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41. 发明申请

WO2020030629A1 METHOD FOR DYNAMIC FILTRATION OF A CROSS-LINKED HYDROGEL 审中-公开
公开(公告)号：WO2020030629A1
公开(公告)日：2020-02-13
申请号：PCT/EP2019/071096
申请日：2019-08-06
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： PFEIL, Michael , KESSLER, Wolfgang , CONRAD, Manuel , NIEMCZAK, Björn , VUKOVIC, Patrik
IPC分类号： C08B37/00 , A61L27/52 , A61K31/167 , C08B37/08 , C08L5/08
摘要： The present invention relates to a method for dynamic filtration of a cross-linked biopolymer-based hydrogel to remove unwanted molecules from the gel. In particular, the invention relates to dynamic filtration of a hyaluronic acid hydrogel using a dynamic filtration construction with rotating and semipermeable filter discs.

42. 发明申请

WO2018228700A1 FINASTERIDE FOR USE IN THE TREATMENT OF ANDROGENETIC ALOPECIA 审中-公开
公开(公告)号：WO2018228700A1
公开(公告)日：2018-12-20
申请号：PCT/EP2017/064771
申请日：2017-06-16
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： DANYSZ, Wojciech , ABEL, Ulrich , HENGL, Thomas , ABTS, Harry , BODERKE, Peter , HAUPTMEIER, Bernhard
IPC分类号： A61K31/58 , A61K9/00 , A61K9/107 , A61K9/08 , A61P17/14 , A61Q7/00 , A61K8/06
CPC分类号： A61K31/58 , A61K8/63 , A61K9/0014 , A61K9/06 , A61K47/14 , A61K2800/782 , A61P17/14 , A61Q7/00
摘要： The present invention concerns finasteride for use in the treatment of alopecia, wherein the active agent is applied and administrated in a specific manner.

43. 发明申请

WO2017220553A1 BOTULINUM TOXIN PREFILLED SYRINGE SYSTEM 审中-公开
标题翻译： BOTULINUM毒素预填充注射系统
公开(公告)号：WO2017220553A1
公开(公告)日：2017-12-28
申请号：PCT/EP2017/065050
申请日：2017-06-20
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： VOGT, Markus
IPC分类号： A61M5/315 , A61M5/178
摘要： The present invention relates a botulinum toxin prefilled syringe system with desirable injection force characteristics, in particular low gliding force and low break loose force, comprising a syringe barrel of glass containing a liquid botulinum toxin composition, a plunger stopper and a closure device such as a tip cap or a needle shield. In addition, the present invention relates to a kit comprising the botulinum toxin prefilled syringe system, and optionally instructions for use, and to the use of the botulinum toxin prefilled syringe system in therapeutic and cosmetic applications.
摘要翻译：本发明涉及一种具有所需注射力特性，特别是低滑动力和低断裂力的肉毒杆菌毒素预填充注射器系统，其包括含有液体肉毒杆菌毒素组合物的注射器筒体，柱塞塞子和一个封闭装置，例如一个尖端帽或一个针头罩。另外，本发明涉及包含肉毒杆菌毒素预填充注射器系统和任选的使用说明的试剂盒，以及肉毒毒素预填充注射器系统在治疗和美容应用中的用途。

