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31. 发明申请

WO2011086135A1 ACYLATIONS IN MICRO REACTION SYSTEMS 审中-公开
标题翻译：微反应体系中的反应
公开(公告)号：WO2011086135A1
公开(公告)日：2011-07-21
申请号：PCT/EP2011/050412
申请日：2011-01-13
申请人： DSM IP Assets B.V. , BONRATH, Werner , KOSCHINSKI, Ingo , VAN OORDT, Thomas
发明人： BONRATH, Werner , KOSCHINSKI, Ingo , VAN OORDT, Thomas
IPC分类号： C07C67/08 , C07C69/145 , C07C69/14 , B01J19/00
CPC分类号： C07C67/08 , B01J19/0093 , B01J2219/0086 , B01J2219/00873 , B01J2219/00961 , B01J2219/00963 , B01J2219/00984 , C07D311/58 , C07C69/007 , C07C69/145 , C07C69/14
摘要： A method for acylating tertiary alcohols and phenolic compounds with carboxylic acids or their anhydrides in micro-reaction systems wherein the acylation is effected in the absence of any catalyst including water at residence times of at most 30 minutes.
摘要翻译：在微反应体系中用羧酸或其酸酐酰化叔醇和酚类化合物的方法，其中在不存在任何催化剂的情况下进行酰化，包括在最多30分钟的停留时间的水。

32. 发明申请

WO2008101603A2 NOVEL CATALYST AND RELATED HYDROGENATIONS 审中-公开
标题翻译：新型催化剂和相关氢化物
公开(公告)号：WO2008101603A2
公开(公告)日：2008-08-28
申请号：PCT/EP2008/000995
申请日：2008-02-09
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , GRASEMANN, Martin , RENKEN, Albert , SEMAGINA, Natalia , KIWI-MINSKER, Lioubov
发明人： BONRATH, Werner , GRASEMANN, Martin , RENKEN, Albert , SEMAGINA, Natalia , KIWI-MINSKER, Lioubov
CPC分类号： B01J23/60 , B01J23/44 , B01J23/6525 , B01J23/96 , B01J35/006 , B01J35/06 , B01J37/0226 , B01J37/0242 , B01J37/0244 , B01J37/036 , B01J37/18 , B01J38/52 , C07C29/17 , Y02P20/584 , C07C33/03 , C07C31/125
摘要： The invention relates to a structured catalyst based on sintered metal fibers (SMF) coated by a ZnO layer impregnated with Pd-nanoparticles, reactions of organic starting material with hydrogen in the presence of said catalyst and vitamins, carotinoids, perfume ingredients, and/or food or feed ingredients prepared by using this reaction.
摘要翻译：本发明涉及一种基于烧结金属纤维（SMF）的结构化催化剂，其由浸渍有Pd-纳米颗粒的ZnO层，有机原料与氢气在所述催化剂存在下的反应和维生素，类胡萝卜素，香料成分和/或通过使用该反应制备的食物或饲料成分。

