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31. 发明申请

WO2010041105A1 SCINTIGRAPHIC DEVICE WITH SPATIAL HIGH-RESOLUTION 审中-公开
标题翻译：具有空间高分辨率的SCITIGRAPHIC设备
公开(公告)号：WO2010041105A1
公开(公告)日：2010-04-15
申请号：PCT/IB2009/005120
申请日：2009-03-25
申请人： CNR - CONSIGLIO NAZIONALE DELLE RICERCHE , SOLURI, Alessandro , MASSARI, Roberto
发明人： SOLURI, Alessandro , MASSARI, Roberto
IPC分类号： G01T1/164
CPC分类号： G01T1/1644 , A61B6/4258 , G01T1/1647
摘要： A scintigraphic device comprising: a collimator (10) for receiving and directing the electromagnetic radiation (R) from a predetermined source (S); a scintillation structure (20) associated with the collimator (10) for receiving said electromagnetic radiation (R) from said collimator (10) and converting it into visible radiation (V); an electro-optical converter (30) combined with a suitable electronics and associated with said scintillation structure (20) for receiving said visible radiation (V) and converting it into electric signals (E); a processing unit (40) connected to said electro-optical converter (30) for receiving said electric signals (E) and rebuilding, as a function of said electric signals (E), images of said predetermined source (S); an actuating system (50) for mutually moving said predetermined source (S) and at least said collimator (10), the latter being preferably combined with the scintillation structure (20) and said converter (30), to enable said collimator (10) to detect said electromagnetic radiation (R) at different mutual positioning locations of said predetermined source (S) and said collimator (10), said processing unit (40) being adapted to rebuild a plurality of auxiliary images (I1-I4) representative of said predetermined source (S), each auxiliary image (11-14) corresponding to a respective mutual positioning of said predetermined source (S) and said collimator (10), said processing unit (40) being adapted to generate a final image (I) as a function of said auxiliary images (I1-I4), wherein said final image (I) has a spatial resolution the numeric value of which is smaller than the spatial resolution of said auxiliary images (I1-I4).
摘要翻译：一种闪烁照相装置，包括：用于从预定源（S）接收和引导电磁辐射（R）的准直器（10）; 与所述准直器（10）相关联的用于从所述准直器（10）接收所述电磁辐射（R）并将其转换成可见辐射（V）的闪烁结构（20）; 电光转换器（30）与合适的电子器件组合并与所述闪烁结构（20）相关联，用于接收所述可见光（V）并将其转换成电信号（E）; 连接到所述电光转换器（30）的处理单元（40），用于接收所述电信号（E）并根据所述电信号（E）重建所述预定源（S）的图像; 用于相互移动所述预定源（S）和至少所述准直器（10）的致动系统（50），所述准直器（10）优选地与所述闪烁结构（20）和所述转换器（30）组合，以使所述准直器（10）以检测所述预定源（S）和所述准直器（10）的不同相互定位位置处的所述电磁辐射（R），所述处理单元（40）适于重建代表所述预定源（S）和所述准直器的多个辅助图像（I1-I4）预定源（S），对应于所述预定源（S）和所述准直器（10）的相应相互定位的每个辅助图像（11-14），所述处理单元（40）适于生成最终图像（I）作为所述辅助图像（I1-I4）的函数，其中所述最终图像（I）具有其数值小于所述辅助图像（I1-I4）的空间分辨率的空间分辨率。

