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31. 发明申请

WO2018081081A1 MULTIPLEX GENE TARGETING IN PLANTS 审中-公开
标题翻译：植物中的多基因靶基因
公开(公告)号：WO2018081081A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/058031
申请日：2017-10-24
申请人： HUMANES, Javier Gil , VOYTAS, Daniel F. , BALTES, Nicholas J.
发明人： HUMANES, Javier Gil , VOYTAS, Daniel F. , BALTES, Nicholas J.
IPC分类号： C12N15/82
CPC分类号： C12N15/8213 , C12N9/22 , C12N15/11 , C12N15/8201 , C12N2310/20 , C12N2800/80
摘要： Materials and methods for high efficiency gene targeting at multiple genomic sites in a single cell are provided herein.
摘要翻译：本文提供了用于在单细胞中的多个基因组位点进行高效基因靶向的材料和方法。

32. 发明申请

WO2018058064A1 COMPOSITIONS AND METHODS FOR GENE EDITING 审中-公开
公开(公告)号：WO2018058064A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/053307
申请日：2017-09-25
申请人： CASEBIA THERAPEUTICS LIMITED LIABILITY PARTNERSHIP
发明人： BOUCHON, Axel , LUNDBERG, Ante, S. , KLEIN, Lawrence , NELL, Peter, G. , STANKOVICH, Basha
IPC分类号： C12N15/11 , C12N15/90 , C12N15/85 , C12N9/22 , C12N9/14
CPC分类号： C12N15/907 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , A61K48/00 , C12N9/22 , C12N15/11 , C12N15/113 , C12N2310/20 , C12N2750/14143 , C12N2800/80
摘要： Provided include materials and methods for treating a subject with one or more conditions associated with WAS gene whether ex vivo or in vivo. Also provided include materials and methods for editing and/or modulating the expression of WAS gene in a cell by genome editing.

33. 发明申请

WO2018009520A1 IMPROVING A MICROORGANISM BY CRISPR-INHIBITION 审中-公开
标题翻译：通过CRISPR-抑制改善微生物
公开(公告)号：WO2018009520A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/040689
申请日：2017-07-05
申请人： NOVOZYMES A/S , CHERRY, Barbara
发明人： CHERRY, Barbara , RASMUSSEN, Michael Dolberg , PEDERSEN, Poul Erik , HJORT, Carsten
IPC分类号： C12N15/75 , C12N9/22
CPC分类号： C12N15/11 , C12N9/22 , C12N15/75 , C12N2310/20 , C12N2800/80
摘要： The present invention relates to methods for improving at least one property of a microorganism host cell by repressing the expression of one or more genome target sequence of interest by CRISPR-inhibition as well as the resulting host cells and methods of production emplying said host cells.
摘要翻译：本发明涉及通过CRISPR抑制以及所得宿主细胞抑制一种或多种目的基因组靶标序列的表达来改善微生物宿主细胞的至少一种性质的方法，以及生产方法与所述宿主细胞相同。

34. 发明申请

WO2017196861A1 METHODS FOR MODULATING INSECT HYGRO- AND/OR THERMOSENSATION 审中-公开
标题翻译：调节昆虫组织和/或热敏感性的方法
公开(公告)号：WO2017196861A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/031781
申请日：2017-05-09
申请人： BRANDEIS UNIVERSITY
发明人： KNECHT, Zachary , GARRITY, Paul , NI, Lina
IPC分类号： C12N15/113 , G01N33/68
CPC分类号： C12N15/1138 , C07K14/43581 , C12N9/22 , C12N15/11 , C12N2310/20 , C12N2800/80 , G01N33/5085 , G01N33/68
摘要： A method of modulating hygrosensing and/or thermosensing in an animal, particularly, an insect or disease vector, is provided. Also provided is a method of reducing survival, host-seeking, and/or reproductive capability of an animal, particularly an insect or disease vector. The methods involve an effective amount of an agent that modulates the activity and/or expression of a polynucleotide or polypeptide of an ionotropic receptor (Ir) selected from one or more of Ir25a, Ir93a, Ir40a, Ir68a, or Ir21a. A method of identifying an agent that modulates survival, host-seeking, and/or reproductive capability of an animal, e.g., an insect, is further provided.
摘要翻译：提供了调节动物，特别是昆虫或疾病载体中的吸湿和/或热感应的方法。还提供了降低动物，特别是昆虫或疾病载体的存活，寻主和/或繁殖能力的方法。所述方法涉及有效量的调节选自Ir25a，Ir93a，Ir40a，Ir68a或Ir21a中的一种或多种的离子型受体（Ir）的多核苷酸或多肽的活性和/或表达的试剂。还提供了鉴定调节动物（例如昆虫）的存活，寻主和/或繁殖能力的试剂的方法。

