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31. 发明申请

WO2013018083A3 ELECTROSTIMULATION IN TREATING CEREBROVASCULAR CONDITIONS 审中-公开
标题翻译：电解治疗脑血管病变
公开(公告)号：WO2013018083A3
公开(公告)日：2014-08-21
申请号：PCT/IL2012000290
申请日：2012-08-02
申请人： SAMSON NEUROSCIENCES LTD , SHALEV ALON , LEVY RONNIE , BEINART YIFTACH
发明人： SHALEV ALON , LEVY RONNIE , BEINART YIFTACH
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36103 , A61N1/0558 , A61N1/36017 , A61N1/36025 , A61N1/36053 , A61N1/36057 , A61N1/36175 , A61N1/3787
摘要： A system for treating a medical condition in a living body, comprising two subsystems, an implant subsystem and an electrical stimulation unit subsystem. The implant subsystem comprises at least one electrostimulation module, contains at least one electrically conductive electrode and, preferably, an anchoring member. The electrical stimulation unit, adapted for producing and controlling electrical waveforms, is connected to the electrodes. The implant subsystem is implanted adjacent to at least one of the following structures: the carotid sinus nerve, aortic nerve, common carotid artery, external carotid artery, internal carotid artery, carotid artery bifurcation, carotid body, aortic body or aortic arch receptors. The electrical stimulation unit is maintained outside the patient's body and is adapted to program, generate, control and deliver the electrical waveform via a wired or a wireless connection to the implant subsystem, thereby stimulating the structure it is adjacent to and treating the medical condition.
摘要翻译：一种用于治疗生物体内的医疗状况的系统，包括两个子系统，植入子系统和电刺激单元子系统。植入子系统包括至少一个电刺激模块，其包含至少一个导电电极，并且优选地包括锚定构件。适于产生和控制电波形的电刺激单元连接到电极。植入子系统相邻于以下结构中的至少一个：颈动脉窦神经，主动脉神经，颈总动脉，颈外动脉，颈内动脉，颈动脉分叉，颈动脉体，主动脉体或主动脉弓受体。电刺激单元保持在患者身体外部，并且适于通过有线或无线连接对植入物子系统进行编程，生成，控制和传送电波形，从而刺激其与医疗状况相邻并处理的结构。

32. 发明申请

WO2013046039A3 APPARATUS AND METHOD FOR DETECTING A SLEEP DISORDERED BREATHING PRECURSOR 审中-公开
标题翻译：用于检测睡眠障碍呼吸前体的装置和方法
公开(公告)号：WO2013046039A3
公开(公告)日：2014-07-17
申请号：PCT/IB2012002372
申请日：2012-09-28
申请人： MASHIACH ADI
发明人： MASHIACH ADI
IPC分类号： A61N1/00
CPC分类号： A61N1/36075 , A61B5/0031 , A61B5/11 , A61B5/113 , A61B5/4519 , A61B5/4818 , A61B5/682 , A61B5/6822 , A61B5/6833 , A61B5/6876 , A61B2562/164 , A61F5/566 , A61N1/05 , A61N1/0504 , A61N1/0514 , A61N1/0526 , A61N1/0529 , A61N1/0548 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/36003 , A61N1/3601 , A61N1/3605 , A61N1/36057 , A61N1/3606 , A61N1/3611 , A61N1/36117 , A61N1/36125 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37211 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/37264 , A61N1/3727 , A61N1/3756 , A61N1/3787 , A61N2/006 , A61N2/02 , F04C2270/0421
摘要： A device according to some embodiments may include a primary antenna configured to be located external to a subject. The device may also include at least one processor in electrical communication with the primary antenna and configured to receive a condition signal from an implantable device, the condition signal indicative of a precursor to sleep disordered breathing, and cause transmission of a primary signal from the primary antenna to the implantable device, in response to the condition signal, to stimulate at least one nerve in response to the precursor to sleep disordered breathing.
摘要翻译：根据一些实施例的设备可以包括被配置为位于被摄体外部的主天线。该设备还可以包括与主天线电通信的至少一个处理器，并且被配置为从可植入设备接收条件信号，所述条件信号指示睡眠呼吸的无序化的前兆，并且使主信号从初级天线到可植入装置，响应条件信号，刺激至少一个神经响应于前体睡眠呼吸紊乱。

