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31. 发明申请

WO2002066453A1 PROCESS FOR THE PREPARATION OF CITALOPRAM 审中-公开
标题翻译：制备CITALOPRAM的方法
公开(公告)号：WO2002066453A1
公开(公告)日：2002-08-29
申请号：PCT/IN2002/000023
申请日：2002-02-11
申请人： NATCO PHARMA LIMITED , PULLA, Reddy, Muddasani , VENKAIAH, Chowdary, Nannapaneni
发明人： PULLA, Reddy, Muddasani , VENKAIAH, Chowdary, Nannapaneni
IPC分类号： C07D307/87
CPC分类号： C07D307/87
摘要： This invention discloses an improved process for the preparation of citalopram of the formula III which comprises (i) preparing the compound of the formula VIII by reducing an unisolable magnesium salt of a benzophenone derivative of the formula V using sodium borohydride in the presence of a protic solvent, (ii) reacting the compound of the formula VIII obtained in step (i) with an acid catalyst in a non-polar solvent to obtain a compound of the formula I, (iii) reacting the compound of the formula I obtained in step (ii) with copper (I) cyanide in a polar solvent medium and isolating the resulting cyano compound, by recrystallization by using polar and/or alcoholic solvents to obtain the compound of the formula II and (III) reacting the resulting compound of the formula II by conventional methods to form citalopram of the formula III. Citalopram is widely used as an antidepressant.
摘要翻译：本发明公开了一种制备式III西酞普兰的改进方法，其包括（i）通过在质子存在下使用硼氢化钠还原式V的二苯甲酮衍生物的单不溶性镁盐来制备式VIII化合物溶剂，（ⅱ）使步骤（ⅰ）中获得的式Ⅷ的化合物与酸催化剂在非极性溶剂中反应，得到式Ⅰ化合物，（ⅲ）使步骤（ii）在极性溶剂介质中加入氰化铜（I），并通过使用极性和/或醇溶剂重结晶分离得到的氰基化合物，得到式II和（III）的化合物，使所得式 II通过常规方法形成式III的西酞普兰。西酞普兰被广泛用作抗抑郁药。

32. 发明申请

WO2023062649A1 AN IMPROVED PROCESS FOR THE PREPARATION OF ANHYDROUS CRYSTALLINE FORM-I OF BOSCALID 审中-公开
公开(公告)号：WO2023062649A1
公开(公告)日：2023-04-20
申请号：PCT/IN2022/050910
申请日：2022-10-11
申请人： NATCO PHARMA LIMITED
发明人： BOLLEPALLI, Nageswara Rao , SANAKA, Ganapathi , JAMPANI, Amarnath , ARUDRA, Veeraiah , SAMATHAM, Radha Rani , RAVI, Janaki Rama Rao , KONAKANCHI, Durga Prasad , MUDDASANI, Pulla Reddy , NANNAPANENI, Venkaiah Chowdary
IPC分类号： C07D213/82
摘要： The present invention relates to an improved process for the preparation of anhydrous crystalline Form-I of Boscalid.

33. 发明申请

WO2023286078A1 AN IMPROVED PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF BALOXAVIR MORBOXIL 审中-公开
公开(公告)号：WO2023286078A1
公开(公告)日：2023-01-19
申请号：PCT/IN2022/050629
申请日：2022-07-11
申请人： NATCO PHARMA LIMITED
发明人： TALASANI, Shyam Sunder Reddy , BUDIDETI, Shankar Reddy , KOTTE, Rajashekar , SATTI, Venkata Reddy , MALA, Nagendra , MUDDASANI, Pulla Reddy , NANNAPANENI, Venkaiah Chowdary
IPC分类号： C07C51/363 , A61P31/16
摘要： The present invention provides an improved process for the preparation of (12aR)-3,4,12,12a-tetrahydro-7-(phenylmethoxy)-1H-[1,4]oxazino[3,4-c] pyrido[2,1-f] [1,2,4]triazine-6,8-dione of Formula (I). Formula I which is a key intermediate in the synthesis of Baloxavir Morboxil of Formula (II).

34. 发明申请

WO2022258977A1 EGFR INHIBITOR FOR THE TREATMENT OF HEAD AND NECK CANCER 审中-公开
公开(公告)号：WO2022258977A1
公开(公告)日：2022-12-15
申请号：PCT/GB2022/051450
申请日：2022-06-09
申请人： NATCO PHARMA LIMITED , SRINIVASAN, Ravi Chandran
发明人： YADLA, Sheshu Babu , MYNENI, Praveen Chowdary , GOGULA, Venkata Ramana , NANNAPANENI, Venkaiah Chowdary
IPC分类号： A61K31/337 , A61K31/5377 , A61K31/555 , A61K33/243 , A61P35/00
摘要： The invention relates to the treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck (preferably recurrent squamous cell carcinoma of the head and neck) with a compound which is (3-ethynyl-phenyl)-[7-methoxy-6-(3- morpholin-4-yl-propoxy)-quinazolin-4-yl]-amine (NRC-2694) or a pharmaceutically acceptable salt thereof. The invention also relates to the treatment of head and neck cancer with a compound which is (3-ethynyl-phenyl)-[7-methoxy-6-(3-morpholin-4-yl- propoxy)-quinazolin-4-yl]-amine (NRC-2694) or a pharmaceutically acceptable salt thereof, wherein the treating the head and neck cancer comprises reducing the size of one or more tumours associated with the head and neck cancer.

