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41. 发明申请

WO2006129110A2 ASSAY 审中-公开
公开(公告)号：WO2006129110A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006/002030
申请日：2006-06-02
申请人： UNIVERSITY OF WARWICK , VATISH, Manu , PRITLOVE, David Charles
发明人： VATISH, Manu , PRITLOVE, David Charles
IPC分类号： G01N33/68
CPC分类号： G01N33/689 , G01N2333/96486 , G01N2800/368
摘要： The invention relates to a method for screening for pre-eclampsia in a mammal, such as a human, by determining the amount of ACE2 (Angiotensin-converting Enzyme 2), variant, or fragment of ACE2, or mRNA encoding the ACE2. Additionally a new fragment of ACE2 has been identified and isolated. Reagents and kits for carrying out the method are also provided.
摘要翻译：本发明涉及通过测定ACE2（血管紧张素转换酶2），ACE2的变体或片段或编码ACE2的mRNA的量来筛选哺乳动物（例如人）中先兆子痫的方法。另外，ACE2的新片段已被鉴定和分离。还提供了用于实施该方法的试剂和试剂盒。

42. 发明申请

WO2005092058A3 METHODS FOR DETECTING DEFICIENT CELLULAR MEMBRANE TIGHTLY BOUND MAGNESIUM FOR DISEASE DIAGNOSES 审中-公开
标题翻译：用于检测缺陷细胞膜的方法用于疾病诊断的轻微爆炸性MAGNESIUM
公开(公告)号：WO2005092058A3
公开(公告)日：2006-10-19
申请号：PCT/US2005009553
申请日：2005-03-22
申请人： MAGNESIUM DIAGNOSTICS INC
发明人： WELLS IBERT C
IPC分类号： G01N33/53 , A01N1/02 , A61K31/16 , A61K31/165 , A61K39/395 , C12N5/02 , G01N33/50 , G01N33/567 , G01N33/68
CPC分类号： G01N33/502 , A61K31/16 , A61K31/165 , G01N33/6893 , G01N2800/042 , G01N2800/321 , G01N2800/368
摘要： This invention relates to methods for detecting the deficiency of magnesium tightly bound to plasma membranes of somatic cells, referred to as the magnesium binding defect. The invention also relates to methods for assessing certain abnormal physiological states, such as, salt-sensitive essential hypertension, type 2 overt or prediabetes mellitus, and preeclampsia/eclampsia syndrome that are associated with the magnesium binding defect. The invention further relates to methods for generating magnesium deficient cell membranes and for identifying substances which promote binding of magnesium ions to the plasma membranes of somatic cells. Additionally, the invention relates to a binding pair members having affinity for the peptides and promoters of the invention.
摘要翻译：本发明涉及用于检测被认为是镁结合缺陷的体细胞细胞膜紧密结合的镁的缺陷的方法。本发明还涉及用于评估某些异常生理状态的方法，例如与镁结合缺陷相关的盐敏感性原发性高血压，2型明显或前期糖尿病以及先兆子痫/子痫综合征。本发明还涉及产生镁缺乏细胞膜的方法，以及用于鉴定促进镁离子与体细胞质膜结合的物质。另外，本发明涉及对本发明的肽和启动子具有亲和性的结合对成员。

