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31. 发明申请

WO2012142457A2 MACROLACTAM COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA 审中-公开
标题翻译： MACROLACTAM化合物和治疗疟疾的方法
公开(公告)号：WO2012142457A2
公开(公告)日：2012-10-18
申请号：PCT/US2012033586
申请日：2012-04-13
申请人： BROAD INST INC , MUNOZ BENITO , BEAUDOIN JENNIFER , COMER EAMON , LEE MAURICE DUPONT , DUVALL JEREMY , FITZGERALD MARK E , FOLEY MICHAEL , HEIDEBRECHT RICHARD W , MARCAURELLE LISA , MASI DANIELA , MERCIER MARION , MULROONEY CAROL , MUNCIPINTO GIOVANNI , ROWLEY ANN
发明人： MUNOZ BENITO , BEAUDOIN JENNIFER , COMER EAMON , LEE MAURICE DUPONT , DUVALL JEREMY , FITZGERALD MARK E , FOLEY MICHAEL , HEIDEBRECHT RICHARD W , MARCAURELLE LISA , MASI DANIELA , MERCIER MARION , MULROONEY CAROL , MUNCIPINTO GIOVANNI , ROWLEY ANN
IPC分类号： C07D273/01 , A61K31/553 , A61P33/00
CPC分类号： A61K31/553 , C07D273/01 , C07D409/12 , C07D413/06 , C07D413/12 , C07D498/04
摘要： The present invention relates to a macrolactam compound, and methods for treating a subject with malaria using the macrolactam compound, represented by the following structural formula (l), wherein the values and preferred values of the variables are defined herein.
摘要翻译：本发明涉及一种大分子内酰胺化合物，以及使用由以下结构式（1）表示的大环内酰胺化合物用疟疾治疗受试者的方法，其中变量的值和优选值在本文中定义。

32. 发明申请

WO2012030408A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：WO2012030408A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/025022
申请日：2011-02-16
申请人： CANTHERA THERAPEUTICS, INC. , MASSACHUSETTS GENERAL HOSPITAL CORPORATION , FOLEY, Michael, Andrew , GOULD, Robert , ELLIOTT, Peter , MANDINOVA, Anna , LEE, Sam
发明人： FOLEY, Michael, Andrew , GOULD, Robert , ELLIOTT, Peter , MANDINOVA, Anna , LEE, Sam
IPC分类号： A01N43/40 , A01N43/42 , A61K31/44
CPC分类号： A61K31/4412 , A61K31/5377 , C07D211/86
摘要： The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.
摘要翻译：本发明涉及用于治疗和预防癌症的化合物和组合物。本发明还涵盖可以通过选择性调节患病细胞中的活性氧水平与正常细胞来治疗的所有疾病。还公开了制备和施用这些组合物的方法。

33. 发明申请

WO2011028860A2 COMPOUNDS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：WO2011028860A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047615
申请日：2010-09-02
申请人： CANTHERA THERAPEUTICS, INC. , FOLEY, Michael, Andrew , GOULD, Robert , ELLIOT, Peter , MANDINOVA, Anna , LEE, Sam
发明人： FOLEY, Michael, Andrew , GOULD, Robert , ELLIOT, Peter , MANDINOVA, Anna , LEE, Sam
IPC分类号： C07D413/12 , C07D211/76 , A61K31/5377 , A61P35/00
CPC分类号： C07D211/86 , A61K31/4412 , A61K31/5377
摘要： The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.
摘要翻译：本发明涉及用于治疗和预防癌症的化合物和组合物。本发明还包括可以通过选择性调节患病细胞与正常细胞中活性氧水平的水平来治疗的所有疾病。还公开了用于制备和施用这种组合物的方法。

