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41. 发明申请

WO1994026788A1 PROCESS FOR THE PREPARATION OF IODINATED BIOPOLYMERS HAVING DISINFECTANT AND CICATRIZING ACTIVITY, AND THE IODINATED BIOPOLYMERS OBTAINABLE THEREBY 审中-公开
标题翻译：制备具有消毒剂和化学活性的碘化生物聚合物的方法以及可获得的碘化生物聚合物
公开(公告)号：WO1994026788A1
公开(公告)日：1994-11-24
申请号：PCT/IT1994000052
申请日：1994-04-28
申请人： DEVELOPMENT BIOTECHNOLOGICAL PROCESSES S.N.C. DI PELLICCIA MARIA TERESA , IMS-INTERNATIONAL MEDICAL SERVICA S.R.L. , DE ROSA, Alfredo , ROSSI, Armando , AFFAITATI, Pietro
发明人： DEVELOPMENT BIOTECHNOLOGICAL PROCESSES S.N.C. DI PELLICCIA MARIA TERESA , IMS-INTERNATIONAL MEDICAL SERVICA S.R.L.
IPC分类号： C08B37/08
CPC分类号： A61K8/20 , A01N59/12 , A61K8/736 , A61Q15/00 , C08B37/003
摘要： Process for the preparation of complexes of iodine with chitosan or derivatives thereof, and the iodinated compounds thus obtainable. Said compounds take form of powders, which may contain over 60 % of iodine in its elementary form. In a dry state the iodine bound to the chitosan or derivatives thereof does not sublimate. If the percentage content of iodine does not exceed 50 % (by weight), said powders can be dissolved in aqueous solvents of an acid type, such as, for example, diluted acetic acid or glutamic acid. Said solutions are compatible with addition of surfactants, preferably of a non-ionic type, which improve the solubility of the chitosan-iodine complex. Solutions with identical characteristics can, alternatively, be prepared by solubilizing, heating if necessary the iodine in a suitable surfactant, preferably non-ionic, and adding this solution under rapid stirring to the chitosan derivatives thereof, dissolved in water, optionally in the presence of acids or salts. Alternatively, the chitosan or derivatives thereof in a dry state can be added to the solution of iodine in surfactant which rapidly absorbs onto the solid, forming the chitosan-iodine complexes. This material suspended in water or in acid solutions, preferably acetic acid or glutamic acid, solubilizes rapidly. The complexes of iodine with chitosan or derivatives thereof, in the form of aspersable powders, solutions or ointments, thanks to their disinfectant and cicatrizing properties, can be used in the field of surgery post-operative treatment and more generally speaking as products for topical use for medication of wounds and disinfectation of the skin. Another area of interest in which the complexes can be used as an active principle is the field of cosmetics.
摘要翻译：用于制备与壳聚糖或其衍生物的碘络合物的方法以及由此获得的碘化化合物。所述化合物为粉末形式，其可以含有超过60％的基本形式的碘。在干燥状态下，与壳聚糖或其衍生物结合的碘不升华。如果碘的含量不超过50％（重量），则所述粉末可以溶解在酸性水溶剂中，例如稀释的乙酸或谷氨酸。所述溶液与添加优选非离子型表面活性剂相容，其提高壳聚糖 - 碘络合物的溶解度。具有相同特征的溶液可以选择地通过将碘溶解在合适的表面活性剂中，优选非离子的，并在快速搅拌下加入溶于水的壳聚糖衍生物，任选地在酸或盐。或者，干燥状态的壳聚糖或其衍生物可以加入快速吸收到固体上的表面活性剂中的碘溶液中，形成壳聚糖 - 碘络合物。悬浮在水中或在酸性溶液中，优选乙酸或谷氨酸的物质迅速溶解。由于其消毒剂和瘢痕化特性，碘与壳聚糖或其衍生物的复合物可分散的粉末，溶液或软膏形式可用于手术后手术治疗领域，更一般地说，可用于局部使用的产品用于治疗伤口和皮肤消毒。复合物可用作活性成分的另一个领域是化妆品领域。

