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31. 发明申请

WO2007042465A3 COMBINATI0N OF NILOTINIB WITH FARNESYL TRANSFERASE INHIBITORS 审中-公开
标题翻译： NILOTINIB与FARNESYL转移酶抑制剂的联合应用
公开(公告)号：WO2007042465A3
公开(公告)日：2007-10-11
申请号：PCT/EP2006067117
申请日：2006-10-05
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MANLEY PAUL W
发明人： MANLEY PAUL W
IPC分类号： A61K31/506 , A61P35/00 , A61P35/02
CPC分类号： A61K31/506 , A61K2300/00
摘要： The invention provides a pharmaceutical combination comprising: a) a pyrimidylaminobenzamide compound, and b) an farnesyl transferase kinase inhibitor and a method for treating or preventing a proliferative disease using such a combination.
摘要翻译：本发明提供药物组合，其包含：a）嘧啶基氨基苯甲酰胺化合物，和b）法呢基转移酶激酶抑制剂和使用这种组合治疗或预防增殖性疾病的方法。

32. 发明申请

WO2007111705A2 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2007111705A2
公开(公告)日：2007-10-04
申请号：PCT/US2006/060977
申请日：2006-11-16
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , PRASHAD, Mahavir , LIU, Yugang , HU, Bin , GIRGIS, Michael J. , SCHAEFER, Frank
发明人： PRASHAD, Mahavir , LIU, Yugang , HU, Bin , GIRGIS, Michael J. , SCHAEFER, Frank
CPC分类号： C07D211/26 , C07D213/26
摘要： The present invention relates to salts of aryl compounds as discussed below and to methods of manufacture thereof, as well as other subject matter. More particularly, the invention relates to salts useful as intermediates for the synthesis of the cinnamanilide of formula (Y): where R a is selected from H, OH, C 1 , C 2 , C 3 or C 4 alkyl; and R 1 is C 1 , C 2 , C 3 or C 4 alkyl.
摘要翻译：本发明涉及如下所述的芳基化合物的盐及其制备方法以及其它主题。更具体地说，本发明涉及可用作合成式（Y）的肉桂酰苯胺的中间体的盐：其中R a选自H，OH，C 1， C 2，C 3或C 4烷基; 且R 1是C 1，C 2，C 3或C 4，烷基。

33. 发明申请

WO2007109515A3 MUTATIONS AND POLYMORPHISMS OF KNOCKDOWN RESISTANCE POLYPEPTIDE 审中-公开
公开(公告)号：WO2007109515A3
公开(公告)日：2007-09-27
申请号：PCT/US2007/064115
申请日：2007-03-16
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , CULVER, Kenneth Wayne , ZHU, Jian , LILLEBERG, Stan
发明人： CULVER, Kenneth Wayne , ZHU, Jian , LILLEBERG, Stan
IPC分类号： C12Q1/68 , C07K14/71
摘要： This invention relates generally to the analytical testing of tissue samples in vitro, and more particularly to aspects of genetic polymorphisms and mutations of the KDR gene. The invention provides new KDR mutations and SNPs, useful in the diagnosis and treatment of subjects in need thereof. Accordingly, the various aspects of the present invention relate to polynucleotides encoding the KDR mutations of the invention, expression vectors encoding the KDR mutant polypeptides of the invention and organisms that express the KDR mutant and polymorphic polynucleotides and/or KDR mutant/polymorphic polypeptides of the invention. The various aspects of the present invention further relate to diagnostic/theranostic methods and kits that use the KDR mutations and polymorphisms of the invention to identify individuals predisposed to disease or to classify individuals with regard to drug responsiveness, side effects, or optimal drug dose.