34. 发明申请

WO2009067478A3 FASTENER EXTRACTION TOOL 审中-公开
标题翻译：紧固件提取工具
公开(公告)号：WO2009067478A3
公开(公告)日：2009-07-16
申请号：PCT/US2008083972
申请日：2008-11-19
申请人： NAIL JACK TOOLS INC , FOLEY MICHAEL J
发明人： FOLEY MICHAEL J
IPC分类号： B25C11/00 , B25C11/02 , B26B13/00
CPC分类号： B25C11/02
摘要： The hand tool is used to extract a fastener from a material by preferably gripping the fastener from a horizontal orientation. The hand tool has a head with two pivotally joined halves including at least one pair of gripping jaws. The tool head preferably includes tips that may be used to dig beneath a fastener head that is flush with or set below a surface. The tool includes a pair of handles operable to close the gripping jaws. The handles are preferably offset above the plane of the tool head such that they operate as a lever in cooperation with a fulcrum on the bottom of the tool head to extract the fastener. In one embodiment, the forward jaws of the tool have concave curved gripping surfaces. In one embodiment, the rearward jaws have non-complementary surfaces.
摘要翻译：手工具用于通过优选地从水平取向夹紧紧固件从材料中提取紧固件。手工工具具有头部，其具有两个枢轴连接的半部，包括至少一对夹持爪。工具头优选地包括可用于在与表面齐平或设置在表面下方的紧固件头下方挖掘的尖端。该工具包括可操作以闭合夹爪的一对把手。手柄优选地在工具头的平面上方偏移，使得它们与工具头的底部上的支点协作操作，以提取紧固件。在一个实施例中，工具的前爪具有凹曲面的夹紧表面。在一个实施例中，后爪具有非互补表面。

35. 发明申请

WO2007022557A1 MIMOTOPES OF EPSTEIN-BARR VIRUS (EBV) EPITOPES 审中-公开
标题翻译： EPSTEIN-BARR病毒（EBV）抗体的化合物
公开(公告)号：WO2007022557A1
公开(公告)日：2007-03-01
申请号：PCT/AU2006/000279
申请日：2006-03-03
申请人： DIATECH PTY LTD , FOLEY, Michael , CASEY, Joanne, Lois , COLEY, Andrew, Mark , DEVINE, Peter, Leonard
发明人： FOLEY, Michael , CASEY, Joanne, Lois , COLEY, Andrew, Mark , DEVINE, Peter, Leonard
IPC分类号： C07K7/08 , A61K38/10 , A61K39/245 , A61K39/42 , A61P31/22 , C07H21/04 , C07K16/08 , C12N15/10 , G01N33/537 , G01N33/567 , G01N33/577
CPC分类号： C07K16/085 , A61K38/00 , A61K39/00 , C07K14/001 , C07K14/005 , C07K2317/21 , C07K2319/735 , C12N2710/16222 , G01N33/56994
摘要： This invention provides mimotopes to Epstein-Barr Virus (EBV) epitopes. It also provides methods of screening for mimotopes that bind to antibodies that bind to natural EBV epitopes as well as for anti-mimotopes that bind to natural EBV epitopes. The invention further relates to the use EBV mimotopes or anti-mimotopes in the diagnosis of EBV infection and to distinguish between infection by EBV or other Herpes Virus infections.
摘要翻译：本发明提供了Epstein-Barr病毒（EBV）表位的模拟表位。它还提供筛选与结合天然EBV表位的抗体以及结合天然EBV表位的抗模拟表位结合的模拟表位的方法。本发明还涉及在EBV感染的诊断中使用EBV模拟表位或抗模拟表位，并区分EBV或其他疱疹病毒感染的感染。

36. 发明申请

WO2006088786A2 COMPOUNDS AND USES THEREOF 审中-公开
标题翻译：化合物及其用途
公开(公告)号：WO2006088786A2
公开(公告)日：2006-08-24
申请号：PCT/US2006005006
申请日：2006-02-13
申请人： COMBINATORX INC , FOLEY MICHAEL A , KEITH CURTIS , BORCHARDT RONALD T
发明人： FOLEY MICHAEL A , KEITH CURTIS , BORCHARDT RONALD T
IPC分类号： A61K31/554
CPC分类号： C07D317/64 , C07C229/12 , C07C279/04 , C07C2603/32 , C07D267/16 , C07D267/20
摘要： The invention features charge-modified antidepressants and compounds conjugated to either a charged group or a bulky group in a manner that resists in vivo cleavage. The invention provides a method for treating a patient having an inflammatory disease by administering to the patient a compound of the invention.
摘要翻译：本发明的特征在于电荷修饰的抗抑郁药和化合物与带电荷的基团或大体积基团结合，以抵抗体内裂解的方式。本发明提供了通过向患者施用本发明化合物来治疗患有炎性疾病的患者的方法。