44. 发明申请

WO2017162676A1 MODIFIED HYALURONIC ACID, METHOD FOR MAKING SAME AND USES THEREOF 审中-公开
标题翻译：修饰的透明质酸，其制备方法和用途
公开(公告)号：WO2017162676A1
公开(公告)日：2017-09-28
申请号：PCT/EP2017/056701
申请日：2017-03-21
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： KRAUS, Andreas , LINKO, Alexander , VILLAIN, Franck
IPC分类号： C08B37/08 , A61K47/36 , A61K31/728 , C08L5/08 , C08J3/075 , A61L27/20 , A61L27/52
摘要： The present invention generally relates to a modified hyaluronic acid (HA) and to a method for making same, more specifically to a (poly)glycerol-modified HA derivative prepared by grafting glycidol to HA. The present invention also relates to the use of the HA derivative for preparing a dermal filler composition, a hydrogel comprising cross-linked HA and the (poly)glycerol-modified HA derivative, and a method for preparing said hydrogel. Furthermore, the present invention relates to the use of the hydrogel as a cosmetic and/or aesthetic product, in particular as a dermal filler for tissue filling, replacing and/or augmenting.
摘要翻译：本发明一般涉及修饰的透明质酸（HA）及其制备方法，更具体地涉及通过将缩水甘油接枝到HA上制备的（聚）甘油修饰的HA衍生物。本发明还涉及HA衍生物在制备皮肤填充剂组合物，包含交联的HA和（聚）甘油改性的HA衍生物的水凝胶以及制备所述水凝胶的方法中的用途。此外，本发明涉及水凝胶作为化妆品和/或美容产品的用途，特别是作为用于组织填充，替代和/或增强的皮肤填充剂。

45. 发明申请

WO2017148915A1 COMPOSITION COMPRISING BOTULINUM TOXIN 审中-公开
标题翻译：含有肉毒杆菌毒素的组合物
公开(公告)号：WO2017148915A1
公开(公告)日：2017-09-08
申请号：PCT/EP2017/054596
申请日：2017-02-28
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： FINK, Klaus , TAYLOR, Harold , RUSS, Hermann , BODERKE, Peter
IPC分类号： A61K38/48 , A61K47/36 , A61Q19/08
摘要： The present invention concerns a composition comprising (a) botulinum toxin and (b) non-crosslinked hyaluronic acid and its use of the treatment or prevention of dystonia, spasticity and/or wrinkles. Further, the present invention relates to a method for cosmetically smoothing or preventing wrinkles comprising the step of administering the present composition.
摘要翻译：
本发明涉及包含（a）的肉毒杆菌毒素和（b）的非交联的透明质酸和它的使用在治疗或预防肌张力障碍，痉挛状态和/或皱纹的组合物。此外，本发明涉及美容上平滑或预防皱纹的方法，包括施用本发明组合物的步骤。

46. 发明申请

WO2017076495A1 PROCESS FOR DEPLETING EPOXIDE SPECIES IN CROSSLINKED POLY-SACCHARIDE GEL COMPOSITIONS AND COMPOSITIONS OBTAINED THEREBY 审中-公开
标题翻译：交联聚蔗糖凝胶组合物中去除环氧化物物质的方法及由此获得的组合物
公开(公告)号：WO2017076495A1
公开(公告)日：2017-05-11
申请号：PCT/EP2016/001813
申请日：2016-10-31
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： ABEL, Ulrich , KRAUSE, Andreas
IPC分类号： C08B37/00 , A61K8/73 , A61K31/728 , A61K31/738 , C08B37/08 , C08L5/08
CPC分类号： C08B37/0072 , A61K8/042 , A61K8/33 , A61K8/735 , A61K31/728 , A61K31/738 , A61K2800/805 , A61K2800/91 , A61Q19/08 , C08B37/00 , C08L5/08
摘要： The present invention relates to a process for depleting epoxide species in epoxy-crosslinked polysaccharide gel compositions. In addition, the present invention relates to crosslinked polysaccharide gel compositions made by said process and their use in cosmetic and therapeutic applications.
摘要翻译：本发明涉及消除环氧交联多糖凝胶组合物中环氧化物物质的方法。此外，本发明涉及通过所述方法制备的交联多糖凝胶组合物及其在美容和治疗应用中的用途。