42. 发明申请

WO1994023581A1 IODINE BARRIER TEAT DIP 审中-公开
公开(公告)号：WO1994023581A1
公开(公告)日：1994-10-27
申请号：PCT/US1994002243
申请日：1994-02-24
申请人： ECOLAB INC.
发明人： ECOLAB INC. , SCHMIDT, William , IHNS, Deborah, A.
IPC分类号： A01N59/12
CPC分类号： A61K9/0041 , A01N25/24 , A01N59/12 , A01N25/10 , A01N2300/00
摘要： A protective aqueous antimicrobial film forming composition that can be applied to dairy animals to form a protective film. The film can be used to reduce the incidence of both contagious and environmental mastitis in dairy herds and can be formed from an aqueous composition that can contain a nonionic iodine complex, a polyvinyl alcohol composition, having a degree of hydrolysis greater than 92 %, preferably greater than 98 %, and a thickener. The aqueous mixture can be applied to udder and teats of dairy herds to form a protective coating that can prevent infection from staphlococcus, streptococcus, klebsiella and other pathogens. The film can be removed using water in a convenient short period of time permitting efficient milking operations. After milking, the composition can be reapplied to the herd and can protect the herd from mastitis until the herd is again milked. The material of the invention has the property that after application and drying both films and plugs of the protective coating is softened and removed even in cold water in a convenient time frame.
摘要翻译：可用于乳制品动物以形成保护膜的保护性含水抗微生物膜形成组合物。该膜可用于降低乳牛群中传染性和环境性乳腺炎的发生率，并且可以由含有非离子型碘络合物，聚乙烯醇组合物，水解度大于92％的水性组合物形成，优选地大于98％，和增稠剂。含水混合物可以应用于乳牛群的乳头和乳头，以形成可以防止葡萄球菌，链球菌，克雷伯杆菌和其他病原体感染的保护性涂层。可以在方便的短时间内使用水去除胶片，从而允许有效的挤奶操作。挤奶后，可以将组合物重新应用于牛群，并可以保护牛群免受乳腺炎的侵害，直到牛群再次挤奶。本发明的材料具有这样的特征：即使在施用和干燥之后，保护涂层的两个膜和塞子即使在冷水中也能在方便的时间内被软化和去除。

43. 发明申请

WO1993024132A1 SOLID, STORAGE-STABLE, GERMICIDAL, PRE-IODINE COMPOSITION 审中-公开
标题翻译：固体，储存稳定，灭菌，预碘化物组合物
公开(公告)号：WO1993024132A1
公开(公告)日：1993-12-09
申请号：PCT/US1992004336
申请日：1992-05-26
申请人： EPITOPE, INC. , FELLMAN, Jack, H.
发明人： EPITOPE, INC.
IPC分类号： A61K31/70
CPC分类号： A61K33/18 , A01N59/12
摘要： A solid, storage-stable, germicidal, pre-iodine composition comprises in dry admixture with each other, a solid oxy-compound of iodine, a solid reducing agent for the oxy-compound of iodine, and a solid desiccant used in amount sufficient to combine during the storage cycle of the composition with ambient and/or endogenous water. The oxy-compounds of iodine are iodic acid, iodine pentoxide, potassium iodate and sodium iodate. Preferred reducing agents are ascorbic acid, dihydroxy fumaric acid, the thiol sugars and cysteine. A preferred combination desiccant and iodine solvating agent is polyvinyl pyrrolidone having a molecular weight of from 10,000 to 1,000,000. The composition is storage-stable for an indefinite period. Upon the addition of water, the oxy-compound of iodine is reduced to nascent iodine, which, in application, serves its well-known germicidal function.
摘要翻译：固体，储存稳定，杀菌，预碘组合物包含彼此的干混合物，碘的固体氧化合物，碘氧化合物的固体还原剂和固体干燥剂，其用量足以在组合物的储存循环期间与环境和/或内源水结合。碘的氧化合物是碘酸，五氧化二磷，碘酸钾和碘酸钠。优选的还原剂是抗坏血酸，二羟基富马酸，硫醇糖和半胱氨酸。优选的组合干燥剂和碘溶剂是分子量为10,000至1,000,000的聚乙烯吡咯烷酮。该组合物在无限期存储稳定。加入水后，碘的氧化合物被还原成新生的碘，其在应用中可用于其众所周知的杀菌功能。

