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31. 发明申请

WO2009045269A1 STACKED PLATES FILTRATION CARTRIDGE 审中-公开
标题翻译：堆叠板过滤盒
公开(公告)号：WO2009045269A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/010764
申请日：2008-09-16
申请人： MILLIPORE CORPORATION , RAUTIO, Kevin
发明人： RAUTIO, Kevin
IPC分类号： B01D63/08 , B01D65/00
CPC分类号： B01D63/08 , B01D2313/02 , B01D2313/08 , B01D2313/16 , B01D2313/20 , B01D2313/21
摘要： A filtration cartridge (20) is provided comprising one or a stack of filtration units (26) sealed to each other at their inner periphery and to end caps (22, 24) eliminating the need for a housing surrounding the stack. Fluid pathways are provided so that filtration of all incoming feed is assured prior to passing from the cartridge as filtrate. The filtration cartridge can be provided with a single outlet (30).
摘要翻译：提供了一个过滤盒（20），其包括一个或一叠过滤单元（26），其过滤单元（26）在其内周彼此密封，并且端盖（22,24），从而不需要围绕堆叠的壳体。提供流体通道，以便在从滤筒作为滤液通过之前，保证所有进料的过滤。过滤筒可以设置有单个出口（30）。

32. 发明申请

WO2009045268A1 FILTRATION DEVICE 审中-公开
标题翻译：过滤装置
公开(公告)号：WO2009045268A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/010761
申请日：2008-09-16
申请人： MILLIPORE CORPORATION , CLARK, Phillip , DOYLE, Jay
发明人： CLARK, Phillip , DOYLE, Jay
IPC分类号： B01D29/05
CPC分类号： B01D65/003 , B01D29/01 , B01D35/301 , B01D61/08 , B01D61/18 , B01D61/22 , B01D61/32 , B01D63/087 , B01D2201/204 , B01D2201/34 , B01D2201/342 , B01D2313/04 , Y10T29/49863 , Y10T156/10
摘要： The present invention provides a vacuum filter device (10) which includes a filter body (11) having two holders (12, 13) on opposite sides of a filter. Each holder contains a closed container (15, 16) in a fluid-tight, sealed relationship.The filter is retained by a compression sealing element that resiliently applies a sealing pressure to the upper surface of the filter. The sealing element is maintained in place by a compression element formed of a ring that applies a desired compressive force to the sealing element. The compression element is bonded to a portion of the body to hold it, the sealing element and filter in place and under a compression seal. Other aspects of the invention include provisions for forming a port in the compression element that can be aligned with the vent of the device. The invention also can provide for an alignment feature on the compression element that ensures the port is in alignment with the vent of the device. The device also includes a vacuum port (26) communicating with the downstream side of the filter, and hence the filtrate container.
摘要翻译：本发明提供了一种真空过滤器装置（10），其包括在过滤器的相对侧上具有两个保持器（12,13）的过滤器主体（11）。每个保持器包含密封密封的密封容器（15,16）。过滤器由压缩密封元件保持，弹性地将压力施加到过滤器的上表面。通过由环形成的压缩元件将密封元件保持在适当位置，所述压缩元件对密封元件施加期望的压缩力。压缩元件结合到主体的一部分以将其固定，密封元件和过滤器就位并在压缩密封下。本发明的其它方面包括用于在压缩元件中形成可与装置的通气口对准的端口的装置。本发明还可以提供压缩元件上的对准特征，其确保端口与装置的通气口对准。该装置还包括与过滤器的下游侧连通并且因此与滤液容器连通的真空口（26）。

33. 发明申请

WO2009029232A1 SYSTEM AND METHOD FOR DIVERSION OF A LIQUID CHROMATOGRAPHY ELUANT 审中-公开
标题翻译：用于液相色谱仪分散的系统和方法
公开(公告)号：WO2009029232A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/010027
申请日：2008-08-22
申请人： MILLIPORE CORPORATION , JIANG, Tongbo , FOLLO, Cheryl , PHELAN, Maurice, G.
发明人： JIANG, Tongbo , FOLLO, Cheryl , PHELAN, Maurice, G.
IPC分类号： G01N30/38 , G01N30/72 , G01N30/84 , H01J49/04
CPC分类号： G01N30/38 , G01N30/7233 , G01N30/84
摘要： In accordance with an embodiment of the invention, there is provided a method for reducing or eliminating matrix interfering components in a biopharmaceutical product in a liquid chromatography-mass spectrometry system. The method comprises diverting to waste the entire flow of an eluant emerging from liquid chromatography of a sample, for a time period to remove contaminants that cause matrix interference to a degree sufficient to allow a desired accuracy in detection of an extractable; and, after the time period, directing the entire flow of the eluant to a mass spectrometer to detect the presence of the extractable.
摘要翻译：根据本发明的一个实施方案，提供了一种在液相色谱 - 质谱系统中减少或消除生物制药产品中的基质干扰成分的方法。该方法包括转移到从样品的液相色谱法出来的洗脱液的整个流动期间，以一段时间来去除导致基质干扰的污染物，其程度足以允许检测可提取物的期望精度; 并且在该时间段之后，将洗脱液的整个流动引导到质谱仪以检测可萃取物的存在。