33. 发明申请

WO2005121115A1 PROCESS FOR THE MANUFACTURE OF CHROMAN DERIVATIVES, ESPECIALLY α-TOCOPHEROL AND ALKANOATES THEREOF 审中-公开
标题翻译：制备色氨酸衍生物的方法，特别是α-氯代苯甲酸和其它烷基酯
公开(公告)号：WO2005121115A1
公开(公告)日：2005-12-22
申请号：PCT/EP2004/013771
申请日：2004-12-03
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , FORICHER, Yann , NETSCHER, Thomas , WILDERMANN, Angela
发明人： BONRATH, Werner , FORICHER, Yann , NETSCHER, Thomas , WILDERMANN, Angela
IPC分类号： C07D311/00
CPC分类号： C07D311/72
摘要： The present invention relates to novel processes for the manufacture of chroman derivatives such as α-tocopherol (TCP) and alkanoates thereof, especially α-tocopheryl acetate (TCPA), whereby at least one step of the processes is carried out in the presence of a Lewis acid or a mixture of a Lewis acid with a Bronsted acid as the catalyst under pressure, preferably at an absolute pressure of at least 1.1 bar. As starting materials for the manufacture of TCP and its alkanoates either a mixture of 2,3,5-trimethylhydroquinone (TMHQ) or 2,3,6-trimethylhydroquinone-l-alkanoate (TMHQA) and a compound selected from the group consisting of phytol (PH), isophytol (IP) and (iso)phytol derivatives or 2-phytyl-3,5,6-trimethyl-hydroquinone (PTMHQ)/3- phytyl-2,5,6-trimethylhydroquinone-1-alkanoate (PTMHQA) and/or an isomer thereof are used. Suitable Lewis acids are indium(III) salts and scandium(III) salts. Suitable acid mixtures are iron/iron(II) chloride/hydrogen chloride and zinc(II) chloride/hydrogen chloride.
摘要翻译：本发明涉及制造色氨酸衍生物如α-生育酚（TCP）及其链烷酸酯，特别是α-生育酚乙酸酯（TCPA）的新方法，其中至少一个步骤的方法是在路易斯酸或路易斯酸与布朗斯台德酸的混合物作为催化剂，优选在至少1.1巴的绝对压力下进行。作为制备TCP及其链烷酸酯的起始原料是2,3,5-三甲基氢醌（TMHQ）或2,3,6-三甲基氢醌-1-链烷酸酯（TMHQA）的混合物和选自植醇（PH），异植醇（IP）和（异）植醇衍生物或2-植酰基-3,5,6-三甲基 - 氢醌（PTMHQ）/ 3-植酰基-2,5,6-三甲基氢醌-1-链烷酸酯（PTMHQA）和/或其异构体。合适的路易斯酸是铟（III）盐和钪（III）盐。合适的酸混合物是氯化铁/氯化铁（II）/氯化氢和氯化锌（II）/氯化氢。

34. 发明申请

WO2005090356A1 1,3 DIHYDROFURO [3,4-c]PYRIDINES AND THEIR PREPARATION 审中-公开
标题翻译： 1,3二氢呋喃并[3,4-c]吡啶及其制备方法
公开(公告)号：WO2005090356A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/002359
申请日：2005-03-07
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , HELLER, Barbara
发明人： BONRATH, Werner , HELLER, Barbara
IPC分类号： C07D491/04
CPC分类号： C07D491/04
摘要： The present invention relates to novel 1,3-dihydrofuro[3,4-c]pyridines which are useful intermediates in the synthesis of pyridoxines and a method for their preparation by cobalt(I) complex-catalysed [2 + 2 + 2]-cycloaddition of di-[(3-dimethyl-C 1-4 -alkoxysilyl)2-propynyl)] ethers with acetonitrile.
摘要翻译：本发明涉及在合成吡哆醇中有用的中间体的新的1,3-二氢呋喃并[3,4-c]吡啶及其制备方法（I）配合物催化的[2 + 2 + 2] - 二 - [（3-二甲基-C 1-4 - 烷氧基甲硅烷基）-2-丙炔基）]醚与乙腈的环加成反应。