35. 发明申请

WO2017023803A1 MODIFIED CELLS AND METHODS OF THERAPY 审中-公开
标题翻译：改良细胞和治疗方法
公开(公告)号：WO2017023803A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/044858
申请日：2016-07-29
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC.
发明人： MORIARITY, Branden , WEBBER, Beau , MCIVOR, Scott, R. , LARGAESPADA, David , CHOUDHRY, Modassir
IPC分类号： A61K35/00 , A61K35/17 , A61K35/28 , A61K38/00 , C07H21/04 , C07K14/725
CPC分类号： A61K35/17 , C07K14/4718 , C07K14/70503 , C07K14/7051 , C07K14/70521 , C07K14/7158 , C12N5/0636 , C12N9/22 , C12N9/96 , C12N15/113 , C12N15/87 , C12N15/907 , C12N2310/20 , C12N2510/00 , C12N2800/80 , Y02A50/463
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
摘要翻译：公开了用于治疗癌症的转基因组合物，例如非病毒载体和T细胞。还公开了制备和使用转基因组合物治疗癌症的方法。

36. 发明申请

WO2016201174A2 GENE EXPRESSION IN BACTEROIDES 审中-公开
标题翻译：细菌中的基因表达
公开(公告)号：WO2016201174A2
公开(公告)日：2016-12-15
申请号：PCT/US2016/036811
申请日：2016-06-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： LU, Timothy, Kuan-Ta , MIMEE, Mark, K. , VOIGT, Christopher , TUCKER, Alex, C.
IPC分类号： A61K39/02 , C12N1/21
CPC分类号： C12N15/74 , A61K35/741 , A61K48/0066 , C12N9/12 , C12N9/16 , C12N9/22 , C12N9/93 , C12N9/96 , C12N15/11 , C12N15/63 , C12N15/67 , C12N15/902 , C12N2310/14 , C12N2310/20 , C12N2800/80 , C12N2840/203
摘要： Provided herein, in some aspects, are tools (e.g., methods, compositions and nucleic acids) for building genetic circuits in Bacteroides and Parabacteroides bacteria, as well as the bacteria containing the genetic circuits.
摘要翻译：在这里，在一些方面，是用于构建拟杆菌属和拟杆菌属细菌中的遗传回路以及含有遗传回路的细菌的工具（例如，方法，组合物和核酸）。