43. 发明申请

WO2006073447A2 ENRICHED PAG-55 FRACTION AND METHODS FOR EARLY DETECTION OF PREGNANCY IN UNGULATE ANIMALS 审中-公开
标题翻译：丰富的PAG-55馏分和早期检测结核病患者妊娠的方法
公开(公告)号：WO2006073447A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/014458
申请日：2005-04-27
申请人： MONSANTO TECHNOLOGY LLC , MATHIALAGAN, Nagappan , MCGRATH, Michael , SCHENKEL, Robert
发明人： MATHIALAGAN, Nagappan , MCGRATH, Michael , SCHENKEL, Robert
CPC分类号： C07K16/18 , C07K14/4715 , G01N33/689 , G01N2800/368 , Y10S424/811
摘要： Disclosed are methods for determining the pregnancy status of an ungulate animal by detecting the level of PAG-55 protein fraction. These methods may involve the detection of PAG-55 enriched proteins in the PAG-55 protein fraction by using novel polyclonal and monoclonal antibodies that have been generated using the PAG-55 enriched protein fraction as an immu1ogen. The novel PAG-55 protein fraction indicates that the animal is pregnant when the acidic PAG-55 protein fraction, or antigenic components thereof, are present at an elevated level in a sample. The present invention also provides for methods of obtaining the PAG-55 enriched protein fraction. The invention provides accurate methods of detecting pregnancy at early stages and has the benefit of allowing early post partum detection of the pregnancy status with fewl false positive results. The antibodies for detecting PAG-55 proteins will also be useful in combination with detecting elevated progesterone levels in the animal, thus providing an even more effective pregnancy detection method. The benefit of this early pregnancy detection is that identifying animals that are not pregnant very shortly after breeding, allows for timely rebreeding and minimizes the amount of time the animal is open. Also disclosed are methods for making a breeding decision for an animal. These methods allow a herd manager to make breeding decisions based on the levels of PAG-55 protein fraction and optionally, progesterone levels detected in a biological sample taken from an animal suspected of being in the early stages of pregnancy.
摘要翻译：公开了通过检测PAG-55蛋白组分的水平来确定有蹄动物的怀孕状态的方法。这些方法可能涉及通过使用已经使用富集了PAG-55的蛋白质部分作为免疫原生成的新型多克隆和单克隆抗体来检测PAG-55蛋白质级分中富含PAG-55的蛋白质。新的PAG-55蛋白部分表明，当酸性PAG-55蛋白部分或其抗原性组分在样品中以升高的水平存在时，动物是怀孕的。本发明还提供了获得富含PAG-55的蛋白质部分的方法。本发明提供了在早期阶段检测妊娠的准确方法，并且具有允许在怀孕状态的早期检测以及几乎没有假阳性结果的益处。用于检测PAG-55蛋白的抗体也可用于检测动物体内升高的孕酮水平，从而提供更有效的妊娠检测方法。这种早期妊娠检测的好处在于，能够在繁殖后立即识别未怀孕的动物，以便及时回避和避免;繁殖并最大限度地缩短动物开放的时间。还公开了用于对动物进行育种决定的方法。这些方法允许牧群管理者基于从疑似处于怀孕早期阶段的动物采集的生物样品中检测到的PAG-55蛋白质级分和任选的孕酮水平作出育种决定。

44. 发明申请

WO2006026557A2 METHODS AND KITS FOR PREDICTING RISK FOR PETERM LABOR 审中-公开
标题翻译：用于预测皮肤病的风险的方法和工具
公开(公告)号：WO2006026557A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/030685
申请日：2005-08-29
申请人： CERVIMARK, LLC , KOKENYESI, Robert , RAI, Jodie
发明人： KOKENYESI, Robert , RAI, Jodie
IPC分类号： G01N33/76
CPC分类号： G01N33/6893 , G01N33/54366 , G01N2800/368
摘要： The invention is directed to kits and methods that allow one to predict the risk for preterm labor in a pregnant woman. The inventors have discovered that various extracellular matrix components can be detected in cervical secretions. The quantification of certain extracellular matrix proteins found within cervical secretions can be used as a diagnostic for the biomechanical state of the cervix, which indicates whether preterm labor is likely. Some extracellular matrix components that can be found in cervical secretions include hyaluronic acid, thrombospondins and matrix metalloproteinases.
摘要翻译：本发明涉及允许预测孕妇早产的风险的试剂盒和方法。发明人已经发现，可以在宫颈分泌物中检测各种细胞外基质成分。在子宫颈分泌物中发现的某些细胞外基质蛋白的定量可以用作子宫颈生物力学状态的诊断，其指示早产是否可能。可以在宫颈分泌物中发现的一些细胞外基质成分包括透明质酸，血小板反应蛋白和基质金属蛋白酶。

45. 发明申请

WO2006005585A2 SECRETED POLYPEPTIDE SPECIES DIFFERENTIALLY EXPRESSED DURING PREGNANCY 审中-公开
标题翻译：分泌性多肽在PREGNANCY期间不同寻常的表现
公开(公告)号：WO2006005585A2
公开(公告)日：2006-01-19
申请号：PCT/EP2005007563
申请日：2005-07-12
申请人： GENEPROT INC , BOUGUELERET LYDIE , CUSIN ISABELLE , MAHE EVE , NIKNEJAD ANNE , REFFAS SAMIA
发明人： BOUGUELERET LYDIE , CUSIN ISABELLE , MAHE EVE , NIKNEJAD ANNE , REFFAS SAMIA
IPC分类号： G01N33/68 , C07K7/04 , C07K14/47 , C07K16/18 , C12N15/62 , G01N33/52
CPC分类号： C07K14/4715 , G01N33/689 , G01N2800/368
摘要： The invention discloses secreted polypeptides involved in pregnancy. The invention also provides methods of using compositions including the polypeptides and polynucleotides encoding them in detection assays, and for drug development.
摘要翻译：本发明公开了涉及妊娠的分泌多肽。本发明还提供在检测测定中使用包含多肽和编码它们的多核苷酸的组合物以及用于药物开发的方法。

