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31. 发明申请

WO2009106553A3 LIPOLYTIC ENZYME VARIANT WITH IMPROVED STABILITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有改进的稳定性和多核苷酸的脂肪酶变异
公开(公告)号：WO2009106553A3
公开(公告)日：2009-12-10
申请号：PCT/EP2009052247
申请日：2009-02-26
申请人： NOVOZYMES AS
发明人： VIND JESPER , BORCH KIM , SVENDSEN ALLAN , VAN DER LANS ROBERT , MIKKELSEN LISE MUNCH , JOERGENSEN CHRISTIAN ISAK , PATKAR SHAMKANT ANANT
IPC分类号： C12N9/20 , C11D3/386
CPC分类号： C11D3/38627 , C12N9/20 , C12N15/00
摘要： The invention provides lipolytic enzyme variants having improved in-detergent stability and polynucleotides encoding same. Lipolytic enzyme variants with improved in-detergent stability are obtained by substituting certain specified amino acid residues in a parent lipolytic enzyme.
摘要翻译：本发明提供具有改进的洗涤剂稳定性的脂肪分解酶变体和编码它的多核苷酸。通过用母体脂肪分解酶中的某些特定的氨基酸残基取代具有改善的洗涤剂稳定性的脂肪分解酶变体。

32. 发明申请

WO2016164583A3 METHODS FOR SELECTING ENZYMES HAVING ENHANCED ACTIVITY 审中-公开
标题翻译：选择具有增强活性的酶的方法
公开(公告)号：WO2016164583A3
公开(公告)日：2016-11-17
申请号：PCT/US2016026441
申请日：2016-04-07
申请人： NOVOZYMES AS , BLAZEJ ROBERT
发明人： BLAZEJ ROBERT , TORIELLO NICHOLAS , EMRICH CHARLES , SVENDSEN ALLAN
IPC分类号： C12Q1/25 , C12Q1/68
CPC分类号： C12Q1/25
摘要： Provided herein are methods and means for enhancing enzymatic activity. The system makes use of an emulsion for in vitro compartmentalization of a library of synthetic compounds which have a gene and a marked enzymatic substrate both directly linked to a solid phase. Expressed enzymes with greater activity will preferentially release the selectable marker from the solid phase, whereas enzymes with less activity will leave the markers intact. Removal of the marked compounds provides an enriched gene library encoding for more active variants. Also described are synthetic compounds and emulsions which can be used in the methods.
摘要翻译：本文提供了用于增强酶活性的方法和手段。该系统利用乳剂用于体外区分合成化合物文库，该合成化合物具有直接与固相连接的基因和明显的酶底物。具有较高活性的表达酶将优先从固相释放选择标记，而活性较低的酶将使标记保持完整。去除标记的化合物提供了编码更多活性变体的富集基因文库。还描述了可用于该方法中的合成化合物和乳液。

33. 发明申请

WO0060058A3 POLYPEPTIDES HAVING ALKALINE ALPHA-AMYLASE ACTIVITY AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：具有碱性ALPHA-酰胺酶活性的多肽和编码其的核酸
公开(公告)号：WO0060058A3
公开(公告)日：2001-04-12
申请号：PCT/DK0000147
申请日：2000-03-28
申请人： NOVOZYMES AS
发明人： OUTTRUP HELLE , HOECK LISBETH HEDEGAARD , NIELSEN BJARNE ROENFELDT , BORCHERT TORBEN VEDEL , NIELSEN VIBEKE SKOVGAARD , BISGAARD-FRANTZEN HENRIK , SVENDSEN ALLAN , ANDERSEN CARSTEN
IPC分类号： D06L1/12 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/28 , C12N15/09 , C12P7/06 , C12P19/14
CPC分类号： C12N9/2417 , C11D3/386 , Y02E50/17
摘要： The present invention relates to isolated polypeptides having alpha -amylase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有α-淀粉酶活性的分离的多肽和分离的编码多肽的核酸序列。本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及产生和使用多肽的方法。

