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31. 发明申请

WO01035917A1 COMPOSITIONS FOR DYEING KERATINOUS FIBRES CONTAINING 3-AMINO PYRAZOLO-[1,5-A]-PYRIDINES, DYEING METHOD, NOVEL 3-AMINO PYRAZOLO-[1,5-A]-PYRIDINES 审中-公开
标题翻译：用于染色含有3-氨基吡唑并[1,5-a] - 吡啶的染料纤维的组合物，染色方法，3-氨基吡唑并[1,5-a] - 吡啶
公开(公告)号：WO01035917A1
公开(公告)日：2001-05-25
申请号：PCT/FR2000/002903
申请日：2000-10-18
IPC分类号： A61K8/00 , A61K8/20 , A61K8/22 , A61K8/49 , A61Q5/10 , C07D217/06 , C07D471/04 , D06P3/08 , A61K7/13
CPC分类号： A61Q5/10 , A61K8/494 , C07D471/04
摘要： The invention concerns novel oxidative compositions for dyeing keratinous fibres comprising at least a 3-amino-pyrazolo-[1,5-a]-pyridine of Formula (I), the dyeing method using said composition, novel 3-amino pyrazolo-[1,5-a]-pyridines, and the method for preparing them.
摘要翻译：本发明涉及用于染色角质纤维的新型氧化组合物，其包含式（I）的至少3-氨基 - 吡唑并[1,5-a] - 吡啶，使用所述组合物的染色方法，新的3-氨基吡唑并[1 ，5-a] - 吡啶，以及它们的制备方法。

32. 发明申请

WO0077027A3 SERINE PROTEASE INHIBITORS 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂
公开(公告)号：WO0077027A3
公开(公告)日：2001-05-25
申请号：PCT/GB0002291
申请日：2000-06-13
申请人： PROTHERICS MOLECULAR DESIGN LT , LIEBESCHUETZ JOHN WALTER , YOUNG STEPHEN CLINTON , LIVELY SARAH ELIZABETH , HARRISON MARTIN JAMES , WASZKOWYCZ BOHDAN , MORGAN PHILLIP JOHN
发明人： LIEBESCHUETZ JOHN WALTER , YOUNG STEPHEN CLINTON , LIVELY SARAH ELIZABETH , HARRISON MARTIN JAMES , WASZKOWYCZ BOHDAN , MORGAN PHILLIP JOHN
IPC分类号： C07C237/36 , C07C255/60 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D417/06 , C07D487/04 , C07D333/36 , A61K31/166 , A61K31/428 , A61P7/02 , C07D295/12 , C07D295/14 , C07D295/18
CPC分类号： C07D413/14 , C07C237/36 , C07C255/60 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07D209/08 , C07D209/30 , C07D209/34 , C07D209/42 , C07D211/26 , C07D211/34 , C07D211/46 , C07D211/60 , C07D213/53 , C07D213/74 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/06 , C07D231/56 , C07D235/06 , C07D241/24 , C07D277/28 , C07D277/46 , C07D277/64 , C07D277/82 , C07D295/135 , C07D295/185 , C07D317/68 , C07D333/38 , C07D333/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D417/06 , C07D487/04
摘要： Compounds of formula (I) where R2, each X, L, Y, Cy, Lp, D and n are as defined in the specification, are serine protease (especially tryptase) inhibitors useful as antiinflammatory agents.
摘要翻译：其中R2，X，L，Y，Cy，Lp，D和n如说明书中所定义的式（I）化合物是用作抗炎剂的丝氨酸蛋白酶（特别是类胰蛋白酶）抑制剂。

