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41. 发明申请

WO2002083194A1 METHOD AND APPARATUS FOR ENGINEERED REGENERATIVE BIOSTRUCTURES 审中-公开
标题翻译：用于工程化再生生物结构的方法和装置
公开(公告)号：WO2002083194A1
公开(公告)日：2002-10-24
申请号：PCT/US2002/011515
申请日：2002-04-12
申请人： THERICS, INC. , BEAM, Heather, Ann , CHESMEL, Kathleen, D. , BRADBURY, Thomas, J. , GAYLO, Christopher, M. , LITWAK, Alfred, Anthony , LIU, Qing , MATERNA, Peter, Albert , MONKHOUSE, Donald , PATTERSON, Jennifer , PRYOR, Timothy, J. , SAINI, Sunil , SURPRENANT, Henry, Leon , WANG, Chen-Chau , WEST, Thomas, George , YOO, Jaedeok
发明人： BEAM, Heather, Ann , CHESMEL, Kathleen, D. , BRADBURY, Thomas, J. , GAYLO, Christopher, M. , LITWAK, Alfred, Anthony , LIU, Qing , MATERNA, Peter, Albert , MONKHOUSE, Donald , PATTERSON, Jennifer , PRYOR, Timothy, J. , SAINI, Sunil , SURPRENANT, Henry, Leon , WANG, Chen-Chau , WEST, Thomas, George , YOO, Jaedeok
IPC分类号： A61L27/12
CPC分类号： A61L27/46 , A61F2/28 , A61F2002/30034 , A61F2002/30059 , A61F2002/30062 , A61F2002/30225 , A61F2002/30271 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2230/0082 , A61F2250/0031 , A61F2310/00293 , A61L27/12 , A61L27/50 , A61L27/56 , A61L2430/02 , B33Y30/00 , B33Y80/00 , C04B28/34 , C04B35/447 , C04B35/634 , C04B35/638 , C04B38/06 , C04B2111/00181 , C04B2111/00836 , C04B2235/3212 , C04B2235/447 , C04B2235/5436 , C04B2235/6026 , C04B2235/616 , C04B2235/6567 , C04B2235/80 , C04B2235/96 , C04B35/00 , C04B38/0054 , C04B38/0074
摘要： An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.
摘要翻译：用于作为骨替代物植入人体的工程再生生物结构（erb），其包括内部微观结构，介观结构和/或宏观结构以提供改善的骨生长，以及用于制备所述erb的方法。在本发明的一个方面，生物结构具有可再吸收和不可再吸收的区域。在本发明的另一方面，生物结构由羟基磷灰石，磷酸三钙和/或脱矿质骨构成。在本发明的另一方面，多孔生物结构部分或全部注入可再吸收的，不可再吸收或可溶解的材料。

42. 发明申请

WO2002072500A1 CRYSTALLINE COMPOSITIONS OF DOPED ALUMINUM PHOSPHATE 审中-公开
标题翻译：磷酸二氢铝的晶体组成
公开(公告)号：WO2002072500A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/008977
申请日：2002-03-08
申请人： E.I. DUPONT DE NEMOURS AND COMPANY , GAI, Pratibha, Laxman
发明人： GAI, Pratibha, Laxman
IPC分类号： C04B35/447
CPC分类号： C01B25/36 , B01J27/16 , C04B35/447 , C04B2235/3217 , C04B2235/3418 , C04B2235/447 , C04B2235/762
摘要： The disclosed invention relates to novel crystalline compositions which may be obtained by doping the alpha (α) form of AlPO 4 ceramics, which find use as piezoelectric materials, stable supports for catalysts, biotechnology uses, and the like.
摘要翻译：所公开的发明涉及可以通过掺杂作为压电材料使用的α（α）形式的AlPO 4陶瓷，用于催化剂的稳定载体，生物技术用途等获得的新结晶组合物。

