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31. 发明申请

WO2017093469A1 RADIOTHERAPY PLANNING SYSTEMS 审中-公开
标题翻译：放射治疗计划系统
公开(公告)号：WO2017093469A1
公开(公告)日：2017-06-08
申请号：PCT/EP2016/079560
申请日：2016-12-02
申请人： ELEKTA AB (PUBL)
发明人： SJÖLUND, Jens
IPC分类号： A61N5/10
CPC分类号： A61N5/1001 , A61N5/1031 , A61N5/1038 , A61N5/1039 , A61N5/1084
摘要： Existing radiotherapy treatment planning protocols treat a cancer as a fixed entity within a "target volume". Efforts have been directed towards faster or more accurate planning processes and more accurate or reliable delivery methods. We propose a treatment planning system for a radiotherapy apparatus comprising a computational processor applying a set of instructions to an input data set, the input data set comprising a three-dimensional dose distribution which is to be achieved by the radiotherapy apparatus within a volume to be irradiated, a three-dimensional volume image characterising the tissue types within the volume to be irradiated, and a set of apparatus parameters which characterise the radiotherapy apparatus, with the set of instructions including a computational process arranged to output a treatment plan apt to deliver the three-dimensional dose distribution when implemented by the radiotherapy apparatus, by optimising a function that includes at least one term representing a time-dependent response of the tissue types to an applied radiation. The set of instructions can then include a fractional distribution step arranged to assign fractional parts of the dose distribution to successive treatment fractions, taking into account time- and dose-dependent characteristics of the tissue types within the volume image, and the iterative computational process can then be arranged, for each non-identical fraction, to take into account the fractional part of the dose distribution and the set of apparatus parameters, to derive a set of treatment instructions apt to deliver the fractional part when carried out by the radiotherapy apparatus. The three-dimensional volume image will ideally characterise the tissue types according to at least their local chemical composition, to assist in modelling the dose response. The optimisation function can include terms representing time-dependent responses such as a cell repair model and a tumour diffusion model.
摘要翻译：现有的放射治疗计划方案将癌症视为“目标体积”内的固定实体。已经致力于更快或更准确的计划流程以及更准确或可靠的递送方法。我们提出了一种用于放射治疗装置的治疗计划系统，该系统包括将一组指令应用于输入数据集的计算处理器，该输入数据集包括三维剂量分布，该三维剂量分布将由放射治疗装置在要处理的体积内实现照射表征待照射的体积内的组织类型的三维体积图像以及表征放射治疗设备的一组设备参数，其中该组指令包括计算过程，该计算过程被设置为输出适合于将放射治疗设备通过优化包括表示组织类型对所施加的辐射的时间相关响应的至少一个项的函数来优化由放射治疗设备实现的三维剂量分布。然后该组指令可以包括分数分布步骤，该分数分布步骤被布置为考虑体积图像内的组织类型的时间和剂量依赖特性，将剂量分布的分数部分分配给连续的处理部分，并且迭代计算过程可以然后针对每个不相同的部分设置考虑剂量分布的小数部分和设备参数组，以得到当由放射治疗设备执行时适于递送小数部分的一组治疗指令。根据至少它们的局部化学组成，三维体积图像将理想地表征组织类型，以帮助建模剂量响应。优化功能可以包括表示与时间相关的响应的术语，例如细胞修复模型和肿瘤扩散模型。