33. 发明申请

WO01010843A1 4-(SUBSTITUTED PHENYL)-5-HALOPYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME AS THE ACTIVE INGREDIENT 审中-公开
标题翻译： 4-（取代的苯基）-5-甲氧基嘧啶衍生物和含有该活性成分的除草剂
公开(公告)号：WO01010843A1
公开(公告)日：2001-02-15
申请号：PCT/JP2000/005222
申请日：2000-08-03
IPC分类号： A01N43/54 , A01N55/08 , C07D209/08 , C07D211/16 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/38 , C07D213/74 , C07D217/06 , C07D239/42 , C07D307/68 , C07D317/58 , C07D317/68 , C07D401/04 , C07D405/14 , C07F5/02 , C07D239/30 , C07D413/04
CPC分类号： C07D239/42 , A01N43/54 , A01N55/08 , C07D209/08 , C07D211/16 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/38 , C07D213/74 , C07D217/06 , C07D307/68 , C07D317/58 , C07D317/68 , C07D401/04 , C07D405/14 , C07F5/025
摘要： 4-(Substituted phenyl)-5-halopyrimidines of general formula (I) useful as herbicides; and boron compounds of general formula (VI) useful as intermediates for the preparation thereof: wherein j and k are both 0, or alternaltively either of them is 0 and the other is 1; Z, X and Y are each halogeno; R and R are each alkyl or the like; R is alkyl or the like; and R is a substituent on Ar.
摘要翻译：用作除草剂的通式（I）的4-（取代的苯基）-5-卤代嘧啶; 和通式（Ⅵ）的硼化合物可用作其制备的中间体：其中j和k均为0，或其中任一个为0，另一个为1; Z，X 1和Y 1各自为卤素; R 1和R 2各自为烷基等; R 16是烷基等; 并且R 17是Ar上的取代基。

34. 发明申请

WO00068203A1 CYCLIC COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：环状化合物及其用途
公开(公告)号：WO00068203A1
公开(公告)日：2000-11-16
申请号：PCT/JP2000/002825
申请日：2000-04-28
IPC分类号： A61K31/351 , A61K31/352 , A61K31/381 , A61K31/4025 , A61K31/44 , A61K31/4709 , A61K31/4725 , A61K31/661 , A61P31/18 , C07D217/06 , C07D309/08 , C07D313/08 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07F9/655 , C07D309/14 , C07D401/12
CPC分类号： C07D405/12 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/4025 , A61K31/44 , A61K31/4709 , A61K31/4725 , A61K31/661 , C07D217/06 , C07D309/08 , C07D313/08 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07F9/65517
摘要： Compounds of general formula (1) or salts thereof, exhibiting preventive and therapeutic effects against HIV infections wherein R is an optionally substituted five- or six-membered ring group; X is a free valency or the like; W is a divalent group represented by, e.g., general formula (2) (wherein A and B are each an optionally substituted five- to seven-membered ring; E1 and E4 are each optionally substituted carbon or the like; E2 and E3 are each oxygen or the like; and a and b are each a single bond or a double bond); X is a divalent group constituting a straight chain moiety; Z is a divalent cyclic group or the like; Z is a free valency or the like; and R is optionally substituted amino or the like.
摘要翻译：通式（1）的化合物或其盐，表现出对HIV感染的预防和治疗作用，其中R 1是任选取代的五元或六元环基团; X 1是自由价或类似物; W是由通式（2）表示的二价基团（其中A和B各自为任选取代的五元至七元环; E1和E4各自为任选取代的碳等; E2和E3各自为氧或类似物; a和b各自为单键或双键）; X 2是构成直链部分的二价基团; Z 1是二价的环状基团等; Z 2是自由价或类似物; 和R 2是任选取代的氨基等。

