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31. 发明申请

WO2006135656B1 PROCESSES FOR THE PREPARATION OF PACLITAXEL 审中-公开
标题翻译：制备PACLITAXEL的方法
公开(公告)号：WO2006135656B1
公开(公告)日：2007-08-16
申请号：PCT/US2006022214
申请日：2006-06-08
申请人： UNIV FLORIDA STATE RES FOUND , VU PHONG , HOLTON ROBERT A
发明人： VU PHONG , HOLTON ROBERT A
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , Y02P20/55
摘要： The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon based protecting group. The resulting 7,10 protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.
摘要翻译：本发明提供紫杉醇生产方法。紫杉醇通过用桥连硅基保护基保护10-DAB的C（7）和C（10）羟基而产生。然后将所得的7,10保护的10-DAB衍生物衍生化并去保护以形成紫杉醇。

32. 发明申请

WO2006135670A3 ß-LACTAM SYNTHESIS 审中-公开
标题翻译： ß-LACTAM合成
公开(公告)号：WO2006135670A3
公开(公告)日：2007-04-19
申请号：PCT/US2006022267
申请日：2006-06-08
申请人： UNIV FLORIDA STATE RES FOUND , VU PHONG , HOLTON ROBERT A
发明人： VU PHONG , HOLTON ROBERT A
IPC分类号： C07D205/08
CPC分类号： C07F7/1892 , C07D205/08
摘要： The present invention is directed to a process for the preparation of ß-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the Beta-lactam product in a "one pot" synthesis, this process is generally performed at a higher temperature than conventional processes.
摘要翻译：本发明涉及制备β-内酰胺的方法。通常，亚胺与乙烯酮缩醛或烯醇化物环化缩合以在“一锅”合成中形成β-内酰胺产物，该方法通常在比常规方法更高的温度下进行。

33. 发明申请

WO2006135669A3 RESOLUTION OF ENANTIOMERIC MIXTURES OF ß-LACTAMS 审中-公开
标题翻译： ß-LACTAMS的合成混合物的分解
公开(公告)号：WO2006135669A3
公开(公告)日：2007-04-19
申请号：PCT/US2006022266
申请日：2006-06-08
申请人： UNIV FLORIDA STATE RES FOUND , VU PHONG , HOLTON ROBERT A
发明人： VU PHONG , HOLTON ROBERT A
IPC分类号： C07D205/08 , C07D403/12
CPC分类号： C07D405/04 , C07D205/08 , C07D403/12 , C07D405/14
摘要： A new process for resolution of an enantiomeric mixture of C3-hydroxyl substituted Beta-lactams is disclosed. Generally, the enantiomeric mixture is treated with an optically active proline acylating agent to form a C3-ester substituted Beta-lactam diastereomer or a mixture of C3-ester substituted Beta-lactam diastereomers followed by selective recovery of the unreacted enantiomer or of one of the diastereomers.
摘要翻译：公开了一种用于拆分C3-羟基取代的β-内酰胺的对映体混合物的新方法。通常，用光学活性脯氨酰化剂处理对映异构体混合物以形成C3-酯取代的β-内酰胺非对映体或C3-酯取代的β-内酰胺非对映异构体的混合物，然后选择性回收未反应的对映异构体或其中一种非对映体。

34. 发明申请

WO2006135655A3 PROCESSES FOR THE PRODUCTION OF POLYCYCLIC FUSED RING COMPOUNDS 审中-公开
标题翻译：用于生产多环熔融化合物的方法
公开(公告)号：WO2006135655A3
公开(公告)日：2007-02-15
申请号：PCT/US2006022213
申请日：2006-06-08
申请人： UNIV FLORIDA STATE RES FOUND , VU PHONG , HOLTON ROBERT A
发明人： VU PHONG , HOLTON ROBERT A
IPC分类号： C07F7/18
CPC分类号： C07D305/14 , C07F7/0841 , C07F7/0874 , Y02P20/55
摘要： The present invention provides processes for the production of polycyclic fused ring compounds of formula. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Novel polycyclic fused ring compounds and intermediate compounds are also described. Formula (I).
摘要翻译：本发明提供了制备式的多环稠环化合物的方法。多环稠环化合物通过用桥连硅基保护基保护多环稠环多元醇并连接合适的侧链来制备。还描述了新的多环稠环化合物和中间体化合物。式（I）。