43. 发明申请

WO02056928A1 METHOD FOR THE PRODUCTION OF A BIOCOMPATIBLE POLYMER-CERAMIC COMPOSITE MATERIAL WITH A PREDETERMIDED POROSITY 审中-公开
标题翻译：生产可聚合物 - 陶瓷复合材料的方法，具有预测的孔隙度
公开(公告)号：WO02056928A1
公开(公告)日：2002-07-25
申请号：PCT/IT2002/000030
申请日：2002-01-18
IPC分类号： A61L24/00 , A61L27/12 , A61L27/42 , A61L27/46 , B01D17/038 , C04B26/06 , C04B35/447 , C04B38/00 , A61L26/00 , C08L33/12
CPC分类号： A61L24/0063 , A61L27/12 , A61L27/425 , A61L27/46 , C04B26/06 , C04B35/447 , C04B38/00 , C04B2103/0047 , C04B2111/00836 , C04B14/366 , C04B40/00
摘要： Method for the production of a biocompatible polymer-ceramic composite material with a predetermined porosity, designed and determined a priori, which includes a first phase (a) of the production of a suspension of a bioceramic material in distilled water, a second phase (b) in the which a compact of the bioceramic material containing a desired quantity of water is obtained from the suspension, and a third phase (c) in the which the compact is mixed with a polymeric material and/or a liquid monomer.
摘要翻译：生产具有预定孔隙率的生物相容性聚合物 - 陶瓷复合材料的方法，其先前设计和确定，其包括在蒸馏水中生产生物陶瓷材料的悬浮液的第一阶段（a），第二相（b ），其中从悬浮液中获得含有所需量的水的生物陶瓷材料的压块，以及将压块与聚合物材料和/或液体单体混合的第三相（c）。

44. 发明申请

WO2002045650A1 錠剤の製造方法及び錠剤の製造装置审中-公开
标题翻译：生产片剂的方法和装置
公开(公告)号：WO2002045650A1
公开(公告)日：2002-06-13
申请号：PCT/JP2001/010663
申请日：2001-12-06
申请人：協和醗酵工業株式会社 , 渡邊靖 , 早川公章 , 廣田英一郎 , 森本清
发明人：渡邊　靖 , 早川公章 , 廣田英一郎 , 森本　清
IPC分类号： A61J3/06
CPC分类号： C04B41/009 , A61J3/10 , B01J2/00 , B01J2/16 , B01J2/22 , B30B15/0011 , C04B41/5022 , C04B2111/00836 , C04B41/4523 , C04B35/10 , C04B35/119 , C04B35/443 , C04B35/447
摘要： An apparatus for producing tablets which has a gas generating device (G), a lubricant powder puffing device (51) puffing a lubricant powder into the gas from the gas generating device (G) in an amount depending on that of the gas, followed by mixing and dispersing, a lubricant applying device (91) spraying the lubricant powder puffed from the lubricant powder puffing device (51) and mixed with and dispersed in the gas generated from the gas generating device (G) onto the surface contacting with a material of each of a mortar, an upper pounder and an under pounder, and an oxygen concentration measuring device (131a) measuring an oxygen concentration of the gas present in the vicinity of the lubricant applying device (91), wherein the amount of the gas to be supplied into the lubricant applying device is controlled based on the oxygen concentration measured by the oxygen concentration measuring device (131a).
摘要翻译：一种具有气体发生装置（G）的片剂的制造装置，将来自气体发生装置（G）的气体中的润滑剂粉末向气体膨胀的润滑剂粉末膨胀装置（51）的润滑剂膨胀装置（51）混合和分散，润滑剂施加装置（91），喷涂从润滑剂粉末膨化装置（51）膨胀的润滑剂粉末，并将其与从气体发生装置（G）产生的气体混合并分散在与材料接触的表面上每个研钵，上部爆炸物和下部爆炸物，以及测量存在于润滑剂施加装置（91）附近的气体的氧浓度的氧浓度测量装置（131a），其中气体的量基于由氧浓度测量装置（131a）测量的氧气浓度来控制供应到润滑剂施加装置中。

45. 发明申请

WO01094274A1 FOAMED CERAMICS 审中-公开
标题翻译：泡沫陶瓷
公开(公告)号：WO01094274A1
公开(公告)日：2001-12-13
申请号：PCT/GB2001/002507
申请日：2001-06-07
IPC分类号： A61K6/033 , A61L27/12 , C04B35/447 , C04B38/06
CPC分类号： A61K6/033 , A61L27/12 , C04B35/447 , C04B38/06
摘要： A method for the production of a glass-reinforced ceramic foam material for use in biomedical applications and comprising hydroxyapatite and a biocompatible glass, which method comprises: a) providing a foam carrier; b) providing a slip comprising a liquid carrier and either (i) a biocompatible glass particulate and a ceramic particulate selected from one or both of hydroxyapatite and apatite or (ii) a composite ceramic-glass particulate comprising a biocompatible glass with one or both of apatite and hydroxyapatite; c) coating the foam carrier with the slip; and d) heating the slip-coated foam carrier at a temperature sufficient to substantially burn out the precursor foam carrier.
摘要翻译：一种用于生产用于生物医学应用并包含羟基磷灰石和生物相容性玻璃的玻璃纤维增强陶瓷泡沫材料的方法，该方法包括：a）提供泡沫载体; b）提供包含液体载体的滑动剂和（i）生物相容性玻璃颗粒和选自羟基磷灰石和磷灰石中的一种或两种的陶瓷颗粒，或（ii）包含生物相容性玻璃的复合陶瓷 - 玻璃颗粒，磷灰石和羟磷灰石; c）用泡沫涂覆泡沫载体; 以及d）在足以基本上燃烧前体泡沫载体的温度下加热涂布的泡沫载体。