47. 发明申请

WO2017036597A1 METHOD OF MAKING A CROSS-LINKED POLYMER GEL AND DEVICE FOR PERFORMING THE METHOD 审中-公开
标题翻译：制造交联聚合物凝胶的方法和用于实施该方法的装置
公开(公告)号：WO2017036597A1
公开(公告)日：2017-03-09
申请号：PCT/EP2016/001470
申请日：2016-08-31
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： FRIEDRICH, Josef
IPC分类号： C08J3/075 , A61L27/52 , A61K8/73 , A61K47/36 , B01F7/00 , B01D61/24 , B01D61/28 , B01D63/00 , A61K31/728 , C08B37/08 , C08J3/24
CPC分类号： C08J3/24 , A61K31/728 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/041 , A61L2400/06 , B01D61/243 , B01D61/28 , B01F7/00 , B01F7/161 , B01F7/30 , B01F15/00253 , B01F15/0237 , B01F2015/00642 , B01F2215/0481 , C08B37/0072 , C08J3/075 , C08L27/12 , C08L5/08
摘要： The present invention relates to a method of making a composition, the composition comprising a cross-linked polymer and water, comprising at least the following steps: a) providing a first mixture, comprising at least one polymer and an aqueous alkaline solution; b) generating a gel by cross-linking the at least one polymer with a cross- linking agent; c) neutralizing the generated gel by using a neutralization solution; d) optionally adding a second mixture, comprising a cross-linked and/or non-cross- linked polymer and water, to the neutralized gel obtained in step c); e) dialyzing the gel obtained in step d) or dialyzing the gel obtained in step c) and optionally subsequent addition of the second mixture, comprising a cross-linked and/or non-cross-linked polymer and water; and f) filling the dialyzed gel obtained in step e) into a container, wherein at least two or three or four or five or all of steps a) to f) are automated.
摘要翻译：本发明涉及一种制备组合物的方法，所述组合物包含交联聚合物和水，所述组合物至少包括以下步骤：a）提供包含至少一种聚合物和碱性水溶液的第一混合物; b）通过使所述至少一种聚合物与交联剂交联而产生凝胶; c）使用中和溶液中和产生的凝胶; d）任选地将包含交联和/或非交联聚合物和水的第二混合物加入到步骤c）中获得的中和凝胶中; e）透析步骤d）中获得的凝胶或透析步骤c）中获得的凝胶，并任选地随后加入包含交联和/或非交联的聚合物和水的第二混合物; 以及f）将步骤e）中获得的透析凝胶填充到容器中，其中步骤a）至f）中的至少两个或三个或四个或五个或全部是自动化的。

48. 发明申请

WO2016198163A1 NOVEL RECOMBINANT CLOSTRIDIAL NEUROTOXINS WITH INCREASED DURATION OF EFFECT 审中-公开
标题翻译：新的重组离子神经毒素具有增加的作用时间
公开(公告)号：WO2016198163A1
公开(公告)日：2016-12-15
申请号：PCT/EP2016/000962
申请日：2016-06-10
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： FREVERT, Juergen , HOFMANN, Fred , SCHMIDT, Michael , LOPEZ DE LA PAZ, Manuela , SCHEPS, Daniel
IPC分类号： A61K38/48 , C07K14/33
CPC分类号： A61K38/164 , A61K38/00 , C07K14/33 , C12N15/52 , C12N15/70 , C12Y304/24068 , C12Y304/24069 , Y02A50/469
摘要： This invention relates to novel recombinant clostridial neurotoxins exhibiting increased duration of effect and to methods for the manufacture of such recombinant clostridial neurotoxins. These novel recombinant clostridial neurotoxins comprise a random coil domain, and the methods comprise the steps of inserting a nucleic acid sequence coding for a random coil domain into a nucleic acid sequence coding for a parental clostridial neurotoxin and expression of the recombinant nucleic acid sequence comprising the random coil domain-coding sequence in a host cell. The invention further relates to novel recombinant single-chain precursor clostridial neurotoxins used in such methods, nucleic acid sequences encoding such recombinant single-chain precursor clostridial neurotoxins, and pharmaceutical compositions comprising the recombinant clostridial neurotoxin with increased duration of effect.
摘要翻译：本发明涉及显示出增加的作用持续时间的新型重组梭菌神经毒素和制备这种重组梭菌神经毒素的方法。这些新型的重组梭菌神经毒素包括无规卷曲结构域，并且所述方法包括以下步骤：将编码无规卷曲结构域的核酸序列插入到编码亲本梭菌神经毒素的核酸序列中，并且重组核酸序列的表达包括随机线圈域编码序列在宿主细胞中。本发明还涉及用于这些方法的新型重组单链前体梭菌神经毒素，编码这种重组单链前体梭菌神经毒素的核酸序列，以及包含具有增加的作用持续时间的重组梭菌神经毒素的药物组合物。