37. 发明申请

WO2016197136A2 IMPROVED PRODUCTIVITY AND BIOPRODUCT FORMATION IN PHOTOTROPIN KNOCK/OUT MUTANTS IN MICROALGAE 审中-公开
标题翻译：在微藻中改善光合作用的生物量和生物量
公开(公告)号：WO2016197136A2
公开(公告)日：2016-12-08
申请号：PCT/US2016/036077
申请日：2016-06-06
申请人： NMC, INC. , LOS ALAMOS NATIONAL SECURITY, LLC
发明人： NEGI, Sangeeta , SAYRE, Richard, Thomas , STARKENBURG, Shawn, Robert
IPC分类号： C12P19/04 , C12N1/13
CPC分类号： C12N9/12 , C07K14/405 , C12N1/12 , C12N9/0051 , C12N9/1205 , C12N9/22 , C12N15/01 , C12N15/11 , C12N2310/20 , C12N2800/80 , C12P7/64 , C12P19/04 , C12P23/00 , C12Y108/01009 , C12Y207/11
摘要： Phototropin is a blue light receptor, which mediates a variety of blue-light elicited physiological processes in plants and algae. In higher plants these processes include phototropism, chloroplast movement and stomatal opening. In the green alga Chlamydomonas reinhardtii , phototropin plays a vital role in progression of the sexual life cycle and in the control of the eye spot size and light sensitivity. Phototropin is also involved in blue-light mediated changes in the synthesis of chlorophylls, carotenoids, chlorophyll binding proteins. We compared the transcriptome of phototropin knock out (PHOT KO) mutant and wild-type parent to analyze differences in gene expression in high light grown cultures {500 μmol photons m -2 s -1 ). Our results indicate the up-regulation of genes involved in photosynthetic electron transport chain, carbon fixation pathway, starch, lipid, and cell cycle control genes. With respect to photosynthetic electron transport genes, genes encoding proteins of the cytochrome b6f and ATP synthase complex were up regulated potentially facilitating proton-coupled electron transfer. In addition genes involved in limiting steps in the Calvin cycle Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), Sidoheptulose 1,7 bisphosphatase (SBPase), Glyceraldehyde-3-phosphate dehydrogenase (3PGDH) and that mediate cell-cycle control (CDK) were also up regulated along with starch synthase and fatty acid biosynthesis genes involved in starch and lipid synthesis. In addition, transmission electron micrographs show increased accumulation of starch granules in PHOT mutant compared to wild type, which is consistent with the higher expression of starch synthase genes. Collectively, the altered patterns of gene expression in the PHOT mutants were associated with a two-fold increase in growth and biomass accumulation compared to wild type when grown in environmental photobioreactors (Phenometrics) that simulate a pond environment. In conclusion, our studies suggest that phototropin may be a master gene regulator that suppresses rapid cell growth and promotes gametogenesis and sexual recombination in wild type strains.
摘要翻译：光吗啉是蓝光受体，其介导植物和藻类中各种蓝光引发的生理过程。在高等植物中，这些过程包括光转动，叶绿体运动和气孔开放。在绿藻类莱茵衣藻中，光皮质素在性生活周期的进展和眼斑大小和光敏感性的控制中起着至关重要的作用。光滑素还涉及蓝光介导的叶绿素，类胡萝卜素，叶绿素结合蛋白的合成变化。我们比较了Phototropin敲除（PHOT KO）突变体和野生型亲本的转录组，以分析高光生长培养物（500μmol光子m-2 s-1）中基因表达的差异。我们的结果表明参与光合电子传递链，碳固定途径，淀粉，脂质和细胞周期控制基因的基因的上调。对于光合电子转运基因，编码细胞色素b6f和ATP合成酶复合物蛋白质的基因上调可能促进质子 - 偶联电子转移。另外参与限制加尔文循环中的步骤的核糖核酸-1,5-二磷酸羧化酶/加氧酶（RuBisCO），Sidoheptulose 1,7二磷酸酶（SBPase），甘油醛-3-磷酸脱氢酶（3PGDH），并介导细胞周期控制（CDK）也与淀粉合成酶和参与淀粉和脂质合成的脂肪酸生物合成基因一起上调。此外，与野生型相比，透射电子显微照片显示淀粉颗粒在PHOT突变体中的积累增加，这与淀粉合成酶基因的较高表达一致。总之，在模拟池塘环境的环境光生物反应器（Phenometrics）中生长时，与野生型相比，PHOT突变体中基因表达的改变模式与生长和生物量积累相比增加了两倍。总之，我们的研究表明光滑素可能是一个主要的基因调节器，抑制快速的细胞生长和促进野生型菌株的配子形成和性重组。