32. 发明申请

WO2007137597A1 TESTS FOR DETECTION OF HOT SPOT MUTATIONS AND METHYLATION OF RETINOBLASTOMA-LIKE 2 GENE (RBL2) AS DIAGNOSTIC AND PROGNOSTIC MARKERS OF TUMORS 审中-公开
标题翻译：用于检测热点突变的试验和雷公藤素样基因（RBL2）作为肿瘤的诊断和预防标记的甲基化
公开(公告)号：WO2007137597A1
公开(公告)日：2007-12-06
申请号：PCT/EP2006/005019
申请日：2006-05-26
申请人： CNR CONSIGLIO NAZIONALE DELLE RICERCHE , CINTI, Caterina , LA SALA, Dario
发明人： CINTI, Caterina , LA SALA, Dario
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2531/113
摘要： The present invention utilizes human gene sequence, a specific CpG island of RBL2 retinoblastoma-like 2 (pl30) gene, and designs primers based on base mismatch principle selected to constitute CpG island methylation test reagent kit for diagnosing tumor and screening demethylation medicine. The reagent kit includes primers specific for MSP- PCR reaction system. The complete CpG island sensitive to methylation is also provide. Moreover specific primers for detection of "hot-spot" mutations at exon 1, identified as tumor biomarkers and the PCR reaction are provided. Three RBL2 retinoblastoma-like 2 (pl30) regions rich in CpG dinucleotide, the promoter region immediately 5'- flanking to the transcription start site (ATG) , the exon 1 and the intron 1, are target to epigenetic events in tumors. Two specific exon 1 mutations, inside a CpG region sensitive to methylation, are present in different cancer hystotype representing tumor-specific marker. Analysis of methylation patterns in the RBL2 retinoblastoma-like 2 (pl30) regions rich in CpG dinucleotide by Methylation Specific PCR (MSP) and mutational analysis of exon 1 provide methods for diagnosis and prognosis and for targeting therapy in cancer patients.
摘要翻译：本发明利用人基因序列，RBL2视网膜母细胞瘤样2（pl30）基因的特异性CpG岛，设计基于碱基失配原理的引物，构成用于诊断肿瘤和筛选去甲基化药物的CpG岛甲基化试剂盒。试剂盒包含特异于MSP-PCR反应体系的引物。还提供了对甲基化敏感的完整CpG岛。此外，提供了用于检测外显子1的“热点”突变的鉴定为肿瘤生物标志物和PCR反应的特异性引物。三个具有CpG二核苷酸的RBL2视网膜母细胞瘤样2（pl30）区域，即转录起始位点（ATG）的5'侧的启动子区域，外显子1和内含子1是靶向肿瘤中的表观遗传事件。在甲基化敏感的CpG区域内的两个特异性外显子1突变存在于代表肿瘤特异性标记的不同癌症囊肿中。通过甲基化特异性PCR（MSP）和外显子1的突变分析对富含CpG二核苷酸的RBL2视网膜母细胞瘤样2（pl30）区域中甲基化模式的分析提供了诊断和预后以及癌症患者靶向治疗的方法。

33. 发明申请

WO2007093883A2 method for activation of chemical or chemical-physical processes by a simultaneous use of microwaves and ultrasonic pulses and chemical reactor that carries out this method 审中-公开
标题翻译：通过同时使用微波和超声脉冲激活化学或化学物理过程的方法以及执行该方法的化学反应器
公开(公告)号：WO2007093883A2
公开(公告)日：2007-08-23
申请号：PCT/IB2007/000334
申请日：2007-02-13
申请人： UNIVERSITA' DEGLI STUDI DI MILANO , CNR - CONSIGLIO NAZIONALE DELLE RICERCHE , LONGO, Iginio , RAGAINI, Vittorio
发明人： LONGO, Iginio , RAGAINI, Vittorio
IPC分类号： B01J19/10 , B01J19/12
CPC分类号： B01J19/10 , B01J19/126 , B01J2219/00141 , B01J2219/1206 , B01J2219/1215 , B01J2219/1224 , B01J2219/1233 , B01J2219/1239 , B01J2219/1254 , B01J2219/126 , B01J2219/1278 , B01J2219/1281 , B01J2219/1284 , B01J2219/1293 , B01L7/00 , B01L2300/18 , B01L2300/1866 , B01L2400/0439 , H05B6/806
摘要： An apparatus (1) for activation of chemical-physical processes comprising a microwave source (40), for example a magnetron or a klystron or a solid state oscillator (FET transistor) , operatively connected at one end of a microwave antenna, for example a co-axial antenna (3) , at a connector (13) . The apparatus, furthermore, comprises a generator of electric current (45) at high frequency connected to an ultrasonic transducer (2) for example by a shielded cable, not shown in the figure. In operative conditions, the antenna (3) and the ultrasonic transducer (2) are arranged substantially at right angles and at direct contact with a reacting mass (15) contained container (10) in order to activate it and then to complete a desired chemical and/or physical process. More in detail, the reacting mass (15) is subject contemporaneously, or alternatively, to an electromagnetic field generated by the antenna (3), diagrammatically indicated (30) , and from the ultrasonic field (20) generated by the ultrasonic transducer (2) . By arranging the microwave antenna (3) and the ultrasonic transducer (2) in the reacting mass (15) the efficiency of the process is optimized achieving a synergistic effect thanks to the combination of the electromagnetic field and the ultrasonic field.
摘要翻译：一种用于激活化学物理过程的装置（1），其包括在微波天线的一端可操作地连接的微波源（40），例如磁控管或速调管或固态振荡器（FET晶体管），例如同轴天线（3），在连接器（13）处。此外，该装置还包括高频连接到超声换能器（2）的电流（45）的发生器，例如通过图中未示出的屏蔽电缆。在操作条件下，天线（3）和超声波换能器（2）基本成直角地布置并且与反应物料（15）容纳的容器（10）直接接触，以激活它，然后完成所需的化学物质和/或物理过程。更详细地，反应物质（15）同时或替代地由天线（3）产生的电磁场，示意性地表示（30），以及由超声波换能器（2）产生的超声波场（20））。通过将微波天线（3）和超声换能器（2）布置在反应物质（15）中，由于电磁场和超声场的组合，该方法的效率被优化，从而达到协同效应。

