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31. 发明申请

WO2021220803A1 表示制御方法、表示制御装置、表示制御プログラム及び診断支援システム审中-公开
公开(公告)号：WO2021220803A1
公开(公告)日：2021-11-04
申请号：PCT/JP2021/015391
申请日：2021-04-14
申请人：ソニーグループ株式会社
发明人：細井　泉澄
IPC分类号： G02B21/36 , G02B21/00 , G06T1/00
摘要：表示制御装置１００は、深度方向において異なる焦点位置で撮影された病理に関する複数の画像を含むスタック情報を基に生成される３次元点群情報であって、前記スタック情報に含まれる複数の画像において焦点の合った点を残した前記３次元点群情報を表示し、前記３次元点群情報に含まれるいずれかの点を選択された場合に、選択された点に対応する画像を特定し、特定した画像を表示する。

32. 发明申请

WO2021219700A1 SCANNER AND METHOD OF USING THE SCANNER DURING A STAIN ASSESSMENT 审中-公开
公开(公告)号：WO2021219700A1
公开(公告)日：2021-11-04
申请号：PCT/EP2021/061094
申请日：2021-04-28
申请人： LEEDS TEACHING HOSPITALS NHS TRUST , UNIVERSITY OF LEEDS
发明人： BRETTLE, David , TREANOR, Darren
IPC分类号： G02B21/00 , G02B21/08 , G02B21/26 , G02B21/36 , G02B5/02
摘要： A scanner for scanning a QA test slide as part of a stain QA method, and method of using the scanner are described. The scanner comprises a housing defining an interior of the scanner, a slide holder within the housing and configured to receive a QA test slide, a digital camera within the housing and arranged to capture an image of the QA test slide when located in the slide holder, and a light source within the housing and arranged to illuminate both a rear side and a front side of the QA test slide when located in the slide holder.

33. 发明申请

WO2021219613A1 METHOD FOR ACCELERATED MICROSCOPY OF LARGE SAMPLES 审中-公开
公开(公告)号：WO2021219613A1
公开(公告)日：2021-11-04
申请号：PCT/EP2021/060945
申请日：2021-04-27
申请人： TILL I.D. GMBH
发明人： SEEBACHER, Christian , DEEG, Andreas , UHL, Rainer
IPC分类号： G02B21/00 , G02B21/36
摘要： A method for acquiring microscope-images of sample being larger than a field of view of a microscope, the method comprising creating a continuous relative movement between a sample and the microscope, wherein the optical axis of a microscope objective is substantially perpendicular to the vector of the relative movement, illuminating a part of the sample through the microscope objective, wherein the illuminated part of the sample is smaller than the field of view and forms an illumination slit, moving the illumination slit in a scanning direction across the field of view, and detecting light from the sample collected by the microscope objective, wherein the sample is moved in the same direction as the scanning direction or in a direction perpendicular to the scanning direction while the illumination slit is moved across the field of view.

34. 发明申请

WO2021216400A1 TIME-RESOLVING HYPERSPECTRAL IMAGING SPECTROSCOPY 审中-公开
公开(公告)号：WO2021216400A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/027883
申请日：2021-04-19
申请人： RESEARCH INSTRUMENTS CORPORATION
发明人： ADAMS, Bernhard Werner
IPC分类号： G01J3/30 , G01N21/64 , G01J3/28 , G02B21/00
摘要： In general, in one aspect, the invention features a method of fluorescence spectroscopy including providing a high-performance sensor that combines imaging with high intrinsic time resolution and high-rate capability, and resolving fluorescence data in four dimensions. The invention features a method for rapidly performing a Fluorescence-Lifetime Imaging Microscopy measurement including engaging a sensor that delivers a continuous data stream of time-and-location-tagged light detection events, and at a high rate of many light-detection events within the fluorescent lifetime of the molecular species of interest.

35. 发明申请

WO2021216157A1 OPTICAL MODULE WITH THREE OR MORE COLOR FLUORESCENT LIGHT SOURCES AND METHODS FOR USE THEREOF 审中-公开
公开(公告)号：WO2021216157A1
公开(公告)日：2021-10-28
申请号：PCT/US2021/015248
申请日：2021-01-27
申请人： ESSEN INSTRUMENTS, INC. d/b/a ESSEN BIOSCIENCE, INC.
发明人： NEAGLE, Bradley , RIGGS, Alan , KUSNER, Michael , SCHUTTE, Kyle , ENDSLEY, Eric
IPC分类号： G02B21/00 , G01N21/64 , G01N33/58
摘要： An imaging apparatus comprising a fluorescence microscope (115), an imaging sensor (120) an optical module (110) and a phase lamp (125) is provided to facilitate epifluorescent imaging of three (or more) color channels and to perform phase contrast and/or bright field imaging of samples without manual adjustment of the imaging apparatus. This allows for automated imaging, over extended periods of time, of a plurality of samples by the imaging apparatus located inside an incubator (180) without disturbing the incubator environment to manually adjust the apparatus. Also provided are embodiments to facilitate user swapping of removable optical modules (110) and/or transillumination modules (125) to allow the imaging apparatus to be adapted to different combinations of assays and/or fluorescent indicators so as to increase the variety of experiments and/or fluorescent dyes that can be imaged using the imaging apparatus.