34. 发明申请

WO2008085956A3 HIGH EXPRESSION CELL LINE THAT ELIMINATES GENE AMPLIFICATION 审中-公开
公开(公告)号：WO2008085956A3
公开(公告)日：2008-07-17
申请号：PCT/US2008/000230
申请日：2008-01-08
申请人： MILLIPORE CORPORATION , DILEO, Anthony , KOPACIEWICZ, William
发明人： DILEO, Anthony , KOPACIEWICZ, William
IPC分类号： C12N15/67
摘要： The present invention relates to methods, cell lines and kits for producing high titers of recombinant proteins without the need for gene amplification.

35. 发明申请

WO2008079280A1 PURIFICATION OF PROTEINS 审中-公开
标题翻译：蛋白质的纯化
公开(公告)号：WO2008079280A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/026040
申请日：2007-12-20
申请人： MILLIPORE CORPORATION , MOYA, Wilson , JABER, Jad
发明人： MOYA, Wilson , JABER, Jad
IPC分类号： C07K1/14 , C07K1/30 , C07K1/36
CPC分类号： C07K1/32 , C07K1/30 , C07K16/00
摘要： The present invention relates to a selectively soluble polymer capable of binding to a desired biomolecules in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired biomolecule (protein, polypeptide, etc) and remains capable of binding to that biomolecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.
摘要翻译：本发明涉及能够在含有各种生物材料的混合物中结合所需生物分子的选择性可溶性聚合物以及使用这种聚合物从这种混合物中纯化生物分子的方法。聚合物在一定的工艺条件例如pH或温度和/或盐浓度下可溶于混合物中，并且在工艺条件改变时变得不溶解并沉淀出溶液。聚合物能够结合所需的生物分子（蛋白质，多肽等），并且即使在聚合物从溶液中沉淀出来之后仍然能够结合该生物分子。然后可以从流的剩余部分中过滤出沉淀物，并回收所需的生物分子，例如通过洗脱和进一步处理。

36. 发明申请

WO2005077528A1 POROUS ADSORPTIVE OR CHROMATOGRAPHIC MEDIA 审中-公开
标题翻译：多孔吸收或色谱介质
公开(公告)号：WO2005077528A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/003281
申请日：2005-02-03
申请人： MILLIPORE CORPORATION , DILEO, Anthony , MCCUE, Justin , MOYA, Wilson , QUINONES-GARCIA, Igor , SOICE, Neil, P. , THOM, Volkmar , YUAN, Sarah
发明人： DILEO, Anthony , MCCUE, Justin , MOYA, Wilson , QUINONES-GARCIA, Igor , SOICE, Neil, P. , THOM, Volkmar , YUAN, Sarah
IPC分类号： B01J20/32
CPC分类号： B01D15/20 , B01D15/265 , B01D15/361 , B01J20/26 , B01J20/28023 , B01J20/28033 , B01J20/28042 , B01J20/28078 , B01J20/28097 , B01J20/286 , B01J20/3064 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/328 , B01J20/3282 , B01J20/3289 , B01J20/3293 , B01J2220/54 , B01J2220/58 , B01J2220/62
摘要： A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity. The substrate may be cross-linked, have one or more capture chemistries attached to it and is useful as a chromatography media for the selective filtratin of desired species including biomolecules such as proteins and DNA fragments.
摘要翻译：能够吸附过滤具有多孔自支撑基底和一种或多种多孔吸附聚合物涂层的多孔基底，其包含基底孔隙体积的约1至约80％。所得到的底物具有良好的对流和扩散流量和容量。底物可以是交联的，具有一个或多个捕获化学物质连接到其上，并且可用作用于选择性过滤所需物质（包括生物分子如蛋白质和DNA片段）的色谱介质。