33. 发明申请

WO2014096969A2 SYSTEMS AND METHODS FOR HYPERTENSION CONTROL 审中-公开
标题翻译：高压控制系统与方法
公开(公告)号：WO2014096969A2
公开(公告)日：2014-06-26
申请号：PCT/IB2013003215
申请日：2013-12-19
申请人： MASHIACH ADI
发明人： MASHIACH ADI
IPC分类号： A01N1/02
CPC分类号： A61N1/36117 , A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00577 , A61B2018/1465 , A61N1/0551 , A61N1/36057 , A61N1/36125 , A61N1/37223
摘要： Systems and methods for hypertension control via energy delivery to one or more nerves affecting blood pressure are provided. Systems may include implantable devices configured for non-contacting neuromodu!ation. Implantable devices may be configured for intravascular implantation. Systems may also include external devices configured to communicated with implantable neuromodulation devices, Additional systems may include non-implantable devices for delivering modulation energy and ablation energy to one or more nerves affecting blood pressure.
摘要翻译：提供了通过能量输送到影响血压的一个或多个神经进行高血压控制的系统和方法。系统可以包括配置用于非接触神经瘤的植入式装置。可植入装置可以被配置用于血管内植入。系统还可以包括被配置为与可植入神经调节装置通信的外部装置。附加系统可以包括用于将影响血压的一个或多个神经传递调制能量和消融能量的非植入式装置。

34. 发明申请

WO2013134667A1 MODULATING AFFERENT SIGNALS TO TREAT MEDICAL CONDITIONS 审中-公开
标题翻译：调整相关信号以治疗医疗条件
公开(公告)号：WO2013134667A1
公开(公告)日：2013-09-12
申请号：PCT/US2013/029930
申请日：2013-03-08
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： JOYNER, Michael J. , JOHNSON, Bruce D. , OLSON, Thomas P.
IPC分类号： A61N1/32 , A61K31/245 , A61P23/00
CPC分类号： A61N1/36114 , A61K31/245 , A61K31/4468 , A61N1/36057 , A61N1/3611 , A61N1/36117 , A61N1/36146 , A61N2/02
摘要： This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.
摘要翻译：本文件提供了调节传入神经信号以治疗诸如CHF，CHF呼吸，呼吸困难，外周血管疾病（例如外周动脉疾病或静脉功能不全），高血压（例如年龄相关性高血压，耐药性高血压，或慢性难治性高血压），COPD，睡眠呼吸暂停和慢性形式的肺部疾病，其中肌肉功能障碍是疾病病理生理学的一部分。例如，提供了使用电和/或化学技术阻止或减少传入神经信号（例如来自骨骼肌和/或肾脏的III和/或IV族传入物的神经信号）的方法和材料。

35. 发明申请

WO2013046038A3 APPARATUS AND METHODS FOR FEEDBACK-BASED NERVE MODULATION 审中-公开
标题翻译：基于反馈的神经调制的装置和方法
公开(公告)号：WO2013046038A3
公开(公告)日：2013-07-25
申请号：PCT/IB2012002370
申请日：2012-09-28
申请人： MASHIACH ADI
发明人： MASHIACH ADI
IPC分类号： A61N1/00
CPC分类号： A61N1/36075 , A61B5/0031 , A61B5/11 , A61B5/113 , A61B5/4519 , A61B5/4818 , A61B5/682 , A61B5/6822 , A61B5/6833 , A61B5/6876 , A61B2562/164 , A61F5/566 , A61N1/05 , A61N1/0504 , A61N1/0514 , A61N1/0526 , A61N1/0529 , A61N1/0548 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/36003 , A61N1/3601 , A61N1/3605 , A61N1/36057 , A61N1/3606 , A61N1/3611 , A61N1/36117 , A61N1/36125 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37211 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/37264 , A61N1/3727 , A61N1/3756 , A61N1/3787 , A61N2/006 , A61N2/02 , F04C2270/0421
摘要： A device according to some embodiments may include a housing configured for location external to a body of a subject The device may also include at least one processor associated with the housing and configured to communicate with a circuit implanted in the subject within proximity to a tongue of the subject, wherein the circuit is in electrical communication with at least one electrode, receive a physiological signal from the subject via the circuit, and send a control signal to the implanted circuit in response to the physiological signal, wherein the control signal is predetermined to activate neuromuscular tissue within the tongue.
摘要翻译：根据一些实施例的装置可以包括构造成用于位于对象身体外部的位置的外壳。所述装置还可以包括与所述外壳相关联的至少一个处理器，并且被配置为与植入在所述对象中的电路邻近所述对象，其中所述电路与至少一个电极电连通，经由所述电路从所述对象接收生理信号，并且响应于所述生理信号向所述注入电路发送控制信号，其中所述控制信号预定为激活舌头内的神经肌肉组织。

