C259/06 , C07C259/10 , C07C317/44 , C07C323/12 , C07C323/56 , C07C323/62 , C07D307/52 , C07F9/3834 , C07F9/3882
摘要： New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF- beta activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
摘要翻译：新型苯二甲酸衍生物化合物; 包括那些化合物的药物组合物，诊断方法和诊断试剂盒; 以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平被改变的疾病，影响神经元活性，影响TGF-β活性，抑制血管发生和治疗谷氨酸异常，神经病，疼痛，强迫症，前列腺疾病，癌症，和青光眼。

50. 发明申请

WO01094305A1 SULFONATED PERFLUOROVINYL FUNCTIONAL MONOMERS 审中-公开
标题翻译：磺化全氟代功能单体
公开(公告)号：WO01094305A1
公开(公告)日：2001-12-13
申请号：PCT/US2000/025589
申请日：2000-09-18
IPC分类号： C07C309/87 , C07C311/48 , C08F16/32 , C07C311/21 , C08F30/04
CPC分类号： C08F16/32 , C07C309/87 , C07C311/48 , C07C2601/04
摘要： The present invention provides a monomer having the formula A-B, wherein A is represented by Formula I:wherein B is selected from -OCF=CF2 and -A; wherein, when B is -OCF=CF2, the orientation of B is meta or para to the trifluorovinyloxy group of A; wherein, when B is A, the bond joining the A groups is para to the trifluorovinyloxy group of each A; and wherein each Z is independently selected from -SO2F, -SO2Cl, -SO3H, -SO2-N(M)-SO2CF3, and -SO2-N(M)-SO2Rf ; wherein M is any suitable cation and Rf is a C1 to C10 fluorocarbon or fluorinated ether group. The present invention also provides a monomer according to Formula II:wherein X is F, Cl, or N(M)SO2Rf; wherein M is any suitable cation and Rf is a C1 to C10 fluorocarbon or fluorinated ether group.
摘要翻译：本发明提供具有式A-B的单体，其中A由式I表示：其中B选自-OCF = CF 2和-A; 其中当B为-OCF = CF 2时，B的取向为A的三氟乙烯氧基的间位或对位; 其中，当B为A时，连接A基团的键对于每个A的三氟乙烯基氧基; 并且其中每个Z独立地选自-SO 2 F，-SO 2 Cl，-SO 3 H，-SO 2 -N（M）-SO 2 CF 3和-SO 2 -N（M）-SO 2 R f; 其中M是任何合适的阳离子，Rf是C1至C10碳氟化合物或氟化醚基团。本发明还提供根据式II的单体：其中X是F，Cl或N（M）SO 2 R f; 其中M是任何合适的阳离子，Rf是C1至C10碳氟化合物或氟化醚基团。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式