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41. 发明申请

WO2012017083A1 METHODS AND PRODUCTS FOR PRODUCTION OF WAX ESTERS 审中-公开
标题翻译：用于生产异黄酮的方法和产品
公开(公告)号：WO2012017083A1
公开(公告)日：2012-02-09
申请号：PCT/EP2011/063542
申请日：2011-08-05
申请人： NIELSEN, Jens , SHI, Shuobo
发明人： NIELSEN, Jens , SHI, Shuobo
IPC分类号： C12N9/10 , C12N15/81 , C12P7/64
CPC分类号： C12P7/649 , C12N9/1029 , C12N15/81 , Y02E50/13
摘要： The present invention relates to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing different fatty acids and specifically fatty acid ethyl esters (FAEE), the main components of biodiesel. An increased in fatty acid production, and hence in FAEE, is obtained in the first place by expressing different heterologous polypeptides in combination with the down-regulation, attenuation, deletion or over-expression of specially selected genes, wherein said genes encode enzymes involved in the fatty acids synthesizing pathway, fatty acid consuming pathways, carbohydrate biosynthesis pathways or enzyme acting as wax ester transporters or a combination thereof. The methods and products of the invention would allow large-scale production of FAEE with carbohydrates as the only externally-supplied substrate.
摘要翻译：本发明涉及提供转基因真菌细胞，例如具有改善生产不同脂肪酸的能力的酵母细胞，特别是生物柴油的主要成分的脂肪酸乙酯（FAEE）。通过表达不同的异源多肽与特别选择的基因的下调，减弱，缺失或过度表达的组合，首先获得增加的脂肪酸产生，因此获得FAEE，其中所述基因编码涉及的酶脂肪酸合成途径，脂肪酸消耗途径，碳水化合物生物合成途径或作为蜡酯转运蛋白的酶或其组合。本发明的方法和产品将允许以碳水化合物作为唯一外部供应的底物大规模生产FAEE。

42. 发明申请

WO2009144245A1 METHOD FOR INCREASING GROWTH RATE 审中-公开
标题翻译：增加增长率的方法
公开(公告)号：WO2009144245A1
公开(公告)日：2009-12-03
申请号：PCT/EP2009/056449
申请日：2009-05-27
申请人： NOVOZYMES A/S , PANAGIOTOU, Gianni , OLSSON, Lisbeth , NIELSEN, Jens
发明人： PANAGIOTOU, Gianni , OLSSON, Lisbeth , NIELSEN, Jens
IPC分类号： C12N1/15 , C12P21/02 , C12N9/12
CPC分类号： C12R1/66 , C12P21/02
摘要： A method of producing a polypeptide of interest, comprising culturing the recombinant filamentous fungal host cell, wherein an NAD(H) kinase activity is increased compared to an otherwise identical wild type host cell cultured under identical conditions, and said recombinant filamentous fungal host cell further expresses a polypeptide of interest.
摘要翻译：一种产生感兴趣多肽的方法，包括培养重组丝状真菌宿主细胞，其中与在相同条件下培养的其他相同的野生型宿主细胞相比，NAD（H）激酶活性增加，所述重组丝状真菌宿主细胞进一步表达感兴趣的多肽。

43. 发明申请

WO2008040359A1 ESCAPE SYSTEM WITH SELF-ADJUSTING LENGTH 审中-公开
标题翻译：具有自调节长度的ESCAPE系统
公开(公告)号：WO2008040359A1
公开(公告)日：2008-04-10
申请号：PCT/DK2007/050136
申请日：2007-10-04
申请人： VIKING LIFE-SAVING EQUIPMENT A/S , NIELSEN, Jens
发明人： NIELSEN, Jens
IPC分类号： A62B1/20
CPC分类号： A62B1/20
摘要： An escape system (1) for evacuation is disclosed including a chute (2) comprising a succession of linked and spaced apart shaping sections (7), the succession including a number of shaping sections being connected by elastic cords (9) and linking successive shaping sections in a direction corresponding to a longitudinal axis (18) of the succession of shaping sections, and at least one tunnel-like device (6) being adapted to enable a person (16) who is being evacuated to move from a first position (3) to a second position (4) through the tunnel-like device, and wherein the chute (2) is arranged to have a self adjusting length (20, 22) and hereby operable at least two relative different chute lengths (20, 22) when the chute (2) has been launched and the chute is hanging substantially vertically from the higher position to the lower position, and the escape system comprises length limiting means (32, 36, 38) for changing between operation modes (24, 26) between the at least two relative different chute lengths (20, 22).
摘要翻译：公开了一种用于抽真空的逃逸系统（1），包括一系列连接和间隔开的整形部分（7）的滑槽（2），该连续件包括多个通过弹性帘线（9）连接的成形部分，在与所述连续成形部分的纵向轴线（18）相对应的方向上的部分，以及至少一个隧道状装置（6），其适于使得被疏散的人（16）能够从第一位置移动 3）通过隧道状装置到达第二位置（4），并且其中滑槽（2）被布置成具有自调节长度（20,22），并且因此可操作至少两个相对不同的斜槽长度（20,22）），当斜槽（2）已经被启动并且滑槽从较高位置垂直悬挂到下部位置时，并且逃逸系统包括用于在操作模式（24,26）之间改变的长度限制装置（32,36,38））在至少两个相对d之间不同的滑槽长度（20,22）。

