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31. 发明申请

WO1994021293A1 METHOD OF TREATMENT OF TUMORS WITH AN ANTIBODY BINDING TO TENASCIN 审中-公开
标题翻译：用抗体结合治疗肿瘤的方法
公开(公告)号：WO1994021293A1
公开(公告)日：1994-09-29
申请号：PCT/US1994002703
申请日：1994-03-14
申请人： DUKE UNIVERSITY , BIGNER, Darell, D. , ZALUTSKY, Michael
发明人： DUKE UNIVERSITY
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K51/1066
摘要： Methods of treating solid and cystic tumors are disclosed. The method comprises administering to a subject afflicted with a cystic tumor an antibody which binds to tenascin in a therapeutically effective amount. The administering step is carried out by depositing the antibody in the cyst cavity of the cystic tumor. For solid tumors, disclosed is a method involving first, removing a solid tumor from a solid tissue organ of an afflicted subject; then forming an enclosed resection cavity in the organ of the subject at the location from which the solid tumor was removed; and then administering to the subject an antineoplastic agent by depositing the antineoplastic agent in the resection cavity. Particularly preferred for carrying out the foregoing is the monoclonal antibody 81C6 and antibodies which bind to the epitope bound by monoclonal antibody 81C6.
摘要翻译：公开了治疗固体和囊性肿瘤的方法。该方法包括向患有囊性肿瘤的受试者施用以治疗有效量结合腱生蛋白的抗体。施用步骤通过将抗体沉积在囊性肿瘤的囊腔中来进行。对于实体瘤，公开的方法是首先从受影响的受试者的固体组织器官去除实体瘤; 然后在移除实体瘤的位置形成被检体器官中的封闭切除腔; 然后通过将抗肿瘤剂沉积在切除腔中向受试者施用抗肿瘤剂。特别优选进行上述操作的是单克隆抗体81C6和与由单克隆抗体81C6结合的表位结合的抗体。

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