35. 发明申请

WO00050377A1 EFFICIENT SYNTHESIS OF SECONDARY AMINES BY SELECTIVE ALKYLATION OF PRIMARY AMINES 审中-公开
标题翻译：通过主要选择性碱性氨基酸有效地合成二级氨基
公开(公告)号：WO00050377A1
公开(公告)日：2000-08-31
申请号：PCT/US2000/004739
申请日：2000-02-25
IPC分类号： C07B43/02 , C07B61/00 , C07C209/08 , C07C213/08 , C07C227/18 , C07C271/12 , C07C271/14 , C07C271/16 , C07C271/18 , C07C271/22 , C07C319/14 , C07C319/20 , C07C323/25 , C07D209/14 , C07D211/14 , C07D211/16 , C07D213/74 , C07D213/75 , C07D217/04 , C07D217/06 , C07D295/205 , C07D307/14 , C07D307/33 , C07D307/52 , C07D333/20 , C07F7/18
CPC分类号： C07F7/188 , C07B43/02 , C07C209/08 , C07C213/08 , C07C227/18 , C07C269/04 , C07C319/14 , C07C319/20 , C07C2601/02 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D209/14 , C07D211/14 , C07D211/16 , C07D213/74 , C07D213/75 , C07D217/04 , C07D217/06 , C07D295/205 , C07D307/14 , C07D307/33 , C07D307/52 , C07D333/20 , C07F7/1852 , C40B40/00 , Y02P20/55 , C07C323/25 , C07C271/12 , C07C271/14 , C07C271/16 , C07C271/18 , C07C271/22
摘要： A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23 DEG C; does not cause racemization when used with enantiomerically-pure chiral substrates such as L- alpha -aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73 % yield.
摘要翻译：在温和的反应条件下，不需要保护基团，伯胺的选择性单-N-烷基化制备基本上不含过烷基化的叔胺和季铵盐的仲胺的方法。通过在0.1至3摩尔当量的铯碱的存在下，使烷基卤化物与烷基胺在无水溶剂，优选二甲基亚砜或N，N-二甲基甲酰胺中反应来制备仲胺类化合物。任选地，通过加入用于除去由反应产生的水的粉末状分子筛材料的反应混合物和/或四丁基碘化铵促进卤化物交换，增强了单-N-烷基化的程度和选择性。本发明允许在23℃下选择性和有效的单种N-烷基化多种底物; 当与对映体纯的手性底物如L-α-氨基酯一起使用时，不引起外消旋化; 并用于固相合成，由此固定烷基胺或烷基卤。该方法另外用于制备多胺，如N-（2-（2-氨基乙硫基）乙基）乙二胺，产率为73％。

36. 发明申请

WO00039081A2 CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS 审中-公开
标题翻译：细胞粘附抑制抗炎和免疫抑制化合物
公开(公告)号：WO00039081A2
公开(公告)日：2000-07-06
申请号：PCT/US1999/031162
申请日：1999-12-29
IPC分类号： C07D295/12 , A61K31/16 , A61K31/164 , A61K31/165 , A61K31/167 , A61K31/40 , A61K31/4015 , A61K31/404 , A61K31/407 , A61K31/417 , A61K31/438 , A61K31/44 , A61K31/443 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/45 , A61K31/453 , A61K31/454 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/541 , A61P29/00 , A61P37/02 , C07C323/00 , C07C323/62 , C07C323/63 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/273 , C07D207/34 , C07D207/36 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/66 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/82 , C07D215/04 , C07D215/36 , C07D217/06 , C07D233/61 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/18 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/16 , C07D295/18 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D411/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/10 , C07D487/08 , C07D491/10
CPC分类号： C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
摘要： The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
摘要翻译：本发明涉及可用于治疗炎症和免疫疾病的新颖的肉桂酰胺化合物，含有这些化合物的药物组合物，以及哺乳动物抑制炎症或抑制免疫应答的方法。