44. 发明申请

WO2007143999A1 ENHANCED CITRATE PRODUCTION 审中-公开
标题翻译：加强生产
公开(公告)号：WO2007143999A1
公开(公告)日：2007-12-21
申请号：PCT/DK2007/000289
申请日：2007-06-14
申请人： DANMARKS TEKNISKE UNIVERSITET , NIELSEN, Jens , DE JONGH, Wian
发明人： NIELSEN, Jens , DE JONGH, Wian
IPC分类号： C12P7/48
CPC分类号： C12P7/48
摘要： The present invention discloses a method for enhanced fungal production of citrate by the cytosolic overproduction of malate and/or fumarate and/or succinate.
摘要翻译：本发明公开了通过苹果酸盐和/或富马酸盐和/或琥珀酸盐的胞质过量产生来提高柠檬酸盐的真菌产生的方法。

45. 发明申请

WO2007143995A1 ESCAPE SYSTEM FOR EMERGENCY EVACUATION 审中-公开
标题翻译：用于紧急撤离的ESCAPE系统
公开(公告)号：WO2007143995A1
公开(公告)日：2007-12-21
申请号：PCT/DK2007/000284
申请日：2007-06-12
申请人： VIKING LIFE-SAVING EQUIPMENT A/S , BAUNGAARD, Thyge , NIELSEN, Jens
发明人： BAUNGAARD, Thyge , NIELSEN, Jens
IPC分类号： A62B1/20
CPC分类号： A62B1/20
摘要： The invention relates to an improved escape system including a chute adapted to compensate for varying vertical distance. Elastic cords extend in a course of direction which progresses differently from vertically when the escape system has been launched and the chute is hanging vertically from the higher position to the lower position, such that tension is applied to the elastic cords. By the present invention it is realised that a longer elongation of the chute may be obtained without increasing the minimum length when the elastic cords extend in such a course of direction, because the cords hereby become longer than in a course of direction progressing straight and vertically. Since any elastic cord has a maximum strain which it may safely endure, a longer extent of such a cord subjected to maximum strain will result in a longer elongation, and hence longer maximum length while maintaining or even reducing the minimum length. One effect is therefore that the ability of the escape system to compensate for varying evacuation height is improved.
摘要翻译：本发明涉及一种改进的逃生系统，包括适于补偿不同垂直距离的斜槽。当逸出系统已经启动并且滑槽从较高位置垂直悬挂到下部位置时，弹性帘线在与垂直方向不同的方向上延伸的方向延伸，使得张力施加到弹性帘线。通过本发明，可以看出，当弹性帘线沿着这样的方向延伸时，可以获得更长的滑槽伸长率，而不会增加弹性帘线的最小长度，因为帘线比在直线和垂直方向前进的过程中长。由于任何弹性绳具有可以安全地承受的最大应变，所以经受最大应变的较长程度的帘线将导致更长的伸长率，并因此延长最大长度，同时保持或甚至减小最小长度。因此，一个效果是提高逃生系统补偿不同排空高度的能力。

46. 发明申请

WO2007093962A2 METHOD FOR PRODUCING TERPENES AND MEP-TRANSFORMED MICROORGANISMS THEREFORE 审中-公开
标题翻译：生产萜类和其转化的微生物的方法
公开(公告)号：WO2007093962A2
公开(公告)日：2007-08-23
申请号：PCT/IB2007/050474
申请日：2007-02-13
申请人： FIRMENICH SA , CLARK, Anthony , MAURY, Jérôme , ASADOLLAHI, Mohammad Ali , MØLLER, Kasper , NIELSEN, Jens , SCHALK, Michel
发明人： CLARK, Anthony , MAURY, Jérôme , ASADOLLAHI, Mohammad Ali , MØLLER, Kasper , NIELSEN, Jens , SCHALK, Michel
IPC分类号： C12N9/00
CPC分类号： C12N15/52 , C12P23/00
摘要： The present invention relates to a microorganism capable of producing a terpene of choice. The microorganism expresses a heterologous pathway for the formation of isoprene units and, preferably, a heterologous terpene synthase. In this way, high amounts of terpene can be isolated from the medium of the microorganism.
摘要翻译：本发明涉及能够产生选择的萜的微生物。微生物表达异戊二烯单元形成的异源途径，优选异源萜烯合酶。这样，可以从微生物的培养基中分离出大量的萜烯。

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