37. 发明申请

WO2006009907A2 ISOXAZOLIDINE COMPOUNDS FOR TREATMENT OF BACTERIAL INFECTIONS 审中-公开
标题翻译：用于治疗细菌感染的ISOXAZOLIDINE化合物
公开(公告)号：WO2006009907A2
公开(公告)日：2006-01-26
申请号：PCT/US2005021589
申请日：2005-06-17
申请人： INFINITY PHARMACEUTICALS INC , CHRISTENSEN BURTON G , FOLEY MICHAEL A , GEORGES EVANGELINOS ASIMINA T , LIU TAO , PORTER JAMES R , RIPKA AMY S , ZHANG LINPING
发明人： CHRISTENSEN BURTON G , FOLEY MICHAEL A , GEORGES EVANGELINOS ASIMINA T , LIU TAO , PORTER JAMES R , RIPKA AMY S , ZHANG LINPING
IPC分类号： C07D413/00
CPC分类号： C07D261/02 , C07D413/12
摘要： The present invention relates to antibiotic compounds and intermediates useful in their preparation. Many of the antibiotic compounds contain a substituted isoxazolidine ring. The invention also relates to pharmaceutical compositions containing a compound of the invention. The invention further provides processes for the preparation of compounds of the invention, and methods for their use as therapeutic agents.
摘要翻译：本发明涉及可用于其制备的抗生素化合物和中间体。许多抗生素化合物含有取代的异恶唑烷环。本发明还涉及含有本发明化合物的药物组合物。本发明还提供了制备本发明化合物的方法及其用作治疗剂的方法。

38. 发明申请

WO2005117847A2 METHODS AND COMPOUNDS FOR THE TREATMENT OF NEOPLASMS 审中-公开
标题翻译：治疗NEOPLASMS的方法和化合物
公开(公告)号：WO2005117847A2
公开(公告)日：2005-12-15
申请号：PCT/US2005019324
申请日：2005-06-01
申请人： COMBINATORX INC , KEITH CURTIS , LEE MARGARET S , FOLEY MICHAEL A , STOCKWELL BRENT R
发明人： KEITH CURTIS , LEE MARGARET S , FOLEY MICHAEL A , STOCKWELL BRENT R
IPC分类号： A61K31/00 , C07D279/28
CPC分类号： C07D279/28
摘要： The invention features compounds of 'formula (I) and their use in preparing 'medicaments for treating a patient having a cancer or other neoplasm. R' R9 R8 R N R7
摘要翻译：本发明具有式（I）化合物及其在制备用于治疗患有癌症或其他肿瘤的患者的药物中的用途。 R'R9 R8 R N R7

39. 发明申请

WO2005020913A2 FORMULATIONS, CONJUGATES, AND COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS 审中-公开
标题翻译：药物治疗NEOPLASMS的制剂，结合物和组合
公开(公告)号：WO2005020913A2
公开(公告)日：2005-03-10
申请号：PCT/US2004027695
申请日：2004-08-25
申请人： COMBINATORX INC , NICHOLS JAMES M , FOLEY MICHAEL A , KEITH CURTIS , PADVAL MAHESH , ELLIOTT PETER
发明人： NICHOLS JAMES M , FOLEY MICHAEL A , KEITH CURTIS , PADVAL MAHESH , ELLIOTT PETER
IPC分类号： A61K20060101 , A61K31/5415 , A61P35/00 , C07D417/02 , A61K
CPC分类号： A61K47/645 , A61K47/60 , A61K47/61
摘要： The invention provides formulations and structural modifications for phenothiazine compounds which result in altered biodistributions, thereby reducing the occurrence of adverse reactions associated with this class of drug.
摘要翻译：本发明提供了吩噻嗪化合物的制剂和结构修饰，其导致改变的生物分布，从而减少与该类药物相关的不良反应的发生。

40. 发明申请

WO2004063885A2 DYNAMIC ADVANCE PURCHASE ADMISSION TO A VENUE 审中-公开
标题翻译：动态购买进入场地
公开(公告)号：WO2004063885A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000422
申请日：2004-01-08
申请人： DISNEY ENTERPRISES INC. , JUNGEN, Michael , FOLEY, Michael, K. , BROWN, Steven, K.
发明人： JUNGEN, Michael , FOLEY, Michael, K. , BROWN, Steven, K.
IPC分类号： G06F
CPC分类号： G07F7/10 , G06Q20/342 , G06Q20/347 , G06Q30/06 , G06Q40/04 , G07B15/00 , G07F7/025 , G07F7/1075
摘要： A dynamic advance purchase admission system to a venue is disclosed by providing a computer programmable media, such as a card, readable by a card reader. Identifying characters are provided on the media and activated at a location remote from the venue to provide access to the venue when read at the venue.
摘要翻译：通过提供可由读卡器读取的计算机可编程介质（例如卡）来公开对场地的动态提前购买入场系统。在媒体上提供识别字符，并且在远离场地的位置激活，以在场地读取时提供对场地的访问。

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