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41. 发明申请

WO2009023281A1 A MULTIPLE MODE DIGITIZATION SYSTEM FOR A NON-DESTRUCTIVE INSPECTION INSTRUMENT 审中-公开
标题翻译：非破坏性检查仪器的多模式数字化系统
公开(公告)号：WO2009023281A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/009832
申请日：2008-08-18
申请人： OLYMPUS NDT , DRUMMY, Michael , THOMAS, Andrew , LAQUERRE, Denys , LAROCHELLE, David , LANGLOIS, Pierre , BESSER, Steven
发明人： DRUMMY, Michael , THOMAS, Andrew , LAQUERRE, Denys , LAROCHELLE, David , LANGLOIS, Pierre , BESSER, Steven
IPC分类号： G01R27/28
CPC分类号： G01R19/2509 , G01N29/262 , G01N29/44
摘要： A multiple mode digitization system for a non-destructive inspection instrument which makes use of a multiplexing circuit and a single set of analog to digital converters to efficiently digitize analog test signals from a plurality of inputs. In the preferred embodiment, each of the analog to digital converters in the system is driven with an independent and separate clock signal, allowing for propagation delay compensation among the plurality of test signals as well as interleaved sampling such that custom sampling rates can be used for each input without the need for more than one clock frequency. In an alternate embodiment, phase adjustments on the sampling clocks are used only for interleave sampling, and digital filters are used to provide signal propagation delay compensation.
摘要翻译：一种用于非破坏性检查仪器的多模式数字化系统，其利用多路复用电路和单组模数转换器来有效地数字化来自多个输入的模拟测试信号。在优选实施例中，系统中的每个模数转换器都用独立和分离的时钟信号驱动，允许多个测试信号之间的传播延迟补偿以及交错采样，使得定制采样速率可用于每个输入不需要多于一个时钟频率。在替代实施例中，采样时钟上的相位调整仅用于交织采样，并且使用数字滤波器来提供信号传播延迟补偿。

42. 发明申请

WO2007082806A1 ARYL-ISOXAZOL-4-YL-IMIDAZO[1,2-A]PYRIDINE USEFUL FOR THE TREATMENT OF ALZHEIMER’S DISEASE VIA GABA RECEPTORS 审中-公开
标题翻译： ARYL-ISOXAZOL-4-YL-IMIDAZO [1,2-A]吡啶可用于通过GABA受体治疗阿尔茨海默病
公开(公告)号：WO2007082806A1
公开(公告)日：2007-07-26
申请号：PCT/EP2007/050137
申请日：2007-01-08
申请人： F. HOFFMANN-LA ROCHE AG , BUETTELMANN, Bernd , HAN, Bo , KNUST, Henner , THOMAS, Andrew
发明人： BUETTELMANN, Bernd , HAN, Bo , KNUST, Henner , THOMAS, Andrew
IPC分类号： C07D471/04 , A61K31/437 , A61P25/28
CPC分类号： C07D471/04
摘要： The present invention is concerned with aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives of formula (I): wherein R 1 is hydrogen, halogen, hydroxy, lower alkyl, benzyloxy or -O-(CH 2 )-(CO)-5 or 6 membered heteroaryl optionally substituted by aryl or by lower alkyl; R 2 is hydrogen, halogen, lower alkyl, lower alkynyl, amino, -NHC(O)-R a or -(CO)-R a ; R 3 is hydrogen, halogen, cyano, lower alkyl, lower alkynyl, amino, -NHC(O)-R a , -(CO)-R a , -5 or 6-membered heterocycloalkyl in 1-position, optionally substituted 10 by =O or is a -5 or 6-membered heteroaryl in 1-position; R 4 is hydrogen or -5 or 6-membered heteroaryl; R 5 is lower alkyl or cycloalkyl; R a is lower alkoxy or NR'R'', wherein R' and R'' are each independently hydrogen, lower alkyl optionally substituted by hydroxy, lower alkynyl, -(CH 2 ) n -cycloalkyl, 15 -(CH 2 ) n -5 or 6-membered heterocycloalkyl or -(CH 2 ) n -5 or 6-membered heteroaryl; n is 0 to 3; as well as pharmaceutically acceptable acid addition salts thereof. It has been found that this class of compounds show high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
摘要翻译：本发明涉及式（I）的芳基 - 异恶唑-4-基 - 咪唑并[1,2-a]吡啶衍生物：其中R 1是氢，卤素，羟基，低级烷基，任选被芳基或低级烷基取代的苄氧基或-O-（CH 2 - ） - （CO）-5或6元杂芳基; R 2是氢，卤素，低级烷基，低级炔基，氨基，-NHC（O）-R a或 - （CO）-R a， SUP>; R 3是氢，卤素，氰基，低级烷基，低级炔基，氨基，-NHC（O）-R a， - （CO）-R a 1-位的-5或6-元杂环烷基，任选地被10取代或被1位置的5或6元杂芳基取代; R 4是氢或-5或6元杂芳基; R 5是低级烷基或环烷基; R“是低级烷氧基或NR'R”，其中R'和R“各自独立地为氢，任选被羟基取代的低级烷基，低级炔基， - （CH 2） 15 - （CH 2）n - 或 - 或 - 6元杂环烷基或 - （CH 2） -5或6元杂芳基; n为0〜3; 以及其药学上可接受的酸加成盐。已经发现，这类化合物显示出对GABA A a5受体结合位点的高亲和力和选择性，并且可用作认知增强剂或用于治疗认知障碍如阿尔茨海默氏病。

