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41. 发明申请

WO2013127918A1 NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE 审中-公开
标题翻译：治疗帕金森病的新疗法
公开(公告)号：WO2013127918A1
公开(公告)日：2013-09-06
申请号：PCT/EP2013/054026
申请日：2013-02-28
申请人： PHARNEXT
发明人： COHEN, Daniel , NABIROCHKIN, Serguei , CHUMAKOV, Ilya , HAJJ, Rodolphe
IPC分类号： A61K31/137 , A61K31/138 , A61K31/185 , A61K31/195 , A61K31/42 , A61K31/64 , A61P25/16
CPC分类号： A61K31/519 , A61K31/137 , A61K31/138 , A61K31/155 , A61K31/185 , A61K31/192 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/403 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/44 , A61K31/4402 , A61K31/4422 , A61K31/445 , A61K31/506 , A61K45/06 , A61K31/24 , A61K2300/00 , A61K31/64 , A61K31/48 , A61K31/428 , A61K31/4045 , A61K31/485 , A61K31/135 , A61K31/165 , A61K31/5513 , A61K31/551 , A61K31/343 , A61K31/4525 , A61K31/13 , A61K31/27 , A61K31/353 , A61K31/55 , A61K31/416 , A61K31/4178 , A61K31/4458 , A61K31/505 , A61K31/4184
摘要： The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder.
摘要翻译：本发明涉及治疗帕金森病和相关疾病的组合物和方法。更具体地，本发明涉及帕金森氏病的新组合疗法和针对α-突触核蛋白聚集网络的相关病症。特别地，本发明涉及单独或组合可有效保护神经元细胞免受α-突触核蛋白聚集体的化合物。本发明还涉及生产用于治疗帕金森病的药物或药物组合的方法以及治疗帕金森病或相关病症的方法。

42. 发明申请

WO2019211859A1 ESTIMATION OF DYNAMICAL PROPERTIES OF FLUIDS USING OPTICAL DEFECTS IN SOLIDS 审中-公开
公开(公告)号：WO2019211859A1
公开(公告)日：2019-11-07
申请号：PCT/IL2019/050623
申请日：2019-05-30
申请人： RETZKER, Alex , COHEN, Daniel , JELEZKO, Fedor , KHODAS, Maxim , PRIOR, Javier
发明人： RETZKER, Alex , COHEN, Daniel , JELEZKO, Fedor
IPC分类号： G01R33/32 , G01R33/30 , B01L3/00
摘要： A novel method for measurement of velocity and diffusion constant in microfluidic channels is presented using nano-NMR techniques. The fluid molecules of interest interact with color centers implanted in a suitable substrate such as diamond. A magnetic dipolar interaction between the fluid molecule spins influences the state of the NV, which can be probed using known NMR techniques. The color center response is read out optically and the NMR spectrum can be reconstructed from this optical information. The noise in the NMR spectra can be analyzed (e.g. in terms of its correlation function) to directly yield measurements of velocity and diffusion constant in the fluid, at orders of magnitude greater accuracy than otherwise possible.

43. 发明申请

WO2016189523A1 TAMPER RESISTANT CASE 审中-公开
标题翻译：防潮箱
公开(公告)号：WO2016189523A1
公开(公告)日：2016-12-01
申请号：PCT/IL2016/050032
申请日：2016-01-12
申请人： COHEN, Daniel , TONKICH, Vladimir
发明人： COHEN, Daniel , TONKICH, Vladimir
IPC分类号： H05K5/00 , B60R16/02
CPC分类号： H05K5/0208
摘要： A tamper resistant casing capable of encasing an electronic control unit (ECU), the casing comprising a top portion, having a plurality of top holes extending through the entire length of the top portion, and a bottom portion engageable with the top portion, the bottom portion having a plurality of bottom holes, wherein the top holes and the bottom holes are also engageable, and wherein the top portion and the bottom portion are configured to encase the ECU.
摘要翻译：一种能够封装电子控制单元（ECU）的防篡改套管，所述壳体包括顶部，所述顶部具有延伸穿过所述顶部的整个长度的多个顶孔，以及可与所述顶部接合的底部，所述底部部分具有多个底部孔，其中顶部孔和底部孔也可接合，并且其中顶部部分和底部部分构造成包围ECU。