35. 发明申请

WO2004036011A2 BIOMOLECULAR-BASED ACTUATOR 审中-公开
标题翻译：基于生物分子的执行器
公开(公告)号：WO2004036011A2
公开(公告)日：2004-04-29
申请号：PCT/US0332974
申请日：2003-10-17
申请人： UNIV FLORIDA STATE
发明人： CHASE BRYANT P , HONG SEUNGHUN , MOERLAND TIMOTHY S , VON MOLNAR STEPHAN , XIONG PENG
IPC分类号： C07K14/00 , C07K17/14 , F02B20060101 , F03H1/00 , G01N33/53 , H02N11/00 , F02B
CPC分类号： H02N11/006 , B82Y5/00 , B82Y15/00 , B82Y30/00
摘要： This invention relates to actuators having biologically-based components, and methods of making and using the same. The actuator of the invention has a movable member that moves substantially linearly as a result of a biomolecular interaction of biologically-based components within the actuator. These actuators can be utilized in nanoscale mechanical devices to, e.g., pump fluids, open and close valves, and provide translational movement.
摘要翻译：本发明涉及具有基于生物学的部件的致动器及其制造和使用方法。本发明的致动器具有可移动构件，其作为致动器内基于生物基的组分的生物分子相互作用的结果基本上线性地移动。这些致动器可以用于纳米尺度的机械装置，例如泵流体，打开和关闭阀，并提供平移运动。

36. 发明申请

WO02085500A8 METHOD OF PREPARING FREE POLYELECTROLYTE MEMBRANES 审中-公开
标题翻译：制备游离多聚电解质膜的方法
公开(公告)号：WO02085500A8
公开(公告)日：2002-12-12
申请号：PCT/US0211917
申请日：2002-04-16
申请人： UNIV FLORIDA STATE RES FOUND , SCHLENOFF JOSEPH B , DUBAS STEPHAN T
发明人： SCHLENOFF JOSEPH B , DUBAS STEPHAN T
IPC分类号： B01D69/12 , B01D71/80 , C08J5/22 , B01D13/04 , B01D67/00
CPC分类号： C08J5/2275 , B01D69/12 , B01D69/122 , B01D71/80 , C08J2325/04
摘要： A releaseable membrane structure for producing a free membrane containing a substrate, a release stratum on the substrate and a membrane stratum on the release stratum. The release stratum and the membrane stratum contain oppositely-charged polyelectrolytes that are associated. The oppositely-charged polyelectrolytes of the release stratum are selected to dissociate upon application of stimulus whereas those of the membrane stratum are selected to remain associated upon application of the stimulus. Thus, when the stimulus is applied the polyelectrolytes in release stratum dissociate and the membrane stratum is released from the substrate and is a free membrane.
摘要翻译：一种用于生产游离膜的可释放膜结构，所述游离膜包含基底，基底上的释放层和释放层上的膜层。释放层和膜层含有相关的带相反电荷的聚电解质。选择释放层的相反电荷的聚电解质以在施加刺激时解离，而选择膜层的那些以在施加刺激时保持缔合。因此，当施加刺激时，释放层中的聚电解质解离并且膜层从基底释放并且是游离膜。

37. 发明申请

WO0129245A8 ENZYMATIC PROCESS FOR THE RESOLUTION OF ENANTIOMERIC MIXTURES OF beta -LACTAMS 审中-公开
标题翻译：酶解法测定β-内酰胺类对映体混合物的分解
公开(公告)号：WO0129245A8
公开(公告)日：2001-10-04
申请号：PCT/US0041204
申请日：2000-10-17
申请人： UNIV FLORIDA STATE
发明人： HOLTON ROBERT A , VU PHONG
IPC分类号： C07D205/08 , C07D401/04 , C07D405/04 , C07D409/04 , C12P17/02 , C12P17/10 , C12P17/16 , C12P41/00
CPC分类号： C07D401/04 , C07B2200/07 , C07D205/08 , C07D405/04 , C07D409/04 , C12P17/16 , C12P41/001
摘要： A process for the resolution of an enantiomeric mixture of beta -lactams containing an ester, the process comprising selectively hydrolyzing the ester of one of the enantiomers by combining the mixture with homogenized liver.
摘要翻译：一种拆分含有酯的β-内酰胺的对映体混合物的方法，所述方法包括通过将所述混合物与均化的肝组合来选择性水解所述对映体之一的酯。

38. 发明申请

WO0125421B1 MATERIALS AND METHOD FOR DETECTING INTERACTION OF CFTR POLYPEPTIDES 审中-公开
标题翻译：用于检测CFTR多肽相互作用的材料和方法
公开(公告)号：WO0125421B1
公开(公告)日：2001-09-27
申请号：PCT/US0027900
申请日：2000-10-06
申请人： UNIV FLORIDA STATE RES FOUND , TEEM JOHN L
发明人： TEEM JOHN L
IPC分类号： C07K14/47 , C12N1/19 , C12N15/10 , C12N15/12 , C12Q1/68 , C12N15/62 , C12N15/81
CPC分类号： G01N33/564 , C07K14/4712 , C07K2319/00 , C12N15/1055 , C12Q1/6895 , C12Q1/6897 , C12Q2565/201
摘要： The subject invention concerns materials and methods for detecting the interaction of CFTR proteins. In one embodiment, the method can be used to determine whether one CFTR polypeptide interacts with a second CFTR polypeptide. The subject invention also concerns materials and methods for screening for drugs or compositions that can restore or enhance interaction of CFTR proteins containing mutation(s) that reduce or prevent dimerization of the proteins. The assay of the present invention can be used to screen a large number of compounds in a high throughput format. The subject invention also pertains to host cells useful in the methods of the invention. The subject invention also concerns compositions and methods for treating patients afflicted with cystic fibrosis.
摘要翻译：本发明涉及检测CFTR蛋白质相互作用的材料和方法。在一个实施方案中，该方法可用于确定一种CFTR多肽是否与第二种CFTR多肽相互作用。本发明还涉及用于筛选药物或组合物的材料和方法，所述药物或组合物可以恢复或增强含有减少或防止蛋白质二聚化的突变的CFTR蛋白质的相互作用。本发明的测定法可用于以高通量形式筛选大量化合物。本发明还涉及可用于本发明方法的宿主细胞。本发明还涉及用于治疗患有囊性纤维化的患者的组合物和方法。