35. 发明申请

WO2005054223A2 PROCESS FOR THE MANUFACTURE OF ALKENYLATED HYDROXYLATED AROMATIC COMPOUNDS, OF CHROMAN COMPOUNDS AND OF THEIR ACYLATED DERIVATIVES 审中-公开
标题翻译：烷基化羟基化合物，化合物及其衍生物的制备方法
公开(公告)号：WO2005054223A2
公开(公告)日：2005-06-16
申请号：PCT/EP2004/013788
申请日：2004-12-03
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , FORICHER, Yann , NETSCHER, Thomas , WILDERMANN, Angela
发明人： BONRATH, Werner , FORICHER, Yann , NETSCHER, Thomas , WILDERMANN, Angela
IPC分类号： C07D311/00
CPC分类号： C07D311/72 , Y02P20/582
摘要： The present invention relates to a novel process for the manufacture of alkenylated aromatic compounds featuring at least one hydroxy group, their ring-closure reactions to chroman derivatives, as well as the acylation of the latter and the aromatic compounds featuring at least one hydroxy group themselves. The present invention relates especially to a process for the manufacture of tocol, tocopherols and their alkanoates such as α-tocopherol (TCP) and alkanoates (TCPA) thereof, preferably α-tocopheryl acetate (TCPAc). The processes of the present invention are characterized in that at least one step of the processes is carried out in the presence of an indium salt as the catalyst. Thus, an object of the present invention is the use of an indium salt as the catalyst in Friedel-Crafts alkylation reactions of aromatic compounds featuring at least one hydroxy group and ring-closure reactions of the latter to produce chroman-ring compounds in organic solvents. According to another aspect of the invention indium salts can be used as the catalyst in processes for the manufacture of tocyl alkanoates, tocopheryl alkanoates and alkanoates of aromatic compounds featuring at least one hydroxy group by reacting tocols, tocopherol and aromatic compounds featuring at least one hydroxy group, respectively, with an acylating agent. Suitable indium salts are indium(III) salts, especially indium trichloride, indium tribromide or indium triiodide, indium(III) triflate, indium(III) bis(trifluoromethanesulfonamide) and indium(III) acetate. In preferred embodiments of the invention the processes are carried out at a pressure of at least 0.96 bar, whereby the acylation can be carried out at an absolute pressure of at least 0.02 bar.
摘要翻译：本发明涉及一种制备具有至少一个羟基的烯基化芳族化合物的新方法，它们对苯并二氢吡喃衍生物的闭环反应以及后者的酰化反应和具有至少一个羟基的芳族化合物本身。本发明尤其涉及一种生产托生物，生育酚及其链烷酸酯如α-生育酚（TCP）和链烷酸酯（TCPA），优选醋酸α-生育酚酯（TCPAc）的方法。本发明的方法的特征在于，在作为催化剂的铟盐存在下进行至少一个步骤。因此，本发明的目的是在Friedel-Crafts烷基化反应中使用铟盐作为催化剂，其特征在于具有至少一个羟基和后者的闭环反应，在有机溶剂中产生苯并二氢吡喃酮化合物。根据本发明的另一方面，铟盐可以用作制备烷基链烷酸酯，生育酚基链烷酸酯和具有至少一个羟基的芳族化合物的链烷酸酯的方法，所述芳族化合物是通过使醇，生育酚和具有至少一个羟基分别与酰化剂。合适的铟盐是铟（III）盐，特别是三氯化铟，三溴化铟或三碘化铟，三氟甲磺酸铟（III），三氟甲磺酰胺铟（III）和乙酸铟（III））。在本发明的优选实施方案中，该方法在至少0.96巴的压力下进行，由此酰化可以在至少0.02巴的绝对压力下进行。

36. 发明申请

WO2005026181A2 A NEW ROUTE TO α-TOCOPHEROL, α-TOCOPHERYL ALKANOATES AND PRECURSORS THEREOF 审中-公开
标题翻译： α-生育酚，α-生育酚烷醇酸酯及其前体的新途径
公开(公告)号：WO2005026181A2
公开(公告)日：2005-03-24
申请号：PCT/EP2004/009748
申请日：2004-09-02
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , BREUNINGER, Manfred , MALAISE, Gregory , NETSCHER, Thomas
发明人： BONRATH, Werner , BREUNINGER, Manfred , MALAISE, Gregory , NETSCHER, Thomas
IPC分类号： C07F7/18
CPC分类号： C07D311/72 , C07C67/293 , C07C67/475 , C07C69/017 , C07C69/16
摘要： The present invention is concerned with a novel process for the manufacture of ( E/Z )-4-alkanoyloxy-3,5,6-trimethyl-2-phytylphenyI esters and silyl ethers, precursors of α- tocopherol and α-tocopheryl alkanoates, by cross-metathesis reaction of 2-alkenyl-3,5,6-trimethylhydroquinone dialkanoates or 4-alkanoyloxy-2-alkenyl-3,5,6-trimethylphenyI silylethers with 2,6,10,14-tetramethylpentadecene or a phytol derivative, e.g. phytyl acetate, in the presence of a cross-metathesis catalyst. As the cross-metathesis catalyst especially ruthenium metal carbene complexes are suitable which possess (a) ruthenium metal center(s), have an electron count of 16 or 18 and are penta- or hexa- coordinated. A further object of the invention is a process for the manufacture of α-tocopherol and α-tocopheryl alkanoates comprising this reaction.
摘要翻译：本发明涉及制备（E / Z）-4-烷酰氧基-3,5,6-三甲基-2-叶基苯基酯的新方法和甲硅烷基醚，α-生育酚和α-生育酚链烷酸酯的前体通过2-链烯基-3,5,6-三甲基氢醌二链烷酸酯或4-链烷酰氧基-2-链烯基-3,5,6-三甲基苯基甲硅烷基醚的交叉复分解反应与2,6,10,14-四甲基十五碳烯或叶绿醇衍生物植酸乙酯在交叉复分解催化剂存在下进行。由于交叉复分解催化剂尤其是钌金属卡宾络合物是合适的，其具有（a）钌金属中心，具有16或18的电子数并且是五或六配位的。本发明的另一个目的是制备包含该反应的α-生育酚和α-生育酚链烷酸酯的方法。