34. 发明申请

WO2015181119A2 LIPASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：脂肪变体和编码其的多核苷酸
公开(公告)号：WO2015181119A2
公开(公告)日：2015-12-03
申请号：PCT/EP2015061509
申请日：2015-05-26
申请人： NOVOZYMES AS
发明人： BALUMURI PADMAVATHI , SAIKIA RAKHI , SVENDSEN ALLAN , BAUNSGAARD LONE
IPC分类号： C12P7/64
CPC分类号： C12N9/20 , C12P7/6418 , C12Y301/01003
摘要： The present invention relates to a lipase variant of a parent lipase, which variant has lipase activity, at least 75% but less than 100% sequence identity to SEQ ID NO: 3 and comprises a substitution at one or more positions corresponding to positions 1; 2; 3; 4; 5; 6; 7; 9; 10; 11; 12; 16; 19; 30; 31; 34; 36; 37; 39; 40; 42; 44; 51; 52; 53; 54; 56; 58; 59; 70; 71; 72; 73; 83; 84; 86; 88; 90; 92; 93; 95; 96; 100; 101; 102; 104; 106; 109; 110; 112; 117; 119; 124; 125; 127; 128; 131; 132; 133; 134; 135; 137; 158; 159; 160; 161; 162; 163; 165; 166; 167; 168; 170; 181; 182; 183; 189; 190; 192; 194; 196; 202; 210; 211; 212; 220; 225; 227; 228; 229; 230; 231; 233; 237; 238; 239; 240; 242; 246; 247; 248; 252; 259; 262; 264; 269 of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
摘要翻译：本发明涉及母体脂肪酶的脂肪酶变体，该变体具有脂肪酶活性，与SEQ ID NO：3具有至少75％但小于100％的序列同一性，并且包含在对应于位置1的一个或多个位置的取代; 2; 3; 4; 5; 6; 7; 9; 10; 11; 12; 16; 19; 30; 31; 34; 36; 37; 39; 40; 42; 44; 51; 52; 53; 54; 56; 58; 59; 70; 71; 72; 73; 83; 84; 86; 88; 90; 92; 93; 95; 96; 100; 101; 102; 104; 106; 109; 110; 112; 117; 119; 124; 125; 127; 128; 131; 132; 133; 134; 135; 137; 158; 159; 160; 161; 162; 163; 165; 166; 167; 168; 170; 181; 182; 183; 189; 190; 192; 194; 196; 202; 210; 211; 212; 220; 225; 227; 228; 229; 230; 231; 233; 237; 238; 239; 240; 242; 246; 247; 248; 252; 259; 262; 264; 269。本发明还涉及编码变体的多核苷酸; 核酸构建体，载体和包含多核苷酸的宿主细胞; 以及使用这些变体的方法。

35. 发明申请

WO2006066596A2 HYBRID ENZYMES 审中-公开
标题翻译：混合酶
公开(公告)号：WO2006066596A2
公开(公告)日：2006-06-29
申请号：PCT/DK2005000819
申请日：2005-12-22
申请人： NOVOZYMES AS
发明人： SVENDSEN ALLAN , ANDERSEN CARSTEN , SPENDLER TINA , VIKSOE-NIELSEN ANDERS , OESTDAL HENRIK
IPC分类号： C07K19/00 , A21D8/04 , C12N9/28 , C12N15/56
CPC分类号： C12N9/2417 , A21D8/042 , Y02E50/17
摘要： The present invention relates to a polypeptide and the use thereof.
摘要翻译：本发明涉及多肽及其用途。

36. 发明申请

WO0188107A3 ALPHA-AMYLASE VARIANTS WITH ALTERED 1,6-ACTIVITY 审中-公开
标题翻译：具有改变的1,6活性的阿尔法 - 氨基酸变体
公开(公告)号：WO0188107A3
公开(公告)日：2002-06-27
申请号：PCT/DK0100323
申请日：2001-05-10
申请人： NOVOZYMES AS
发明人： SVENDSEN ALLAN , JOERGENSEN CHRISTEL THEA , NIELSEN BJARNE ROENFELDT
IPC分类号： C11D3/386 , C12N9/28 , C12N15/56
CPC分类号： C12Y302/01001 , C11D3/38681 , C12N9/2417
摘要： The present invention relates to variants of parent Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in the alpha-1,6-D-glucosidic branch linkage cleavage activity of amylopectin and limit dextrins.
摘要翻译：本发明涉及亲本类戊酰样α-淀粉酶的变体，该变体具有α-淀粉酶活性，并且表现出支链淀粉和极限糊精的α-1,6-D-糖苷分支链裂解活性的改变。

37. 发明申请

WO2009109500A1 POLYPEPTIDES HAVING LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 审中-公开
标题翻译：具有脂酶活性的多肽和编码其的多核苷酸
公开(公告)号：WO2009109500A1
公开(公告)日：2009-09-11
申请号：PCT/EP2009052246
申请日：2009-02-26
申请人： NOVOZYMES AS
发明人： VIND JESPER , KNOETZEL JUERGEN CARSTEN FRANZ , BORCH KIM , SVENDSEN ALLAN , CALLISEN THOMAS HOENGER , YAVER DEBBIE , BJOERNVAD MADS ESKELUND , HANSEN PETER KAMP
IPC分类号： C12N9/20 , C12N5/10 , C12N15/00
CPC分类号： C12N9/20
摘要： The invention provides polypeptides obtained by introducing mutations in one or more regions identified in a parent lipase. The polypeptides of the present invention have surprisingly been found to have a low specific activity towards short chain fatty acids leading to a reduced odor generation and an increased BR over the lipases known in the art.
摘要翻译：本发明提供通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的多肽。令人惊奇地发现本发明的多肽对短链脂肪酸具有低比活性，导致气味产生减少，并且在本领域已知的脂肪酶上增加BR。

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