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41. 发明申请

WO9956785A3 CELL MEDIATED GENE DELIVERY USING MUSCLE DERIVED CELLS FOR TREATING MUSCLE-AND BONE-RELATED INJURY OR DYSFUNCTION 审中-公开
标题翻译：使用肌肉衍生细胞进行细胞介导的基因交付，用于治疗肌肉和骨骼相关的伤害或功能障碍
公开(公告)号：WO9956785A3
公开(公告)日：2001-04-19
申请号：PCT/US9909451
申请日：1999-04-30
申请人： UNIV PITTSBURGH
发明人： CHANCELLOR MICHAEL B , HUARD JOHNNY
IPC分类号： A61K35/34 , A61K38/18 , A61K38/44 , A61K48/00 , A61P13/02 , A61P19/08 , A61P21/00 , C12N5/077 , C12N5/06 , C12N5/08 , C12N5/10
CPC分类号： A61K35/34 , A61K48/00 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/113 , C12N2501/115 , C12N2501/13 , C12N2510/00 , C12N2510/04
摘要： The present invention provides muscle-derived cells, preferably myoblasts and muscle-derived stem cells, genetically engineered to contain and express one or more heterologous genes or functional segments of such genes, for delivery of the encoded gene products at or near sites of musculoskeletal, bone, ligament, meniscus, cartilage or genitourinary disease, injury, defect, or dysfunction. Ex vivo myoblast mediated gene delivery of human inducible nitric oxide synthase, and the resulting production of nitric oxide at and around the site of injury, are particularly provided by the invention as a treatment for lower genitourinary tract dysfunctions. Ex vivo gene transfer for the musculoskeletal system includes genes encoding acidic fibroblast growth factor, basic fibroblast growth factor, epidermal growth factor, insulin-like growth factor, platelet derived growth factor, transforming growth factor- beta , transforming growth factor- alpha , nerve growth factor and interleukin-1 receptor antagonist protein (IRAP), bone morphogenetic protein (BMPs), cartilage derived morphogenetic protein (CDMPs), vascular endothelial growth factor (VEGF), and sonic hedgehog proteins.
摘要翻译：本发明提供肌肉衍生的细胞，优选成肌细胞和来自肌肉的干细胞，其被遗传工程化以含有和表达这种基因的一个或多个异源基因或功能区段，用于在肌肉骨骼的位点或附近递送编码的基因产物，骨，韧带，半月板，软骨或泌尿生殖系疾病，损伤，缺陷或功能障碍。本发明特别提供离体成肌细胞介导的人诱导型一氧化氮合酶的基因递送以及所产生的损伤部位周围及其周围的一氧化氮，作为降低泌尿生殖道功能障碍的治疗。肌肉骨骼系统的离体基因转移包括编码酸性成纤维细胞生长因子，碱性成纤维细胞生长因子，表皮生长因子，胰岛素样生长因子，血小板衍生生长因子，转化生长因子-β，转化生长因子-α，神经生长的基因因子和白细胞介素-1受体拮抗蛋白（IRAP），骨形态发生蛋白（BMPs），软骨来源的形态发生蛋白（CDMPs），血管内皮生长因子（VEGF）和声音刺猬蛋白。

42. 发明申请

WO01000031A1 STEM CELLS DERIVED FROM SKELETAL MUSCLE 审中-公开
标题翻译：来自骨骼肌的干细胞
公开(公告)号：WO01000031A1
公开(公告)日：2001-01-04
申请号：PCT/US2000/017064
申请日：2000-06-21
IPC分类号： A61K35/12 , A61K48/00 , C12N5/02 , C12N5/077 , A01N63/00 , C12N5/00 , C12N15/86
CPC分类号： C12N5/0659 , A61K35/12 , A61K48/00 , C12N2510/00
摘要： Materials and methods are provided related to a novel discovery that muscle stem cells (also called satellite cells) can generate at least the major hematopoietic lineages in individual mice over time as shown in the figure and the cells retain their regenerative potential after they are transferred to secondary recipients.
摘要翻译：提供了与新发现相关的材料和方法，如图所示，肌肉干细胞（也称为卫星细胞）可以随时间产生至少个体小鼠中的主要造血谱系，并且细胞在转移至其后保留其再生潜力次要接受者

43. 发明申请

WO1998027995A1 TREATMENT OF MAMMALIAN MYOCARDIUM WITH MORPHOGEN LOCALLY, OR WITH MORPHOGENICALLY-TREATED MYOGENIC PRECURSOR CELLS 审中-公开
标题翻译：用局部或具有多形态处理的生殖细胞前体细胞的MORMALIAN MYCARDIUM治疗
公开(公告)号：WO1998027995A1
公开(公告)日：1998-07-02
申请号：PCT/US1997023611
申请日：1997-12-19
申请人： CREATIVE BIOMOLECULES, INC. , COHEN, Charles, M. , SAMPATH, Kuber, T.
发明人： CREATIVE BIOMOLECULES, INC.
IPC分类号： A61K38/18
CPC分类号： C12N5/0657 , A61K35/12 , A61K38/1875 , C12N5/0659 , C12N2501/155
摘要： The present invention provides methods for the treatment, and pharmaceuticals for use in the treatment, of mammalian subjects at risk of, or afflicted with, loss of or damage to myocardial tissue. The methods involve the administration of certain morphogens, inducers of those morphogens, agonists of the corresponding morphogen receptors, or small molecule morphogenic activators, or implantation of cells induced with those agents. The morphogens useful in the invention include OP1, CBMP-2A (BMP-2), CBMP-2B (BMP-4), and other members of the morphogens family of the TGF beta superfamily of growth and differentiation factors.
摘要翻译：本发明提供了用于治疗患有心肌组织损失或损害的危险或受损害的哺乳动物受试者和用于治疗的药物的方法。所述方法包括施用某些形态发生剂，那些形态发生物的诱导剂，相应的形态发生受体的激动剂或小分子形态发生激活剂，或用这些试剂诱导的细胞的植入。可用于本发明的形态发生物包括生长和分化因子的TGFβ超家族的形态发生体家族中的OP1，CBMP-2A（BMP-2），CBMP-2B（BMP-4）和其他成员。

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