34. 发明申请

WO2007098503A2 NEW SALT 审中-公开
标题翻译：新盐
公开(公告)号：WO2007098503A2
公开(公告)日：2007-08-30
申请号：PCT/US2007/062666
申请日：2007-02-23
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , FENG, Lili , KARPINSKI, Piotr , WU, Raeann
发明人： FENG, Lili , KARPINSKI, Piotr , WU, Raeann
CPC分类号： C07C237/22
摘要： The invention relates to a new salt of aliskiren, the respective production and usage, and pharmaceutical preparations containing such a salt.
摘要翻译：本发明涉及阿利吉仑的新盐，各自的生产和使用，以及含有这种盐的药物制剂。

35. 发明申请

WO2007095032A2 MUTATIONS AND POLYMORPHISMS OF PTK2B 审中-公开
标题翻译： PTK2B的突变和多态性
公开(公告)号：WO2007095032A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003280
申请日：2007-02-07
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , CULVER, Kenneth Wayne , ZHU, Jian , LILLEBERG, Stan
发明人： CULVER, Kenneth Wayne , ZHU, Jian , LILLEBERG, Stan
CPC分类号： C12Q1/6886 , C12N9/1205 , C12Q2600/106 , C12Q2600/172
摘要： This invention relates generally to the analytical testing of tissue samples in vitro, and more particularly to aspects of genetic polymorphisms and mutations of the PTK2B gene. The invention provides new PTK2B mutations and SNPs, useful in the diagnosis and treatment of subjects in need thereof. Accordingly, the various aspects of the present invention relate to polynucleotides encoding the PTK2B mutations of the invention, expression vectors encoding the PTK2B mutant polypeptides of the invention and organisms that express the PTK2B mutant and polymorphic polynucleotides and/or PTK2B mutant/polymorphic polypeptides of the invention. The various aspects of the present invention further relate to diagnostic/theranostic methods and kits that use the PTK2B mutations and polymorphisms of the invention to identify individuals predisposed to disease or to classify individuals with regard to drug responsiveness, side effects, or optimal drug dose.
摘要翻译：本发明一般涉及体外组织样品的分析检测，更具体地涉及PTK2B基因的遗传多态性和突变的方面。本发明提供了新的PTK2B突变和SNP，其可用于诊断和治疗有需要的受试者。因此，本发明的各个方面涉及编码本发明的PTK2B突变的多核苷酸，编码本发明的PTK2B突变体多肽的表达载体和表达PTK2B突变体的生物和表达PTK2B突变体的多态性多核苷酸和/或PTK2B突变体/多态性多肽发明。本发明的各个方面还涉及使用本发明的PTK2B突变和多态性的诊断/诊断方法和试剂盒来鉴定易患疾病的个体或针对药物反应性，副作用或最佳药物剂量对个体进行分类。

36. 发明申请

WO2007090872A2 SECRETED FRIZZLED RELATED PROTEIN-4 (SFRP-4) PROTEIN BINDING AGENTS 审中-公开
标题翻译：分泌的相关蛋白-4（SFRP-4）蛋白质结合剂
公开(公告)号：WO2007090872A2
公开(公告)日：2007-08-16
申请号：PCT/EP2007/051229
申请日：2007-02-08
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , ZAAR, Annette , HILLENBRAND, Rainer , VITALITI, Alessandra
发明人： ZAAR, Annette , HILLENBRAND, Rainer , VITALITI, Alessandra
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K2039/505
摘要： This invention relates generally to the preparation of SFRP-4-binding agents and uses of the same. In particular the present invention relates to the preparation of anti-SFRP-4 antibodies and their use for SFRP-4 detection and modulation of SFRP-4-mediated function. The compositions and methods of the invention can be employed in diverse tissues to detect disorders manifested by altered SFRP-4 polypeptide expression as well as to affect therapeutic and prophylactic relief for such SFRP-4 polypeptide-associated disorders in a subject in need thereof.
摘要翻译：本发明一般涉及SFRP-4-结合剂的制备及其用途。特别地，本发明涉及抗SFRP-4抗体的制备及其用于SFRP-4检测和调节SFRP-4介导的功能的用途。本发明的组合物和方法可用于多种组织中以检测由改变的SFRP-4多肽表达所表现的疾病，并且可影响有此需要的受试者中的这种SFRP-4多肽相关疾病的治疗和预防性缓解。