46. 发明申请

WO2005092058A2 METHODS FOR DETECTING DEFICIENT CELLULAR MEMBRANE TIGHTLY BOUND MAGNESIUM FOR DISEASE DIAGNOSES 审中-公开
标题翻译：用于检测缺陷细胞膜的方法用于疾病诊断的轻微爆炸性MAGNESIUM
公开(公告)号：WO2005092058A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/009553
申请日：2005-03-22
申请人： MAGNESIUM DIAGNOSTICS, INC.
发明人： WELLS, Ibert, C.
IPC分类号： A61K31/16 , A61K31/165 , G01N33/50 , G01N33/68
CPC分类号： G01N33/502 , A61K31/16 , A61K31/165 , G01N33/6893 , G01N2800/042 , G01N2800/321 , G01N2800/368
摘要： This invention relates to methods for detecting the deficiency of magnesium tightly bound to plasma membranes of somatic cells, referred to as the magnesium binding defect. The invention also relates to methods for assessing certain abnormal physiological states, such as, salt-sensitive essential hypertension, type 2 overt or prediabetes mellitus, and preeclampsia/eclampsia syndrome that are associated with the magnesium binding defect. The invention further relates to methods for generating magnesium deficient cell membranes and for identifying substances which promote binding of magnesium ions to the plasma membranes of somatic cells. Additionally, the invention relates to a binding pair members having affinity for the peptides and promoters of the invention.
摘要翻译：本发明涉及用于检测被认为是镁结合缺陷的体细胞细胞膜紧密结合的镁的缺陷的方法。本发明还涉及用于评估某些异常生理状态的方法，例如与镁结合缺陷相关的盐敏感性原发性高血压，2型明显或前期糖尿病以及先兆子痫/子痫综合征。本发明还涉及产生镁缺乏细胞膜的方法，以及用于鉴定促进镁离子与体细胞质膜结合的物质。另外，本发明涉及对本发明的肽和启动子具有亲和性的结合对成员。

47. 发明申请

WO2005080980A1 A METHOD FOR DIAGNOSING IMMUNITY RECURRENT SPONTANEOUS ABORTION AND METHOD FOR TREATING AND MONITORING 审中-公开
公开(公告)号：WO2005080980A1
公开(公告)日：2005-09-01
申请号：PCT/CN2004/000134
申请日：2004-02-20
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N33/6875 , G01N33/689 , G01N2800/368 , G01N2800/52
摘要： The invention discloses a method for diagnosing immunity recurrent spontaneous abortion, which comprising detecting the level of antinuclear antibody of patients humor in vitro and comparing with the level of control women. In the method of the invention, especially using no2 chromosome separated from male or fragment comprising fibronectin encoding gene as antigen, to detect the level of antinuclear antibody of patients humor sample. The invention also discloses a kit used for diagnosing immunity recurrent spontaneous abortion, and kit used for monitoring therapeutics effect of immunity recurrent spontaneous abortion.

48. 发明申请

WO2005037059A3 MULTI-MARKER SCREENING PROTOCOL FOR FETAL ABNORMALITIES 审中-公开
标题翻译：多重标记筛选方案，用于非法异常
公开(公告)号：WO2005037059A3
公开(公告)日：2005-06-23
申请号：PCT/US2004031928
申请日：2004-09-29
申请人： NTD LAB INC
发明人： ORLANDI FRANCESCO , KRANTZ DAVID A
IPC分类号： A61B5/107 , A61B8/08 , G01N33/68 , G01N33/48 , A61B10/00 , G01N31/00 , G06K9/20 , G06K9/36
CPC分类号： A61B8/0866 , A61B5/1075 , A61B8/0808 , G01N33/689 , G01N2800/36 , G01N2800/368 , G01N2800/387 , Y10S128/916
摘要： A method of assessing a pregnant woman's risk of having a fetus with a fetal abnormality by determining the fetus' BPD/OFD ratio and using the BPD/OFD ratio in conjunction with one or more other screening markers for the fetal abnormality. Also provided is a method of determining whether a pregnant woman is screenpositive or screen-negative by comparing the BPD/OFD ratio of the pregnant woman's fetus to a risk cut-off level.
摘要翻译：通过确定胎儿的BPD / OFD比率并使用BPD / OFD比例与胎儿异常的一种或多种其他筛选标记物来评估孕妇胎儿胎儿异常胎儿的风险的方法。还提供了一种通过将孕妇胎儿的BPD / OFD比与风险截止水平进行比较来确定怀孕妇女是否具有阳性或阴性的方法。