32. 发明申请

WO2015118021A1 IMAGE GUIDED RADIOTHERAPY 审中-公开
标题翻译：图像指导放射治疗
公开(公告)号：WO2015118021A1
公开(公告)日：2015-08-13
申请号：PCT/EP2015/052322
申请日：2015-02-04
申请人： ELEKTA AB (PUBL)
发明人： CARLSSON, Per
IPC分类号： A61N5/10
CPC分类号： A61N5/1082 , A61N5/103 , A61N5/1049 , A61N5/1067 , A61N2005/1061
摘要： A table with 6 degrees of freedom is regarded as essential in order to adjust the patient position to correct for positioning errors and the like. However, this imposes a significant cost, has a redundant axis in a conventional linac treatment system, and adds to the volume of the table. We disclose a way of dealing with rotation of the patient in an axis about which the source has a limited range of rotation, without needing a rotational adjustment of the table. An apparatus comprises a radiotherapy delivery apparatus having a radiation source adapted to emit a beam of radiation and to rotate around at least one axis that intersects with the beam, the rotation being confined to a limited range of rotation, an associated imaging device, and a control means controlling both the source and the imaging device, together with a treatment planning computer that accepts an image of a patient and parameters defining the machine capabilities, and creates a treatment plan based on both, wherein the source is capable of rotation in that axis through a range of at least x degrees, and a parameter is passed to the treatment planning computer defining the source's available range as x-e where e>0 , and the control means is adapted to detect the patient position using the imaging device, determine a rotation r of the patient around the axis relative to the image used by the treatment planning computer, and if r compensate for the rotation by offsetting the source by a rotation equal to r . The limited range of rotation is typically less than 360 degrees although this need not necessarily be the case. An example of the type of radiotherapy apparatus to which this invention is applicable is shown in our earlier patent application WO2005/041774, but it can equally be applied to other types.
摘要翻译：被认为是具有6个自由度的表以便调整患者位置以校正定位误差等。然而，这带来了显着的成本，在常规线性加速器处理系统中具有冗余轴，并增加了表的体积。我们公开了一种处理患者旋转轴的方式，围绕该轴旋转源具有有限的旋转范围，而不需要对该台的旋转调节。一种装置包括放射治疗输送装置，其具有适于发射辐射束的辐射源，并围绕与光束相交的至少一个轴线旋转，旋转被限制在有限的旋转范围内，相关的成像装置和控制装置同时控制源和成像装置，以及接受患者图像的治疗计划计算机和定义机器能力的参数，并且基于两者创建治疗计划，其中源能够在该轴上旋转通过至少x度的范围，并且将参数传递到定义源的可用范围的治疗计划计算机作为xe，其中e> 0，并且控制装置适于使用成像装置检测患者位置，确定旋转 r相对于治疗计划计算机使用的图像在轴线周围，并且如果r

33. 发明申请

WO2014154861A1 MARKERS, PHANTOMS AND ASSOCIATED METHODS FOR CALIBRATING IMAGING SYSTEMS 审中-公开
标题翻译：标记，用于校准成像系统的相关方法和相关方法
公开(公告)号：WO2014154861A1
公开(公告)日：2014-10-02
申请号：PCT/EP2014/056272
申请日：2014-03-28
申请人： ELEKTA AB
发明人： SELL, Martin , MILLS, David , BYRNE, Julian , ALLEN, John , ROBERTS, David Anthony
IPC分类号： A61B19/00 , G01R33/58 , A61B17/00
CPC分类号： A61B6/584 , A61B6/582 , A61B6/583 , A61B90/39 , A61B2017/00707 , A61B2017/00725 , A61B2090/3954 , A61B2090/3966 , A61B2090/3995 , A61N5/1075 , A61N2005/1076 , G01R33/4808 , G01R33/4812 , G01R33/58
摘要： Embodiments of the present invention provide markers, phantoms, and associated methods of calibration which are suitable for use in both medical resonance imaging and radiographic imaging systems. A marker (10) includes a first component (12) having a first hydrogen proton density and a first mass density; and a second component (14) having a second hydrogen proton density different than the first hydrogen proton density, and a second mass density different than the first mass density. The first and second components are non magnetic.
摘要翻译：本发明的实施例提供适用于医学共振成像和放射照相成像系统中的标记物，幽灵和相关联的校准方法。标记物（10）包括具有第一氢质子密度和第一质量密度的第一组分（12）和具有与第一氢质子密度不同的第二氢质子密度的第二组分（14）和不同于第一质量密度的第二质量密度。第一和第二组件是非磁性的。

34. 发明申请

WO2013159787A1 RADIOTHERAPY APPARATUS 审中-公开
标题翻译：放射治疗仪
公开(公告)号：WO2013159787A1
公开(公告)日：2013-10-31
申请号：PCT/EP2012/001767
申请日：2012-04-25
申请人： ELEKTA AB (PUBL) , CHEN, Rui
发明人： CHEN, Rui
IPC分类号： A61N5/10
CPC分类号： A61N5/1049
摘要： Patients are told to keep still during radiotherapy treatment, but they receive no feedback as to their position during the treatment. We propose a process of active position correction by the patient, based on movement feedback to the patient. To this end, we provide a radiotherapy apparatus comprising a source of radiation, a patient support for locating a patient in the field of the source of radiation, a position detector for determining a position of a patient on the patient support, a comparator for comparing the output of the position detector with a predetermined position, and a feedback system for informing the patient of the output of the comparator. The feedback system can comprise a visual display, or an audible signal, or a haptic response, or any combination of these.
摘要翻译：告诉患者在放疗期间保持静止，但在治疗期间他们没有收到关于其位置的反馈。我们提出了一个基于对患者的运动反馈的患者主动位置矫正的过程。为此，我们提供一种包括辐射源的放射治疗装置，用于将患者定位在辐射源领域的患者支架，用于确定患者在患者支架上的位置的位置检测器，比较器具有预定位置的位置检测器的输出，以及用于向患者通知比较器的输出的反馈系统。反馈系统可以包括视觉显示或听觉信号，或触觉响应，或这些的任何组合。