44. 发明申请

WO1991004940A1 METHOD AND DEVICE FOR PRODUCING PURE ELEMENTAL IODINE 审中-公开
标题翻译：用于生产纯元素碘的方法和装置
公开(公告)号：WO1991004940A1
公开(公告)日：1991-04-18
申请号：PCT/CA1990000265
申请日：1990-08-20
申请人： IOMECH LIMITED , O'DOWD, Dennis, Hardy
发明人： IOMECH LIMITED
IPC分类号： C01B07/14
CPC分类号： A01N59/12 , B01D61/36 , C01B7/14
摘要： A method and device for producing thermodynamically free iodine in which a source material containing thermodynamically free iodine is introduced to one side of an iodine solving solid barrier through which the thermodynamically free iodine passes by dispersion to the other side of the solid barrier until an equilibrium of thermodynamically free iodine vapour pressure is reached across the barrier. In a preferred embodiment of the invention, the degree to which the thermodynamically free iodine disperses to the other side of the iodine solving solid barrier may be controlled by means which reduce the vapour pressure of thermodynamically free iodine such as the variation of temperature of the iodine source material or of the other side of the barrier as well as the use of an iodine complexing compound in conjuction or in combination with the source material.
摘要翻译：一种生产热力学游离碘的方法和装置，其中将含有热力学游离的碘的原料引入碘解析固体屏障的一侧，通过该碘阻挡固体屏障，热力学游离的碘通过分散体通过固体屏障的另一侧直到平衡跨越屏障达到热力学游离的碘蒸汽压力。在本发明的一个优选实施方案中，可以通过降低热力学游离碘的蒸汽压的方法来控制热解动态游离碘分散到碘解析固体屏障的另一侧的程度，例如碘的温度变化源材料或屏障的另一侧，以及结合使用碘络合化合物或与源材料组合使用。

45. 发明申请

WO1985002422A1 MICROBICIDAL MATERIALS 审中-公开
标题翻译：微生物材料
公开(公告)号：WO1985002422A1
公开(公告)日：1985-06-06
申请号：PCT/US1984001264
申请日：1984-08-13
申请人： AVTEX FIBERS INC. , SMITH, Frederick, R.
发明人： AVTEX FIBERS INC.
IPC分类号： D01F06/18
CPC分类号： D06M11/09 , A01N25/32 , A01N25/34 , A01N59/12 , A61L15/18 , A61L15/46 , A61L31/16 , A61L2300/202 , A61L2300/404 , C08K3/02 , D01F1/103 , A01N2300/00
摘要： Germicidal shaped objects containing germicidally effective amounts of iodine are composed of a major amount of a fiber-forming component, e.g., regenerated cellulose, cellulose acetate, a vinyl chloride copolymer, an acrylonitrile copolymer, or cross-linked alginic acid and a minor amount of an alloying component capable of complexing iodine to a different degree of stability, preferably more firmly, e.g., a polyvinyl pyrrolidone or starch. To prevent iodine from being released into the atmosphere a protective iodine-capturing layer may be used.
摘要翻译：含有杀菌有效量的碘的杀菌形状的物质由大量的纤维形成成分组成，例如再生纤维素，乙酸纤维素，氯乙烯共聚物，丙烯腈共聚物或交联藻酸和少量的能够将碘络合到不同程度的稳定性的合金成分，优选更牢固地例如聚乙烯吡咯烷酮或淀粉。为了防止碘被释放到大气中，可以使用保护性碘捕获层。

46. 发明申请

WO2016109344A1 BACTERICIDAL COMPOSITION 审中-公开
标题翻译：杀菌剂组合物
公开(公告)号：WO2016109344A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/067395
申请日：2015-12-22
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： OKUNO, Masashi , SCHOLZ, Matthew T.
IPC分类号： A01N25/22 , A45D27/46 , A61K31/717
CPC分类号： A61K31/79 , A01N25/24 , A01N59/12 , A61K9/0014 , A61K9/08 , A61K33/18 , A61K47/14 , A61K47/38 , A01N31/02
摘要： A bactericidal composition comprising a carboxy group-containing cellulose ester or carboxy group-containing cellulose ether, a bactericide, alcohol, and water. Some embodiments further comprise a plasticizer. The compositions described herein may be used to disinfect the surface of skin in preparation for surgical procedures.
摘要翻译：包含含羧基的纤维素酯或含羧基的纤维素醚，杀菌剂，醇和水的杀菌组合物。一些实施方案还包含增塑剂。本文所述的组合物可用于消毒皮肤表面以准备外科手术。