49. 发明申请

WO2016124213A1 BOTULINUM TOXIN PREFILLED CONTAINER 审中-公开
标题翻译： BOTULINUM TOXIN预充型容器
公开(公告)号：WO2016124213A1
公开(公告)日：2016-08-11
申请号：PCT/EP2015/002600
申请日：2015-12-22
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： VOGT, Markus
IPC分类号： A61K9/00 , A61K38/48 , A61K47/26 , A61Q19/08 , A61M5/31 , A61M5/315
CPC分类号： A61M5/3129 , A61K8/64 , A61K8/66 , A61K9/0019 , A61K38/4893 , A61K47/26 , A61K2800/87 , A61K2800/91 , A61M5/24 , A61M5/31505 , A61M5/31513 , A61M5/3202 , A61M2005/3131 , A61M2205/0216 , A61M2205/0222 , A61M2205/0238 , A61Q19/08 , C12Y304/24069 , Y02A50/469
摘要： The present invention relates to a prefilled plastic container, such as a plastic syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled plastic container is stable for a prolonged time period. Furthermore, the present invention relates to a kit comprising the prefilled plastic container, and to the use of the prefilled plastic container for therapeutic and cosmetic purposes.
摘要翻译：本发明涉及一种预充式塑料容器，例如塑料注射器，其包含肉毒杆菌毒素制剂。预填充塑料容器中的肉毒杆菌毒素制剂在长时间内是稳定的。此外，本发明涉及包含预填充塑料容器的试剂盒，以及用于治疗和美容目的的预填充塑料容器的用途。

50. 发明申请

WO2016102068A1 BOTULINUM TOXIN PREFILLED CONTAINER 审中-公开
标题翻译： BOTULINUM TOXIN预充型容器
公开(公告)号：WO2016102068A1
公开(公告)日：2016-06-30
申请号：PCT/EP2015/002602
申请日：2015-12-22
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： VOGT, Markus
IPC分类号： A61K9/00 , A61K38/48 , A61K47/26 , A61Q19/08 , A61M5/31 , A61M5/315
CPC分类号： A61M5/3129 , A61K8/64 , A61K9/0019 , A61K38/4893 , A61K47/26 , A61K47/42 , A61K2800/87 , A61K2800/91 , A61M5/31513 , A61M2005/3131 , A61M2205/0222 , A61M2205/0238 , A61Q19/08 , C12Y304/24069
摘要： The present invention relates to a prefilled glass container, such as a prefilled glass syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled container is stable at low to ambient temperature for a prolonged time period. Furthermore, the present invention relates to a kit comprising the botulinum toxin prefilled container, and to the use of the botulinum toxin prefilled container in therapeutic and cosmetic applications.
摘要翻译：本发明涉及预充式玻璃容器，例如预充式玻璃注射器，其包含肉毒杆菌毒素制剂。预填充容器中的肉毒杆菌毒素制剂在低至环境温度下长时间稳定。此外，本发明涉及包含肉毒杆菌毒素预填充容器的试剂盒，以及在治疗和美容应用中使用肉毒杆菌毒素预填充容器。

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