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    • 33. 发明申请
    • SYNTHESIS OF SUBSTITUTED AMINOPYRIMIDINES
    • 取代的氨基嘧啶的合成
    • WO2015011010A1
    • 2015-01-29
    • PCT/EP2014/065377
    • 2014-07-17
    • ABBOTT HEALTHCARE PRODUCTS BVABBOTT LABORATORIES
    • ACQUASALIENTE, MaurizioLAGERWEIJ, GertDESHPANDE, MahendraSHAH, Rajendra
    • C07D403/12
    • C07D403/12
    • The present invention relates to a novel process for the manufacture of certain substituted aminopyrimidines having Formula (I) or a tautomer or salt thereof, wherein R 1 is selected from hydrogen, halogen, C 1-4 alkoxy, C 1-4 alklthio, C 1-4 alkyl, C 3-5 cycloalkyl, for example R1 is halogen such as chloro; R2 is C 1-4 alkyl, for example methyl, ethyl, i-propyl, n-propyl or butyl (any isomer), such as methyl; and R3 is selected from hydrogen, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkyl, C 3-5 cycloalkyl, for example C 1-4 alkyl such as methyl, ethyl, i-propyl, n-propyl or butyl (any isomer), for example methyl; crystalline forms thereof as well as chemical intermediates suitable for use in performing the process.
    • 本发明涉及制备具有式(I)或其互变异构体或其盐的某些取代的氨基嘧啶的新方法,其中R 1选自氢,卤素,C 1-4烷氧基,C 1-4烷硫基,C 1-4烷基, 5环烷基,例如R 1是卤素如氯; R 2是C 1-4烷基,例如甲基,乙基,异丙基,正丙基或丁基(任何异构体),例如甲基; 和R 3选自氢,C 1-4烷氧基,C 1-4烷硫基,C 1-4烷基,C 3-5环烷基,例如C 1-4烷基如甲基,乙基,异丙基,正丙基或丁基(任何异构体),例如 甲基; 其结晶形式以及适合用于执行该方法的化学中间体。