37. 发明申请

WO2005026142A2 A NEW ROUTE TO α- TOCOPHERYL ALKANOATES AND PERCURSORS THEROF 审中-公开
标题翻译：一种新的α-生育酚烷醇酸酯及其制备方法
公开(公告)号：WO2005026142A2
公开(公告)日：2005-03-24
申请号：PCT/EP2004/009749
申请日：2004-09-02
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , BREUNINGER, Manfred , MALAISE, Grègory , NETSCHER, Thomas
发明人： BONRATH, Werner , BREUNINGER, Manfred , MALAISE, Grègory , NETSCHER, Thomas
IPC分类号： C07D311/00
CPC分类号： C07C69/017 , C07C67/08 , C07C67/28 , C07C67/29 , C07C67/293 , C07C67/475 , C07C69/157 , C07D311/72 , C07C69/16 , C07C69/145 , C07C69/07 , C07C69/78 , C07C69/007
摘要： The present invention is concerned with a novel process for the manufacture of 4alkanoyloxy-2,3,5-trimethylphenyI (E/ Z )-phytyl ethers, precursors of α.-tocopheryl alkanoates, by cross-metathesis reaction of alkenyl ethers of 1-alkanoyloxy-2,3,6-trimethylhydroquinone with 2,6,10,14-tetramethylpentadecene or a phytol derivative, e.g. an ester, an ether or a silyl ether, in the presence of a cross-metathesis catalyst. As the crossmetathesis catalyst especially ruthenium metal carbene complexes are suitable which possess (a) ruthenium metal center(s), have an electron count of 16 or 18 and are penta- or hexa- coordinated. A further object of the invention is a process for the manufacture of αtocopheryl alkanoates comprising this reaction.
摘要翻译：本发明涉及制备α的前体4-烷酰氧基-2,3,5-三甲基苯基（E / Z） - 植基醚的新方法。 - 链烷酰氧基-2,3,6-三甲基对苯二酚的链烯基醚与2,6,10,14-四甲基十五碳烯或叶绿醇衍生物的交叉复分解反应，例如酯，醚或甲硅烷基醚，在交叉复分解催化剂存在下进行。由于交叉易位催化剂尤其是钌金属卡宾配合物是合适的，其具有（a）钌金属中心，具有16或18的电子数并且是五配位或六配位的。本发明的另一个目的是制备包含该反应的α-生育酚链烷酸酯的方法。