35. 发明申请

WO2012146262A1 IMPROVEMENTS IN OR RELATING TO RADIOTHERAPY 审中-公开
标题翻译：改善或相关放射治疗
公开(公告)号：WO2012146262A1
公开(公告)日：2012-11-01
申请号：PCT/EP2011/002130
申请日：2011-04-28
申请人： ELEKTA AB (publ) , CLAESSON, Bengt Ake
发明人： CLAESSON, Bengt Ake
IPC分类号： A61N5/10
CPC分类号： A61N5/1045
摘要： Radiotherapy apparatus is disclosed, comprising a radiation source capable of emitting a beam of therapeutic radiation along a beam axis, collimation apparatus for delimiting the beam and comprising (i) a block of sufficient width to extend across the width of the beam, selectively movable into the beam from a first side of the beam axis, and (ii) an array of individually moveable elongate narrow leaves arranged side-by-side in a direction perpendicular to the beam, each being moveable longitudinally into the beam from a second and opposing side of the beam axis, in which there is no array of individually moveable elongate narrow leaves arranged side-by-side in a direction perpendicular to the beam moveable longitudinally into the beam from the first side of the beam axis. Thus, there is in effect a single bank of MLC leaves on one side of the aperture and a block collimator on the other. This is suitable for IMRT-based treatments. The block and the array of individually moveable elongate narrow leaves can be the only collimation apparatus in the head, offering weight reductions and height reductions relative to known radiation heads. The block can comprise an adjustable section defining its leading edge, capable of adjustment so as to vary the angle between the leading edge and the beam axis. This allows the leading edge of the block to be aligned to the local beam direction regardless of how far into the beam the block is positioned. This reduces the penumbra of the block and creates a better definition of the radiation field. Alternatively, the block can comprise a plurality of plates stacked in the direction of the beam axis and moveable relative to each other so that the leading edge of the thus-defined block is adjustable so as to vary the angle between the leading edge and the beam axis.
摘要翻译：公开了放射治疗装置，其包括能够沿着光束轴发射治疗辐射束的辐射源，用于限定光束的准直装置，并且包括（i）足够宽度的块以跨过光束的宽度延伸，可选择性地移动到所述光束从所述光束轴线的第一侧起，以及（ii）在垂直于所述光束的方向上并排布置的可单独移动的细长窄叶片的阵列，每个可从第二和相对侧纵向移动到所述光束中其中在垂直于梁的方向上并排设置有单独可移动的细长窄叶片阵列，该波束从波束轴线的第一侧纵向移动到波束中。因此，实际上，一个单一的MLC叶片在孔的一侧留下，另一个是块准直器。这适用于基于IMRT的治疗。可单独移动的细长窄叶片的块和阵列可以是头部中唯一的准直装置，相对于已知的辐射头提供减重和降低高度。该块可以包括限定其前缘的可调节部分，其能够进行调节，以改变前缘和梁轴线之间的角度。这允许块的前沿与局部波束方向对准，而不管块被定位到多远的多远。这减少了块的半影，并创建了更好的辐射场定义。或者，块可以包括沿着梁轴线的方向堆叠的多个板，并且可以相对于彼此移动，使得如此限定的块的前缘是可调节的，以便改变前缘和梁之间的角度轴。

36. 发明申请

WO2012126587A3 LINEAR ACCELERATOR 审中-公开
公开(公告)号：WO2012126587A3
公开(公告)日：2012-09-27
申请号：PCT/EP2012/001117
申请日：2012-03-13
申请人： ELEKTA AB (PUBL) , ALLEN, John , LARGE, Terry Arthur
发明人： ALLEN, John , LARGE, Terry Arthur
IPC分类号： H05H7/18 , H05H7/22 , H05H9/04
摘要： The present invention provides a linear accelerator in which a rotatable conductive vane is employed to vary the electromagnetic coupling between adjacent accelerating cells. The vane is sealed off from the rest of the linear accelerator by an insulating partition, so the pressure around the vane can be higher than in the rest of the accelerator. This greatly simplifies the mechanisms which may be used to control the rotation of the vane, allowing a higher bakeout temperature in manufacture and a higher rate of rotation in use.