34. 发明申请

WO2002061880A2 INTERSTITIAL MICROWAVE ANTENNA WITH MINIATURIZED CHOKE FOR HYPERTHERMIA IN MEDICINE AND SURGERY 审中-公开
标题翻译：用于医学和手术中的超微结构的微型化天竺葵的天体微波天线
公开(公告)号：WO2002061880A2
公开(公告)日：2002-08-08
申请号：PCT/IB2002/000299
申请日：2002-01-31
申请人： CNR CONSIGLIO NAZIONALE DELLE RICERCHE , LONGO, Iginio
发明人： LONGO, Iginio
IPC分类号： H01Q9/30
CPC分类号： H01Q9/30 , A61B18/18 , A61B18/1815
摘要： The present invention relates to minimally invasive surgery techniques. It provides a method for manufacturing an antenna for percutaneous acute hyperthermia microwave applications of the monopole or dipole co-axial type provided with trap, commonly called choke, for blocking the propagation of the backwards reflecting wave towards the generator. The miniaturisation of the device allows a use minimally invasive for interstitial hyperthermia in medicine and surgery, in particular for oncology. The method of manufacturing the antenna provides a metal needle (1) for the introduction of the antenna (2, 3, 4) in the target tissue. On the external conductor (4) of the antenna (2) a metal collar (6) is connected in a predetermined position; a plastics sheath (5) is applied in order to cover the external conductor (2) in the portion between the feed (7) and the collar (6); the inner wall of the metal needle (1) wherein the antenna is inserted is then used for containing and guiding the collar (6) and the sheath (5); in particular, the collar (6) being in electrical contact with the inner wall of the metal needle (1). An antenna is thus obtained with choke of variable length and with miniaturized diameter. A thermocouple can be introduced through the choke that protrudes the directly in the ''feed'' zone. (Figure 3)
摘要翻译：本发明涉及微创手术技术。它提供了一种用于制造用于经皮急性热疗微波应用的天线的方法，所述天线具有设置有通常称为扼流圈的陷阱的单极或偶极同轴型，用于阻止向后反射波向发生器的传播。该装置的小型化允许在医学和手术中使用微创的间质性高热，特别是用于肿瘤学。制造天线的方法提供了一种用于在目标组织中引入天线（2,3,4）的金属针（1）。在天线（2）的外部导体（4）上，金属环（6）连接在预定位置; 施加塑料护套（5）以便在进料（7）和轴环（6）之间的部分中覆盖外部导体（2）。然后将天线插入的金属针（1）的内壁用于容纳和引导套环（6）和护套（5）; 特别地，套环（6）与金属针（1）的内壁电接触。因此，获得具有可变长度和小型化直径的扼流圈的天线。可以通过直接在“进料”区域中突出的扼流圈引入热电偶。（图3）

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