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31. 发明申请

WO2004050860A3 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2004050860A3
公开(公告)日：2004-06-17
申请号：PCT/US2003/040063
申请日：2003-12-04
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
IPC分类号： C12N15/12
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.

32. 发明申请

WO2004053081A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO PROSTATE SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，SPLICE变体和与前列腺特异性基因和蛋白相关的方法
公开(公告)号：WO2004053081A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038877
申请日：2003-12-08
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
IPC分类号： C12N
CPC分类号： C07K14/47
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic prostate cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating prostate cancer and non-cancerous disease states in prostate, identifying prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤前列腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗前列腺中的前列腺癌和非癌性疾病状态，鉴定前列腺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程前列腺组织的生产。

33. 发明申请

WO2005017102A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO OVARIAN SPECIFIC NUCLEIC ACIDS AND PROTEINS 审中-公开
标题翻译：与OVARIAN特异性核酸和蛋白质有关的组合物，群体变异和方法
公开(公告)号：WO2005017102A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/017156
申请日：2004-06-01
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
IPC分类号： C12N
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

34. 发明申请

WO2004089301A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组成物，裂解物变体和与结肠特异性基因和蛋白质有关的方法
公开(公告)号：WO2004089301A2
公开(公告)日：2004-10-21
申请号：PCT/US2004/010531
申请日：2004-04-02
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
IPC分类号： A61K
CPC分类号： C07K14/47 , A61K2039/53
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和瘤形成性结肠细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂的组合物和使用这些组合物的方法。这些用途包括鉴定，诊断，监测，分期，成像和治疗结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。这些用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化结肠组织的生产。

35. 发明申请

WO2004053077A2 COMPOSITIONS,SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，与乳腺特异性基因和蛋白相关的差异变异和方法
公开(公告)号：WO2004053077A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038815
申请日：2003-12-05
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , CHEN, Huei-Mei , RODRIGUEZ, Maria
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , CHEN, Huei-Mei , RODRIGUEZ, Maria
IPC分类号： C12N
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/47 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57415 , G01N2500/00
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

36. 发明申请

WO2004053079A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO OVARIAN SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与OVARIAN特异性基因和蛋白质相关的组合物，群体变异和方法
公开(公告)号：WO2004053079A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038855
申请日：2003-12-08
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Shu-Hui , CHEN, Huei-Mei
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , LIU, Shu-Hui , CHEN, Huei-Mei
IPC分类号： C12N
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

37. 发明申请

WO2004053075A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：组合物，与乳腺特异性基因和蛋白相关的差异变异和方法
公开(公告)号：WO2004053075A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038739
申请日：2003-12-05
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
IPC分类号： C12N
CPC分类号： C12Q1/6886 , A61K39/00 , A61K48/00 , C07K14/47 , C12Q2600/112 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

38. 发明申请

WO2004052290A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO BREAST SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与乳腺特异性基因和蛋白相关的组成，剪切变体和方法
公开(公告)号：WO2004052290A2
公开(公告)日：2004-06-24
申请号：PCT/US2003/038829
申请日：2003-12-05
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming
IPC分类号： A61K
CPC分类号： C07K14/47 , A61K38/00 , C07H21/04 , C12Q1/6886 , C12Q2600/112 , G01N33/57415
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和赘生性乳房细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂的组合物和使用这些组合物的方法。这些用途包括鉴定，诊断，监测，分期，成像和治疗乳房中的乳腺癌和非癌性疾病状态，鉴定乳房组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。这些用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化乳腺组织的生产。

39. 发明申请

WO2004050858A2 COMPOSITIONS, SPLICE VARIANTS AND METHODS RELATING TO COLON SPECIFIC GENES AND PROTEINS 审中-公开
公开(公告)号：WO2004050858A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/038808
申请日：2003-12-04
申请人： DIADEXUS, INC. , MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , RODRIGUEZ, Maria , BURCHAM, Timothy, S.
发明人： MACINA, Roberto, A. , TURNER, Leah, R. , SUN, Yongming , RODRIGUEZ, Maria , BURCHAM, Timothy, S.
IPC分类号： C12N
CPC分类号： C12Q1/6886 , A61K39/00 , C07K14/47 , C12Q2600/112
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.

40. 发明申请

WO2003020899A2 COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS 审中-公开
标题翻译：与肺特异性基因和蛋白质相关的组合物和方法
公开(公告)号：WO2003020899A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/027771
申请日：2002-08-29
申请人： DIADEXUS, INC. , SUN, Yongming , LIU, Chenghua , CHEN, Sei-Yu
发明人： SUN, Yongming , LIU, Chenghua , CHEN, Sei-Yu
IPC分类号： C12N
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention, also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性肺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括识别，诊断，监测，分期，成像和治疗肺中的肺癌和非癌性疾病状态，识别肺组织，监测和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程化肺组织的生产。

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