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31. 发明申请

WO2012049156A1 NON-STARCH BASED SOFT CHEWABLES 审中-公开
标题翻译：非基于非基于软件的软件
公开(公告)号：WO2012049156A1
公开(公告)日：2012-04-19
申请号：PCT/EP2011/067699
申请日：2011-10-11
申请人： BAYER ANIMAL HEALTH GMBH , VENKATA-RANGARAO, Kanikanti , HAMANN, Hans-Jürgen
发明人： VENKATA-RANGARAO, Kanikanti , HAMANN, Hans-Jürgen
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/0056 , A61K9/2018 , A61K9/2022 , A61K9/2054 , A61K9/2059
摘要： The present invention generally relates to soft chewables, especially suitable for delivering active ingredients to animals and processes for the preparation thereof. In various embodiments, the soft chewable comprises a pharmaceutically effective amount of at least one active ingredient, a flavoring agent, a disintegrant, a humectant, an antioxidant, a preservative, and water. In accordance with preferred embodiments, the soft chewable is essentially free of starch, oil, glycols, waxes, and soy products.
摘要翻译：本发明一般涉及软质咀嚼物，特别适用于将活性成分输送给动物及其制备方法。在各种实施方案中，软咀嚼物包含药学有效量的至少一种活性成分，调味剂，崩解剂，保湿剂，抗氧化剂，防腐剂和水。根据优选实施方案，软咀嚼基本上不含淀粉，油，二醇，蜡和大豆制品。

32. 发明申请

WO2009135593A3 SOLID PHARMACEUTICAL FORMULATION WITH DELAYED RELEASE 审中-公开
标题翻译：固体药物制剂缓释
公开(公告)号：WO2009135593A3
公开(公告)日：2011-01-06
申请号：PCT/EP2009002951
申请日：2009-04-23
申请人： BAYER ANIMAL HEALTH GMBH , KANIKANTI VENKATA-RANGARAO , BACH THOMAS , TRAEUBEL MICHAEL , ALTREUTHER GERTRAUT , REHAGEN MARTINA , SCHMIDT AXEL
发明人： KANIKANTI VENKATA-RANGARAO , BACH THOMAS , TRAEUBEL MICHAEL , ALTREUTHER GERTRAUT , REHAGEN MARTINA , SCHMIDT AXEL
IPC分类号： A61K9/22 , A61K31/4152 , A61K31/495 , A61K31/662 , A61K31/7048 , A61K38/15
CPC分类号： A61K47/32 , A61K9/0056 , A61K9/2027 , A61K31/4152 , A61K31/495 , A61K31/4985 , A61K31/662 , A61K31/7048 , A61K38/15 , A61K47/34 , A61K2300/00
摘要： The invention relates to a solid pharmaceutical preparation with a delayed release of the active substances, particularly suitable for use in animals.
摘要翻译：本发明涉及与活性成分的持续释放，这是特别适合于在动物中使用的固体药物制剂。

33. 发明申请

WO2009156071A8 COMBINATION OF AMIDINE DERIVATES WITH CYCLIC DEPSIPEPTIDES 审中-公开
标题翻译：衍生物组合脒与环酯肽
公开(公告)号：WO2009156071A8
公开(公告)日：2010-12-29
申请号：PCT/EP2009004304
申请日：2009-06-16
申请人： BAYER ANIMAL HEALTH GMBH , HARDER ACHIM , NERGER DITTMAR , BACH THOMAS , KANIKANTI VENKATA-RANGARAO , KUJANEK RICHARD
发明人： HARDER ACHIM , NERGER DITTMAR , BACH THOMAS , KANIKANTI VENKATA-RANGARAO , KUJANEK RICHARD
IPC分类号： A61K31/155 , A61K38/15 , A61P33/10
CPC分类号： A61K31/155 , A61K38/15
摘要： The present invention relates to a combination of aminophenylamidine derivates with cyclic depsipeptides, to products comprising said combination, and to the use of said agents in combinations for combating endoparasites in humans and animals.
摘要翻译：本发明涉及具有环状缩肽，包含该组合产品和组合使用这些试剂的用于人类和动物体内寄生虫的控制Aminophenylamidin衍生物的组合。