37. 发明申请

WO99036398A1 AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS 审中-公开
标题翻译：作为神经钙通道活性的调节剂的氨基磺酰苯胺衍生物
公开(公告)号：WO99036398A1
公开(公告)日：1999-07-22
申请号：PCT/GB1999/000099
申请日：1999-01-13
IPC分类号： C07D295/22 , A61K31/18 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/5375 , A61P25/00 , A61P43/00 , C07C311/16 , C07D207/09 , C07D211/96 , C07D217/06 , C07D295/185 , C07D295/26 , C07D295/12 , C07D295/18
CPC分类号： C07D295/185 , C07C311/16 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D217/06 , C07D295/26
摘要： A pharmaceutical compound of formula (I) in which the aminosulfonyl group is attached at the 3- or 4-position, and in which R is hydrogen, C1-6 Alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl or optionally substituted phenyl-C1-4 alkyl, R is C1-6 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, optionally substituted phenyl-C1-4 alkyl or -(CH2)2NR R where R and R are each hydrogen or C1-6 alkyl, and R and R are each C1-6 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, C3-6 alkenyl, optionally substituted phenyl or optionally substituted phenyl-C1-4 alkyl, or R and R , or R and R , or R and R , together with the nitrogen atom to which they are attached, form a carbocyclic group containing 4 to 7 carbon atoms optionally substituted with one to three methyl or ethyl groups and optionally containing an oxygen atom or a further nitrogen atom, said carbocyclic group being optionally fused to an optionally substituted phenyl group; or a salt thereof.
摘要翻译：其中氨基磺酰基在3-或4-位连接并且其中R 1是氢，C 1-6烷基，C 3-10环烷基，C 3-10环烷基-C 1的式（I）的药物化合物 -4-烷基或任选取代的苯基-C 1-4烷基，R 2是C 1-6烷基，C 3-10环烷基，C 3-10环烷基-C 1-4烷基，任选取代的苯基-C 1-4烷基或 - （CH 2 ）2NR 5 R 6其中R 5和R 6各自为氢或C 1-6烷基，R 3和R 4各自为C 1-6烷基，C 3-10环烷基， C 3-10环烷基-C 1-4烷基，C 3-6烯基，任选取代的苯基或任选取代的苯基-C 1-4烷基，或R 1和R 2，或R 3和R 4，或R 5和R 6与它们所连接的氮原子一起形成任选被1-3个甲基或乙基取代的含有4至7个碳原子的碳环基，并且任选地含有氧原子或进一步的氮原子，所述碳环基任选地与任选取代的苯基稠合; 或其盐。

38. 发明申请

WO1993001174A1 THIAZOLIDINE DERIVATIVES AND THEIR USE AS ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：噻唑烷衍生物及其作为抗病毒化合物的用途
公开(公告)号：WO1993001174A1
公开(公告)日：1993-01-21
申请号：PCT/EP1992001494
申请日：1992-07-03
申请人： GLAXO GROUP LIMITED , KITCHIN, John , HOLMES, Duncan, Stuart , HUMBER, David, Cedric , STORER, Richard , DOLAN, Simon, Charles , HANN, Michael, Menteith , MCMEEKIN, Peter , MURRAY-RUST, Peter , PATEL, Binakumari , WEINGARTEN, Gordon, Gad
发明人： GLAXO GROUP LIMITED
IPC分类号： C07D217/06
CPC分类号： C07D417/12 , C07D277/06 , C07D417/14
摘要： The present invention provides compounds of formula (I), wherein R is hydrogen, alkyl or CH2alkyl where the alkyl portion is substituted by OH; A represents either a group CHR CHR OH or a group (II), where R is hydrogen, alkyl, cycloalkylalkyl or Aralkyl, R is hydrogen, alkyl, cycloalkylalkyl, aralkyl, CHR CONR R (where R is hydrogen, alkyl, cycloalkylalkyl or Aralkyl, R is hydrogen or methyl and R is hydrogen, alkyl optionnally substituted by one or two hydroxyl groups, aryl, heteroaryl, cycloalkylalkyl, Aralkyl wherein the alkyl portion is optionnally substituted by hydroxymethyl, or Hetalkyl) or CHR NHCOR (where R is alkyl, cycloalkylalkyl or an aralkyl), R is alkoxy or NR R (where R is hydrogen or methyl and R is hydrogen, alkyl, aryl, aralkyl or cycloalkylalkyl); X is a group -CHR (CHR )r(CHR )sCHR -, where R and R are hydrogen, r is 1, s is zero and R is hydroxyl or hydroxymethyl, or R and R are hydrogen, r and s are 1 and R and R are each hydrogen or hydroxyl provided that at least one of R and R is hydroxyl, or one of R and R is hydrogen and the other is hydroxymethyl and r and s are zero; useful in chemotherapy, particularly of viral infections.
摘要翻译：本发明提供式（I）化合物，其中R 1是氢，烷基或C 2烷基，其中烷基部分被OH取代; A代表基团CHR 21 CHR 22 OH或基团（II），其中R 21是氢，烷基，环烷基烷基或芳烷基，R 22是氢，烷基，环烷基烷基，芳烷基，CHR 24 R CONR 25 R 26（其中R 24是氢，烷基，环烷基烷基或芳烷基，R 25是氢或甲基，R 26是氢，烷基选择性地被一个或两个羟基取代，芳基，杂芳基，环烷基烷基，芳烷基，其中烷基部分选择性地被羟甲基或Hetalkyl取代）或CHR 24 NHCOR 27（其中R 27是烷基，环烷基烷基或芳烷基），R 23是烷氧基或NR 28 R 29（其中R 28是氢或甲基，R 29是氢，烷基，芳基，芳烷基或环烷基烷基）; X是基团-CHR 30（CHR 31）r（CHR 32）s CHR 33，其中R 30和R 33是氢，r是1，s是0，R 31是羟基或羟甲基，或R 30和R 33是氢，r和s是1，R 31和R 32各自是氢或羟基，条件是R 31中至少有一个且R 32为羟基，R 30和R 33之一为氢，另一个为羟甲基，r和s为0; 可用于化疗，特别是病毒感染。