36. 发明申请

WO2013046044A3 MODULATOR APPARATUS CONFIGURED FOR IMPLANTATION 审中-公开
标题翻译：配置用于植入的调制器装置
公开(公告)号：WO2013046044A3
公开(公告)日：2013-05-30
申请号：PCT/IB2012002418
申请日：2012-09-28
申请人： MASHIACH ADI
发明人： MASHIACH ADI
IPC分类号： A61N1/05
CPC分类号： A61N1/36075 , A61B5/0031 , A61B5/11 , A61B5/113 , A61B5/4519 , A61B5/4818 , A61B5/682 , A61B5/6822 , A61B5/6833 , A61B5/6876 , A61B2562/164 , A61F5/566 , A61N1/05 , A61N1/0504 , A61N1/0514 , A61N1/0526 , A61N1/0529 , A61N1/0548 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/36003 , A61N1/3601 , A61N1/3605 , A61N1/36057 , A61N1/3606 , A61N1/3611 , A61N1/36117 , A61N1/36125 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37211 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/37264 , A61N1/3727 , A61N1/3756 , A61N1/3787 , A61N2/006 , A61N2/02 , F04C2270/0421
摘要： An implant unit according to some embodiments may include a flexible carrier, at least one pair of modulation electrodes on the flexible carrier, and at least one implantable circuit in electrical communication with the at least one pair of modulation electrodes. The at least one pair of modulation electrodes and the at least one circuit may be configured for implantation through derma on an underside of a subject's chin and for location proximate to terminal fibers of the medial branch of the subject's hypoglossaS nerve, such that an electric field extending from the at least one pair of modulation electrodes can modulate one or more of the terminal fibers of the medial branch of the hypoglossal nerve.
摘要翻译：根据一些实施例的植入单元可以包括柔性载体，柔性载体上的至少一对调制电极以及与至少一对调制电极电连通的至少一个可植入电路。所述至少一对调制电极和所述至少一个电路可以被配置用于通过被检体下巴的下侧的皮肤进行植入，并且用于邻近受试者hypoglossaS神经的内侧分支的终端纤维的位置，使得电场从至少一对调制电极延伸可以调制舌下神经的内侧分支的一个或多个末端纤维。

37. 发明申请

WO2013061164A2 SYSTEM AND METHOD FOR NERVE MODULATION USING NONCONTACTING ELECTRODES 审中-公开
标题翻译：使用非绝缘电极进行神经调制的系统和方法
公开(公告)号：WO2013061164A2
公开(公告)日：2013-05-02
申请号：PCT/IB2012/002913
申请日：2012-09-28
申请人： MASHIACH, Adi
发明人： MASHIACH, Adi
IPC分类号： A61N1/36
CPC分类号： A61N1/36075 , A61B5/0031 , A61B5/11 , A61B5/113 , A61B5/4519 , A61B5/4818 , A61B5/682 , A61B5/6822 , A61B5/6833 , A61B5/6876 , A61B2562/164 , A61F5/566 , A61N1/05 , A61N1/0504 , A61N1/0514 , A61N1/0526 , A61N1/0529 , A61N1/0548 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/36003 , A61N1/3601 , A61N1/3605 , A61N1/36057 , A61N1/3606 , A61N1/3611 , A61N1/36117 , A61N1/36125 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37211 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/37264 , A61N1/3727 , A61N1/3756 , A61N1/3787 , A61N2/006 , A61N2/02 , F04C2270/0421
摘要： An implant unit configured for implantation into a body of a subject may include an antenna configured to receive a signal. The implant unit may also include at least one pair of modulation electrodes configured to be implanted into the body of the subject in the vicinity of at least one nerve to be modulated, the at least one pair of modulation electrodes being configured to receive an applied electric signal in response to the signal received by the antenna and generate an electrical field to modulate the at least one nerve from a position where the at least one pair of modulation electrodes does not contact the at least one nerve.
摘要翻译：被配置用于植入物体的体内的植入单元可以包括配置成接收信号的天线。所述植入单元还可以包括至少一对调制电极，所述至少一对调制电极被配置为在被调制的至少一个神经附近被植入到所述受试者的身体中，所述至少一对调制电极被配置为接收所施加的电响应于天线接收的信号产生信号，并产生电场以从至少一对调制电极不接触至少一个神经的位置调制至少一个神经。