34. 发明申请

WO2010063387A1 EXTRUDATE MIT NADELFÖRMIGEN WIRKSTOFFEN 审中-公开
标题翻译：挤出针状物质
公开(公告)号：WO2010063387A1
公开(公告)日：2010-06-10
申请号：PCT/EP2009/008341
申请日：2009-11-24
申请人： BAYER ANIMAL HEALTH GMBH , KANIKANTI, Venkata-Rangarao , HAMANN, Hans-Juergen , KLEINEBUDDE, Peter , DRAHEIM, Rieke
发明人： KANIKANTI, Venkata-Rangarao , HAMANN, Hans-Juergen , KLEINEBUDDE, Peter , DRAHEIM, Rieke
IPC分类号： A61K9/00 , A61K9/16 , A61K9/14 , A61K47/14 , A61K47/44
CPC分类号： A61K31/196 , A61K9/145 , A61K9/146 , Y10T428/2982
摘要： Die Erfindung betrifft Extrudate, enthaltend mindestens eine pharmazeutisch wirksame Substanz in Form von Nadeln, wobei das Verhältnis von Partikelgröße der nadelförmigen pharmazeutisch wirksamen Substanz zu Strangdurchmesser mindestens 1 :15 beträgt, sowie die Verwendung dieser Extrudate zur Herstellung von Arzneimitteln.
摘要翻译：本发明涉及含有在针的形式的至少一种药物活性物质的挤出物，其中，所述针状药物活性物质的粒径的比例股线直径为至少1：15，以及用于生产药物的用途，这些挤出物。

35. 发明申请

WO2009077162A1 NEUE VERWENDUNG VON AMIDIN-DERIVATEN 审中-公开
标题翻译：导数的脒新用途
公开(公告)号：WO2009077162A1
公开(公告)日：2009-06-25
申请号：PCT/EP2008/010692
申请日：2008-12-16
申请人： BAYER ANIMAL HEALTH GMBH , HARDER, Achim , NERGER, Dittmar
发明人： HARDER, Achim , NERGER, Dittmar
IPC分类号： A61K31/155
CPC分类号： A61K31/155
摘要： Die vorliegende Erfindung betrifft die Verwendung von Amidin-Derivaten wie Tribendimidin zur Bekämpfung von Endoparasiten bei Nutztieren.
摘要翻译：本发明涉及使用脒衍生物，如Tribendimidin用于动物体内寄生虫控制。

36. 发明申请

WO2008135153A1 NEUE POLYMORPHE FORM VON 2-(4-FLUOROPHENYL)-4-3-HYDROXY-3-METHYL-1-BUTOXY)-5-[4-METHYL-SULFONYL)PHENYL]-3(2H)-PYRIDAZINON (FHMP) 审中-公开
标题翻译：的2-（4-氟苯基）-4-3羟基-3-甲基-1-丁氧基）新多晶型-5- [4-甲基磺酰基） - 苯基] -3（2H） - 哒嗪酮（FHMP）
公开(公告)号：WO2008135153A1
公开(公告)日：2008-11-13
申请号：PCT/EP2008/003170
申请日：2008-04-19
申请人： BAYER ANIMAL HEALTH GMBH , GRUNENBERG, Alfons , MAIS, Franz-Josef , MÜLLER, Hartwig , KEIL, Birgit
发明人： GRUNENBERG, Alfons , MAIS, Franz-Josef , MÜLLER, Hartwig , KEIL, Birgit
IPC分类号： C07D237/16 , A61K31/50 , A61P19/00 , A61P29/00 , A61P11/06 , A61P35/00
CPC分类号： C07D237/16
摘要： Die vorliegende Erfindung betrifft eine neue polymorphe Form von FHMP (Formel (I)), Verfahren zu deren Herstellung, diese enthaltende Arzneimittel sowie deren Verwendung bei der Bekämpfung von Krankheiten.
摘要翻译：本发明涉及FHMP的新型多晶型物（式（I）），它们的制备方法，含有它们和它们在防治疾病的药物组合物。

37. 发明申请

WO2023036821A1 NEW QUINOLINE DERIVATIVES 审中-公开
公开(公告)号：WO2023036821A1
公开(公告)日：2023-03-16
申请号：PCT/EP2022/074866
申请日：2022-09-07
申请人： BAYER ANIMAL HEALTH GMBH
发明人： HÜBSCH, Walter , GRIEBENOW, Nils , ZHUANG, Wei , HEISLER, Iring , KULKE, Daniel , BOERNGEN, Kirsten , TAHTAOUI, Chouaib , SELBACH, Claudia
IPC分类号： C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D498/08 , A61P33/10 , A61K31/4709
摘要： The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.