35. 发明申请

WO2020058987A1 AN IMPROVED PROCESS FOR THE PREPARATION OF SUGAMMADEX SODIUM AND ITS NOVEL POLYMORPHIC FORM 审中-公开
公开(公告)号：WO2020058987A1
公开(公告)日：2020-03-26
申请号：PCT/IN2019/050681
申请日：2019-09-18
申请人： NATCO PHARMA LIMITED
发明人： PRABHAKAR, Vanga , SAIDULU, Baddula , RAJASHEKAR, Kotte , RAJASEKHARA REDDY, Peddi , NAGA VASANTA SRINIVASU, Vuppalapati , SRINIVASA KRISHNA MURTHY, Konduri , SHANKAR REDDY, Budideti , PULLA REDDY, Muddasani , VENKAIAH CHOWDARY, Nannapaneni
IPC分类号： A61K31/724 , C08B37/00 , C08B37/16
摘要： The present invention provides an improved process for the preparation of Sugammadex sodium of formula (I) having more than 98.5% purity along with less than 1.0% monohydroxy Sugammadex sodium and less than 0.15% any other known or unknown impurities by HPLC.

36. 发明申请

WO2019155486A1 PROCESS FOR THE PREPARATION OF SORAFENIB TOSYLATE POLYMORPH III 审中-公开
公开(公告)号：WO2019155486A1
公开(公告)日：2019-08-15
申请号：PCT/IN2019/050084
申请日：2019-02-05
申请人： NATCO PHARMA LIMITED
发明人： PULLA REDDY, Muddasani , SHANKAR REDDY, Budideti , SAMBASIVA RAO, Talasila , SRINIVASACHARY, Chintalapati , TIRUPATHI, Kotte , SAHU, Arabinda , VENKAIAH CHOWDARY, Nannapaneni
IPC分类号： C07D213/81
摘要： The present invention relates to a process for the preparation of sorafenib tosylate form III from sorafenib base through sorafenib tosylate methanol solvate. The present invention relates to an improved process for the preparation of Sorafenib tosylate form III with high purity and high yield. The present process controls the genotoxic impurities content in final API.

37. 发明申请

WO2019102490A1 INTERMEDIATES FOR THE PREPARATION OF ERIBULIN THEREOF 审中-公开
公开(公告)号：WO2019102490A1
公开(公告)日：2019-05-31
申请号：PCT/IN2018/050765
申请日：2018-11-20
申请人： NATCO PHARMA LIMITED
发明人： VIPPARLA, Bulli Babi , NAGAPURI, Sreenivas , KANDULA, Sathaiah , RAVI, Janaki Rama Rao , KONAKANCHI, Durga Prasad , MUDDASANI, Pulla Reddy , NANNAPANENI, Venkaiah Chowdary
IPC分类号： C07D519/00
CPC分类号： C07D307/20
摘要： The present invention relates to novel intermediates of Eribulin and process for the preparation of the same. The process of the present invention is commercially viable and can be easily adopted for plant scale operations. The present invention relates to tetrahydrofuran compounds of formula I, X, XI, D and B.

38. 发明申请

WO2018229784A1 PHARMACEUTICAL COMPOSITIONS OF DABIGATRAN 审中-公开
公开(公告)号：WO2018229784A1
公开(公告)日：2018-12-20
申请号：PCT/IN2017/050315
申请日：2017-07-31
申请人： NATCO PHARMA LIMITED
发明人： KURRA, Venkateswara Rao , BHAVANASI, Krishna Murthy , BHAT, Pavan , NANNAPANENI, Venkaiah Chowdary
IPC分类号： A61K9/16 , A61K9/60 , A61K31/00 , C07D401/12
摘要： The invention relates to oral pharmaceutical compositions of dabigatran or a pharmaceutically acceptable salts thereof and process for the preparation of such compositions.

39. 发明申请

WO2018178997A1 NOVEL CRYSTALLINE FORM OF TICAGRELOR 审中-公开
公开(公告)号：WO2018178997A1
公开(公告)日：2018-10-04
申请号：PCT/IN2017/050244
申请日：2017-06-19
申请人： NATCO PHARMA LIMITED
发明人： MUDDASANI, Pulla Reddy , BUDIDETI, Shankar Reddy , KONDURI, Srinivasa Krishna murthhy , HANUMARA, Satya Srinivas , KOKKU, Santhosh Kumar , BANDLA, Venkateswarlu , POTHABATHULA, Govinda Raju , ADIBHATLA, Kali Satya Bhujanga Rao , NANNAPANENI, Venkaiah Chowdary
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel crystalline form, Form N of Ticagrelor and process for preparation of the same.

40. 发明申请

WO2017221261A1 PROCESS FOR THE PREPARATION OF POMALIDOMIDE AND ITS PURIFICATION 审中-公开
标题翻译：制备恶丁胺及其纯化方法
公开(公告)号：WO2017221261A1
公开(公告)日：2017-12-28
申请号：PCT/IN2016/050278
申请日：2016-08-22
申请人： NATCO PHARMA LIMITED
发明人： KONAKANCHI, Durga Prasad , GONGALLA, Buchappa , RAGIDI, Dharmendher , KOTRA, Uma Naresh Babu , ADIBHATLA, Kali Satya Bhujanga Rao , NANNAPANENI, Venkaiah Chowdary
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： The present invention is related to an improved process for the preparation of Pomalidomide with higher yields and high purity. Particularly the present invention relates to form A preparation of Pomalidomide and its purification. wherein the present process doesn't involve use of dioxane solvent and avoids higher temperatures.
摘要翻译：本发明涉及用于制备具有更高产率和高纯度的泊马度胺的改进方法。具体地说，本发明涉及Pomalidomide的A型制剂及其纯化。其中本发明方法不涉及使用二恶烷溶剂并避免较高温度。

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