47. 发明申请

WO2016108041A1 ANTIBIOFILM COMPOSITIONS 审中-公开
标题翻译：抗生素组合物
公开(公告)号：WO2016108041A1
公开(公告)日：2016-07-07
申请号：PCT/GB2015/054117
申请日：2015-12-22
申请人： TRIO HEALTHCARE LIMITED
发明人： SAMBASIVAM, Mahesh , CUTTING, Keith , PEARCE, Lloyd
IPC分类号： A61K9/00 , A61K9/06 , A61K9/14 , A61K31/047 , A61K31/194 , A61K31/198 , A61L15/42 , A61K31/4425 , A61K31/444 , A61K31/7028 , A61K31/785 , A61K33/14 , A61K33/38 , A61P31/02
CPC分类号： A61K45/06 , A01N37/36 , A01N37/44 , A01N41/10 , A01N43/10 , A01N43/40 , A61K31/047 , A61K31/194 , A61K31/198 , A61K31/381 , A61K31/4425 , A61K31/7032 , A61K31/785 , A61K33/18 , A61K33/38 , A61L15/46 , A61L26/0066 , A61K2300/00 , A01N47/44 , A01N59/12 , A01N59/16
摘要： The present disclosure relates to antibiofilm compositions, kits, and methods of disrupting biofilms, and inhibiting and/or reducing microbes in wound environment and medical device surfaces.
摘要翻译：本公开涉及抗生物膜组合物，试剂盒和破坏生物膜的方法，以及抑制和/或减少伤口环境和医疗器械表面中的微生物。

48. 发明申请

WO2016024339A1 細胞修復剤および殺菌消毒システム审中-公开
标题翻译：细胞修复剂和消毒系统
公开(公告)号：WO2016024339A1
公开(公告)日：2016-02-18
申请号：PCT/JP2014/071330
申请日：2014-08-12
申请人：菅野稔
发明人：菅野　稔 , 庭野　吉己 , 菅野　太郎
IPC分类号： A61K31/192 , A61K31/216 , A61K31/353 , A61P1/02 , A61P17/00 , A61P17/02 , A61P31/02 , A61P39/02 , A61P43/00
CPC分类号： A61K31/353 , A01N25/32 , A01N37/38 , A01N37/40 , A01N43/16 , A61K9/0019 , A61K31/192 , A61K31/216 , A61K33/00 , A61K33/20 , A61K2300/00 , A01N47/44 , A01N59/00 , A01N59/12
摘要：【課題】酸性電解水などの酸化力により障害を受けた細胞を修復することができる細胞修復剤、ならびに、安全かつ効率的に、皮膚や口腔内の感染創傷の殺菌および治癒を促進することができる殺菌消毒システムを提供する。【解決手段】細胞修復剤は、下記の一般式（１）で表わされるポリフェノール、その重合体および医薬上許容可能なその塩のうちの、少なくとも１種を含む。Ｒ２およびＲ３は、水素原子であり、Ｒ１は、水素原子または水酸基であることが好ましい。
摘要翻译：本发明提供能够修复由于酸性电解水等物质的氧化能力而被破坏的细胞的细胞修复剂，以及能够安全有效地促进皮肤感染的伤口的灭菌和愈合的消毒系统，在口腔中。 [溶液]细胞修复剂含有选自由通式（1）表示的多酚中的至少一种化合物，其聚合物及其药学上可接受的盐。在该式中，R 2和R 3优选表示氢原子，R 1优选表示氢原子或羟基。