38. 发明申请

WO2022162205A1 VACCINE COMPOSITION FOR BREAKING SELF-TOLERANCE 审中-公开
公开(公告)号：WO2022162205A1
公开(公告)日：2022-08-04
申请号：PCT/EP2022/052154
申请日：2022-01-29
申请人： BAYER ANIMAL HEALTH GMBH
发明人： ILG, Thomas
IPC分类号： C07K16/24 , A61K39/00
摘要： The present invention relates to a vaccine composition for breaking self-tolerance against a self-protein of a host, in particular for breaking self-tolerance against endogenous cytokines, in particular against the endogenous IL-4, IL-5, IL-13, IL-31 and IL-33 proteins in an animal host. The vaccine composition of the invention contains a polyprotein, a DNA encoding for the polyprotein and/or an RNA encoding for the polyprotein and one or more immunostimulatory oligonucleotides. The polyprotein comprises at least two self-protein segments of the host and one or more T-cell epitopes of non-host origin in between and/or adjacent to the at least two self-protein segments. The present invention further concerns the use of the vaccine composition for the prevention and/or treatment of diseases including the prevention and/or treatment of a pruritic condition and/or an allergic condition. In another aspect, the present invention provides a method for detecting the presence of autoantibodies against self-proteins that can be generated with the vaccine composition of the invention.

39. 发明申请

WO2022162204A1 VACCINE COMPOSITION FOR BREAKING SELF-TOLERANCE 审中-公开
公开(公告)号：WO2022162204A1
公开(公告)日：2022-08-04
申请号：PCT/EP2022/052153
申请日：2022-01-29
申请人： BAYER ANIMAL HEALTH GMBH
发明人： ILG, Thomas , WEISS, Christian , FOIT, Sabrina
IPC分类号： C07K16/24 , A61K39/00
摘要： The present invention relates to a vaccine composition for breaking self-tolerance against a self-protein of a host, in particular for breaking self-tolerance against endogenous cytokines in an animal host. The vaccine composition of the invention contains a polyprotein, a DNA encoding for the polyprotein and/or an RNA encoding for the polyprotein and one or more immunostimulatory oligonucleotides. The polyprotein comprises at least two self-protein segments of the host and one or more T-cell epitopes of non-host origin in between and/or adjacent to the at least two self-protein segments. The present invention further concerns the use of the vaccine composition for the prevention and/or treatment of diseases including the prevention and/or treatment of a pruritic condition and/or an allergic condition. In another aspect, the present invention provides a method for detecting the presence of autoantibodies against self-proteins that can be generated with the vaccine composition of the invention.

40. 发明申请

WO2021180603A1 SOFT CHEWABLE FORMED BODY FOR THE ADMINISTRATION TO ANIMALS 审中-公开
公开(公告)号：WO2021180603A1
公开(公告)日：2021-09-16
申请号：PCT/EP2021/055685
申请日：2021-03-05
申请人： BAYER ANIMAL HEALTH GMBH
发明人： BLAND, Christopher Robert , KANIKANTI, Venkata-Rangarao , ORLOVIUS, Anne-Katrin Laura , KIEFER, Philipp , KLEINEBUDDE, Peter
IPC分类号： A61K9/16 , A61K31/435 , A61P33/10
摘要： The invention relates to a formed body for the administration to animals and to a process for the production of the formed body for the administration to animals. The formed body serves in particular for the oral administration of pharmaceutically active substances to animals. The formed body for the administration to animals comprises one or more pharmaceutically active substance, one or more flavouring agents, one or more binding agents, one or more gel- forming agents, one or more fillers, water and glycerol.

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