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31. 发明申请

WO1983000503A1 HUMAN NONSECRETORY PLASMACYTOID CELL LINE 审中-公开
标题翻译：人类非特异性PLASMACYTOID细胞系
公开(公告)号：WO1983000503A1
公开(公告)日：1983-02-17
申请号：PCT/US1982001084
申请日：1982-08-10
申请人： RESEARCH CORPORATION
发明人： RESEARCH CORPORATION , RITTS, Roy, Ellot, Jr.
IPC分类号： C12N05/00
CPC分类号： C12N5/163 , C07K16/085 , C12N2500/02 , Y10S435/948
摘要： Une ligne continue de cellules plasmacytoïdes humaines non sécrétrices, établie depuis cinq ans dans plus de 150 passages, est normale d'un point de vue karyotypique, se cultive facilement et possède les caractéristiques d'un plasmablaste à l'exception de son manque de sécrétion, et peut être utilisée pour la préparation d'hybridromes humains-humains avec des B-lymphocites humains et la séparation des hybridomes résultant de la ligne de cellule de plasmacytome par une croissance dans un milieu contenant du CO2, ou par triage de cellules activées par fluorescence, ou par ces deux procédés.

32. 发明申请

WO1982003089A1 MONOCLONAL ANTIBODY 审中-公开
标题翻译：单克隆抗体
公开(公告)号：WO1982003089A1
公开(公告)日：1982-09-16
申请号：PCT/GB1982000076
申请日：1982-03-08
申请人： CELLTECH LTD , LENNOX EDWIN SAMUEL , SACKS STEVEN HOWARD
发明人： CELLTECH LTD
IPC分类号： C12P01/00
CPC分类号： C07K16/34 , C07K16/283 , Y10S435/948 , Y10S530/808 , Y10S530/809 , Y10S530/864
摘要： Un anticorps monoclonique possede une specificite pour un determinant antigene d'une cellule du sang de type B. L'anti-B monoclonique, produit par une cellule hybridoma (hybride) (dont la preparation est decrite), permet d'obtenir un agent de reaction de groupement sanguin defini, specifique et peu couteux. L'anticorps monoclonique est defini par sa specificite et son affinite fonctionnelle.

33. 发明申请

WO1982001072A1 IMMUNOASSAY UTILIZING MONOCLONAL HIGH AFFINITY IGM ANTIBODIES 审中-公开
标题翻译：免疫力使用单克隆高危IGM抗体
公开(公告)号：WO1982001072A1
公开(公告)日：1982-04-01
申请号：PCT/US1981001270
申请日：1981-09-21
申请人： MASSACHUSETTS GENERAL HOSPITAL
发明人： MASSACHUSETTS GENERAL HOSPITAL , WANDS J , ZURAWSKI V , SCHOENMAKER H
IPC分类号： G01N33/54
CPC分类号： C07K14/005 , A61K39/00 , C07K16/082 , C07K16/10 , C12N2730/10122 , Y10S435/948 , Y10S436/804 , Y10S436/811 , Y10S436/82 , Y10S530/826 , Y10S530/864
摘要： Anticorps IgM monocloniques produits de maniere hybridomale possedant une affinite elevee, utile pour l'analyse immunologique et la purification d'antigenes viraux.