46. 发明申请

WO00059845A1 SINTERABLE STRUCTURES AND A METHOD OF PRODUCING THE SAME 审中-公开
标题翻译：可烧结结构及其生产方法
公开(公告)号：WO00059845A1
公开(公告)日：2000-10-12
申请号：PCT/US2000/009366
申请日：2000-04-06
IPC分类号： C04B26/28 , C04B38/06 , C04B38/00
CPC分类号： B22F3/1121 , C04B26/28 , C04B35/111 , C04B35/447 , C04B35/624 , C04B35/6365 , C04B38/062 , C04B38/0635 , C04B2111/00793 , C04B2111/0081 , C04B2235/5436 , C04B2235/5445 , C04B2235/602 , C04B2235/6021 , C04B2235/658 , C04B2235/9661 , C04B35/00 , C04B38/0058 , C04B14/366 , C04B24/12 , C04B40/0028 , C04B40/0268 , C04B38/0054
摘要： A method of producing an open, porous structure having an outer surface defining a shape having a bulk volume and having interconnecting openings extending throughout said volume and opening through said surface, and products resulting from the method. The method comprises preparing a viscous mixture comprising a sinterable powder dispersed in a sol of a polymer in a primary solvent, replacing the primary solvent with a secondary liquid in which the polymer is insoluble to produce a gel comprising an open polymeric network having the sinterable powder arranged therein, removing the secondary liquid from the gel; removing the polymer network, and sintering the sinterable powder to form the open, porous structure. Also disclosed are shaped, porous products resulting from methods of the invention.
摘要翻译：一种制造开放多孔结构的方法，其具有限定具有本体体积的形状的外表面，并且具有贯穿所述体积延伸并穿过所述表面的互连开口，以及由该方法产生的产品。该方法包括制备粘性混合物，其包含分散在聚合物溶胶中的可烧结粉末于主溶剂中，用第二液体代替第一溶剂，其中聚合物不溶于其中以产生包含具有可烧结粉末的开放聚合物网络的凝胶布置在其中，从凝胶中除去第二液体; 去除聚合物网络，并烧结可烧结粉末以形成开放的多孔结构。还公开了由本发明的方法得到的成形的多孔产品。

47. 发明申请

WO1997023428A1 BONE GRAFT SUBSTITUTE AND ITS PREPARATION 审中-公开
标题翻译：骨髓替代品及其制备
公开(公告)号：WO1997023428A1
公开(公告)日：1997-07-03
申请号：PCT/IL1996000182
申请日：1996-12-19
申请人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY, OF THE HEBRE W UNIVERSITY OF JERUSALEM , BEN-BASSAT, Hannah , SARIG, Sara
发明人： HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY, OF THE HEBRE W UNIVERSITY OF JERUSALEM
IPC分类号： C04B35/00
CPC分类号： A61F2/28 , A61F2/3094 , A61F2002/2835 , A61F2310/00293 , A61L27/12 , A61L2430/02 , C04B35/447
摘要： A solid ceramic composition comprising beta -TCP, hydroxy apatite and a substantial amount of alpha -TCP as shown in the x-ray diffraction spectrum, which is useful as a bone graft substitute. A process for preparing the composition by subjecting a mixture of ionic calcium, phosphate, aspartic acid and carbonate to microwave irradiation and quenching the irradiated mixture.
摘要翻译：包含β-TCP，羟基磷灰石和大量α-TCP的固体陶瓷组合物，如x-射线衍射光谱所示，其可用作骨移植物替代物。通过使离子钙，磷酸盐，天冬氨酸和碳酸盐的混合物进行微波照射并淬灭所述被照射的混合物来制备组合物的方法。