37. 发明申请

WO2011076271A1 EFFECTIVE VOLUME FILLING WITH TEMPLATES 审中-公开
标题翻译：有效的体积填充与模板
公开(公告)号：WO2011076271A1
公开(公告)日：2011-06-30
申请号：PCT/EP2009/067809
申请日：2009-12-22
申请人： ELEKTA AB (publ) , DANIELSSON, Karl , NORDSTRÖM, Håkan , SOMELL, Björn , LIDBERG, Pär
发明人： DANIELSSON, Karl , NORDSTRÖM, Håkan , SOMELL, Björn , LIDBERG, Pär
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1031
摘要： The present invention relates to the field of radiation therapy. In particular, the invention relates to a method and a dose planning module for planning a treatment session of a patient by means of a radiation therapy system com¬ prising a radiation therapy unit having a fixed radiation focus point. The method according to the invention comprises: obtaining a target volume of a region of a patient to be treated during a treatment of a patient in a radiation therapy unit, the target volume being modeled as a three-dimensional voxel representation; Selecting an isodose level for the planned treatment; determining shots to be delivered during the treatment, each shot being modelled by a spatial dose volume distribution of radiation represented by a three-dimensional voxel representation, the shape of the spatial distribution depending on the specific collimator setting and the selected isodose level; and selecting shots in a decreasing volume order for the dose planning comprising: d1) initiating a position search for a specific shot to find an accepted position within the target volume; d2) iteratively mapping different positions for the voxel representation of a current shot on the voxel representation of the target volume; d3) checking whether predetermined conditions for each specific position are satisfied; and d4) if the predetermined conditions are satisfied for a specific position, defining that position as an accepted position and continue with step d1) - d3) for a shot having the similar shape; or d5) if the predetermined conditions are not satisfied for any position within the target volume, continuing with step d1) - d4) for a subsequent shot in the decreasing volume order.
摘要翻译：本发明涉及放射治疗领域。特别地，本发明涉及一种用于通过具有固定辐射聚焦点的放射线治疗单元的辐射治疗系统来规划患者治疗过程的方法和剂量计划模块。根据本发明的方法包括：在放射治疗单元中的患者治疗期间获得要治疗的患者的区域的目标体积，所述目标体积被建模为三维体素表示; 为计划治疗选择等剂量水平; 确定在治疗期间要传送的射击，每个射击由由三维体素表示所表示的辐射的空间剂量体积分布建模，空间分布的形状取决于具体的准直仪设置和所选择的等剂量水平; 以及以剂量计划的递减量顺序选择镜头，其包括：d1）启动特定镜头的位置搜索以在所述目标体积内找到接受的位置; d2）迭代地映射目标体积的体素表示上的当前拍摄的体素表示的不同位置; d3）检查是否满足每个特定位置的预定条件; 和d4）如果对于特定位置满足预定条件，将该位置定义为接受位置，并且对于具有相似形状的镜头继续步骤d1）-d3）或d5），如果针对目标体积内的任何位置不满足预定条件，继续执行步骤d1）-d4），以减小音量顺序的后续拍摄。

38. 发明申请

WO2010031452A1 CALIBRATION METHOD 审中-公开
标题翻译：校准方法
公开(公告)号：WO2010031452A1
公开(公告)日：2010-03-25
申请号：PCT/EP2008/062644
申请日：2008-09-22
申请人： ELEKTA AB (publ) , MINOZ, Alain , BACKMAN, Gunnar
发明人： MINOZ, Alain , BACKMAN, Gunnar
IPC分类号： A61N5/10 , G01S7/497 , G01T1/24
CPC分类号： A61N5/1049 , A61N5/1084 , G01T7/005
摘要： The invention relates to a method for calibrating a measurement tool for measuring the radiation in a radiation system, such as a radiation therapy system. The measurement tool, including a holder and at least one photodiode element, is adapted to be mounted in a positioning unit of the radiation system. The radiation sensitive volume of the photodiode element is embedded in a light transparent coating transparent for, for instance, light in the visible spectrum. Thereby, the position of the sensitive volume can easily be determined or calculated with high accuracy relatively the holder on which the photodiode element is arranged, from which the position of the sensitive volume can be determined or calculated in relation to the positioning unit of the radiation system. The invention also relates to a calibration system for performing the calibration method and a measurement tool for use in the calibration system.
摘要翻译：本发明涉及一种用于校准测量工具的方法，该测量工具用于测量辐射系统（例如放射治疗系统）中的辐射。包括保持器和至少一个光电二极管元件的测量工具适于安装在辐射系统的定位单元中。光敏二极管元件的辐射敏感体积被嵌入透明的透明涂层中，例如可见光谱中的光。因此，相对于其上布置有光电二极管元件的保持器，可以以高精度容易地确定或计算灵敏体积的位置，从该位置可以相对于辐射的定位单元确定或计算灵敏体积的位置系统。本发明还涉及一种用于执行校准方法的校准系统和用于校准系统中的测量工具。