34. 发明申请

WO0211742A3 METHODS FOR PREVENTING REOVIRUS RECOGNITION FOR THE TREATMENT OF CELLULAR PROLIFERATIVE DISORDERS 审中-公开
标题翻译：预防治疗细胞增殖性疾病的逆转录病毒识别方法
公开(公告)号：WO0211742A3
公开(公告)日：2002-04-18
申请号：PCT/CA0101055
申请日：2001-07-20
申请人： ONCOLYTICS BIOTECH INC , COFFEY MATTHEW C , THOMPSON BRADLEY G
发明人： COFFEY MATTHEW C , THOMPSON BRADLEY G
IPC分类号： A61K45/00 , A61K35/76 , A61K38/00 , A61K38/13 , A61K39/15 , A61P1/00 , A61P1/16 , A61P1/18 , A61P7/00 , A61P11/00 , A61P13/08 , A61P13/12 , A61P15/00 , A61P25/00 , A61P31/12 , A61P35/00 , C12N9/12
CPC分类号： A61K35/765 , A61K38/13 , C07K16/081 , C07K16/10 , C07K16/4216 , C12N9/1205 , C12N2720/12232 , Y10S435/948 , Y10S435/975 , A61K2300/00
摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression,immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.
摘要翻译：本发明涉及在哺乳动物中治疗细胞增殖性病症，特别是ras介导的细胞增殖性病症中预防呼肠孤病毒识别的方法。哺乳动物可以选自狗，猫，绵羊，山羊，牛，马，猪，小鼠，人类和非人灵长类动物。该方法包括抑制或以其他方式抑制哺乳动物的免疫系统，同时或随后在导致增殖细胞基本裂解的条件下向增殖细胞施用有效量的一种或多种呼肠孤病毒。具体而言，所述方法提供免疫抑制或免疫缺陷哺乳动物的呼肠孤病毒治疗以治疗增殖性疾病。免疫抑制，免疫抑制或以其他方式诱导哺乳动物的免疫缺陷状态使得呼肠孤病毒更有效。该方法可以包括选择性去除可能干扰病毒全身递送的免疫成分; 防止宿主免疫系统识别呼肠孤病毒; 并在用呼肠孤病毒治疗后从免疫抑制或免疫不全宿主中除去病毒。或者，可以在导致增殖细胞大量裂解的条件下将呼肠弧病毒给予具有减少的免疫应答系统的哺乳动物。免疫系统可能受到以下一种或多种危害：HIV感染; 作为化疗或放疗的副作用; 通过选择性去除B和/或T细胞群体; 通过除去抗体（抗抗病毒抗体或全部抗体）等。

35. 发明申请

WO0066710A3 METHOD FOR THE PRESERVATION OF VIRUSES AND MYCOPLASMA 审中-公开
标题翻译：用于保存病毒和MYCOPLASMA的方法
公开(公告)号：WO0066710A3
公开(公告)日：2001-02-08
申请号：PCT/GB0001524
申请日：2000-05-03
申请人： WORRALL ERIC EDWARD
发明人： WORRALL ERIC EDWARD
IPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , C12N1/04 , C12N7/02 , C12R1/93 , A61K39/13 , A61K39/155 , A61K39/165 , A61K39/17 , A61K39/20
CPC分类号： C12N7/00 , A61K39/00 , C12N1/04 , C12N2760/18451 , Y10S435/87 , Y10S435/948
摘要： A biologically-active material comprising a live virus or mycoplasma is preserved by a method of desiccation, without lyophilisation, in a matrix of glassy trehalose having a residual moisture content of not greater than 2 %. The method comprises two vacuum drying stages. In a cycle time much shorter than a typical freeze drying process a virus or mycoplasma can be preserved to provide a material that can be rehydrated to give a vaccine having potency.
摘要翻译：包含活病毒或支原体的生物活性物质通过干燥方法在没有冻干的情况下在具有不大于2％的残余水分含量的玻璃质海藻糖的基质中进行保存。该方法包括两个真空干燥阶段。在比典型的冷冻干燥过程短得多的循环时间中，可以保存病毒或支原体以提供可以被再水化以产生具有效力的疫苗的材料。