48. 发明申请

WO1996027697A1 SELECTIVE METAL CATION-CONDUCTING CERAMICS 审中-公开
标题翻译：选择性金属导电陶瓷
公开(公告)号：WO1996027697A1
公开(公告)日：1996-09-12
申请号：PCT/US1995002871
申请日：1995-03-06
申请人： CERAMATEC, Inc.
发明人： CERAMATEC, Inc. , BALAGOPAL, Shekar, H. , GORDON, John, Howard , VIRKAR, Anil, V. , JOSHI, Ashok, V.
IPC分类号： C25B09/00
CPC分类号： C25B13/04 , C04B35/16 , C04B35/19 , C04B35/447 , C04B2235/3201 , C04B2235/3224 , C04B2235/3225 , C04B2235/3227 , C04B2235/604 , C04B2235/662 , C04B2235/77 , C04B2235/79 , C04B2235/9661 , C04B2235/9692 , C25B1/46 , H01M6/185 , H01M8/1016
摘要： Ceramic materials (24) are disclosed which have comprehensive characteristics of high ion-conductivity for alkali metal cations at low temperatures, high selectivity for alkaly metal ions, good current efficiency and stability in water and corrosive media under static and electrochemical conditions. Also disclosed is an electrochemical cell (20), the electrolyte (24) of which employs the disclosed ceramic materials, for use in the electrolysis of aqueous alkali salt solutions to form caustic.
摘要翻译：公开了对于碱金属阳离子在低温下具有高离子电导率，对于碱金属离子具有高选择性，良好的电流效率以及在静电和电化学条件下在水和腐蚀性介质中的稳定性的综合特性的陶瓷材料（24）。还公开了电化学电池（20），其电解质（24）采用所公开的陶瓷材料，用于电解碱金属盐溶液以形成苛性碱。

49. 发明申请

WO1985001676A1 INSULATION SYSTEM 审中-公开
标题翻译：绝缘系统
公开(公告)号：WO1985001676A1
公开(公告)日：1985-04-25
申请号：PCT/US1984001691
申请日：1984-10-16
申请人： MANVILLE SERVICE CORPORATION
发明人： MANVILLE SERVICE CORPORATION , SMITH, William, Hahn
IPC分类号： B05B07/06
CPC分类号： C04B41/5092 , B05B7/0075 , C04B28/342 , C04B30/02 , C04B35/447 , C04B35/6306 , C04B41/009 , C04B41/85 , C04B2111/00155 , F27D1/002 , C04B14/104 , C04B14/30 , C04B14/307 , C04B14/46 , C04B22/0013 , C04B40/0028 , C04B40/0263 , C04B35/00
摘要： A method and apparatus for directing a stream (15) of bulk fibers while simultaneously spraying an inorganic temperature resistant tacky binder material into the stream (15) of fibers. A layer of high temperature insulating fibers may thus be formed. The binder may be a phosphate tackifying agent mixture or a colloidal suspension of materials with the tackifying agent. The takifying agent is preferably montmorillonite clay. Spray gun (14) is employed to direct the refractory fiber stream (24) through conduit (23) so as to emerge from an annular path defined by deflector body (25) and manifold (26).
摘要翻译：一种用于引导散装纤维流（15）同时将无机耐温粘性粘合剂材料喷射到纤维流（15）中的方法和装置。因此可以形成一层高温绝缘纤维。粘合剂可以是磷酸盐增粘剂混合物或具有增粘剂的材料的胶体悬浮液。收集剂优选为蒙脱石粘土。喷枪（14）用于通过导管（23）引导耐火纤维流（24），以便从由偏转器本体（25）和歧管（26）限定的环形路径露出。

50. 发明申请

WO2018000794A1 一种可降解含镁和锶的硫磷灰石多孔复合生物支架审中-公开
公开(公告)号：WO2018000794A1
公开(公告)日：2018-01-04
申请号：PCT/CN2017/000103
申请日：2017-01-04
申请人：李亚屏
发明人：李亚屏 , 李桑 , 蒋国强 , 汤亭亭 , 傅俊 , 彭兆祥 , 毛海蛟 , 熊汉锋 , 聂磊 , 郑建民 , 张国锋
IPC分类号： A61L27/12 , A61L27/02 , A61L27/56 , A61L27/50 , A61L27/54 , C04B38/08 , C04B35/447
CPC分类号： A61L27/02 , A61L27/12 , A61L27/50 , A61L27/54 , A61L27/56 , C04B35/447 , C04B38/08
摘要：一种可降解含镁和锶的硫磷灰石多孔复合生物支架及其制备方法。该制备方法包括将牛煅烧松质骨骨矿多孔支架用含有镁源、锶源、硫源及磷源的四元体系处理，取出干燥后，高温煅烧。该可降解含镁和锶的硫磷灰石多孔复合生物支架兼具良好三维互通网孔结构与骨传导性、可降解性、较好机械强度和生物相容性，同时网孔内有较大长径比的硫酸钙晶须生长，可增加材料的比表面积，可改善细胞粘附。

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