43. 发明申请

WO2007039389A1 ISOXAZOLO DERIVATIVES AS GABA A ALPHA5 INVERSE AGONISTS 审中-公开
标题翻译： ISOXAZOLO衍生物作为GABA ALPHA5反相激动剂
公开(公告)号：WO2007039389A1
公开(公告)日：2007-04-12
申请号：PCT/EP2006/066094
申请日：2006-09-07
申请人： F. HOFFMANN-LA ROCHE AG , BUETTELMANN, Bernd , HAN, Bo , HENNER, Knust , NETTEKOVEN, Matthias , THOMAS, Andrew
发明人： BUETTELMANN, Bernd , HAN, Bo , HENNER, Knust , NETTEKOVEN, Matthias , THOMAS, Andrew
IPC分类号： C07D413/14 , C07D413/06 , C07D451/06 , A61P25/28 , A61K31/42
CPC分类号： C07D413/14 , C07D413/06 , C07D451/06
摘要： The present invention is concerned with aryl-isoxazole-4-carbonyl-pyrrole-2-carboxylic acid amide derivatives of formula (I) wherein R 1 is hydrogen, halogen, lower alkoxy, phenyloxy or benzyloxy; R 2 is lower alkyl, (CH2)n-O-lower alkyl or phenyl; R 3 is hydrogen or lower alkyl; R 4 /R 5 are independently from each other hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkynyl or -(CHR)n-aryl, unsubstituted or substituted by halogen, lower alkyl or lower alkoxy, -(CH 2 ) n -non aromatic heterocyclic ring, unsubstituted or substituted by one or two lower alkyl groups, -(CH 2 ) n -aromatic heterocyclic rings -(CR 2 ) n -cycloalkyl, unsubstituted or substituted by one to three substituents, selected from the group consisting of hydroxy or lower alkyl, -(CHR) n -O-lower alkyl, -(CR 2 ) n -OH, -(CHR) n -NR’R", or R 4 /R 5 form together with the N-atom to which they are attached the ring - 8-aza-bicyclo[3.2.1] octane, substituted by hydroxy, or - 3,4-dihydro- l H -isoquinoline, or - a non aromatic heterocyclic ring, unsubstituted or substituted by one or two substituents, selected from the group consisting of C(O)O-lower alkyl, lower alkyl, lower alkyl substituted by halogen, cycloalkyl, hydroxy, halogen, N(R)C(O)-lower alkyl, -(CΗ 2 ) n -O-lower alkyl, or by an aromatic heterocyclic ring; R is hydrogen, hydroxy, or lower alkyl, wherein R may be the same or different in case of R 2 ; R’/R" are independently from each other hydrogen or lower alkyl; n is O, 1, 2, 3 or 4; m is 1, 2 or 3; and with their pharmaceutically acceptable acid addition salts. It has been found that this class of compounds show high affinity and selectivity for GABA Aα5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
摘要翻译：本发明涉及式（I）的芳基 - 异恶唑-4-羰基 - 吡咯-2-羧酸酰胺衍生物，其中R 1是氢，卤素，低级烷氧基，苯氧基或苄氧基; R 2是低级烷基，（CH 2）n -O-低级烷基或苯基; R 3是氢或低级烷基; R 4和R 5彼此独立地为氢，低级烷基，被卤素取代的低级烷基，低级炔基或 - （CHR）n - 芳基，未取代或被卤素，低级烷基或低级烷氧基， - 未被取代或被一个或两个低级烷基取代的 - （CH 2 N 2）n - 芳族杂环， - （CH

44. 发明申请

WO2005072328A2 SYSTEM AND METHOD FOR MANAGING THE DELIVERY OF ORDERS FOR GOODS 审中-公开
标题翻译：用于管理物品订单交付的系统和方法
公开(公告)号：WO2005072328A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/002299
申请日：2005-01-25
申请人： W.W. GRAINGER, INC. , THOMAS, Andrew
发明人： THOMAS, Andrew
IPC分类号： G06Q10/00
CPC分类号： G06Q10/08 , G06Q10/00 , G06Q10/083 , G06Q10/0833 , G06Q10/087
摘要： A system and method for managing the delivery of goods. The system and method particularly provides for manifesting and controlling route-based delivery of orders or packages from a vendor to one or more locations accessible by customers. The locations may include automated, self-service vending machines and/or will-call lockers, under the control of a system (ideally centralized and automated) that can receive and actively manage manifest information.
摘要翻译：用于管理货物交付的系统和方法。该系统和方法特别提供用于显示和控制从供应商到客户可访问的一个或多个位置的基于路线的订单或包裹的递送。这些位置可以包括自动化的，自助服务的售货机和/或将在可以接收和主动管理显示信息的系统（理想的是集中和自动的）的控制下的自动售货机。

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