36. 发明申请

WO00066710A2 METHOD FOR THE PRESERVATION OF VIRUSES AND MYCOPLASMA 审中-公开
标题翻译：用于保存病毒和MYCOPLASMA的方法
公开(公告)号：WO00066710A2
公开(公告)日：2000-11-09
申请号：PCT/GB2000/001524
申请日：2000-05-03
IPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , C12N1/04 , C12N7/02 , C12R1/93 , A61K39/155 , A61K39/165 , A61K39/20 , A61K39/13 , A61K39/17
CPC分类号： C12N7/00 , A61K39/00 , C12N1/04 , C12N2760/18451 , Y02A50/388 , Y02A50/466 , Y10S435/87 , Y10S435/948
摘要： A biologically-active material comprising a live virus or mycoplasma is preserved by a method of desiccation, without lyophilisation, in a matrix of glassy trehalose having a residual moisture content of not greater than 2 %. The method comprises two vacuum drying stages. In a cycle time much shorter than a typical freeze drying process a virus or mycoplasma can be preserved to provide a material that can be rehydrated to give a vaccine having potency.
摘要翻译：包含活病毒或支原体的生物活性物质通过干燥方法在没有冻干的情况下在具有不大于2％的残余水分含量的玻璃质海藻糖的基质中进行保存。该方法包括两个真空干燥阶段。在比典型的冷冻干燥过程短得多的循环时间中，可以保存病毒或支原体以提供可以被再水化以产生具有效力的疫苗的材料。

37. 发明申请

WO99057297A1 VIRAL PRODUCTION PROCESS 审中-公开
标题翻译：病毒生产过程
公开(公告)号：WO99057297A1
公开(公告)日：1999-11-11
申请号：PCT/US1999/009813
申请日：1999-05-04
IPC分类号： C12N15/09 , C12N5/10 , C12N7/00 , C12N7/01 , C12N15/86 , C12M3/00
CPC分类号： C12N7/00 , A61K48/0091 , C12N15/86 , C12N2531/00 , C12N2710/10043 , C12N2710/10343 , Y10S435/948
摘要： The present invention is directed to a method of producing recombinant viral vectors at high titers incorporating a variety of important advancements over the art. The method of the present invention incorporates multiple features which provide enhanced production of viruses, particularly those viruses encoding exogenous transgenes. The specifically illustrated method describes a method for the high titer serum-free media production of recombinant replication defective adenoviruses containing an exogenous transgene. The invention provides methods of preparing microcarriers, methods for seeding bioreactors at high cell density, increasing the infectivity of the producer cells to the virus, methods to increase product yield through synchronization of the cell cycle of the producer cells, and methods to minimize the deleterious effects of exogenous transgenes. The invention further provides producer cells prepared by the process of the invention. The invention further provides viruses produced by the process.
摘要翻译：本发明涉及一种以高滴度生产重组病毒载体的方法，该方法结合了本领域的各种重要进步。本发明的方法包含提供增强的病毒生产的多个特征，特别是编码外源转基因的那些病毒。具体说明的方法描述了含有外源转基因的重组复制缺陷型腺病毒的高滴度无血清培养基的制备方法。本发明提供了制备微载体的方法，用于以高细胞密度接种生物反应器的方法，增加生产细胞对病毒的感染性，通过生产细胞的细胞周期同步来提高产量的方法，以及使有害细菌最小化的方法外源转基因的作用。本发明还提供了通过本发明的方法制备的生产细胞。本发明还提供了通过该方法产生的病毒。

38. 发明申请

WO9909410A3 RAPID ASSAY FOR SIMULTANEOUS DETECTION AND DIFFERENTIATION OF ANTIBODIES TO HIV 审中-公开
标题翻译：快速检测抗艾滋病毒抗体的同时检测和分化
公开(公告)号：WO9909410A3
公开(公告)日：1999-06-17
申请号：PCT/US9816506
申请日：1998-08-07
申请人： ABBOTT LAB
发明人： VALLARI ANADRUZELA S , HACKETT JOHN R JR , HICKMAN ROBERT K , VARITEK VINCENT A JR , NECKLAWS ELIZABETH C , GOLDEN ALAN M , BRENNAN CATHERINE A , DEVARE SUSHIL G
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/569 , G01N33/558
CPC分类号： G01N33/56988 , G01N33/54386 , Y10S435/948 , Y10S435/974 , Y10S435/975 , Y10S530/826
摘要： A method of performing a rapid assay for the simultaneous detection and differentiation of the analytes HIV-1 group M, HIV-1 group O and HIV-2 utilizing a sequence specific polypeptide of each analyte as capture reagents. An analytical device also is provided for performing the method which includes these capture reagents. Also provided is a test kit which includes the analytical device which further can include a positive and negative control.
摘要翻译：使用每种分析物的序列特异性多肽同时检测和分化HIV-1组M，HIV-1组O和HIV-2的快速测定方法作为捕获试剂。还提供了用于执行包括这些捕获试剂的方法的分析装置。还提供了一种测试试剂盒，其包括进一步可以包括阳性和阴性对照的分析装置。