37. 发明申请

WO2005077500A1 METHOD OF FORMING COATED STRUCTURES 审中-公开
标题翻译：形成涂层结构的方法
公开(公告)号：WO2005077500A1
公开(公告)日：2005-08-25
申请号：PCT/US2005/003333
申请日：2005-02-03
申请人： MILLIPORE CORPORATION , MOYA, Wilson
发明人： MOYA, Wilson
IPC分类号： B01D67/00
CPC分类号： B01D69/125 , B01D67/0011 , B01D67/0093 , B01D69/10 , B01D71/08 , B01D2323/08 , B01D2323/30 , B01J20/261 , B01J20/28033 , B01J20/28042 , B01J20/28045 , B01J20/286 , B01J20/3064 , B01J20/3208 , B01J20/321 , B01J20/3272 , B01J20/328 , B01J20/3282 , B01J2220/54
摘要： A process for forming room temperature water soluble polymer coatings on porous substrates by forming a solution of a room temperature water soluble polymer, one or more crosslinkers, a solvent for the room temperature water soluble polymer such as water and optionally one or more porogens, or functional agents, stirring the mixture until all the components are dissolved, adding the solution to a porous structure such as a non-woven fabric or a porous membrane and drying the solution on to the substrate as a coating before subjecting the coating to crosslinking. Alternatively, the coating may be partially crosslinked before drying the solution. Porous structures having a room temperature water soluble polymer coating and being capable of convective flow through the pores of the structure and diffusive flow through the coating can be formed.
摘要翻译：通过形成室温水溶性聚合物，一种或多种交联剂，室温水溶性聚合物如水和任选的一种或多种致孔剂的溶剂形成室温水溶性聚合物溶液，形成室温水溶性聚合物涂层的方法，或功能剂，搅拌混合物直到所有组分溶解，将溶液加入到诸如无纺织物或多孔膜的多孔结构中，并将该溶液作为涂层干燥，作为涂层，然后使涂层交联。或者，涂层在干燥溶液之前可以部分交联。可以形成具有室温水溶性聚合物涂层并且能够对流流过结构的孔和通过涂层的扩散流的多孔结构。

38. 发明申请

WO2005042037A1 MODULE FOR PURIFYING A FLUID CONTAINING A CLEANING AGENT, AND METHODS OF FABRICATING AND USING THIS KIND OF MODULE 审中-公开
标题翻译：用于净化含有清洁剂的流体的模块以及制造和使用该模块的方法
公开(公告)号：WO2005042037A1
公开(公告)日：2005-05-12
申请号：PCT/IB2004/003724
申请日：2004-10-28
申请人： MILLIPORE CORPORATION , GAIGNET, Yves , KANO, Ichiro
发明人： GAIGNET, Yves , KANO, Ichiro
IPC分类号： A61L2/16
CPC分类号： B01D65/06 , A61L2/186 , A61L2202/16 , B01D29/62 , B01D61/025 , B01D61/027 , B01D61/04 , B01D61/10 , B01D61/145 , B01D61/147 , B01D61/16 , B01D61/20 , B01D65/00 , B01D65/02 , B01D65/022 , B01D2311/04 , B01D2311/16 , B01D2321/168 , B01F1/0027 , C02F1/281 , C02F1/283 , C02F1/44 , C02F1/50 , C02F5/145 , C02F2201/006 , B01D2311/12 , B01D2311/2626
摘要： The invention consists in a disposable module (31) for purifying a fluid, in particular water, adapted to form part of a fluid purification system and comprising fluid purification means (25, 28), a housing (35) in which the purification means are housed, and means for removably connecting the purification module (31) to the purification system to establish fluid communication between the purification system and the purification module (31), characterized in that the housing (35) contains from the outset a cleaning agent (36) disposed to come into contact with the fluid caused to circulate inside the housing (35) to clean at least a portion of the purification system. It also consists in the purification system and corresponding fabrication and cleaning methods.
摘要翻译：本发明包括用于净化流体（尤其是水）的一次性模块（31），其适于形成流体净化系统的一部分，并且包括流体净化装置（25,28），其中净化装置以及用于将净化模块（31）可移除地连接到净化系统以建立净化系统和净化模块（31）之间的流体连通的装置，其特征在于，所述壳体（35）从一开始就包含清洁剂（36））设置成与所述流体接触以在所述壳体（35）内循环以清洁所述净化系统的至少一部分。它还包括净化系统和相应的制造和清洁方法。