44. 发明申请

WO2009137053A1 OPTICAL COMPONENTS, SYSTEMS INCLUDING AN OPTICAL COMPONENT, AND DEVICES 审中-公开
标题翻译：光学元件，包括光学元件的系统和器件
公开(公告)号：WO2009137053A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/002796
申请日：2009-05-06
申请人： QD VISION, INC. , COE-SULLIVAN, Seth , COHEN, Daniel , RITTER, John, E. , LINTON, John, R.
发明人： COE-SULLIVAN, Seth , COHEN, Daniel , RITTER, John, E. , LINTON, John, R.
IPC分类号： G02B6/10
CPC分类号： G02B6/0015 , G02B6/005 , G02B6/0065
摘要： A lighting system including a light source capable of generating light, and an optical component optically coupled to receive at least a portion of the light generated by the light source and convert at least a portion of the light so received to a predetermined wavelength such that the light emitted by the lighting system includes light emission from the light source supplemented with light emission at the predetermined wavelength, wherein the optical component including an optical material comprises quantum confined semiconductor nanoparticles. Also disclosed is an optical component comprising a light guide plate and an optical material disposed over at least a portion of a surface of the light guide plate, the optical material comprising quantum confined semiconductor nanoparticles capable of emitting light in a predetermined spectral region. Devices are also disclosed.
摘要翻译：一种包括能够产生光的光源的照明系统和光耦合的光学部件，用于接收由光源产生的光的至少一部分，并将至少一部分如此接收的光转换成预定波长，使得由照明系统发射的光包括来自补充有预定波长的发光的来自光源的光发射，其中包括光学材料的光学部件包括量子限制的半导体纳米颗粒。还公开了一种光学部件，其包括导光板和设置在导光板的至少一部分表面上的光学材料，该光学材料包括能够在预定光谱区域中发光的量子限制半导体纳米粒子。还公开了设备。

45. 发明申请

WO2007060246A2 A METHOD FOR HEALTH MONITORING 审中-公开
标题翻译：一种健康监测方法
公开(公告)号：WO2007060246A2
公开(公告)日：2007-05-31
申请号：PCT/EP2006/068978
申请日：2006-11-28
申请人： NAKOSTECH SARL , POULETTY, Philippe , COHEN, Daniel
发明人： POULETTY, Philippe , COHEN, Daniel
CPC分类号： G06T7/0012 , G06T2207/30004
摘要： This invention relates to methods for monitoring the anatomy of an individual, which methods comprise the steps of : (i) subjecting a healthy or asymptomatic individual to non-invasive analysis techniques, such as imaging or acoustic techniques, to obtain images or data on determined cells, tissue(s) or organs, at different time points over a period of more than one month, preferably over years; (ii) collecting the images or data in a database; (iii) comparing the images or data to the images or data previously acquired for the same individual, in essentially the same conditions; wherein said comparison of images or data obtained at different time points allows definition of non-pathological baseline anatomy for this individual.
摘要翻译：本发明涉及用于监测个体的解剖结构的方法，所述方法包括以下步骤：（i）使健康或无症状的个体经历非侵入性分析技术，诸如成像或声学技术以在超过一个月的时间，优选超过几年的时间内在不同时间点获得确定的细胞，组织或器官上的图像或数据; （ii）收集数据库中的图像或数据; （iii）在基本上相同的条件下将图像或数据与之前针对同一个体获得的图像或数据进行比较; 其中所述在不同时间点获得的图像或数据的比较允许定义该个体的非病理性基线解剖结构。

46. 发明申请

WO2002063832A1 A SYSTEM AND METHOD FOR FILTERING UNAVAILABLE DEVICES IN A PRESENCE AND AVAILABILITY MANAGEMENT SYSTEM 审中-公开
标题翻译：一种在存在和可用性管理系统中过滤不可用设备的系统和方法
公开(公告)号：WO2002063832A1
公开(公告)日：2002-08-15
申请号：PCT/US2002/003478
申请日：2002-02-05
申请人： PERSONITY, INC. , DIACAKIS, Athanassios , COHEN, Daniel
发明人： DIACAKIS, Athanassios , COHEN, Daniel
IPC分类号： H04L12/28
CPC分类号： H04L61/2038 , G06Q10/087 , G06Q10/10 , G06Q10/107 , H04L29/06 , H04L29/12066 , H04L29/12254 , H04L51/043 , H04L51/14 , H04L51/28 , H04L51/36 , H04L61/1511 , H04L67/16 , H04L67/18 , H04L67/24 , H04L67/306 , H04L69/329
摘要： A method for communicating communication network availability information regarding an individual to at least one subscriber (16) of the individual's availability information. According to one embodiment, the method includes detecting (18) whether the individual is present on at least one communication network and determining (20) availability of the individual for each access level of a profile of the individual. The method further includes publishing via a network the availability of the individual to the subscriber based on an access level of the subscriber and the presence information. In addition, the method includes filtering the availability of the individual when it is detected that the individual is no longer present on the communication network.
摘要翻译：一种用于将关于个人的通信网络可用性信息传达到个人可用性信息的至少一个订户（16）的方法。根据一个实施例，该方法包括检测（18）个体是否存在于至少一个通信网络上，并且确定（20）个人对个体的简档的每个访问级别的可用性。该方法还包括基于用户的访问级别和存在信息，经由网络向用户发布个人的可用性。此外，该方法包括当检测到个体不再存在于通信网络上时过滤个体的可用性。