49. 发明申请

WO2015116454A3 MATERIALS, DEVICES, SYSTEMS, AND METHODS FOR IDENTIFYING FEMALE URETHRA 审中-公开
标题翻译：用于鉴定女性尿道炎的材料，装置，系统和方法
公开(公告)号：WO2015116454A3
公开(公告)日：2015-11-05
申请号：PCT/US2015012297
申请日：2015-01-21
申请人： BARD INC C R
发明人： HAWKINS-ROPER CLORISSA , ZIADIE JOSHUA DANIEL , CHAPMAN BRIAN , MADIGAN HENRI , GOLDMAN DAVID , MANN GREGORY , LEONARD CHRYSTIE , LEWIS EMILY , REINEKE CHASE , RUSSELL SHANNON , WALTHALL JILL M , LAN BETTY , CHEN FUNG BOR , URBAN JOSEPH , WAN BEATRICE , CHANCY HUDSON
IPC分类号： A61M25/01
CPC分类号： A61M25/01 , A01N59/12 , A61B42/10 , A61K49/006 , A61M25/0017 , A61M2025/0206 , A61M2205/0227 , A61M2205/583 , A61M2205/584 , A61M2210/1092 , A61M2210/1475
摘要： Embodiments of the invention include materials, devices, systems, and methods for identifying female urethra and facilitating catheterization. For instance, materials, devices, systems, and methods described herein may facilitate marking of female urethra, which may lead to increase in insertion accuracy and may reduce time for completing the catheterization procedure.
摘要翻译：本发明的实施例包括用于识别女性尿道并促进导管插入的材料，装置，系统和方法。例如，本文描述的材料，装置，系统和方法可促进女性尿道的标记，这可能导致插入精度的增加并且可能减少完成导管插入过程的时间。

50. 发明申请

WO2015003912A1 DETERGENT COMPOSITION 审中-公开
标题翻译：洗涤剂组合物
公开(公告)号：WO2015003912A1
公开(公告)日：2015-01-15
申请号：PCT/EP2014/063470
申请日：2014-06-26
申请人： UNILEVER N.V. , UNILEVER PLC , CONOPCO, INC., D/B/A UNILEVER
发明人： BISWAS, Sarmistha , DASGUPTA, Anindya , NETHAJI, Alagirisamy , SAJI, Maya Treesa , SHRESTH, Rudra Saurabh
IPC分类号： A01N59/12 , C11D3/48 , C11D1/04 , C11D1/12 , C11D1/66 , C11D1/38 , A61Q17/00 , A61K8/20 , C11D1/14 , C11D1/22
CPC分类号： C11D1/04 , A01N59/12 , A61K8/20 , A61K8/466 , A61Q17/005 , C11D1/12 , C11D1/143 , C11D1/22 , C11D1/38 , C11D1/66 , C11D3/48 , A01N25/30 , A01N33/12 , A01N41/02 , A01N41/04
摘要： The invention relates to cleaning compositions having anti-microbial benefits, in particular cleaning compositions having enhanced anti-microbial benefit because of the synergistic interaction between a surfactant and an iodine containing inorganic salt. Detergent compositions having a neutral to alkaline pH and that have low levels of halogens, halogen oxidants, or halogen salts providing good cleaning and improved anti-microbial benefits remain to be desired. It is an object of the present invention to provide a detergent composition with good cleaning and enhanced anti-microbial benefit and at neutral to alkaline pH and having low levels of halogens, halogen oxidants or halogen salts. It has been found that at a neutral to alkaline pH, a synergistic anti-microbial activity may be obtained between a surfactant selected from sulphonated or carboxylated anionic, cationic or non-ionic surfactants and an iodine containing inorganic salt selected from iodate or iodide salts in a concentration of less than 0.5%w.
摘要翻译：本发明涉及具有抗微生物益处的清洁组合物，特别是由于表面活性剂与含碘无机盐之间的协同相互作用而具有增强的抗微生物益处的清洁组合物。具有中性至碱性pH并且具有低水平卤素，卤素氧化剂或提供良好清洁和改善的抗微生物益处的卤素盐的洗涤剂组合物仍然是需要的。本发明的目的是提供具有良好清洁性和增强的抗微生物益处以及中性至碱性pH并具有低水平卤素，卤素氧化剂或卤素盐的洗涤剂组合物。已经发现，在中性至碱性pH下，可以在选自磺化或羧化的阴离子，阳离子或非离子表面活性剂的表面活性剂和选自碘酸盐或碘盐中的含碘无机盐之间获得协同的抗微生物活性浓度小于0.5％w。

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