36. 发明申请

WO2021185557A1 FLUORESCENCE MICROSCOPE AND METHOD FOR IMAGING AN OBJECT 审中-公开
公开(公告)号：WO2021185557A1
公开(公告)日：2021-09-23
申请号：PCT/EP2021/054862
申请日：2021-02-26
申请人： LEICA MICROSYSTEMS CMS GMBH
发明人： SCHUMANN, Christian
IPC分类号： G01N21/64 , G02B21/00
摘要： A fluorescence microscope (100) for imaging an object (102) including different fluorop ho re species having distinct spectral emission characteristics. The fluorescence microscope (100) comprises an optical system (104) configured to collect fluorescent light (220) emitted from the different fluorophore species within a field of view (FOV) and to focus the fluorescent light for detection. The fluorescence microscope (100) includes a spectral splitting arrangement (218) configured to split the fluorescent light (220) collected within said field of view (FOV) into at least two spectrally different fluorescent light components (223, 225) and a multi-channel detector system (230) comprising at least two image sensors (232, 234) configured to detect at least two spatial light intensity distributions based on said at least two spectrally different fluorescent light components (223, 225), each spatial light intensity distribution representing an image of the object (102) over said field of view (FOV). The fluorescence microscope (100) further includes a processor (110) configured to determine spatial distributions of the different fluorophore species based on a spectral unmixing analysis of each spatial light intensity distribution, wherein the processor (110) is further configured to obtain compensation information representing a variation of spectral characteristics of the spectral splitting arrangement (218) over said field of view (FOV) and to determine a spatial distribution of each fluorophore species by taking into account said compensation information.

37. 发明申请

WO2021171419A1 検体観察装置、検体観察方法审中-公开
公开(公告)号：WO2021171419A1
公开(公告)日：2021-09-02
申请号：PCT/JP2020/007741
申请日：2020-02-26
申请人：株式会社日立ハイテク
发明人：西浦　健斗
IPC分类号： G02B21/00 , G02B21/26 , G02B21/36
摘要：本開示は、オートフォーカスシステムを用いて垂直方向におけるフォーカス位置を調整する前であっても、検体容器の検体観察領域と撮像視野との間の水平方向における相対位置決めを確実に実施することができる技術を提供する。本開示に係る検体観察装置は、オートフォーカスを実施する前において、検体容器の複数の箇所における画像の輝度値を取得し、高輝度領域の個数とその幅とを用いて、前記検体容器の水平方向における中心位置を特定するか、または、低輝度領域の個数とその幅とを用いて、前記検体容器の前記水平方向における中心位置を特定する（図１参照）。

38. 发明申请

WO2021161162A1 ROBOTIC MICROSURGERY ASSEMBLY, OPERATING ARENA AND METHOD 审中-公开
公开(公告)号：WO2021161162A1
公开(公告)日：2021-08-19
申请号：PCT/IB2021/051029
申请日：2021-02-09
申请人： MEDICAL MICROINSTRUMENTS S.P.A.
发明人： BAGHERI GHAVIFEKR, Matteo , PINESCHI, Nicola , SIMI, Massimiliano , PRISCO, Giuseppe Maria
IPC分类号： A61B34/37 , A61B34/30 , A61B34/00 , A61B90/00 , A61B90/50 , G02B21/00 , A61B34/20
摘要： Robotic surgery assembly (401) for robotc-aided microsurgery comprising at least one transmission component (410); at least one motorized manipulator (420, 520) comprising at least one motorized linear slider (423; 424; 425); at least one sterile adapter (430, 530), comprising a coupling device (433) suitable for connecting to a surgical instrument (440, 540); wherein said transmission component (410) is interposed between said at least one motorized manipulator (420, 520) and at least one sterile adapter (430, 530), so to rigidly determine at least the relative mutual position of said at least one motorized linear slider (423; 424; 425) of the motorized manipulator (420) and said coupling device (433) sterile adapter (430, 530).

39. 发明申请

WO2021148767A1 COMPACT MICROSCOPE STAGE 审中-公开
公开(公告)号：WO2021148767A1
公开(公告)日：2021-07-29
申请号：PCT/GB2020/053360
申请日：2020-12-23
申请人： IOLIGHT LIMITED
发明人： MONK, Andrew , DR WILLIAMS, Richard
IPC分类号： G02B21/26 , G02B21/00 , G02B21/0092 , G02B21/06
摘要： A microscope stage comprising a planar base (1) with two or more parallel grooves (2) formed extending in a first direction (5). A carriage (3) is mounted on the base with at least two projections (4) that slide in the grooves. The carriage receives a microscope slide or other sample holder (6). The carriage includes at least one guide and a biasing means (7) to urge the sample holder against the guide while permitting it to move relative to the guide in a second direction (8) orthogonal to the first direction.

40. 发明申请

WO2021147198A1 多光子显微镜透明化标本适配器及其成像方法审中-公开
公开(公告)号：WO2021147198A1
公开(公告)日：2021-07-29
申请号：PCT/CN2020/087188
申请日：2020-04-27
申请人：广东湛江海洋医药研究院 , 南方海洋科学与工程广东省实验室（湛江）
发明人：吴科锋 , 赖子嘉 , 吴瀚 , 陈海琪 , 叶华 , 周心 , 朱宇珍 , 韦俊任 , 戚怡 , 林灵辉 , 莫小敏
IPC分类号： G02B21/00
摘要：一种多光子显微镜透明化标本适配器及其成像方法，其中，多光子显微镜透明化标本适配器包括底座（1）以及观察皿（2），底座（1）上设有用于放置生物标本的容纳腔（111），观察皿（2）包括本体（21）以及设于本体（21）上的观察孔（23）和连接套筒（22）；连接套筒（22）的一端与观察孔（23）相连通，另一端与容纳腔（111）相连通，可便于生物标本的固定、寻找以及提高成像效果。

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