47. 发明申请

WO2017001360A3 NEW DIAGNOSTIC TOOLS FOR CHARCOT-MARIE-TOOTH DISEASE 审中-公开
公开(公告)号：WO2017001360A3
公开(公告)日：2017-01-05
申请号：PCT/EP2016/064918
申请日：2016-06-28
申请人： PHARNEXT
发明人： COHEN, Daniel , CHUMAKOV, Ilya , NABIROCHKIN, Serguei
IPC分类号： G01N33/68 , G01N33/92
摘要： The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth (CMT) and related disorders. More specifically, the invention relates to development, validation and application of new biomarkers, which can be used for detecting the presence or risk of CMT disease and related disorders. In particular, the present invention relates to metabolite, lipid, carbohydrate and proteinaceous biomarkers that can be measured in biological body fluids and easily available extracts of biopsies, which can be used to aid in the detection, prediction of drug treatment and follow up of this treatment of neurodegenerative disorders, including CMT disease. The present invention also relates to methods for identification of CMT disease sub-types, assessing the responsiveness to the treatments and the efficacy of treatments in subjects having CMT or a related disorder.

48. 发明申请

WO2017001360A2 NEW DIAGNOSTIC TOOLS FOR CHARCOT-MARIE-TOOTH DISEASE 审中-公开
标题翻译：用于CHARCOT-MARIE-TOOTH疾病的新诊断工具
公开(公告)号：WO2017001360A2
公开(公告)日：2017-01-05
申请号：PCT/EP2016/064918
申请日：2016-06-28
申请人： PHARNEXT
发明人： COHEN, Daniel , CHUMAKOV, Ilya , NABIROCHKIN, Serguei
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/6896 , G01N33/92 , G01N2800/52
摘要： The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth (CMT) and related disorders. More specifically, the invention relates to development, validation and application of new biomarkers, which can be used for detecting the presence or risk of CMT disease and related disorders. In particular, the present invention relates to metabolite, lipid, carbohydrate and proteinaceous biomarkers that can be measured in biological body fluids and easily available extracts of biopsies, which can be used to aid in the detection, prediction of drug treatment and follow up of this treatment of neurodegenerative disorders, including CMT disease. The present invention also relates to methods for identification of CMT disease sub-types, assessing the responsiveness to the treatments and the efficacy of treatments in subjects having CMT or a related disorder.
摘要翻译：本发明特别涉及检测Charcot-Marie-Tooth（CMT）和相关病症的倾向或诊断和/或预后的方法。更具体地说，本发明涉及新的生物标记的开发，验证和应用，其可用于检测CMT疾病和相关病症的存在或风险。具体而言，本发明涉及可在生物体液中测量的代谢物，脂质，碳水化合物和蛋白质类生物标志物以及活检样品的容易获得的提取物，其可用于帮助检测，预测药物治疗并跟踪此治疗神经退行性疾病，包括CMT疾病。本发明还涉及用于鉴定CMT疾病亚型的方法，评估对具有CMT或相关病症的受试者的治疗的应答性和治疗效果。

49. 发明申请

WO2015124763A1 NEW COMPOSITIONS FOR TREATING MECHANICAL NEURONAL INJURIES 审中-公开
标题翻译：用于治疗机械性神经损伤的新组合物
公开(公告)号：WO2015124763A1
公开(公告)日：2015-08-27
申请号：PCT/EP2015/053700
申请日：2015-02-23
申请人： PHARNEXT
发明人： COHEN, Daniel , NABIROCHKIN, Serguei , CHUMAKOV, Ilya
IPC分类号： A61K31/047 , A61K31/195 , A61K31/485 , A61P25/00
CPC分类号： A61K31/195 , A61K31/047 , A61K31/485 , A61K2300/00
摘要： The present invention relates to compositions and methods for the treatment of the mechanical neuronal insu
摘要翻译：本发明涉及用于治疗机械神经元绝缘的组合物和方法

50. 发明申请

WO2014195394A1 STABLE ORAL SOLUTIONS FOR COMBINED API 审中-公开
标题翻译：用于组合API的稳定的口头解决方案
公开(公告)号：WO2014195394A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061664
申请日：2014-06-05
申请人： PHARNEXT
发明人： COHEN, Daniel , CHUMAKOV, Ilya , NABIROCHKIN, Serguei , BERTRAND, Viviane
IPC分类号： A61K9/00 , A61K9/08 , A61K31/7004 , A61K45/06 , A61K47/12 , A61K47/26 , A61K31/19 , A61K31/485
CPC分类号： A61K9/0053 , A61K9/0095 , A61K9/08 , A61K31/047 , A61K31/195 , A61K31/197 , A61K31/485 , A61K47/12 , A61K47/14 , A61K47/26 , A61K2300/00
摘要： The present invention relates to a homogeneous, stable, and palatable pharmaceutical solution comprising baclofen, sorbitol and naltrexone.
摘要翻译：本发明涉及包含巴氯芬，山梨糖醇和纳曲酮的均匀，稳定和可口的药物溶液。

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