39. 发明申请

WO2004108286A1 UNIVERSAL MULTIWELL FILTRATION PLATE 审中-公开
标题翻译：通用多通道过滤板
公开(公告)号：WO2004108286A1
公开(公告)日：2004-12-16
申请号：PCT/US2004/013865
申请日：2004-05-04
申请人： MILLIPORE CORPORATION
发明人： OLIVIER, Stephane, Jean-Marie , MULLER, Gerard , BUSNACH, Jeffrey, S.
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L2200/02 , B01L2200/12 , B01L2300/0829 , B01L2400/0409 , B01L2400/0487
摘要： The present invention relates to a multiwell plate having a series of wells, each well having an inner bore, an open top and a bottom, the bottom being sealed with a liquid permeable filter, and an insert contained within the inner bore of each well, each insert having an outer dimension the same or larger than that of the inner bore and a through bore of a dimension less than that of the outer dimension of the insert. The use of inserts allows one to take a standard one-piece plate design with a heat sealed membrane and arrange for a universal plate format. The insert may act as a base for an extension plate that can be adhered, heat sealed or overmolded over the plate top and insert top to form a deep well plate. The plate conforms to the Society of Biological Standards Microplate Standards. Additionally, the inserts may be configured to give one a different well diameter (smaller, tapered, etc), to include various media such as chromatography resins, to include multiple layers of membrane and the like. A variety of inserts may be used in the same plate to create a minilab on a plate that is capable of conducting several steps of a process on the same (e.g (e.g. filter, wash, bind, elute, label, etc).
摘要翻译：本发明涉及具有一系列井的多孔板，每个孔具有内孔，开口顶部和底部，底部用液体可渗透的过滤器密封，以及包含在每个孔的内孔内的插入件，每个插入件具有与内孔相同或更大的外部尺寸和尺寸小于插入件的外部尺寸尺寸的通孔。使用插入件可以使用带有热密封膜的标准单片板设计，并安排通用板格式。插入件可以用作延伸板的基部，该延伸板可以在板顶上粘附，热密封或包覆成型，并且插入顶部以形成深孔板。该板符合生物标准微孔板标准协会。此外，插入件可以被配置成给出一个不同的孔直径（更小，锥形等），以包括各种介质，例如色谱树脂，以包括多层膜等。可以在同一板中使用各种插入物以在板上产生能够在相同的过程上进行几个步骤（例如过滤器，洗涤，结合，洗脱，标记等）的小拉伸。

40. 发明申请

WO2004103530A1 PROCESS FOR PREFILTRATION OF A PROTEIN SOLUTION 审中-公开
标题翻译：蛋白质溶液的预处理方法
公开(公告)号：WO2004103530A1
公开(公告)日：2004-12-02
申请号：PCT/US2003/015790
申请日：2003-05-19
申请人： MILLIPORE CORPORATION
发明人： SIWAK, Marty , AN, Hong , CORMIER, Jason, R. , KINZLMAIER, Dana
IPC分类号： B01D61/14
CPC分类号： B01D15/00 , B01D29/41 , B01D61/00 , B01D61/142 , B01D61/145 , B01D61/147 , B01D69/141 , B01J20/24 , B01J20/26 , B01J20/28023 , B01J20/28028 , B01J20/28052 , B01J2220/4825 , C07K1/34 , C07K1/36 , G01N1/34 , G01N1/4077
摘要： A process is provided for selectively removing plugging constituents from a biomolecule containing solution in a normal flow (NFF) filtration process before viral filtration. Preferably, it relates to a process for selectively removing plugging constituents from a biomolecule solution in a normal flow (NFF) filtration process and virus particles from the solution in a two-step filtration process. In a first step, a biomolecule solution is filtered through a filtration device containing one or more plugging constituent removing media in the form of one or more layers of adsorptive depth filters, filled microporous membranes or a small bed of media in a normal flow filtration mode of operation, to produce a plugging constituent -free stream. The plugging constituent-free stream can then be filtered through one or more ultrafiltration membranes to retain virus particles at a retention level of at least 3 LRV and to allow passage therethrough of a plugging constituent- free and virus-free biomolecule containing solution.
摘要翻译：提供了一种方法，用于在病毒过滤之前以正常流（NFF）过滤方法从含有生物分子的溶液中选择性地除去堵塞成分。优选地，其涉及在正常流（NFF）过滤方法中选择性地从生物分子溶液中除去堵塞成分的方法和在两步过滤方法中从溶液中除去病毒颗粒的方法。在第一步骤中，通过含有一种或多种堵塞成分的过滤装置过滤生物分子溶液，该过滤装置以一层或多层吸附深度过滤器，填充的微孔膜或以正常流过滤模式的小床介质的操作，以产生无堵塞成分的流。然后可以通过一个或多个超滤膜过滤堵塞成分的物流，以将病毒颗粒保持在至少3 LRV的保留水平，并允许通过其中含有阻塞成分的无病毒生物分子的溶液。

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