39. 发明申请

WO1995017503A1 THERMOSTABLE VARICELLA ZOSTER VIRUS 审中-公开
标题翻译：耐热的VARICELLA ZOSTER VIRUS
公开(公告)号：WO1995017503A1
公开(公告)日：1995-06-29
申请号：PCT/US1994014722
申请日：1994-12-19
申请人： MERCK & CO., INC. , PROVOST, Philip, J. , WADSWORTH, Cathy, Warren
发明人： MERCK & CO., INC.
IPC分类号： C12N07/04
CPC分类号： C12N7/00 , A61K39/12 , A61K39/25 , C12N2710/16734 , C12N2710/16761 , Y10S435/948
摘要： A thermostable varicella zoster virus (tVZV) is useful for the preparation of a vaccine against chickenpox. The tVZV was selected from a population of virus which survived stringent heat inactivation conditions. The surviving virus is used to provide seed virus to produce a new vaccine with enhanced stability.
摘要翻译：耐热水痘带状疱疹病毒（tVZV）可用于制备针对水痘的疫苗。 tVZV选自经过严格热灭活条件的病毒群体。存活的病毒用于提供种子病毒以产生具有增强的稳定性的新疫苗。

40. 发明申请

WO1995005460A2 FELINE IMMUNODEFICIENCY VIRUS ISOLATE NCSU 1 审中-公开
标题翻译： FELINE IMMUNODICICENCY VIRUS ISOLATE NCSU 1
公开(公告)号：WO1995005460A2
公开(公告)日：1995-02-23
申请号：PCT/US1994008364
申请日：1994-07-25
申请人： NORTH CAROLINA STATE UNIVERSITY , TOMPKINS, Wayne, A., F. , TOMPKINS, Mary, B.
发明人： NORTH CAROLINA STATE UNIVERSITY
IPC分类号： C12N15/10
CPC分类号： C07K14/005 , A01K67/027 , A61K39/00 , C12N7/00 , C12N2740/15021 , C12N2740/15022 , Y10S435/948
摘要： Disclosed is an isolated and purified feline immunodeficiency virus (FIV) culture having the identifying characteristics of FIV isolate NCSU1. A biologically pure culture of host cells containing an FIV having the identifying characteristics of FIV isolate NCSU1 is also disclosed, along with isolated and purified DNA coding for (a) an FIV having the identifying characteristics of FIV isolate NCSU1, or (b) an antigenic fragment of an FIV having the identifying characteristics of FIV isolate NCSU1. Various vaccine formulations containing active agents derived from the foregoing FIV virus, DNA encoding the virus, and DNA encoding antigenic fragments of the virus are also disclosed herein. Also disclosed are immunodeficient mice containing feline tissue, which feline tissue is capable of infection with a feline immunodeficiency virus such as (but not limited to) FIV isolate NCSU1.
摘要翻译：公开了具有FIV分离物NCSU1的鉴定特征的分离和纯化的猫免疫缺陷病毒（FIV）培养物。还公开了含有具有FIV分离物NCSU1的鉴定特征的FIV的宿主细胞的生物学纯培养物，以及分离和纯化的DNA，其编码（a）具有FIV分离物NCSU1的鉴定特征的FIV，或（b）抗原性具有FIV分离NCSU1的识别特征的FIV的片段。本文还公开了含有源自前述FIV病毒的活性剂，编码病毒的DNA和编码病毒的抗原性片段的DNA的各种疫苗制剂。还公开了含有猫组织的免疫缺陷小鼠，猫组织能够感染猫免疫缺陷病毒，例如（但不限于）FIV分离株NCSU1。

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