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31. 发明申请

WO2008124176A2 SOLUBLE AND MEMBRANE-ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS 审中-公开
标题翻译： LASSA病毒亚型蛋白质的可溶性和膜结合形式
公开(公告)号：WO2008124176A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/004622
申请日：2008-04-10
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , BRANCO, Luis, M. , MATSCHINER, Alexander , ILLICK, Megan, M. , SAMPEY, Darryl, B. , GARRY, Robert, F. , BAUSCH, Daniel, G. , FAIR, Joseph, N. , GUTTIERI, Mary, C. , CASHMAN, Kathleen, A. , WILSON, Russell, B. , KULAKOSKY, Peter, C. , GESKE, F., Jon
发明人： BRANCO, Luis, M. , MATSCHINER, Alexander , ILLICK, Megan, M. , SAMPEY, Darryl, B. , GARRY, Robert, F. , BAUSCH, Daniel, G. , FAIR, Joseph, N. , GUTTIERI, Mary, C. , CASHMAN, Kathleen, A. , WILSON, Russell, B. , KULAKOSKY, Peter, C. , GESKE, F., Jon
IPC分类号： C07K14/08 , A61K38/16 , A61K39/12
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C07K2319/24 , C07K2319/30 , C12N2760/10022 , C12N2760/10033 , G01N33/56983 , G01N2333/08
摘要： The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses.
摘要翻译：本发明公开了包含Lassa病毒（LASV）糖蛋白1（GP1），糖蛋白2（GP2），糖蛋白前体（GPC），核衣壳蛋白（NP）和编码这些蛋白质的核酸的可溶性和膜锚定形式的组合物。本发明还涉及使用这些组合物的诊断和预防方法。预防方法包括疫苗的制备以及抑制LASV感染性的因子（例如小分子）。此外，本发明涉及包括中和抗体在内的诊断和治疗性抗体，用于预防和治疗由LASV和其他的微卫星型病毒感染。

32. 发明申请

WO2008085494A1 SHORT BIO-ACTIVE PEPTIDES FOR CELLULAR AND IMMUNOLOGICAL MODULATION 审中-公开
标题翻译：短生物活性肽细胞和免疫调节
公开(公告)号：WO2008085494A1
公开(公告)日：2008-07-17
申请号：PCT/US2007/026368
申请日：2007-12-27
申请人： HELIX BIOMEDIX INC. , HARRIS, Scott, M. , ZHANG, Lijuan , FALLA, Timothy, J.
发明人： HARRIS, Scott, M. , ZHANG, Lijuan , FALLA, Timothy, J.
IPC分类号： C07K14/435 , A61K38/00
CPC分类号： C07K14/43563 , A61K38/00 , C07K5/1024 , C07K7/08
摘要： Peptides having four to fourteen residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory properties. As keratinocytes are especially sensitive to these effects, the disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.
摘要翻译：披露具有四至十四个残基的肽具有生物活性。这些肽构成肽HB-107（SEQ ID NO：1）的短片段，其本身是抗微生物蛋白质天蚕素B的片段，并且具有细胞刺激性，迁移性和抗炎性质。由于角质形成细胞对这些作用特别敏感，所公开的肽包括用于治疗皮肤损伤（例如糖尿病性溃疡）的有用试剂。这些肽也有效地预防和逆转由各种环境污染引起的皮肤表面损伤。重要的是，肽的治疗效果以等于或大于肽HB-107的浓度表现，因此代表开发有效疗法的较便宜，更通用的手段。还公开了生产和使用这些肽的方法。

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