39. 发明申请

WO2009118021A8 RADIOTHERAPEUTIC TREATMENT PLANNING APPARATUS AND METHODS 审中-公开
公开(公告)号：WO2009118021A8
公开(公告)日：2009-10-01
申请号：PCT/EP2008/002340
申请日：2008-03-25
申请人： ELEKTA AB (publ) , ERIKSSON JÄRLIDEN, Andréas, Lars, Gunnar
发明人： ERIKSSON JÄRLIDEN, Andréas, Lars, Gunnar
IPC分类号： G06T7/00
摘要： A treatment planning apparatus comprises a means for receiving a three dimensional representation of a patient, a means for displaying at least a part of the representation, a means for user-designation of sub-regions of the representation, and a computing means adapted to segment the representation into a region within an anatomical structure and a region outside the anatomical structure on the basis of the locations of the sub-regions and the degree of similarity of voxels to neighbouring voxels in the representation. The treatment planning apparatus preferably further comprises means for designating sub- regions as being inside the structure, means for designating sub-regions as being outside the structure, and/or means for designating sub-regions as being at a border of the structure. In the latter case, we prefer that the size of border sub-regions is adjustable. The computing means can segment the representation by minimising a cost function. We also prefer that the initial values of the function in sub-regions designated as being in a border region are constrained to a different preset value. In an particularly useful aspect of this invention, after minimisation of the function the values in sub-regions designated as being in a border region are then un-constrained, the remaining values are constrained, and the function is then minimised a second time.

40. 发明申请

WO2009118020A1 3D MEDICAL IMAGE SEGMENTATION 审中-公开
标题翻译： 3D医学图像分割
公开(公告)号：WO2009118020A1
公开(公告)日：2009-10-01
申请号：PCT/EP2008002339
申请日：2008-03-25
申请人： ELEKTA AB , ERIKSSON JAERLIDEN ANDREAS LAR
发明人： ERIKSSON JAERLIDEN ANDREAS LAR
IPC分类号： G06T7/00
CPC分类号： G06T7/143 , G06T7/11 , G06T2200/24 , G06T2207/10076 , G06T2207/30016 , G06T2207/30061 , G06T2207/30068
摘要： A treatment planning apparatus comprises a means for receiving a three dimensional representation of a patient, a means for displaying at least a part of the representation, a means for user-designation of sub-regions of the representation, and a computing means adapted to segment the representation into a region within an anatomical structure and a region outside the anatomical structure on the basis of the locations of the sub-regions, the degree of similarity of voxels to neighbouring voxels in the representation, and a dataset representing an a priori assumption of the correct segmentation. The dataset preferably comprises a probability distribution of each pixel being within the segmentation, e.g. obtained from a segmentation of a previous image of the patient, for example by smoothing the previous segmentation. The at least part of the representation comprises one or more sections through the representation, such as axial, sagittal and/or coronal views of the patient. The computing means can segment the representation by minimising a function.
摘要翻译：治疗计划装置包括用于接收患者的三维表示的装置，用于显示表示的至少一部分的装置，用于表示的子区域的用户指定的装置，以及适于分段的计算装置基于子区域的位置，在解剖结构内的区域和解剖结构之外的区域的表示，表示中的体素与相邻体素的相似度，以及表示先验假设的数据集正确的分割。数据集优选地包括分割内的每个像素的概率分布，例如。从患者的先前图像的分割获得，例如通过平滑先前的分割。该表示的至少一部分包括通过该表示的一个或多个部分，例如患者的轴向，矢状和/或冠状视图。计算装置可以通过使功能最小化来分割表示。

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