38. 发明申请

WO2016196738A1 COMPOSITIONS AND METHODS FOR DELIVERY OF A POLYNUCLEOTIDE INTO A PLANT 审中-公开
标题翻译：将多核苷酸输送到植物中的组合物和方法
公开(公告)号：WO2016196738A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035435
申请日：2016-06-02
申请人： MONSANTO TECHNOLOGY LLC
发明人： BENNETT, Michael J. , HUANG, Shihshieh , IANDOLINO, Alberto B. , LINDFORS, Heather A. , OAKES, Janette V. , PEEL, Gregory John , RADKE, Sharon E. , SCHWARTZ, Steven H.
IPC分类号： A01N25/30 , C12N15/113 , C12N15/87
CPC分类号： C12N15/113 , A01N57/16 , C12N9/20 , C12N9/22 , C12N9/96 , C12N15/11 , C12N15/1137 , C12N15/8213 , C12N15/87 , C12N2310/14 , C12N2310/20 , C12N2800/80 , A01N25/30
摘要： The present disclosure provides compositions and methods for delivering a polynucleotide from the exterior surface of a plant or plant part into the interior of a plant cell. More specifically, the present disclosure relates to compositions comprising at least one polynucleotide and at least one agent that is able to disrupt at least one barrier of the plant or plant part.
摘要翻译：本公开提供了将多核苷酸从植物或植物部分的外表面递送到植物细胞内部的组合物和方法。更具体地，本公开涉及包含至少一种多核苷酸和能够破坏植物或植物部分的至少一个屏障的至少一种试剂的组合物。

39. 发明申请

WO2016195598A1 VECTORS 审中-公开
标题翻译：向量
公开(公告)号：WO2016195598A1
公开(公告)日：2016-12-08
申请号：PCT/SG2016/050258
申请日：2016-06-02
申请人： NATIONAL UNIVERSITY OF SINGAPORE
发明人： PATZEL, Volker
IPC分类号： C12N15/85 , C12N15/64
CPC分类号： C12N15/85 , A61K48/00 , C12N9/22 , C12N9/96 , C12N15/11 , C12N15/113 , C12N15/63 , C12N15/67 , C12N2310/11 , C12N2310/20 , C12N2310/531 , C12N2330/51 , C12N2800/24 , C12N2800/80 , C12N2810/10 , C12N2830/42 , C12N2840/445 , C12P19/34
摘要： We disclose dumbbell-shaped vectors adapted for efficient expression in mammalian cells. We also disclose a novel method allowing the efficient synthesis of dumbbell-shaped vectors at low cost for delivery of recombinant DNA and RNA into host cells; and the use of dumbbell-shaped vectors for transient expression in, for example, primary human cells.
摘要翻译：我们公开了适合在哺乳动物细胞中有效表达的哑铃形载体。我们还公开了一种允许低成本有效合成哑铃形载体的新方法，用于将重组DNA和RNA递送到宿主细胞中; 以及使用哑铃形载体用于例如原代人细胞中的瞬时表达。

40. 发明申请

WO2016183345A1 ENHANCING ENDONUCLEASE BASED GENE EDITING IN PRIMARY CELLS 审中-公开
标题翻译：在初级细胞中增强基于内切酶的基因编码
公开(公告)号：WO2016183345A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/032153
申请日：2016-05-12
申请人： SEATTLE CHILDREN' S HOSPITAL (DBA SEATTLE CHILDREN 'S RESEARCH INSTITUTE)
发明人： SCHARENBERG, Andrew , RAWLINGS, David , JENSEN, Michael, C. , GWIAZDA, Kamila , GRIER, Alexandra
IPC分类号： A61K48/00 , C12N15/64 , C12N15/85
CPC分类号： C12N15/907 , A61K38/465 , A61K48/00 , A61K48/005 , A61P35/00 , C12N7/00 , C12N7/045 , C12N15/113 , C12N15/86 , C12N15/8616 , C12N2310/20 , C12N2750/14143 , C12N2800/80
摘要： Disclosed herein are nuclease-based systems for genome editing and methods of using the system for genome editing. Also, disclosed are approaches to enhance Cas9- mediated gene editing efficiency in primary human cells with minimal toxicity when using adeno-associated virus vectors (AAV) to express the guide RNAs necessary for CRISPR/Cas9-based genome editing in the presence of helper proteins.
摘要翻译：本文公开了用于基因组编辑的基于核酸酶的系统和使用该系统进行基因组编辑的方法。此外，公开的是当使用腺相关病毒载体（AAV）在辅助蛋白存在下表达基于CRISPR / Cas9的基因组编辑所必需的指导RNA时，以最小的毒性增强原代人细胞中Cas9介导的基因编辑效率的方法。

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