49. 发明申请

WO2004043238A2 BIOMARKERS FOR INTRO-AMINIOTIC INFLAMMATION 审中-公开
标题翻译：生物标志物用于内分泌炎
公开(公告)号：WO2004043238A2
公开(公告)日：2004-05-27
申请号：PCT/US0336120
申请日：2003-11-13
申请人： CIPHERGEN BIOSYSTEMS INC , BUHIMSCHI IRINA A , CHRISTNER ROBERT
发明人： BUHIMSCHI IRINA A , CHRISTNER ROBERT
IPC分类号： A23J1/00 , A61B20060101 , C07K1/00 , C07K14/00 , C07K16/00 , C12M1/34 , C12M3/00 , C12N11/00 , C12N11/16 , C12Q1/00 , G01N33/48 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/567 , G01N33/68 , A61B
CPC分类号： G01N33/689 , G01N2333/4721 , G01N2333/4727 , G01N2800/36 , G01N2800/368
摘要： Biomarkers have been discovered that are capable of identifying intra-amniotic inflammation. A single biomarker or combination of biomarkers can beused to qualify the risk of preterm delivery in a patient, provided that at least one of the biomarkers is a calgranulin, preferably calgranulin A or C. The result is a rapid and reliable proteomic approach to identifying intra-amniotic inflammation. In particular, the concentrations of the biomarkers correlate with the magnitude of intra-amniotic inflammation and, hence, of preterm delivery.
摘要翻译：已经发现能识别羊膜内炎症的生物标志物。可以使用单个生物标志物或生物标志物的组合来限定患者早产的风险，只要至少一个生物标志物是钙粒蛋白，优选钙粒蛋白A或C.结果是快速和可靠的蛋白质组学方法来鉴定内羊膜炎症。特别地，生物标志物的浓度与羊膜内炎症的程度以及因此与早产的相关。

50. 发明申请

WO2003050532A1 血液細胞分離システム审中-公开
标题翻译：血细胞分离系统
公开(公告)号：WO2003050532A1
公开(公告)日：2003-06-19
申请号：PCT/JP2002/012839
申请日：2002-12-09
申请人：株式会社ネーテック , 由良洋文 , 斎藤芳夫 , 北川道弘
发明人：由良洋文 , 斎藤芳夫 , 北川道弘
IPC分类号： G01N33/48
CPC分类号： G01N33/689 , G01N33/537 , G01N33/56966 , G01N2400/00 , G01N2800/368
摘要： It is intended to provide a blood cell separation system whereby rare embryo-origin nuclear cells contained in the blood of a pregnant woman can be precisely separated and concentrated to conveniently give test specimens usable in prenatal chromosome/gene diagnosis. Namely, a blood cell separation system which comprises (1) a separation unit whereby anucleate erythrocytes, leukocytes and platelets are mainly eliminated from a blood specimen collected from a pregnant woman to give a primarily separated specimen; (2) a secondary separation unit whereby anucleate erythrocytes and leukocytes remaining in the primarily separated specimen obtained by the above-described unit are eliminated by using the sugar chain-lectin method to thereby give a secondly separated specimen having concentrated embryo nucleated cells; and (3) a sampling unit whereby the secondly separated specimen obtained by the secondarily separating unit is sampled.
摘要翻译：旨在提供一种血细胞分离系统，其中可以精确地分离和浓缩孕妇血液中含有的罕见胚胎起源细胞，以方便地产生可用于产前染色体/基因诊断的测试标本。即，一种血细胞分离系统，其特征在于，包括：（1）分离单元，其中从孕妇收集的血液样本中主要去除未核的红细胞，白细胞和血小板，得到主要分离的样本; （2）二次分离单元，其中通过使用糖链凝集素方法除去残留在通过上述单元获得的主要分离的样品中的无核红细胞和白细胞，从而得到具有浓缩胚胎有核细胞的第二分离的样品; 和（3）采样单元，其中由二次分离单元获得的第二分离的样本被采样。

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