38. 发明申请

WO2013046043A2 ELECTRODE CONFIGURATION FOR IMPLANTABLE MODULATOR 审中-公开
标题翻译：可植入调制器的电极配置
公开(公告)号：WO2013046043A2
公开(公告)日：2013-04-04
申请号：PCT/IB2012/002399
申请日：2012-09-28
申请人： MASHIACH, Adi
发明人： MASHIACH, Adi
IPC分类号： A61N1/05
CPC分类号： A61N1/36075 , A61B5/0031 , A61B5/11 , A61B5/113 , A61B5/4519 , A61B5/4818 , A61B5/682 , A61B5/6822 , A61B5/6833 , A61B5/6876 , A61B2562/164 , A61F5/566 , A61N1/05 , A61N1/0504 , A61N1/0514 , A61N1/0526 , A61N1/0529 , A61N1/0548 , A61N1/0551 , A61N1/0553 , A61N1/36 , A61N1/36003 , A61N1/3601 , A61N1/3605 , A61N1/36057 , A61N1/3606 , A61N1/3611 , A61N1/36117 , A61N1/36125 , A61N1/36135 , A61N1/36139 , A61N1/36146 , A61N1/37211 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/37264 , A61N1/3727 , A61N1/3756 , A61N1/3787 , A61N2/006 , A61N2/02 , F04C2270/0421
摘要： A device according to some embodiments may include an implantable flexible carrier and a pair of electrodes located on the carrier. The electrodes may be spaced from each other by a distance greater than 3 mm, and may be configured to cause, when supplied with an electrical signal, a unidirectional electric field sufficient to modulate at least one nerve.
摘要翻译：根据一些实施例的装置可以包括可植入的柔性载体和位于载体上的一对电极。电极可以彼此间隔大于3mm的距离，并且可以被配置为当被提供有电信号时导致足以调制至少一个神经的单向电场。

39. 发明申请

WO2012082979A3 TIBIAL NERVE STIMULATION 审中-公开
标题翻译：胫骨神经刺激
公开(公告)号：WO2012082979A3
公开(公告)日：2012-09-07
申请号：PCT/US2011065052
申请日：2011-12-15
申请人： AMS RES CORP , JAHNS SCOTT E
发明人： JAHNS SCOTT E
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61N1/37223 , A61N1/36007 , A61N1/36057 , A61N1/37205 , A61N1/37229
摘要： An implantable stimulation device (102) comprises one or more electrodes (134), a receiving antenna coil (128A), a transmitting antenna coil (128B) and a control circuit (110). The receiving antenna coil is in a first layer, the transmitting antenna coil is in a second layer and the control circuit is in a third layer between the first and second layers. The control circuit is configured to receive signals using the receiving antenna coil, transmit signals using the transmitting antenna coil, and deliver stimulation signals to the one or more electrodes. The receiving antenna coil, the transmitting antenna coil and the control circuit are contained in a hermetically sealed container (130).
摘要翻译：可植入刺激设备（102）包括一个或多个电极（134），接收天线线圈（128A），发射天线线圈（128B）和控制电路（110）。接收天线线圈处于第一层中，发射天线线圈处于第二层中，并且控制电路处于第一层与第二层之间的第三层中。控制电路被配置为使用接收天线线圈来接收信号，使用发送天线线圈发送信号，并且向一个或多个电极递送刺激信号。接收天线线圈，发送天线线圈和控制电路被容纳在密封容器（130）中。

40. 发明申请

WO2012083259A2 METHOD, SYSTEM AND APPARATUS FOR CONTROL OF PANCREATIC BETA CELL FUNCTION TO IMPROVE GLUCOSE HOMEOSTATIS AND INSULIN PRODUCTION 审中-公开
标题翻译：用于控制胰岛β细胞功能以改善葡萄球菌和胰岛素生产的方法，系统和装置
公开(公告)号：WO2012083259A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/065653
申请日：2011-12-16
申请人： NEURAL DIABETES FOUNDATION, INC. , PERRYMAN, Laura, Tyler
发明人： PERRYMAN, Laura, Tyler
CPC分类号： A61N1/372 , A61N1/36057 , A61N1/36121
摘要： The present invention provides methods, systems and apparatuses for effecting excitation or inhibition of small sensory nerve fibers, such as C-afferent fibers, by electrical stimulation of nerves innervating the pancreas. In an aspect the methods are directed to affecting insulin production (either enhancement or inhibition) and for the treatment of pre-diabetes and diabetes. This invention includes a closed or open loop feedback control system in which biomarker levels are monitored in order to direct electrical stimulation. An implantable or external neural stimulation device is also provided.
摘要翻译：本发明提供了通过电刺激神经支配胰腺来实现小感觉神经纤维如C传入纤维的激发或抑制的方法，系统和装置。在一方面，该方法旨在影响胰岛素产生（增强或抑制）和治疗前期糖尿病和糖尿病。本发明包括封闭或开环反馈控制系统，其中监测生物标志物水平以引导电刺激。还提供了可植入或外部神经刺激装置。

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