37. 发明申请

WO2007089697A3 POLISHING OF OPTICAL TOOLS (MASTER MOLDS) FOR MAKING MOLDS USED IN DOUBLE-SIDED MOLDING PROCESSES 审中-公开
公开(公告)号：WO2007089697A3
公开(公告)日：2007-08-09
申请号：PCT/US2007/002384
申请日：2007-01-30
申请人： NOVARTIS AG , NOVARTIS PHARMA GmbH , KENDIG, Stephen , HONEA, Dee Anna , GOLINSKI, James
发明人： KENDIG, Stephen , HONEA, Dee Anna , GOLINSKI, James
IPC分类号： B24B13/00 , B29D11/00 , B29C33/38
摘要： This invention is related to contact lenses. In particular, the present invention is related to methods for improving mold flow by polishing optical and non-optical tools used to create molds for contact lenses.

38. 发明申请

WO2007088019A1 USE OF NAPHTHYRIDINE DERIVATIVES AS MEDICAMENTS 审中-公开
标题翻译：作为药物使用萘啶衍生物
公开(公告)号：WO2007088019A1
公开(公告)日：2007-08-09
申请号：PCT/EP2007/000747
申请日：2007-01-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , McCARTHY, Clive , PRESS, Neil John
发明人： McCARTHY, Clive , PRESS, Neil John
IPC分类号： A61K31/4375 , A61P9/00 , A61P11/00
CPC分类号： A61K31/4375
摘要： Compounds of formula (I) in free or salt form for the preparation of a medicament for the treatment of pulmonary hypertension, where R 1 and R 2 have the meanings as indicated in the specification. Pharmaceutical compositions that contain the compounds are also described.
摘要翻译：游离或盐形式的式（I）化合物用于制备治疗肺动脉高压的药物，其中R 1和R 2具有如规格。还描述了含有这些化合物的药物组合物。

39. 发明申请

WO2007084344A2 COMPOSITIONS AND METHODS OF USE FOR ANTIBODIES OF DICKKOPF-1 审中-公开
标题翻译：用于DICKKOPF-1抗体的组合物和方法
公开(公告)号：WO2007084344A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/000777
申请日：2007-01-12
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , SHULOK, Janine , CONG, Feng , FISHMAN, Mark , ETTENBERG, Seth , BARDROFF, Michael , DONZEAU, Mariel , URLINGER, Stefanie
发明人： SHULOK, Janine , CONG, Feng , FISHMAN, Mark , ETTENBERG, Seth , BARDROFF, Michael , DONZEAU, Mariel , URLINGER, Stefanie
CPC分类号： C07K16/22 , A61K31/675 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Antibodies and fragments that bind to the protein target Dickkopf (DKK1) are provided, as are methods of use and kits, for treating a target cell, in particular, a cell associated with an osteolytic condition.
摘要翻译：提供与蛋白质靶标Dickkopf（DKK1）结合的抗体和片段，以及用于治疗靶细胞，特别是与溶骨性病症相关的细胞的使用方法和试剂盒。

40. 发明申请

WO2007082713A1 OLIGONUCLEOTIDE SYNTHESIS USING PHOTOCLEAVABLE LINKERS 审中-公开
标题翻译：使用光电连接器的寡核苷酸合成
公开(公告)号：WO2007082713A1
公开(公告)日：2007-07-26
申请号：PCT/EP2007/000337
申请日：2007-01-16
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , NATT, François Jean-Charles , HUNZIKER, Jürg
发明人： NATT, François Jean-Charles , HUNZIKER, Jürg
IPC分类号： C07H21/02 , C07H21/04
CPC分类号： C07H21/02 , C07H21/04
摘要： The present invention relates to a process for the preparation of an oligomeric compound made up of two or more individual oligomers, in which said oligomeric compound the individual oligomers are separated by a photocleavable linker, comprising the step of photoactively cleaving said linker.
摘要翻译：本发明涉及制备由两种或更多种单体寡聚物组成的低聚化合物的方法，其中所述低聚化合物各自的低聚物被光可透洗接头分离，包括光致切割所述接头的步骤。

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