39. 发明申请

WO9703548A2 METHOD AND APPARATUS FOR BROADBAND DECOUPLING IN NUCLEAR MAGNETIC RESONANCE WITH CHIRP PULSES 审中-公开
标题翻译：用于芯片磁共振的宽带解码方法与装置
公开(公告)号：WO9703548A2
公开(公告)日：1997-02-06
申请号：PCT/US9611731
申请日：1996-07-15
申请人： UNIV FLORIDA STATE
发明人： FU RIQIANG , BODENHAUSEN GEOFFREY
IPC分类号： G01R33/46
CPC分类号： G01R33/4616
摘要： Methods and apparatus for broadband decoupling in nuclear magnetic resonance with chirp and other RF pulses are disclosed. Such methods may include the step of positioning the sample in a static magnetic field. Additional steps may define a first cycle of pulses, such as chirp pulses, wherein at least two of the pulses have a different initial phase angle from each other and may define a second cycle of pulses wherein at least two of the pulses in the second cycle have an initial phase angle different from the initial phase angles of the pulses in the first cycle. Further steps may repeatedly generate a supercycle of the first and second cycles to produce pulses for inverting the longitudinal magnetization in the sample and may also detect the signals emitted by the sample in response to inversion of the longitudinal magnetization. Alternatively, the chirp pulses in the first and second cycles may be defined to sweep a bandwidth of 100 kHz or more. The first and second cycles may also be defined to include linear frequency modulated RF pulses wherein each of the RF pulses has an amplitude which is substantially constant during at least about 50 % of the pulses. Apparatus for performing the disclosed methods is also disclosed. Other methods and apparatus are also disclosed.
摘要翻译：公开了用于啁啾和其他RF脉冲的核磁共振中宽带解耦的方法和装置。这样的方法可以包括将样品定位在静态磁场中的步骤。附加步骤可以定义脉冲的第一周期，例如啁啾脉冲，其中至少两个脉冲具有彼此不同的初始相位角，并且可以限定第二周期的脉冲，其中第二周期中的至少两个脉冲具有与第一周期中的脉冲的初始相位角不同的初始相位角。进一步的步骤可以重复地产生第一和第二循环的超级循环，以产生用于反转样品中的纵向磁化强度的脉冲，并且还可以响应于纵向磁化的反转来检测由样品发射的信号。或者，第一和第二周期中的啁啾脉冲可以被定义为扫描100kHz或更大的带宽。第一和第二周期也可以被定义为包括线性调频RF脉冲，其中每个RF脉冲具有在脉冲的至少约50％期间基本上恒定的幅度。还公开了用于执行所公开方法的装置。还公开了其它方法和装置。

40. 发明申请

WO2015059638A3 CNS STIMULANT AND OPIOID RECEPTOR ANTAGONIST COMBINATION AS A NON- ADDICTIVE, NON-AVERSIVE AND SYNERGISTIC ANTI-OBESITY TREATMENT 审中-公开
标题翻译： CNS刺激剂和阿片类药物受体拮抗剂联合治疗作为非上瘾性，非恶性和协同性抗肥胖症治疗
公开(公告)号：WO2015059638A3
公开(公告)日：2015-08-06
申请号：PCT/IB2014065510
申请日：2014-10-21
申请人： UNIV FLORIDA STATE RES FOUND , GEN HOSPITAL CORP
发明人： BHIDE PRADEEP G , ZHU JINMIN , BIEDERMAN JOSEPH , SPENCER THOMAS J
IPC分类号： A61K31/44 , A61K31/40 , A61P3/00 , A61P3/04
CPC分类号： A61K31/485 , A61K31/4458
摘要： Combinations comprise a therapeutically effective amount of one or more stimulants and and/or pharmaceutically acceptable analogs, salts, or hydrates of the one or more stimulants, and one or more non-selective opioid receptor antagonists, and/or pharmaceutically acceptable analogs, salts or hydrates of the one or more non-selective opioid receptor antagonists. These combinations may be used for treating obesity via administration to a subject having a need thereof.
摘要翻译：组合包含治疗有效量的一种或多种兴奋剂和/或药学上可接受的类似物，盐或水合物和一种或多种非选择性阿片受体拮抗剂，和/ 一种或多种非选择性阿片受体拮抗剂的水合物。这些组合可以用于通过向需要治疗的受试者施用来治疗肥胖症。

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