39. 发明申请

WO2023002165A1 INHIBITOR COMPOUNDS 审中-公开
公开(公告)号：WO2023002165A1
公开(公告)日：2023-01-26
申请号：PCT/GB2022/051846
申请日：2022-07-18
申请人： NEOPHORE LIMITED
发明人： BLAGG, Julian , DRYSDALE, Martin , CLARK, David , WINSHIP, Paul
IPC分类号： C07D405/12 , C07D209/44 , C07D401/04 , C07D403/12 , C07D413/12 , C07D401/12 , C07D405/14 , C07D217/06 , C07D401/14 , C07D471/04 , C07D409/12 , C07D403/14 , C07F5/02 , A61P35/00 , A61K31/4035 , A61K31/4375 , A61K31/4725 , A61K31/496 , A61K31/501
摘要： P324681WO 319 ABSTRACT INHIBITOR COMPOUNDS The present invention relates to compounds of Formula (I) that target the MLH1 or MLH1 and PMS2 proteins that are components of the DNA Mismatch Repair (MMR) process: Formula (I) wherein R6, Y1, Y2, A1, A2, A3, A4, R11, R12, R13 and R14 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which MLH1 or MLH1 and PMS2 activity is implicated.

40. 发明申请

WO2021055630A1 SUBSTITUTED, SATURATED AND UNSATURATED N-HETEROCYCLIC CARBOXAMIDES AND RELATED COMPOUNDS FOR THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS 审中-公开
公开(公告)号：WO2021055630A1
公开(公告)日：2021-03-25
申请号：PCT/US2020/051308
申请日：2020-09-17
申请人： BIAL- BIOTECH INVESTMENTS, INC. , FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
发明人： SKERLJ, Renato T. , BOURQUE, Elyse Marie Josee , RAY, Soumya , SCARPELLI, Rita , CILIBRASI, Vincenzo
IPC分类号： C07D401/04 , C07D241/04 , C07D403/04 , C07D211/16 , C07D211/46 , C07D215/08 , C07D215/233 , C07D217/06 , C07D221/20 , A61P3/00 , C07D207/06 , C07D241/38 , A61P25/28 , A61P25/16 , A61P29/00 , C07D265/34 , A61P35/00 , C07D405/04 , C07D471/04 , C07D491/107
摘要： The invention provides substituted, saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

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