38. 发明申请

WO2004018400A1 ETHYNYLATION PROCESS 审中-公开
标题翻译：乙酰化方法
公开(公告)号：WO2004018400A1
公开(公告)日：2004-03-04
申请号：PCT/EP2003/008867
申请日：2003-08-09
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , SCHEER, Peter, L. , TSCHUMI, Johannes , ZENHAEUSERN, Reto
发明人： BONRATH, Werner , SCHEER, Peter, L. , TSCHUMI, Johannes , ZENHAEUSERN, Reto
IPC分类号： C07C29/42
CPC分类号： C07C29/42 , C07C33/042 , C07C33/048
摘要： A process for the manufacture of an acetylenically unsaturated alcohol comprising reacting formaldehyde, an aldehyde or a ketone (a carbonyl compound) with acetylene in the presence of ammonia and an alkali metal hydroxide, the molar ratio of the alkali metal hydroxide to the carbonyl compound being less than 1 : 200. The reaction products, which depending on the starting carbonyl compound are propargyl alcohol or 1-monosubstituted or 1,1-disubstituted derivatives thereof, are of use as intermediates in the synthesis of many useful end products, inter alia in the field of vitamins and carotenoids.
摘要翻译：一种制备炔属不饱和醇的方法，包括在氨和碱金属氢氧化物的存在下使甲醛，醛或酮（羰基化合物）与乙炔反应，碱金属氢氧化物与羰基化合物的摩尔比为小于1：200。取决于起始的羰基化合物的反应产物是炔丙醇或其1-取代或1,1-二取代的衍生物，可用作合成许多有用的最终产物的中间体，特别是在维生素和类胡萝卜素的领域。

39. 发明申请

WO2012175398A1 NEW INTERMEDIATES FOR THE VITAMIN A AND β-CAROTENE SYNTHESIS 审中-公开
标题翻译：维生素A和ß-卡诺合成的新中间体
公开(公告)号：WO2012175398A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061294
申请日：2012-06-14
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , NETSCHER, Thomas , SCHÜTZ, Jan , WÜSTENBERG, Bettina
发明人： BONRATH, Werner , NETSCHER, Thomas , SCHÜTZ, Jan , WÜSTENBERG, Bettina
IPC分类号： C07C403/12 , C07C403/16 , B01J27/185
CPC分类号： C07C403/12 , C07C403/08 , C07C403/16 , C07C403/24 , C07C2601/16 , C07F15/006
摘要： The present invention relates to compounds of formula (I) wherein R 1 signifies a C 1 -C 15 alkyl moiety or a C 2 to C 18 alkenyl moiety, to their process of production as well as to their use in organic synthesis, especially as intermediates (building blocks) in the synthesis of vitamin A or β-carotene or derivatives thereof, or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin, preferably vitamin A.
摘要翻译：本发明涉及其中R1表示C1-C15烷基部分或C2至C18烯基部分的式（I）化合物及其在有机合成中的用途，特别是作为中间体（构成单元）在维生素A或β-胡萝卜素或其衍生物或其他类胡萝卜素的合成中，例如，角黄素，虾青素或玉米黄质，优选维生素A.

40. 发明申请

WO2012175396A1 PROCESS FOR THE PRODUCTION OF 1,3,3-TRIMETHYL-2-(3-METHYLPENT-2-EN-4-YNYL)CYCLOHEX-1-ENE 审中-公开
标题翻译：制备1,3,3-三甲基-2-（3-甲基-2-烯-4-基）环己基-1-环己烯的方法
公开(公告)号：WO2012175396A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061280
申请日：2012-06-14
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , NETSCHER, Thomas , SCHÜTZ, Jan , WÜSTENBERG, Bettina
发明人： BONRATH, Werner , NETSCHER, Thomas , SCHÜTZ, Jan , WÜSTENBERG, Bettina
IPC分类号： C07C403/02
CPC分类号： C07C403/24 , C07C1/24 , C07C2/86 , C07C13/20 , C07C403/02 , C07C403/08 , C07C403/16 , C07C2601/16
摘要： The present invention relates to an improved process for the production of 1,3,3-trimethyl-2-(3-methylpent-2-en-4-ynyl)cyclohex-1-ene, highly enriched in the Z-isomer, and the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) the synthesis of vitamin A or β-carotene or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin.
摘要翻译：本发明涉及生产高度富含Z-异构体的1,3,3-三甲基-2-（3-甲基戊-2-烯-4-炔基）环己-1-烯的改进方法，以及这些化合物在有机合成中的用途，特别是在形成中间体（构成基团）的过程中维生素A或β-胡萝卜素或其他类胡萝卜素的合成，例如角黄素，虾青素或玉米黄质。

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